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Papers authored by Grover GJ

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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation (dagger) ( big up tri, open).

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Nirschl AA, Zou Y, Krystek SR, Sutton JC, Simpkins LM, Lupisella JA, Kuhns JE, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Egan D, Fura A, Vyas VP, Li YX,

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Journal of medicinal chemistry 52(9):2794-8, 2009 May 14 - Who cited this? | PubMed ID: 19351168 | Fulltext

Thyroid hormone antagonists: potential medical applications and structure activity relationships.

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Malm J, Färnegârdh M, Grover GJ, and Ladenson PW

Current medicinal chemistry 16(25):3258-66, 2009 - Who cited this? | PubMed ID: 19548868 | Fulltext

Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141.

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Bryzgalova G, Effendic S, Khan A, Rehnmark S, Barbounis P, Boulet J, Dong G, Singh R, Shapses S, Malm J, Webb P, Baxter JD, and Grover GJ

The Journal of steroid biochemistry and molecular biology 111(3-5):262-7, 2008 Sep - Who cited this? | PubMed ID: 18621127 | Fulltext

Energetic signalling in the control of mitochondrial F(1)F(0) ATP synthase activity in health and disease.

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Grover GJ, Marone PA, Koetzner L, and Seto-Young D

The international journal of biochemistry & cell biology 40(12):2698-701, 2008 - Who cited this? | PubMed ID: 18707016 | Fulltext

Pharmacological Profile of the Selective Mitochondrial FF ATP Hydrolase Inhibitor BMS-199264 in Myocardial Ischemia.

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Grover GJ and Malm J

Cardiovascular therapeutics 26(4):287-96, 2008 - Who cited this? | PubMed ID: 19035880 | Fulltext

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.

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Manfredi MC, Bi Y, Nirschl AA, Sutton JC, Seethala R, Golla R, Beehler BC, Sleph PG, Grover GJ, Ostrowski J, and Hamann LG

Bioorganic & medicinal chemistry letters 17(16):4487-90, 2007 Aug 15 - Who cited this? | PubMed ID: 17574413 | Fulltext

Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats.

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Grover GJ, Dunn C, Nguyen NH, Boulet J, Dong G, Domogauer J, Barbounis P, and Scanlan TS

The Journal of pharmacology and experimental therapeutics 322(1):385-90, 2007 Jul - Who cited this? | PubMed ID: 17440037 | Fulltext

Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.

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Li JJ, Sutton JC, Nirschl A, Zou Y, Wang H, Sun C, Pi Z, Johnson R, Krystek SR, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Fura A, Vyas VP,

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Journal of medicinal chemistry 50(13):3015-25, 2007 Jun 28 - Who cited this? | PubMed ID: 17552509 | Fulltext

Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes.

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Grover GJ, Mellström K, and Malm J

Current vascular pharmacology 5(2):141-54, 2007 Apr - Who cited this? | PubMed ID: 17430219 | Fulltext

Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.

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Ostrowski J, Kuhns JE, Lupisella JA, Manfredi MC, Beehler BC, Krystek SR, Bi Y, Sun C, Seethala R, Golla R, Sleph PG, Fura A, An Y, Kish KF, Sack JS, Mookhtiar KA,

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Endocrinology 148(1):4-12, 2007 Jan - Who cited this? | PubMed ID: 17008401 | Fulltext

Recent advances in the development of agonists selective for beta1-type thyroid hormone receptor.

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Malm J, Grover GJ, and Färnegårdh M

Mini reviews in medicinal chemistry 7(1):79-86, 2007 Jan - Who cited this? | PubMed ID: 17266640 | Fulltext

The isolated, perfused pseudo-working heart model.

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Grover GJ and Singh R

Methods in molecular medicine 139:145-50, 2007 - Who cited this? | PubMed ID: 18287669 | Fulltext

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.

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Sun C, Robl JA, Wang TC, Huang Y, Kuhns JE, Lupisella JA, Beehler BC, Golla R, Sleph PG, Seethala R, Fura A, Krystek SR, An Y, Malley MF, Sack JS, Salvati ME,

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Journal of medicinal chemistry 49(26):7596-9, 2006 Dec 28 - Who cited this? | PubMed ID: 17181141 | Fulltext

Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.

