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Papers authored by Freeman GJ

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T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.

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Dekruyff RH, Bu X, Ballesteros A, Santiago C, Chim YL, Lee HH, Karisola P, Pichavant M, Kaplan GG, Umetsu DT, Freeman GJ, and Casasnovas JM

Journal of immunology (Baltimore, Md. : 1950) 184(4):1918-30, 2010 Feb 15 - Who cited this? | PubMed ID: 20083673 | Fulltext

Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion.

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Blackburn SD, Crawford A, Shin H, Polley A, Freeman GJ, and Wherry EJ

Journal of virology 84(4):2078-89, 2010 Feb - Who cited this? | PubMed ID: 19955307 | Fulltext

PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions.

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Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, and Dekruyff RH

Mucosal immunology 3(1):81-91, 2010 Jan - Who cited this? | PubMed ID: 19741598 | Fulltext

Inhibitory TCR Coreceptor PD-1 Is a Sensitive Indicator of Low-Level Replication of SIV and HIV-1.

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Salisch NC, Kaufmann DE, Awad AS, Reeves RK, Tighe DP, Li Y, Piatak M, Lifson JD, Evans DT, Pereyra F, Freeman GJ, and Johnson RP

Journal of immunology (Baltimore, Md. : 1950) 184(1):476-87, 2010 Jan 1 - Who cited this? | PubMed ID: 19949078 | Fulltext

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.

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Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, and Sharpe AH

The Journal of experimental medicine 206(13):3015-29, 2009 Dec 21 - Who cited this? | PubMed ID: 20008522 | Fulltext

Dual Control of Antitumor CD8 T Cells through the Programmed Death-1/Programmed Death-Ligand 1 Pathway and Immunosuppressive CD4 T Cells: Regulation and Counterregulation.

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Currie AJ, Prosser A, McDonnell A, Cleaver AL, Robinson BW, Freeman GJ, and van der Most RG

Journal of immunology (Baltimore, Md. : 1950) 183(12):7898-908, 2009 Dec 15 - Who cited this? | PubMed ID: 20007574 | Fulltext

Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells.

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Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, and Gordon LK

Investigative ophthalmology & visual science 50(10):4941-8, 2009 Oct - Who cited this? | PubMed ID: 19420345 | Fulltext

Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.

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Sauce D, Larsen M, Abbott RJ, Hislop AD, Leese AM, Khan N, Papagno L, Freeman GJ, and Rickinson AB

Journal of virology 83(18):9068-78, 2009 Sep - Who cited this? | PubMed ID: 19605492 | Fulltext

Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.

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Brainard DM, Seung E, Frahm N, Cariappa A, Bailey CC, Hart WK, Shin HS, Brooks SF, Knight HL, Eichbaum Q, Yang YG, Sykes M, Walker BD, Freeman GJ, Pillai S, Westmoreland SV,

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Journal of virology 83(14):7305-21, 2009 Jul - Who cited this? | PubMed ID: 19420076 | Fulltext

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.

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Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH,

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Proceedings of the National Academy of Sciences of the United States of America 106(26):10734-9, 2009 Jun 30 - Who cited this? | PubMed ID: 19528638 | Fulltext

The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation.

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Cai G and Freeman GJ

Immunological reviews 229(1):244-58, 2009 May - Who cited this? | PubMed ID: 19426226 | Fulltext

Enhancing SIV-specific immunity in vivo by PD-1 blockade.

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Velu V, Titanji K, Zhu B, Husain S, Pladevega A, Lai L, Vanderford TH, Chennareddi L, Silvestri G, Freeman GJ, Ahmed R, and Amara RR

Nature 458(7235):206-10, 2009 Mar 12 - Who cited this? | PubMed ID: 19078956 | Fulltext

Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade.

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Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, and Turley SJ

Journal of immunology (Baltimore, Md. : 1950) 182(4):2102-12, 2009 Feb 15 - Who cited this? | PubMed ID: 19201863 | Fulltext

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade.

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Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, Kaminski M, Gostick E, Price DA, Freeman GJ, Wherry EJ, and Chang KM

PLoS pathogens 5(2):e1000313, 2009 Feb - Who cited this? | PubMed ID: 19247441 | Fulltext

Coregulation of CD8(+) T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

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Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, and Wherry EJ

Nature immunology 10(1):29-37, 2009 Jan - Who cited this? | PubMed ID: 19043418 | Fulltext

Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis.

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Chen L, Pai V, Levinson R, Sharpe AH, Freeman GJ, Braun J, and Gordon LK

Ocular immunology and inflammation 17(1):47-55, 2009 - Who cited this? | PubMed ID: 19294574 | Fulltext

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection.

