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Papers authored by Fraefel C

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Functional roles of the tegument proteins of herpes simplex virus type 1.

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Kelly BJ, Fraefel C, Cunningham AL, and Diefenbach RJ

Virus research 145(2):173-86, 2009 Nov - Who cited this? | PubMed ID: 19615419 | Fulltext

Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/{beta}-Catenin Signaling Pathway.

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Saydam O, Shen Y, Würdinger T, Senol O, Boke E, James MF, Tannous BA, Stemmer-Rachamimov AO, Yi M, Stephens RM, Fraefel C, Gusella JF, Krichevsky AM, and Breakefield XO

Molecular and cellular biology 29(21):5923-40, 2009 Nov - Who cited this? | PubMed ID: 19703993 | Fulltext

Definition of herpes simplex virus type 1 helper activities for adeno-associated virus early replication events.

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Alazard-Dany N, Nicolas A, Ploquin A, Strasser R, Greco A, Epstein AL, Fraefel C, and Salvetti A

PLoS pathogens 5(3):e1000340, 2009 Mar - Who cited this? | PubMed ID: 19282980 | Fulltext

Cloning of Bovine herpesvirus type 1 and type 5 as infectious bacterial artifical chromosomes.

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Gabev E, Fraefel C, Ackermann M, and Tobler K

BMC research notes 2:209, 2009 - Who cited this? | PubMed ID: 19828032 | Fulltext

Live visualization of herpes simplex virus type 1 compartment dynamics.

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de Oliveira AP, Glauser DL, Laimbacher AS, Strasser R, Schraner EM, Wild P, Ziegler U, Breakefield XO, Ackermann M, and Fraefel C

Journal of virology 82(10):4974, 2008 May - Who cited this? | PubMed ID: 18337577 | Fulltext

Targeted integration of functional human ATM cDNA into genome mediated by HSV/AAV hybrid amplicon vector.

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Cortés ML, Oehmig A, Saydam O, Sanford JD, Perry KF, Fraefel C, and Breakefield XO

Molecular therapy : the journal of the American Society of Gene Therapy 16(1):81, 2008 Jan - Who cited this? | PubMed ID: 17998902 | Fulltext

HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation.

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Saydam O, Saydam N, Glauser DL, Pruschy M, Dinh-Van V, Hilbe M, Jacobs AH, Ackermann M, and Fraefel C

Gene therapy 14(15):1143-51, 2007 Aug - Who cited this? | PubMed ID: 17495946 | Fulltext

Gene delivery using helper virus-free HSV-1 amplicon vectors.

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Fraefel C

Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] Chapter 4, 2007 Jul - Who cited this? | PubMed ID: 18428655 | Fulltext

Integration of active human beta-galactosidase gene (100 kb) into genome using HSV/AAV amplicon vector.

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Oehmig A, Cortés ML, Perry KF, Sena-Esteves M, Fraefel C, and Breakefield XO

Gene therapy 14(14):1078-91, 2007 Jul - Who cited this? | PubMed ID: 17460718 | Fulltext

Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector.

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Kummer C, Winkeler A, Dittmar C, Bauer B, Rueger MA, Rueckriem B, Heneka MT, Vollmar S, Wienhard K, Fraefel C, Heiss WD, and Jacobs AH

Molecular imaging : official journal of the Society for Molecular Imaging 6(3):181 - Who cited this? | PubMed ID: 17532884 | Fulltext

Live covisualization of competing adeno-associated virus and herpes simplex virus type 1 DNA replication: molecular mechanisms of interaction.

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Glauser DL, Strasser R, Laimbacher AS, Saydam O, Clément N, Linden RM, Ackermann M, and Fraefel C

Journal of virology 81(9):4732-43, 2007 May - Who cited this? | PubMed ID: 17314170 | Fulltext

Imaging-guided gene therapy of experimental gliomas.