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Koehler K, Gordon S, Brandt P, Carlsson B, Bäcksbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Färnegårdh M, Rehnmark S, and Malm J

Journal of medicinal chemistry 49(23):6635-7, 2006 Nov 16 - Who cited this? | PubMed ID: 17154490 | Fulltext

Negative inotropic effects of C-type natriuretic peptide are attenuated in hypertrophied ventricular myocytes associated with reduced cyclic GMP production.

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Moalem J, Davidov T, Zhang Q, Grover GJ, Weiss HR, and Scholz PM

The Journal of surgical research 135(1):38-44, 2006 Sep - Who cited this? | PubMed ID: 16600302 | Fulltext

Mitochondrial ATP-sensitive potassium channels and mitochondrial protein kinase C: sometimes it's good to have a close neighbor.

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Grover GJ

American journal of physiology. Heart and circulatory physiology 290(5):H1752-3, 2006 May - Who cited this? | PubMed ID: 16603704 | Fulltext

Reduction of skeletal muscle atrophy by a proteasome inhibitor in a rat model of denervation.

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Beehler BC, Sleph PG, Benmassaoud L, and Grover GJ

Experimental biology and medicine (Maywood, N.J.) 231(3):335-41, 2006 Mar - Who cited this? | PubMed ID: 16514182 | Fulltext

Negative inotropic effect of low-dose ethanol in mouse ventricular myocytes is mediated by activation of endothelial nitric oxide synthase.

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Zhang S, Grover GJ, Stokes H, Scholz PM, and Weiss HR

Journal of cardiovascular pharmacology 46(3):343-7, 2005 Sep - Who cited this? | PubMed ID: 16116340 | Fulltext

Mitochondrial KATP channels in hindlimb remote ischemic preconditioning of skeletal muscle against infarction.

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Moses MA, Addison PD, Neligan PC, Ashrafpour H, Huang N, Zair M, Rassuli A, Forrest CR, Grover GJ, and Pang CY

American journal of physiology. Heart and circulatory physiology 288(2):H559-67, 2005 Feb - Who cited this? | PubMed ID: 15458954 | Fulltext

Development of the thyroid hormone receptor beta-subtype agonist KB-141: a strategy for body weight reduction and lipid lowering with minimal cardiac side effects.

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Grover GJ, Mellstrom K, and Malm J

Cardiovascular drug reviews 23(2):133-48, 2005 - Who cited this? | PubMed ID: 16007230 | Fulltext

Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity.

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Grover GJ, Atwal KS, Sleph PG, Wang FL, Monshizadegan H, Monticello T, and Green DW

American journal of physiology. Heart and circulatory physiology 287(4):H1747-55, 2004 Oct - Who cited this? | PubMed ID: 15371268 | Fulltext

Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine.

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Grover GJ, Egan DM, Sleph PG, Beehler BC, Chiellini G, Nguyen NH, Baxter JD, and Scanlan TS

Endocrinology 145(4):1656-61, 2004 Apr - Who cited this? | PubMed ID: 14701670 | Fulltext

Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.

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Atwal KS, Wang P, Rogers WL, Sleph P, Monshizadegan H, Ferrara FN, Traeger S, Green DW, and Grover GJ

Journal of medicinal chemistry 47(5):1081-4, 2004 Feb 26 - Who cited this? | PubMed ID: 14971888 | Fulltext

The mitochondrial K(ATP) channel opener BMS-191095 induces neuronal preconditioning.

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Kis B, Nagy K, Snipes JA, Rajapakse NC, Horiguchi T, Grover GJ, and Busija DW

Neuroreport 15(2):345-9, 2004 Feb 9 - Who cited this? | PubMed ID: 15076766 | Fulltext

[The effect of K(ATP)-channel activation on the electrical stability of myocardium in rats with postinfarction cardiosclerosis].

