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Papers authored by Gurney ME

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Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists.

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Hategan G, Polozov AM, Zeller W, Cao H, Mishra RK, Kiselyov AS, Ramirez J, Halldorsdottir G, Andrésson T, Gurney ME, and Singh J

Bioorganic & medicinal chemistry letters 19(23):6797-800, 2009 Dec 1 - Who cited this? | PubMed ID: 19836233 | Fulltext

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

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Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, and Stewart LJ

Journal of medicinal chemistry 52(15):4694-715, 2009 Aug 13 - Who cited this? | PubMed ID: 19618939 | Fulltext

3-Acrylamide-4-aryloxyindoles: Synthesis, biological evaluation and metabolic stability of potent and selective EP(3) receptor antagonists.

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Zhou N, Zeller W, Zhang J, Onua E, Kiselyov AS, Ramirez J, Palsdottir G, Halldorsdottir G, Andrésson T, Gurney ME, and Singh J

Bioorganic & medicinal chemistry letters 19(5):1528-31, 2009 Mar 1 - Who cited this? | PubMed ID: 19188065 | Fulltext

Peri-substituted hexahydro-indolones as novel, potent and selective human EP(3) receptor antagonists.

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O'Connell M, Zeller W, Burgeson J, Mishra RK, Ramirez J, Kiselyov AS, Andrésson T, Gurney ME, and Singh J

Bioorganic & medicinal chemistry letters 19(3):778-82, 2009 Feb 1 - Who cited this? | PubMed ID: 19121942 | Fulltext

3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists.

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Zhou N, Zeller W, Krohn M, Anderson H, Zhang J, Onua E, Kiselyov AS, Ramirez J, Halldorsdottir G, Andrésson T, Gurney ME, and Singh J

Bioorganic & medicinal chemistry letters 19(1):123-6, 2009 Jan 1 - Who cited this? | PubMed ID: 19022669 | Fulltext

DcpS as a Therapeutic Target for Spinal Muscular Atrophy.

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Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, and Gurney ME

ACS chemical biology, 2008 Oct 8 - Who cited this? | PubMed ID: 18839960 | Fulltext

Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy.

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Thurmond J, Butchbach ME, Palomo M, Pease B, Rao M, Bedell L, Keyvan M, Pai G, Mishra R, Haraldsson M, Andresson T, Bragason G, Thosteinsdottir M, Bjornsson JM, Coovert DD, Burghes AH,

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Journal of medicinal chemistry 51(3):449-69, 2008 Feb 14 - Who cited this? | PubMed ID: 18205293 | Fulltext

Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice.

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Bjarnadottir M, Misner DL, Haverfield-Gross S, Bruun S, Helgason VG, Stefansson H, Sigmundsson A, Firth DR, Nielsen B, Stefansdottir R, Novak TJ, Stefansson K, Gurney ME, and Andresson T

The Journal of neuroscience : the official journal of the Society for Neuroscience 27(17):4519, 2007 Apr 25 - Who cited this? | PubMed ID: 17460065 | Fulltext

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.

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Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson G, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Johannsson H, Gudmundsdottir O, Gurney ME,

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Nature genetics 36(3):233-9, 2004 Mar - Who cited this? | PubMed ID: 14770184 | Fulltext

Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans.

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Ellerbrock BR, Coscarelli EM, Gurney ME, and Geary TG

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 9(2):147-52, 2004 Mar - Who cited this? | PubMed ID: 15006138 | Fulltext

Neuregulin 1 and susceptibility to schizophrenia.

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Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A,

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American journal of human genetics 71(4):877-92, 2002 Oct - Who cited this? | PubMed ID: 12145742 | Fulltext

SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production.

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Li J, Pauley AM, Myers RL, Shuang R, Brashler JR, Yan R, Buhl AE, Ruble C, and Gurney ME

Journal of neurochemistry 82(6):1540-8, 2002 Sep - Who cited this? | PubMed ID: 12354302 | Fulltext

Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord.

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Olsen MK, Roberds SL, Ellerbrock BR, Fleck TJ, McKinley DK, and Gurney ME

Annals of neurology 50(6):730-40, 2001 Dec - Who cited this? | PubMed ID: 11761470 | Fulltext

Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brain.

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Carter DB, Dunn E, McKinley DD, Stratman NC, Boyle TP, Kuiper SL, Oostveen JA, Weaver RJ, Boller JA, and Gurney ME

Annals of neurology 50(4):468-75, 2001 Oct - Who cited this? | PubMed ID: 11601499 | Fulltext

Immunohistochemical study on the distribution of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation.

