Papers authored by Gottschling DE

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The mother enrichment program: a genetic system for facile replicative life span analysis in Saccharomyces cerevisiae.
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Lindstrom DL and Gottschling DE
Genetics 183(2):413-22, 1SI-13SI, 2009 Oct - Who cited this? | PubMed ID: 19652178 | Fulltext
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Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains.
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Dimitrov LN, Brem RB, Kruglyak L, and Gottschling DE
Genetics 183(1):365-83, 2009 Sep - Who cited this? | PubMed ID: 19581448 | Fulltext
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Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect.
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Veatch JR, McMurray MA, Nelson ZW, and Gottschling DE
Cell 137(7):1247-58, 2009 Jun 26 - Who cited this? | PubMed ID: 19563757 | Fulltext
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A mother's sacrifice: what is she keeping for herself?.
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Henderson KA and Gottschling DE
Current opinion in cell biology, 2008 Oct 23 - Who cited this? | PubMed ID: 18848886 | Fulltext
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A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.
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Andersen MP, Nelson ZW, Hetrick ED, and Gottschling DE
Genetics, 2008 Jun 18 - Who cited this? | PubMed ID: 18562670 | Fulltext
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Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.
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van Welsem T, Frederiks F, Verzijlbergen KF, Faber AW, Nelson ZW, Egan DA, Gottschling DE, and van Leeuwen F
Molecular and cellular biology 28(11):3861, 2008 Jun - Who cited this? | PubMed ID: 18391024 | Fulltext
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Does age influence loss of heterozygosity?.
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Carr LL and Gottschling DE
Experimental gerontology 43(3):123-9, 2008 Mar - Who cited this? | PubMed ID: 18054191 | Fulltext
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DNA repair: corrections in the golden years.
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Gottschling DE
Current biology : CB 16(22):R956-8, 2006 Nov 21 - Who cited this? | PubMed ID: 17113375 | Fulltext
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Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin.
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Gardner RG, Nelson ZW, and Gottschling DE
Molecular and cellular biology 25(14):6123-39, 2005 Jul - Who cited this? | PubMed ID: 15988024 | Fulltext
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Degradation-mediated protein quality control in the nucleus.
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Gardner RG, Nelson ZW, and Gottschling DE
Cell 120(6):803, 2005 Mar 25 - Who cited this? | PubMed ID: 15797381 | Fulltext
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Mutations in the nucleosome core enhance transcriptional silencing.
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Xu EY, Bi X, Holland MJ, Gottschling DE, and Broach JR
Molecular and cellular biology 25(5):1846-59, 2005 Mar - Who cited this? | PubMed ID: 15713639 | Fulltext
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Aging and genetic instability in yeast.
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McMurray MA and Gottschling DE
Current opinion in microbiology 7(6):673-9, 2004 Dec - Who cited this? | PubMed ID: 15556042 | Fulltext
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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.
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Schübeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen F, Gottschling DE, O'Neill LP, Turner BM, Delrow J, Bell SP, and Groudine M
Genes & development 18(11):1263, 2004 Jun 1 - Who cited this? | PubMed ID: 15175259 | Fulltext
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Genetic instability in aging yeast: a metastable hyperrecombinational state.
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McMurray MA and Gottschling DE
Cold Spring Harbor symposia on quantitative biology 69:339-47, 2004 - Who cited this? | PubMed ID: 16117666 | Fulltext
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Summary: epigenetics--from phenomenon to field.
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Gottschling DE
Cold Spring Harbor symposia on quantitative biology 69:507-19, 2004 - Who cited this? | PubMed ID: 16117688 | Fulltext
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Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.
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Stellwagen AE, Haimberger ZW, Veatch JR, and Gottschling DE
Genes & development 17(19):2384-95, 2003 Oct 1 - Who cited this? | PubMed ID: 12975323 | Fulltext
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An age-induced switch to a hyper-recombinational state.