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Solenkova NV, Maslov LN, Serebrov VIu, Lishmanov AIu, Bogomaz SA, Gross GJ, and Grover GJ

Eksperimental'naia i klinicheskaia farmakologiia 67(3):10-3, 2004 - Who cited this? | PubMed ID: 15341059 | Fulltext

Sarcolemmal and mitochondrial effects of a KATP opener, P-1075, in "polarized" and "depolarized" Langendorff-perfused rat hearts.

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Jilkina O, Kuzio B, Grover GJ, Folmes CD, Kong HJ, and Kupriyanov VV

Biochimica et biophysica acta 1618(1):39-50, 2003 Dec 3 - Who cited this? | PubMed ID: 14643932 | Fulltext

Protective effect of mitochondrial KATP activation in an isolated gracilis model of ischemia and reperfusion in dogs.

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Grover GJ, Burkett DE, Parham CS, Scalese RJ, and Sadanaga KK

Journal of cardiovascular pharmacology 42(6):790-2, 2003 Dec - Who cited this? | PubMed ID: 14639102 | Fulltext

P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

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Oldenburg O, Yang XM, Krieg T, Garlid KD, Cohen MV, Grover GJ, and Downey JM

Journal of molecular and cellular cardiology 35(9):1035-42, 2003 Sep - Who cited this? | PubMed ID: 12967626 | Fulltext

Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability.

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Grover GJ, Mellström K, Ye L, Malm J, Li YL, Bladh LG, Sleph PG, Smith MA, George R, Vennström B, Mookhtiar K, Horvath R, Speelman J, Egan D, and Baxter JD

Proceedings of the National Academy of Sciences of the United States of America 100(17):10067-72, 2003 Aug 19 - Who cited this? | PubMed ID: 12888625 | Fulltext

K(ATP) opener-induced delayed cardioprotection: involvement of sarcolemmal and mitochondrial K(ATP) channels, free radicals and MEK1/2.

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Gross ER, Peart JN, Hsu AK, Grover GJ, and Gross GJ

Journal of molecular and cellular cardiology 35(8):985-92, 2003 Aug - Who cited this? | PubMed ID: 12878485 | Fulltext

Cardioselective sulfonylthiourea HMR 1098 blocks mitochondrial uncoupling induced by a KATP channel opener, P-1075, in beating rat hearts.

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Jilkina O, Kuzio B, Grover GJ, and Kupriyanov VV

Biochimica et biophysica acta 1638(2):121-8, 2003 Jul 14 - Who cited this? | PubMed ID: 12853117 | Fulltext

[Changes in cardiac resistance to arrhythmogenic effects during ATP-dependent K+ channel activation].

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Bogomaz SA, Maslov LN, Krylatov AV, Solenkova NV, Lishmanov AIu, Budankova EV, and Grover GJ

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk 89(4):409-19, 2003 Apr - Who cited this? | PubMed ID: 12966718 | Fulltext

In vivo characterization of the mitochondrial selective K(ATP) opener (3R)-trans-4-((4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1-benzopyran-6-carbonitril monohydrochloride (BMS-191095): cardioprotective, hemodynamic, and electrophysiological effects.

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Grover GJ, D'Alonzo AJ, Darbenzio RB, Parham CS, Hess TA, and Bathala MS

The Journal of pharmacology and experimental therapeutics 303(1):132-40, 2002 Oct - Who cited this? | PubMed ID: 12235243 | Fulltext

Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats.

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Neckár J, Szárszoi O, Koten L, Papousek F, Ost'ádal B, Grover GJ, and Kolár F

Cardiovascular research 55(3):567-75, 2002 Aug 15 - Who cited this? | PubMed ID: 12160954 | Fulltext

Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts.

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Jilkina O, Kuzio B, Grover GJ, and Kupriyanov VV

Journal of molecular and cellular cardiology 34(4):427-40, 2002 Apr - Who cited this? | PubMed ID: 11991732 | Fulltext

Pharmacologic profile of the selective mitochondrial-K(ATP) opener BMS-191095 for treatment of acute myocardial ischemia.