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Shin CM, Chung YH, Kim MJ, Shin DH, Kim YS, Gurney ME, Lee KW, and Cha CI

Brain research 887(2):309-15, 2000 Dec 29 - Who cited this? | PubMed ID: 11134620 | Fulltext

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

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Johnston JA, Dalton MJ, Gurney ME, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 97(23):12571, 2000 Nov 7 - Who cited this? | PubMed ID: 11050163 | Fulltext

Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly.

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Evans DB, Rank KB, Bhattacharya K, Thomsen DR, Gurney ME, and Sharma SK

The Journal of biological chemistry 275(32):24977-83, 2000 Aug 11 - Who cited this? | PubMed ID: 10818091 | Fulltext

Neurobiology. Stay the executioner's hand.

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Gurney ME, Tomasselli AG, and Heinrikson RL

Science (New York, N.Y.) 288(5464):283-4, 2000 Apr 14 - Who cited this? | PubMed ID: 10777410 | Fulltext

What transgenic mice tell us about neurodegenerative disease.

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Gurney ME

BioEssays : news and reviews in molecular, cellular and developmental biology 22(3):297-304, 2000 Mar - Who cited this? | PubMed ID: 10684590 | Fulltext

Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.

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Cha CI, Chung YH, Shin CM, Shin DH, Kim YS, Gurney ME, and Lee KW

Brain research 853(1):156-61, 2000 Jan 17 - Who cited this? | PubMed ID: 10627320 | Fulltext

Measurement of o- and m-tyrosine as markers of oxidative damage in motor neuron disease.

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Poljak A, Pamphlett R, Gurney ME, and Duncan MW

Redox report : communications in free radical research 5(2-3):137-40, 2000 - Who cited this? | PubMed ID: 10939295 | Fulltext

Reactive astrocytes express p53 in the spinal cord of transgenic mice expressing a human Cu/Zn SOD mutation.

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Cho KJ, Chung YH, Shin C, Shin DH, Kim YS, Gurney ME, Lee KW, and Cha CI

Neuroreport 10(18):3939-43, 1999 Dec 16 - Who cited this? | PubMed ID: 10716237 | Fulltext

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

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Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, and Gurney ME

Nature 402(6761):533-7, 1999 Dec 2 - Who cited this? | PubMed ID: 10591213 | Fulltext

Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.

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Facchinetti F, Sasaki M, Cutting FB, Zhai P, MacDonald JE, Reif D, Beal MF, Huang PL, Dawson TM, Gurney ME, and Dawson VL

Neuroscience 90(4):1483-92, 1999 - Who cited this? | PubMed ID: 10338314 | Fulltext

Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis.

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Andrus PK, Fleck TJ, Gurney ME, and Hall ED

Journal of neurochemistry 71(5):2041-8, 1998 Nov - Who cited this? | PubMed ID: 9798929 | Fulltext

Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis.

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Liu R, Althaus JS, Ellerbrock BR, Becker DA, and Gurney ME

Annals of neurology 44(5):763-70, 1998 Nov - Who cited this? | PubMed ID: 9818932 | Fulltext

Mutant CuZn superoxide dismutase in motor neuron disease.

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Gurney ME, Liu R, Althaus JS, Hall ED, and Becker DA

Journal of inherited metabolic disease 21(5):587-97, 1998 Aug - Who cited this? | PubMed ID: 9728338 | Fulltext

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.

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Hall ED, Oostveen JA, and Gurney ME

Glia 23(3):249-56, 1998 Jul - Who cited this? | PubMed ID: 9633809 | Fulltext

Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS.

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Hall ED, Andrus PK, Oostveen JA, Fleck TJ, and Gurney ME

Journal of neuroscience research 53(1):66-77, 1998 Jul 1 - Who cited this? | PubMed ID: 9670993 | Fulltext

Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice.

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Siklós L, Engelhardt JI, Alexianu ME, Gurney ME, Siddique T, and Appel SH

Journal of neuropathology and experimental neurology 57(6):571-87, 1998 Jun - Who cited this? | PubMed ID: 9630237 | Fulltext

Reactive astrocytes express nitric oxide synthase in the spinal cord of transgenic mice expressing a human Cu/Zn SOD mutation.

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Cha CI, Kim JM, Shin DH, Kim YS, Kim J, Gurney ME, and Lee KW

Neuroreport 9(7):1503-6, 1998 May 11 - Who cited this? | PubMed ID: 9631456 | Fulltext

Presence of Cu/Zn superoxide dismutase (SOD) immunoreactivity in neuronal hyaline inclusions in spinal cords from mice carrying a transgene for Gly93Ala mutant human Cu/Zn SOD.

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Shibata N, Hirano A, Kobayashi M, Dal Canto MC, Gurney ME, Komori T, Umahara T, and Asayama K

Acta neuropathologica 95(2):136-42, 1998 Feb - Who cited this? | PubMed ID: 9498047 | Fulltext

Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis.