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Jacobs AH, Rueger MA, Winkeler A, Li H, Vollmar S, Waerzeggers Y, Rueckriem B, Kummer C, Dittmar C, Klein M, Heneka MT, Herrlinger U, Fraefel C, Graf R, Wienhard K, and Heiss WD

Cancer research 67(4):1706, 2007 Feb 15 - Who cited this? | PubMed ID: 17308112 | Fulltext

Switching on the lights for gene therapy.

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Winkeler A, Sena-Esteves M, Paulis LE, Li H, Waerzeggers Y, Rückriem B, Himmelreich U, Klein M, Monfared P, Rueger MA, Heneka M, Vollmar S, Hoehn M, Fraefel C, Graf R, Wienhard K,

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PLoS ONE 2(6), 2007 - Who cited this? | PubMed ID: 17565381 | Fulltext

Chimeric herpes simplex virus/adeno-associated virus amplicon vectors.

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Glauser DL, Ackermann M, Saydam O, and Fraefel C

Current gene therapy 6(3):315-24, 2006 Jun - Who cited this? | PubMed ID: 16787183 | Fulltext

Herpes simplex virus type-1 amplicon vectors for vaccine generation in acute lymphoblastic leukemia.

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Zibert A, Thomassen A, Müller L, Nguyen L, Glouchkova L, Fraefel C, Roskrow M, Meisel R, and Dilloo D

Gene therapy 12(23):1707-17, 2005 Dec - Who cited this? | PubMed ID: 16034459 | Fulltext

Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo.

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Saydam O, Glauser DL, Heid I, Turkeri G, Hilbe M, Jacobs AH, Ackermann M, and Fraefel C

Molecular therapy : the journal of the American Society of Gene Therapy 12(5):803-12, 2005 Nov - Who cited this? | PubMed ID: 16112910 | Fulltext

Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins.

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Glauser DL, Saydam O, Balsiger NA, Heid I, Linden RM, Ackermann M, and Fraefel C

Journal of virology 79(19):12218, 2005 Oct - Who cited this? | PubMed ID: 16160148 | Fulltext

Herpes simplex virus 1 envelopment follows two diverse pathways.

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Leuzinger H, Ziegler U, Schraner EM, Fraefel C, Glauser DL, Heid I, Ackermann M, Mueller M, and Wild P

Journal of virology 79(20):13047-59, 2005 Oct - Who cited this? | PubMed ID: 16189007 | Fulltext

In vivo gene transfer to the rat retina using herpes simplex virus type 1 (HSV-1)-based amplicon vectors.

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Fraefel C, Mendes-Madeira A, Mabon O, Lefebvre A, Le Meur G, Ackermann M, Moullier P, and Rolling F

Gene therapy 12(16):1283-8, 2005 Aug - Who cited this? | PubMed ID: 15889134 | Fulltext

Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors.

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Rueger MA, Winkeler A, Miletic H, Kaestle C, Richter R, Schneider G, Hilker R, Heneka MT, Ernestus RI, Hampl JA, Fraefel C, and Jacobs AH

Gene therapy 12(7):588, 2005 Apr - Who cited this? | PubMed ID: 15674397 | Fulltext

Gene transfer into hepatocytes mediated by herpes simplex virus-Epstein-Barr virus hybrid amplicons.

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Müller L, Saydam O, Saeki Y, Heid I, and Fraefel C

Journal of virological methods 123(1):65-72, 2005 Jan - Who cited this? | PubMed ID: 15582700 | Fulltext

Herpes simplex virus type 1 amplicons and their hybrid virus partners, EBV, AAV, and retrovirus.

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Oehmig A, Fraefel C, Breakefield XO, and Ackermann M

Current gene therapy 4(4):385-408, 2004 Dec - Who cited this? | PubMed ID: 15578989 | Fulltext

Update on herpesvirus amplicon vectors.

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Oehmig A, Fraefel C, and Breakefield XO

Molecular therapy : the journal of the American Society of Gene Therapy 10(4):630-43, 2004 Oct - Who cited this? | PubMed ID: 15451447 | Fulltext

Spatial and temporal organization of adeno-associated virus DNA replication in live cells.