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Brooks DG, Ha SJ, Elsaesser H, Sharpe AH, Freeman GJ, and Oldstone MB

Proceedings of the National Academy of Sciences of the United States of America 105(51):20428-33, 2008 Dec 23 - Who cited this? | PubMed ID: 19075244 | Fulltext

Simian Immunodeficiency Virus (SIV)-specific CD8+ T cell responses in chronically SIVagm-infected vervet African green monkeys.

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Zahn RC, Rett MD, Korioth-Schmitz B, Sun Y, Buzby AP, Goldstein S, Brown CR, Byrum RA, Freeman GJ, Letvin NL, Hirsch VM, and Schmitz JE

Journal of virology, 2008 Oct 1 - Who cited this? | PubMed ID: 18829748 | Fulltext

Selective expansion of a subset of exhausted CD8 T cells by {alpha}PD-L1 blockade.

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Blackburn SD, Shin H, Freeman GJ, and Wherry EJ

Proceedings of the National Academy of Sciences of the United States of America, 2008 Sep 22 - Who cited this? | PubMed ID: 18809920 | Fulltext

Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.

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Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, and Miao CH

Blood 112(5):1662-72, 2008 Sep 1 - Who cited this? | PubMed ID: 18574023 | Fulltext

Telomerase activity of HIV-1-specific CD8+ T cells: Constitutive upregulation in controllers and selective increase by blockade of PD ligand 1 in progressors.

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Lichterfeld M, Mou D, Cung TD, Williams KL, Waring MT, Huang J, Pereyra F, Trocha A, Freeman GJ, Rosenberg ES, Walker BD, and Yu XG

Blood, 2008 Aug 26 - Who cited this? | PubMed ID: 18728248 | Fulltext

Interaction of human PD-L1 and B7-1.

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Butte MJ, Peña-Cruz V, Kim MJ, Freeman GJ, and Sharpe AH

Molecular immunology 45(13):3567, 2008 Aug - Who cited this? | PubMed ID: 18585785 | Fulltext

Impaired HCV specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection.

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Radziewicz H, Ibegbu CC, Hon H, Osborn MK, Obideen K, Wehbi M, Freeman GJ, Lennox JL, Workowski KA, Hanson HL, and Grakoui A

Journal of virology, 2008 Jul 30 - Who cited this? | PubMed ID: 18667503 | Fulltext

Structures of PD-1 with its ligands: sideways and dancing cheek to cheek.

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Freeman GJ

Proceedings of the National Academy of Sciences of the United States of America 105(30):10275, 2008 Jul 29 - Who cited this? | PubMed ID: 18650389 | Fulltext

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.

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Haspot F, Fehr T, Gibbons C, Zhao G, Hogan T, Honjo T, Freeman GJ, and Sykes M

Blood, 2008 Jun 24 - Who cited this? | PubMed ID: 18577709 | Fulltext

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization.

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Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, and Chang KM

Gastroenterology 134(7):1927, 2008 Jun - Who cited this? | PubMed ID: 18549878 | Fulltext

Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection.

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Bowen DG, Shoukry NH, Grakoui A, Fuller MJ, Cawthon AG, Dong C, Hasselschwert DL, Brasky KM, Freeman GJ, Seth NP, Wucherpfennig KW, Houghton M, and Walker CM

Journal of virology 82(10):5109-14, 2008 May - Who cited this? | PubMed ID: 18337576 | Fulltext

ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.

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Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, and DeKruyff RH

Journal of immunology (Baltimore, Md. : 1950) 180(8):5448, 2008 Apr 15 - Who cited this? | PubMed ID: 18390727 | Fulltext

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection.

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Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, and Ahmed R

The Journal of experimental medicine 205(3):543, 2008 Mar 17 - Who cited this? | PubMed ID: 18332181 | Fulltext

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.

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Lázár-Molnár E, Gácser A, Freeman GJ, Almo SC, Nathenson SG, and Nosanchuk JD

Proceedings of the National Academy of Sciences of the United States of America 105(7):2658, 2008 Feb 19 - Who cited this? | PubMed ID: 18268348 | Fulltext

CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.

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Cai G, Anumanthan A, Brown JA, Greenfield EA, Zhu B, and Freeman GJ

Nature immunology 9(2):176-85, 2008 Feb - Who cited this? | PubMed ID: 18193050 | Fulltext

TIM gene family and their role in atopic diseases.