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McMurray MA and Gottschling DE
Science (New York, N.Y.) 301(5641):1908-11, 2003 Sep 26 - Who cited this? | PubMed ID: 14512629 | Fulltext
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Mass spectrometric quantification of acetylation at specific lysines within the amino-terminal tail of histone H4.
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Smith CM, Gafken PR, Zhang Z, Gottschling DE, Smith JB, and Smith DL
Analytical biochemistry 316(1):23-33, 2003 May 1 - Who cited this? | PubMed ID: 12694723 | Fulltext
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The histone minority report: the variant shall not be silenced.
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van Leeuwen F and Gottschling DE
Cell 112(5):591-3, 2003 Mar 7 - Who cited this? | PubMed ID: 12628179 | Fulltext
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Heritable chromatin structure: mapping "memory" in histones H3 and H4.
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Smith CM, Haimberger ZW, Johnson CO, Wolf AJ, Gafken PR, Zhang Z, Parthun MR, and Gottschling DE
Proceedings of the National Academy of Sciences of the United States of America 99 Suppl 4:16454-61, 2002 Dec 10 - Who cited this? | PubMed ID: 12196632 | Fulltext
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Genome-wide histone modifications: gaining specificity by preventing promiscuity.
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van Leeuwen F and Gottschling DE
Current opinion in cell biology 14(6):756-62, 2002 Dec - Who cited this? | PubMed ID: 12473351 | Fulltext
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A quantitative assay for telomere protection in Saccharomyces cerevisiae.
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DuBois ML, Haimberger ZW, McIntosh MW, and Gottschling DE
Genetics 161(3):995-1013, 2002 Jul - Who cited this? | PubMed ID: 12136006 | Fulltext
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Dot1p modulates silencing in yeast by methylation of the nucleosome core.
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van Leeuwen F, Gafken PR, and Gottschling DE
Cell 109(6):745-56, 2002 Jun 14 - Who cited this? | PubMed ID: 12086673 | Fulltext
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Assays for gene silencing in yeast.
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van Leeuwen F and Gottschling DE
Methods in enzymology 350:165-86, 2002 - Who cited this? | PubMed ID: 12073311 | Fulltext
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Identification of a small molecule inhibitor of Sir2p.
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Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, and Simon JA
Proceedings of the National Academy of Sciences of the United States of America 98(26):15113, 2001 Dec 18 - Who cited this? | PubMed ID: 11752457 | Fulltext
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Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere.
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Diede SJ and Gottschling DE
Current biology : CB 11(17):1336-40, 2001 Sep 4 - Who cited this? | PubMed ID: 11553326 | Fulltext
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The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.
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Peterson SE, Stellwagen AE, Diede SJ, Singer MS, Haimberger ZW, Johnson CO, Tzoneva M, and Gottschling DE
Nature genetics 27(1):64-7, 2001 Jan - Who cited this? | PubMed ID: 11138000 | Fulltext
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Gene silencing: two faces of SIR2.
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Gottschling DE
Current biology : CB 10(19):R708-11, 2000 Oct 5 - Who cited this? | PubMed ID: 11050406 | Fulltext
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Type B histone acetyltransferase Hat1p participates in telomeric silencing.
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Kelly TJ, Qin S, Gottschling DE, and Parthun MR
Molecular and cellular biology 20(19):7051-8, 2000 Oct - Who cited this? | PubMed ID: 10982821 | Fulltext
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All things must end: telomere dynamics in yeast.
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DuBois ML, Diede SJ, Stellwagen AE, and Gottschling DE
Cold Spring Harbor symposia on quantitative biology 65:281-96, 2000 - Who cited this? | PubMed ID: 12760042 | Fulltext
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Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.
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Diede SJ and Gottschling DE
Cell 99(7):723-33, 1999 Dec 23 - Who cited this? | PubMed ID: 10619426 | Fulltext
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DOT4 links silencing and cell growth in Saccharomyces cerevisiae.
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Kahana A and Gottschling DE
Molecular and cellular biology 19(10):6608-20, 1999 Oct - Who cited this? | PubMed ID: 10490600 | Fulltext
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Telomeres: structure of a chromosome's aglet.