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Gurney ME, Fleck TJ, Himes CS, and Hall ED

Neurology 50(1):62-6, 1998 Jan - Who cited this? | PubMed ID: 9443458 | Fulltext

The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies.

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Gurney ME

Journal of the neurological sciences 152 Suppl 1:S67-73, 1997 Oct - Who cited this? | PubMed ID: 9419057 | Fulltext

Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.

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Ferrante RJ, Shinobu LA, Schulz JB, Matthews RT, Thomas CE, Kowall NW, Gurney ME, and Beal MF

Annals of neurology 42(3):326-34, 1997 Sep - Who cited this? | PubMed ID: 9307254 | Fulltext

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis.

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Hottinger AF, Fine EG, Gurney ME, Zurn AD, and Aebischer P

The European journal of neuroscience 9(7):1548-51, 1997 Jul - Who cited this? | PubMed ID: 9240414 | Fulltext

A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis.

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Dal Canto MC and Gurney ME

Acta neuropathologica 93(6):537-50, 1997 Jun - Who cited this? | PubMed ID: 9194892 | Fulltext

Transgenic animal models of familial amyotrophic lateral sclerosis.

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Gurney ME

Journal of neurology 244 Suppl 2:S15-20, 1997 May - Who cited this? | PubMed ID: 9178166 | Fulltext

Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis.

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Kostic V, Gurney ME, Deng HX, Siddique T, Epstein CJ, and Przedborski S

Annals of neurology 41(4):497-504, 1997 Apr - Who cited this? | PubMed ID: 9124807 | Fulltext

Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease.

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Tu PH, Gurney ME, Julien JP, Lee VM, and Trojanowski JQ

Laboratory investigation; a journal of technical methods and pathology 76(4):441-56, 1997 Apr - Who cited this? | PubMed ID: 9111507 | Fulltext

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease.

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Mourelatos Z, Gonatas NK, Stieber A, Gurney ME, and Dal Canto MC

Proceedings of the National Academy of Sciences of the United States of America 93(11):5472-7, 1996 May 28 - Who cited this? | PubMed ID: 8643599 | Fulltext

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

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Tu PH, Raju P, Robinson KA, Gurney ME, Trojanowski JQ, and Lee VM

Proceedings of the National Academy of Sciences of the United States of America 93(7):3155-60, 1996 Apr 2 - Who cited this? | PubMed ID: 8610185 | Fulltext

Brain-derived neurotrophic factor transiently stabilizes silent synapses on developing neuromuscular junctions.

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Kwon YW and Gurney ME

Journal of neurobiology 29(4):503-16, 1996 Apr - Who cited this? | PubMed ID: 8656214 | Fulltext

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis.

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Gurney ME, Cutting FB, Zhai P, Doble A, Taylor CP, Andrus PK, and Hall ED

Annals of neurology 39(2):147-57, 1996 Feb - Who cited this? | PubMed ID: 8967745 | Fulltext

Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase.

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Gurney ME, Cutting FB, Zhai P, Andrus PK, and Hall ED

Pathologie-biologie 44(1):51-6, 1996 Jan - Who cited this? | PubMed ID: 8734301 | Fulltext

Leukemia inhibitory factor influences the timing of programmed synapses withdrawal from neonatal muscles.

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Kwon YW, Abbondanzo SJ, Stewart CL, and Gurney ME

Journal of neurobiology 28(1):35-50, 1995 Sep - Who cited this? | PubMed ID: 8586964 | Fulltext

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis.

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Chiu AY, Zhai P, Dal Canto MC, Peters TM, Kwon YW, Prattis SM, and Gurney ME

Molecular and cellular neurosciences 6(4):349-62, 1995 Aug - Who cited this? | PubMed ID: 8846004 | Fulltext

Single basic amino acid substitutions at position 302 or 320 in the V3 domain of HIV type 1 are not sufficient to alter the antiviral activity of dextran sulfate and heparin.

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Okada T and Gurney ME

AIDS research and human retroviruses 11(5):571-5, 1995 May - Who cited this? | PubMed ID: 7576913 | Fulltext

Inhibition of anti-V3 domain antibody binding to human immunodeficiency virus type-1-infected cells by sulfated polysaccharides.

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Okada T, Patterson BK, and Gurney ME

Biochemical and biophysical research communications 209(3):850-8, 1995 Apr 26 - Who cited this? | PubMed ID: 7537501 | Fulltext

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

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Dal Canto MC and Gurney ME

Brain research 676(1):25-40, 1995 Apr 3 - Who cited this? | PubMed ID: 7796176 | Fulltext

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