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Fraefel C, Bittermann AG, Büeler H, Heid I, Bächi T, and Ackermann M

Journal of virology 78(1):389-98, 2004 Jan - Who cited this? | PubMed ID: 14671120 | Fulltext

Construction of HSV-1 BACs and their use for packaging of HSV-1-based amplicon vectors.

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Heister TG, Vögtlin A, Müller L, Heid I, and Fraefel C

Methods in molecular biology (Clifton, N.J.) 256:241-56, 2004 - Who cited this? | PubMed ID: 15024170 | Fulltext

Assessment of a cellular vaccination approach consisting of crawling dendritic cells (CDCs) transduced with HSV-1-Deltapac vectors.

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Nuñez R, Fraefel C, Suter M, Nuñez-Liman A, Liou HC, and Ackerman M

Immunologic research 30(1):105-24, 2004 - Who cited this? | PubMed ID: 15258314 | Fulltext

One giant genomic leap for gene transfer technology.

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Ackermann M and Fraefel C

Molecular therapy : the journal of the American Society of Gene Therapy 7(5 Pt 1):571, 2003 May - Who cited this? | PubMed ID: 12718898 | Fulltext

Gene delivery using helper virus-free HSV-1 amplicon vectors.

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Fraefel C

Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] Chapter 12, 2002 Aug - Who cited this? | PubMed ID: 18428323 | Fulltext

Herpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19.

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Heister T, Heid I, Ackermann M, and Fraefel C

Journal of virology 76(14):7163-73, 2002 Jul - Who cited this? | PubMed ID: 12072516 | Fulltext

HSV-1-based amplicon particles are able to transduce cells of feline origin with genes encoding biologically functional feline IL-10 or IL-6.

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Vögtlin A, Fraefel C, Kocherhans R, Leutenegger CM, Frei K, Fontana A, and Ackermann M

Veterinary microbiology 86(1-2):103-13, 2002 Apr 22 - Who cited this? | PubMed ID: 11888694 | Fulltext

Transduction of Vero cells and bovine monocytes with a herpes simplex virus-1 based amplicon carrying the gene for the bovine herpesvirus-1 Circ protein.

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Schwyzer M, Fischer-Bracher C, Fraefel C, Bächi T, Nuñez R, Engels M, and Ackermann M

Veterinary microbiology 86(1-2):165-74, 2002 Apr 22 - Who cited this? | PubMed ID: 11888699 | Fulltext

Herpesviruses: balance in power and powers imbalanced.

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Ackermann M, Engels M, Fraefel C, Metzler A, Schwyzer M, Suter M, and Tobler K

Veterinary microbiology 86(1-2):175-81, 2002 Apr 22 - Who cited this? | PubMed ID: 11888700 | Fulltext

Quantification of feline herpesvirus 1 DNA in ocular fluid samples of clinically diseased cats by real-time TaqMan PCR.

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Vögtlin A, Fraefel C, Albini S, Leutenegger CM, Schraner E, Spiess B, Lutz H, and Ackermann M

Journal of clinical microbiology 40(2):519-23, 2002 Feb - Who cited this? | PubMed ID: 11825966 | Fulltext

Herpes simplex virus type 1 amplicon vector-mediated gene transfer to muscle.

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Wang Y, Mukherjee S, Fraefel C, Breakefield XO, and Allen PD

Human gene therapy 13(2):261-73, 2002 Jan 20 - Who cited this? | PubMed ID: 11812282 | Fulltext

HSV-1 amplicon vectors.

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Wang S, Fraefel C, and Breakefield X

Methods in enzymology 346:593-603, 2002 - Who cited this? | PubMed ID: 11883093 | Fulltext

Herpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use.

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Costantini LC, Fraefel C, Breakefield XO, and Isacson O

Methods in molecular medicine 69:461-79, 2002 - Who cited this? | PubMed ID: 11987795 | Fulltext

Flow cytometric assessment of transduction efficiency and cytotoxicity of herpes simplex virus type 1-based amplicon vectors.

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Nunez R, Ackermann M, Saeki Y, Chiocca A, and Fraefel C

Cytometry 44(2):93-9, 2001 Jun 1 - Who cited this? | PubMed ID: 11378858 | Fulltext

Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome.

