Papers authored by Goldberg AL

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Getting to first base in proteasome assembly.
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Besche HC, Peth A, and Goldberg AL
Cell 138(1):25-8, 2009 Jul 10 - Who cited this? | PubMed ID: 19596233 | Fulltext
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S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.
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Kim HT, Kim KP, Uchiki T, Gygi SP, and Goldberg AL
The EMBO journal 28(13):1867-77, 2009 Jul 8 - Who cited this? | PubMed ID: 19387488 | Fulltext
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During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.
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Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, and Goldberg AL
The Journal of cell biology 185(6):1083-95, 2009 Jun 15 - Who cited this? | PubMed ID: 19506036 | Fulltext
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The Ubiquitin-interacting Motif Protein, S5a, Is Ubiquitinated by All Types of Ubiquitin Ligases by a Mechanism Different from Typical Substrate Recognition.
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Uchiki T, Kim HT, Zhai B, Gygi SP, Johnston JA, O'Bryan JP, and Goldberg AL
The Journal of biological chemistry 284(19):12622-32, 2009 May 8 - Who cited this? | PubMed ID: 19240029 | Fulltext
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Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins.
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Medicherla B and Goldberg AL
The Journal of cell biology 182(4):663, 2008 Aug 25 - Who cited this? | PubMed ID: 18725537 | Fulltext
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Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases.
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Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, and Cheng Y
Molecular cell 30(3):360-8, 2008 May 9 - Who cited this? | PubMed ID: 18471981 | Fulltext
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Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle.
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Anderson SB, Goldberg AL, and Whitman M
The Journal of biological chemistry 283(11):7027-35, 2008 Mar 14 - Who cited this? | PubMed ID: 18175804 | Fulltext
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
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Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, 
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Autophagy 4(2):151 - Who cited this? | PubMed ID: 18188003 | Fulltext
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Coordinate activation of autophagy and the proteasome pathway by foxO transcription factor.
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Zhao J, Brault JJ, Schild A, and Goldberg AL
Autophagy 4(3):378-80, 2008 - Who cited this? | PubMed ID: 18227643 | Fulltext
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The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
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Evnouchidou I, Momburg F, Papakyriakou A, Chroni A, Leondiadis L, Chang SC, Goldberg AL, and Stratikos E
PLoS ONE 3(11):e3658, 2008 - Who cited this? | PubMed ID: 18987748 | Fulltext
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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo.
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Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, and Sandri M
Cell metabolism 6(6):458-71, 2007 Dec - Who cited this? | PubMed ID: 18054315 | Fulltext
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FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells.
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Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, and Goldberg AL
Cell metabolism 6(6):472-83, 2007 Dec - Who cited this? | PubMed ID: 18054316 | Fulltext
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On prions, proteasomes, and mad cows.
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Goldberg AL
The New England journal of medicine 357(11):1150-2, 2007 Sep 13 - Who cited this? | PubMed ID: 17855677 | Fulltext
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Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.
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Smith DM, Chang SC, Park S, Finley D, Cheng Y, and Goldberg AL
Molecular cell 27(5):731-44, 2007 Sep 7 - Who cited this? | PubMed ID: 17803938 | Fulltext
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ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea.
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Horwitz AA, Navon A, Groll M, Smith DM, Reis C, and Goldberg AL
The Journal of biological chemistry 282(31):22921-9, 2007 Aug 3 - Who cited this? | PubMed ID: 17553803 | Fulltext
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Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.
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Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, and Goldberg AL
The Journal of biological chemistry 282(24):17375, 2007 Jun 15 - Who cited this? | PubMed ID: 17426036 | Fulltext
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Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation.
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Bhutani N, Venkatraman P, and Goldberg AL
The EMBO journal 26(5):1385-96, 2007 Mar 7 - Who cited this? | PubMed ID: 17318184 | Fulltext
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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy.
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Goldberg AL
Biochemical Society transactions 35(Pt 1):12-7, 2007 Feb - Who cited this? | PubMed ID: 17212580 | Fulltext
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Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases.
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Sacheck JM, Hyatt JP, Raffaello A, Jagoe RT, Roy RR, Edgerton VR, Lecker SH, and Goldberg AL
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21(1):140-55, 2007 Jan - Who cited this? | PubMed ID: 17116744 | Fulltext
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New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis.
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Liu CH, Goldberg AL, and Qiu XB
Chang Gung medical journal 30(6):469-79, 2007 - Who cited this? | PubMed ID: 18350730 | Fulltext
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hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.
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Qiu XB, Ouyang SY, Li CJ, Miao S, Wang L, and Goldberg AL
The EMBO journal 25(24):5742-53, 2006 Dec 13 - Who cited this? | PubMed ID: 17139257 | Fulltext
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PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
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Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, and Spiegelman BM
Proceedings of the National Academy of Sciences of the United States of America 103(44):16260, 2006 Oct 31 - Who cited this? | PubMed ID: 17053067 | Fulltext
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Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.
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York IA, Bhutani N, Zendzian S, Goldberg AL, and Rock KL
Journal of immunology (Baltimore, Md. : 1950) 177(3):1434-43, 2006 Aug 1 - Who cited this? | PubMed ID: 16849449 | Fulltext
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Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
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Lecker SH, Goldberg AL, and Mitch WE
Journal of the American Society of Nephrology : JASN 17(7):1807, 2006 Jul - Who cited this? | PubMed ID: 16738015 | Fulltext
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Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate.
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Kisselev AF, Callard A, and Goldberg AL
The Journal of biological chemistry 281(13):8582, 2006 Mar 31 - Who cited this? | PubMed ID: 16455650 | Fulltext
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ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.