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Umetsu DT, Umetsu SE, Freeman GJ, and DeKruyff RH

Current topics in microbiology and immunology 321:201, 2008 - Who cited this? | PubMed ID: 18727494 | Fulltext

PD-1 and its ligands in tolerance and immunity.

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Keir ME, Butte MJ, Freeman GJ, and Sharpe AH

Annual review of immunology 26:677-704, 2008 - Who cited this? | PubMed ID: 18173375 | Fulltext

TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells.

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Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT,

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Immunity 27(6):927-40, 2007 Dec - Who cited this? | PubMed ID: 18082433 | Fulltext

Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds.

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Santiago C, Ballesteros A, Martínez-Muñoz L, Mellado M, Kaplan GG, Freeman GJ, and Casasnovas JM

Immunity 27(6):941-51, 2007 Dec - Who cited this? | PubMed ID: 18083575 | Fulltext

Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction.

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Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, Moss K,

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Nature immunology 8(11):1246-54, 2007 Nov - Who cited this? | PubMed ID: 17906628 | Fulltext

Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart.

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Grabie N, Gotsman I, DaCosta R, Pang H, Stavrakis G, Butte MJ, Keir ME, Freeman GJ, Sharpe AH, and Lichtman AH

Circulation 116(18):2062-71, 2007 Oct 30 - Who cited this? | PubMed ID: 17938288 | Fulltext

PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues.

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Keir ME, Freeman GJ, and Sharpe AH

Journal of immunology (Baltimore, Md. : 1950) 179(8):5064-70, 2007 Oct 15 - Who cited this? | PubMed ID: 17911591 | Fulltext

PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.

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Sauce D, Almeida JR, Larsen M, Haro L, Autran B, Freeman GJ, and Appay V

AIDS (London, England) 21(15):2005-13, 2007 Oct 1 - Who cited this? | PubMed ID: 17885290 | Fulltext

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.

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Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, and Ahmed R

Proceedings of the National Academy of Sciences of the United States of America 104(39):15430-5, 2007 Sep 25 - Who cited this? | PubMed ID: 17878315 | Fulltext

The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival.

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Shen L, Jin Y, Freeman GJ, Sharpe AH, and Dana MR

Journal of immunology (Baltimore, Md. : 1950) 179(6):3672, 2007 Sep 15 - Who cited this? | PubMed ID: 17785803 | Fulltext

In-fusion assembly: seamless engineering of multidomain fusion proteins, modular vectors, and mutations.

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Zhu B, Cai G, Hall EO, and Freeman GJ

BioTechniques 43(3):354-9, 2007 Sep - Who cited this? | PubMed ID: 17907578 | Fulltext

A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.

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Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, and Najafian N

Journal of immunology (Baltimore, Md. : 1950) 179(2):786-96, 2007 Jul 15 - Who cited this? | PubMed ID: 17617568 | Fulltext

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.

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Butte MJ, Keir ME, Phamduy TB, Sharpe AH, and Freeman GJ

Immunity 27(1):111-22, 2007 Jul - Who cited this? | PubMed ID: 17629517 | Fulltext

Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination.

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Velu V, Kannanganat S, Ibegbu C, Chennareddi L, Villinger F, Freeman GJ, Ahmed R, and Amara RR

Journal of virology 81(11):5819-28, 2007 Jun - Who cited this? | PubMed ID: 17376899 | Fulltext

Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions.

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Tami C, Silberstein E, Manangeeswaran M, Freeman GJ, Umetsu SE, DeKruyff RH, Umetsu DT, and Kaplan GG

Journal of virology 81(7):3437, 2007 Apr - Who cited this? | PubMed ID: 17229699 | Fulltext

Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.

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Tzachanis D, Li L, Lafuente EM, Berezovskaya A, Freeman GJ, and Boussiotis VA

Blood 109(7):2944-52, 2007 Apr 1 - Who cited this? | PubMed ID: 17164348 | Fulltext

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection.

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Sharpe AH, Wherry EJ, Ahmed R, and Freeman GJ

Nature immunology 8(3):239-45, 2007 Mar - Who cited this? | PubMed ID: 17304234 | Fulltext

PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.

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Maier H, Isogawa M, Freeman GJ, and Chisari FV

Journal of immunology (Baltimore, Md. : 1950) 178(5):2714-20, 2007 Mar 1 - Who cited this? | PubMed ID: 17312113 | Fulltext

Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.

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Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, Hanson HL, Steinberg JP, Masopust D, Wherry EJ, Altman JD, Rouse BT, Freeman GJ, Ahmed R, and Grakoui A

Journal of virology 81(6):2545-53, 2007 Mar - Who cited this? | PubMed ID: 17182670 | Fulltext

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