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Grover GJ and Atwal KS

Cardiovascular drug reviews 20(2):121-36, 2002 - Who cited this? | PubMed ID: 12177690 | Fulltext

Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

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Grover GJ, D'Alonzo AJ, Garlid KD, Bajgar R, Lodge NJ, Sleph PG, Darbenzio RB, Hess TA, Smith MA, Paucek P, and Atwal KS

The Journal of pharmacology and experimental therapeutics 297(3):1184-92, 2001 Jun - Who cited this? | PubMed ID: 11356945 | Fulltext

Ifetroban sodium: an effective TxA2/PGH2 receptor antagonist.

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Rosenfeld L, Grover GJ, and Stier CT

Cardiovascular drug reviews 19(2):97-115, 2001 - Who cited this? | PubMed ID: 11484065 | Fulltext

The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity.

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Trost SU, Swanson E, Gloss B, Wang-Iverson DB, Zhang H, Volodarsky T, Grover GJ, Baxter JD, Chiellini G, Scanlan TS, and Dillmann WH

Endocrinology 141(9):3057-64, 2000 Sep - Who cited this? | PubMed ID: 10965874 | Fulltext

The IF(1) inhibitor protein of the mitochondrial F(1)F(0)-ATPase.

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Green DW and Grover GJ

Biochimica et biophysica acta 1458(2-3):343-55, 2000 May 31 - Who cited this? | PubMed ID: 10838049 | Fulltext

ATP-Sensitive potassium channels: a review of their cardioprotective pharmacology.

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Grover GJ and Garlid KD

Journal of molecular and cellular cardiology 32(4):677-95, 2000 Apr - Who cited this? | PubMed ID: 10756123 | Fulltext

Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.

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Ding CZ, Rovnyak GC, Misra RN, Grover GJ, Miller AV, Ahmed SZ, Kelly Y, Normandin DE, Sleph PG, and Atwal KS

Journal of medicinal chemistry 42(18):3711-7, 1999 Sep 9 - Who cited this? | PubMed ID: 10479302 | Fulltext

Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.

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D'Alonzo AJ, Zhu JL, Darbenzio RB, Dorso CR, and Grover GJ

Journal of molecular and cellular cardiology 30(2):415-23, 1998 Feb - Who cited this? | PubMed ID: 9515018 | Fulltext

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

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Atwal KS, Grover GJ, Lodge NJ, Normandin DE, Traeger SC, Sleph PG, Cohen RB, Bryson CC, and Dickinson KE

Journal of medicinal chemistry 41(3):271-5, 1998 Jan 29 - Who cited this? | PubMed ID: 9464357 | Fulltext

Preconditioning in rat hearts is independent of mitochondrial F1F0 ATPase inhibition.

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Green DW, Murray HN, Sleph PG, Wang FL, Baird AJ, Rogers WL, and Grover GJ

The American journal of physiology 274(1 Pt 2):H90-7, 1998 Jan - Who cited this? | PubMed ID: 9458856 | Fulltext

Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.

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Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, and Grover GJ

Circulation research 81(6):1072-82, 1997 Dec - Who cited this? | PubMed ID: 9400389 | Fulltext

Comparison of the protective effects of a highly selective ATP-sensitive potassium channel opener and ischemic preconditioning in isolated human atrial muscle.

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Carr CS, Grover GJ, Pugsley WB, and Yellon DM

Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 11(3):473-8, 1997 Jul - Who cited this? | PubMed ID: 9310276 | Fulltext

Effect of timing of treatment of the glyburide-reversible cardioprotective activity of BMS-180448.

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Gomoll AW, Roth RA, Swillo RE, Baird AJ, Sargent CS, Behling RW, Malone HJ, and Grover GJ

The Journal of pharmacology and experimental therapeutics 281(1):24-33, 1997 Apr - Who cited this? | PubMed ID: 9103476 | Fulltext

Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.

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Grover GJ

Canadian journal of physiology and pharmacology 75(4):309-15, 1997 Apr - Who cited this? | PubMed ID: 9196857 | Fulltext

Adenosine A1 receptor blockade does not abolish the cardioprotective effects of the adenosine triphosphate-sensitive potassium channel opener bimakalim.

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Gross GJ, Mei DA, Sleph PG, and Grover GJ

The Journal of pharmacology and experimental therapeutics 280(2):533-40, 1997 Feb - Who cited this? | PubMed ID: 9023261 | Fulltext

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