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Smith DM, Kafri G, Cheng Y, Ng D, Walz T, and Goldberg AL
Molecular cell 20(5):687, 2005 Dec 9 - Who cited this? | PubMed ID: 16337593 | Fulltext
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The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.
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Chang SC, Momburg F, Bhutani N, and Goldberg AL
Proceedings of the National Academy of Sciences of the United States of America 102(47):17107-12, 2005 Nov 22 - Who cited this? | PubMed ID: 16286653 | Fulltext
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The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling.
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Skurk C, Izumiya Y, Maatz H, Razeghi P, Shiojima I, Sandri M, Sato K, Zeng L, Schiekofer S, Pimentel D, Lecker S, Taegtmeyer H, Goldberg AL, and Walsh K
The Journal of biological chemistry 280(21):20814, 2005 May 27 - Who cited this? | PubMed ID: 15781459 | Fulltext
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Nobel committee tags ubiquitin for distinction.
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Goldberg AL
Neuron 45(3):339, 2005 Feb 3 - Who cited this? | PubMed ID: 15694320 | Fulltext
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The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9.
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Qiu XB and Goldberg AL
The Journal of biological chemistry 280(1):174-82, 2005 Jan 7 - Who cited this? | PubMed ID: 15507451 | Fulltext
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Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates.
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Kisselev AF and Goldberg AL
Methods in enzymology 398:364, 2005 - Who cited this? | PubMed ID: 16275343 | Fulltext
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Preparation of hybrid (19S-20S-PA28) proteasome complexes and analysis of peptides generated during protein degradation.
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Cascio P and Goldberg AL
Methods in enzymology 398:336-52, 2005 - Who cited this? | PubMed ID: 16275341 | Fulltext
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Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases.
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Saric T, Graef CI, and Goldberg AL
The Journal of biological chemistry 279(45):46723-32, 2004 Nov 5 - Who cited this? | PubMed ID: 15328361 | Fulltext
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IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.
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Sacheck JM, Ohtsuka A, McLary SC, and Goldberg AL
American journal of physiology. Endocrinology and metabolism 287(4), 2004 Oct - Who cited this? | PubMed ID: 15100091 | Fulltext
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Post-proteasomal antigen processing for major histocompatibility complex class I presentation.
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Rock KL, York IA, and Goldberg AL
Nature immunology 5(7):670-7, 2004 Jul - Who cited this? | PubMed ID: 15224092 | Fulltext
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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
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Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, and Goldberg AL
Cell 117(3):399-412, 2004 Apr 30 - Who cited this? | PubMed ID: 15109499 | Fulltext
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Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.
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Venkatraman P, Wetzel R, Tanaka M, Nukina N, and Goldberg AL
Molecular cell 14(1):95-104, 2004 Apr 9 - Who cited this? | PubMed ID: 15068806 | Fulltext
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Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones.
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Kandror O, Bretschneider N, Kreydin E, Cavalieri D, and Goldberg AL
Molecular cell 13(6):771-81, 2004 Mar 26 - Who cited this? | PubMed ID: 15053871 | Fulltext
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Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.
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Qiu XB, Markant SL, Yuan J, and Goldberg AL
The EMBO journal 23(4):800, 2004 Feb 25 - Who cited this? | PubMed ID: 14765125 | Fulltext
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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.
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Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, and Goldberg AL
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18(1):39-51, 2004 Jan - Who cited this? | PubMed ID: 14718385 | Fulltext
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Protein degradation and protection against misfolded or damaged proteins.
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Goldberg AL
Nature 426(6968):895, 2003 Dec 18 - Who cited this? | PubMed ID: 14685250 | Fulltext
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The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.
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Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, and Goldberg AL
The Journal of biological chemistry 278(38):35869, 2003 Sep 19 - Who cited this? | PubMed ID: 12815064 | Fulltext
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TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k.
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Li YP, Lecker SH, Chen Y, Waddell ID, Goldberg AL, and Reid MB
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17(9):1048-57, 2003 Jun - Who cited this? | PubMed ID: 12773487 | Fulltext
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The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation.
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York IA, Mo AX, Lemerise K, Zeng W, Shen Y, Abraham CR, Saric T, Goldberg AL, and Rock KL
Immunity 18(3):429-40, 2003 Mar - Who cited this? | PubMed ID: 12648459 | Fulltext
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ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation.
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Benaroudj N, Zwickl P, Seemüller E, Baumeister W, and Goldberg AL
Molecular cell 11(1):69, 2003 Jan - Who cited this? | PubMed ID: 12535522 | Fulltext
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Slowing muscle atrophy: putting the brakes on protein breakdown.
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Lecker SH and Goldberg AL
The Journal of physiology 545(Pt 3):729, 2002 Dec 15 - Who cited this? | PubMed ID: 12482881 | Fulltext
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An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.
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Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, and Goldberg AL
Nature immunology 3(12):1169-76, 2002 Dec - Who cited this? | PubMed ID: 12436109 | Fulltext
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The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.
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York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, and Rock KL
Nature immunology 3(12):1177-84, 2002 Dec - Who cited this? | PubMed ID: 12436110 | Fulltext
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Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3.
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Qiu XB and Goldberg AL
Proceedings of the National Academy of Sciences of the United States of America 99(23):14843, 2002 Nov 12 - Who cited this? | PubMed ID: 12411582 | Fulltext
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Patterns of gene expression in atrophying skeletal muscles: response to food deprivation.
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Jagoe RT, Lecker SH, Gomes M, and Goldberg AL
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16(13):1697-712, 2002 Nov - Who cited this? | PubMed ID: 12409312 | Fulltext
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