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Saeki Y, Fraefel C, Ichikawa T, Breakefield XO, and Chiocca EA

Molecular therapy : the journal of the American Society of Gene Therapy 3(4):591-601, 2001 Apr - Who cited this? | PubMed ID: 11319922 | Fulltext

HSV-1 amplicon vectors--simplicity and versatility.

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Sena-Esteves M, Saeki Y, Fraefel C, and Breakefield XO

Molecular therapy : the journal of the American Society of Gene Therapy 2(1):9-15, 2000 Jul - Who cited this? | PubMed ID: 10899823 | Fulltext

Helper virus-free herpes simplex virus type 1 amplicon vectors for granulocyte-macrophage colony-stimulating factor-enhanced vaccination therapy for experimental glioma.

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Herrlinger U, Jacobs A, Quinones A, Woiciechowsky C, Sena-Esteves M, Rainov NG, Fraefel C, and Breakefield XO

Human gene therapy 11(10):1429-38, 2000 Jul 1 - Who cited this? | PubMed ID: 10910140 | Fulltext

HSV-1 amplicon vectors are a highly efficient gene delivery system for skeletal muscle myoblasts and myotubes.

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Wang Y, Fraefel C, Protasi F, Moore RA, Fessenden JD, Pessah IN, DiFrancesco A, Breakefield X, and Allen PD

American journal of physiology. Cell physiology 278(3):C619-26, 2000 Mar - Who cited this? | PubMed ID: 10712251 | Fulltext

HSV-1 infected cell proteins influence tetracycline-regulated transgene expression.

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Herrlinger U, Pechan PA, Jacobs AH, Woiciechowski C, Rainov NG, Fraefel C, Paulus W, and Reeves SA

The journal of gene medicine 2(5):379-89, 2000 - Who cited this? | PubMed ID: 11045432 | Fulltext

Herpes simplex virus type 1-based amplicon vector systems.

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Fraefel C, Jacoby DR, and Breakefield XO

Advances in virus research 55:425-51, 2000 - Who cited this? | PubMed ID: 11050950 | Fulltext

HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.

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Jacobs A, Breakefield XO, and Fraefel C

Neoplasia (New York, N.Y.) 1(5):387-401, 1999 Nov - Who cited this? | PubMed ID: 10933054 | Fulltext

HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part II. Vector systems and applications.

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Jacobs A, Breakefield XO, and Fraefel C

Neoplasia (New York, N.Y.) 1(5):402-16, 1999 Nov - Who cited this? | PubMed ID: 10933055 | Fulltext

BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1.

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Suter M, Lew AM, Grob P, Adema GJ, Ackermann M, Shortman K, and Fraefel C

Proceedings of the National Academy of Sciences of the United States of America 96(22):12697-702, 1999 Oct 26 - Who cited this? | PubMed ID: 10535985 | Fulltext

Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors.

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Costantini LC, Jacoby DR, Wang S, Fraefel C, Breakefield XO, and Isacson O

Human gene therapy 10(15):2481-94, 1999 Oct 10 - Who cited this? | PubMed ID: 10543613 | Fulltext

Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment.

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Persichetti F, Trettel F, Huang CC, Fraefel C, Timmers HT, Gusella JF, and MacDonald ME

Neurobiology of disease 6(5):364-75, 1999 Oct - Who cited this? | PubMed ID: 10527804 | Fulltext

Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors.

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Saeki Y, Ichikawa T, Saeki A, Chiocca EA, Tobler K, Ackermann M, Breakefield XO, and Fraefel C

Human gene therapy 9(18):2787-94, 1998 Dec 10 - Who cited this? | PubMed ID: 9874276 | Fulltext

A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma.

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Rainov NG, Sena-Esteves M, Fraefel C, Dobberstein KU, Chiocca EA, and Breakefield XO

Advances in experimental medicine and biology 451:393-403, 1998 - Who cited this? | PubMed ID: 10026902 | Fulltext

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