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Gottschling DE and Stoddard B
Current biology : CB 9(5):R164-7, 1999 Mar 11 - Who cited this? | PubMed ID: 10074444 | Fulltext
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Telomeric chromatin modulates replication timing near chromosome ends.
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Stevenson JB and Gottschling DE
Genes & development 13(2):146-51, 1999 Jan 15 - Who cited this? | PubMed ID: 9925638 | Fulltext
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Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.
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Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, Goggin C, Mahowald M, and Gottschling DE
Genetics 150(2):613-32, 1998 Oct - Who cited this? | PubMed ID: 9755194 | Fulltext
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Chromosome dynamics: yeast pulls it apart.
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Gottschling DE and Berg BL
Current biology : CB 8(3):R76-9, 1998 Jan 29 - Who cited this? | PubMed ID: 9443905 | Fulltext
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The ubiquitin-conjugating enzyme Rad6 (Ubc2) is required for silencing in Saccharomyces cerevisiae.
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Huang H, Kahana A, Gottschling DE, Prakash L, and Liebman SW
Molecular and cellular biology 17(11):6693-9, 1997 Nov - Who cited this? | PubMed ID: 9343433 | Fulltext
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The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism.
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Parthun MR, Widom J, and Gottschling DE
Cell 87(1):85-94, 1996 Oct 4 - Who cited this? | PubMed ID: 8858151 | Fulltext
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Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability.
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Sandell LL, Gottschling DE, and Zakian VA
Proceedings of the National Academy of Sciences of the United States of America 91(25):12061-5, 1994 Dec 6 - Who cited this? | PubMed ID: 7991584 | Fulltext
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TLC1: template RNA component of Saccharomyces cerevisiae telomerase.
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Singer MS and Gottschling DE
Science (New York, N.Y.) 266(5184):404-9, 1994 Oct 21 - Who cited this? | PubMed ID: 7545955 | Fulltext
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Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.
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Aparicio OM and Gottschling DE
Genes & development 8(10):1133-46, 1994 May 15 - Who cited this? | PubMed ID: 7926719 | Fulltext
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Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.
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Renauld H, Aparicio OM, Zierath PD, Billington BL, Chhablani SK, and Gottschling DE
Genes & development 7(7A):1133-45, 1993 Jul - Who cited this? | PubMed ID: 8319906 | Fulltext
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Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.
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Gottschling DE
Proceedings of the National Academy of Sciences of the United States of America 89(9):4062-5, 1992 May 1 - Who cited this? | PubMed ID: 1570334 | Fulltext
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Saccharomyces telomeres assume a non-nucleosomal chromatin structure.
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Wright JH, Gottschling DE, and Zakian VA
Genes & development 6(2):197-210, 1992 Feb - Who cited this? | PubMed ID: 1737616 | Fulltext
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Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.
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Aparicio OM, Billington BL, and Gottschling DE
Cell 66(6):1279-87, 1991 Sep 20 - Who cited this? | PubMed ID: 1913809 | Fulltext
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Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.
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Gottschling DE, Aparicio OM, Billington BL, and Zakian VA
Cell 63(4):751-62, 1990 Nov 16 - Who cited this? | PubMed ID: 2225075 | Fulltext
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Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA.
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Gottschling DE and Zakian VA
Cell 47(2):195-205, 1986 Oct 24 - Who cited this? | PubMed ID: 3094961 | Fulltext
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Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex.
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Gottschling DE and Cech TR
Cell 38(2):501-10, 1984 Sep - Who cited this? | PubMed ID: 6432344 | Fulltext
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Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila.
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Gottschling DE, Palen TE, and Cech TR
Nucleic acids research 11(7):2093-109, 1983 Apr 11 - Who cited this? | PubMed ID: 6835846 | Fulltext
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Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
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Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, and Cech TR
Cell 31(1):147, 1982 Nov - Who cited this? | PubMed ID: 6297745 | Fulltext
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