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Papers authored by Flint OP

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Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.

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Zheng M, Wang J, Lubinski J, Flint OP, Krishna R, Yao M, Pursley JM, Thakur A, Boulton DW, Santone KS, Barten DM, Anderson JJ, Felsenstein KM, and Hansel SB

Xenobiotica; the fate of foreign compounds in biological systems 39(7):544-55, 2009 Jul - Who cited this? | PubMed ID: 19480557 | Fulltext

The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular Mechanisms and Clinical Implications.

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Flint OP, Noor MA, Hruz PW, Hylemon PB, Yarasheski K, Kotler DP, Parker RA, and Bellamine A

Toxicologic pathology 37(1):65-77, 2009 - Who cited this? | PubMed ID: 19171928 | Fulltext

Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes.

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Meng W, Ellsworth BA, Nirschl AA, McCann PJ, Patel M, Girotra RN, Wu G, Sher PM, Morrison EP, Biller SA, Zahler R, Deshpande PP, Pullockaran A, Hagan DL, Morgan N, Taylor JR,

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Journal of medicinal chemistry 51(5):1145-9, 2008 Mar 13 - Who cited this? | PubMed ID: 18260618 | Fulltext

Effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity: demonstrable differences in vitro and clinically.

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Noor MA, Flint OP, Maa JF, and Parker RA

AIDS (London, England) 20(14):1813-21, 2006 Sep 11 - Who cited this? | PubMed ID: 16954722 | Fulltext

Endoplasmic reticulum stress links dyslipidemia to inhibition of proteasome activity and glucose transport by HIV protease inhibitors.

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Parker RA, Flint OP, Mulvey R, Elosua C, Wang F, Fenderson W, Wang S, Yang WP, and Noor MA

Molecular pharmacology 67(6):1909-19, 2005 Jun - Who cited this? | PubMed ID: 15755908 | Fulltext

Workshop overview: scientific and regulatory challenges for the reduction, refinement, and replacement of animals in toxicity testing.

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Purchase IF, Botham PA, Bruner LH, Flint OP, Frazier JM, and Stokes WS

Toxicological sciences : an official journal of the Society of Toxicology 43(2):86-101, 1998 Jun - Who cited this? | PubMed ID: 9710950 | Fulltext

Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.

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Flint OP, Masters BA, Gregg RE, and Durham SK

Toxicology and applied pharmacology 145(1):91-8, 1997 Jul - Who cited this? | PubMed ID: 9221828 | Fulltext

HMG CoA reductase inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture.

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Flint OP, Masters BA, Gregg RE, and Durham SK

Toxicology and applied pharmacology 145(1):99-110, 1997 Jul - Who cited this? | PubMed ID: 9221829 | Fulltext

Analysis of the steady-state dynamics of organelle motion in cultured neurites: putative indicator of neurotoxic effect.

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Chute SK, Flint OP, and Durham SK

Clinical and experimental pharmacology & physiology 22(5):360-1, 1995 May - Who cited this? | PubMed ID: 7554429 | Fulltext

In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes.

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Masters BA, Palmoski MJ, Flint OP, Gregg RE, Wang-Iverson D, and Durham SK

Toxicology and applied pharmacology 131(1):163-74, 1995 Mar - Who cited this? | PubMed ID: 7878672 | Fulltext

In vitro tests for teratogens: desirable endpoints, test batteries and current status of the micromass teratogen test.

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Flint OP

Reproductive toxicology (Elmsford, N.Y.) 7 Suppl 1:103-11, 1993 - Who cited this? | PubMed ID: 8400628 | Fulltext

Midbrain micromass cultures: a model for studies of teratogenic and sub-teratogenic effects on CNS development.

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Walum E and Flint OP

Acta physiologica Scandinavica. Supplementum 592:61-72, 1990 - Who cited this? | PubMed ID: 2267944 | Fulltext

Teratogenicity of phenylhydantoins in an in vitro system: molecular orbital-generated quantitative structure-toxicity relationships.

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Brown LP, Lewis DF, Flint OP, Orton TC, and Gibson GG

Xenobiotica; the fate of foreign compounds in biological systems 19(12):1471-81, 1989 Dec - Who cited this? | PubMed ID: 2618094 | Fulltext

In vitro toxicology: a commercial proposition?.

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Flint OP

Xenobiotica; the fate of foreign compounds in biological systems 18(6):707-14, 1988 Jun - Who cited this? | PubMed ID: 3420946 | Fulltext

Prediction of phototoxic potential using human A431 cells and mouse 3T3 cells.

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Duffy PA, Bennett A, Roberts M, and Flint OP

Molecular toxicology 1(4):579-87, 1987 - Who cited this? | PubMed ID: 3509704 | Fulltext

An in vitro test for teratogens: its practical application.

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Flint OP

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 24(6-7):627-31, 1986 - Who cited this? | PubMed ID: 3781419 | Fulltext

In vitro metabolism of teratogens by differentiating rat embryo cells.

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Brown LP, Flint OP, Orton TC, and Gibson GG

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 24(6-7):737-42, 1986 - Who cited this? | PubMed ID: 3781427 | Fulltext

Chemical teratogenesis: testing methods and the role of metabolism.

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Brown LP, Flint OP, Orton TC, and Gibson GG

Drug metabolism reviews 17(3-4):221-60, 1986 - Who cited this? | PubMed ID: 3552539 | Fulltext

An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells.

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Flint OP and Orton TC

Toxicology and applied pharmacology 76(2):383-95, 1984 Nov - Who cited this? | PubMed ID: 6495342 | Fulltext

Differentation of rat embryo cells in culture: response following acute maternal exposure to teratogens and non-teratogens.

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Flint OP, Orton TC, and Ferguson RA

Journal of applied toxicology : JAT 4(2):109-16, 1984 Apr - Who cited this? | PubMed ID: 6736551 | Fulltext

Myogenic cell movement in the developing avian limb bud in presence and absence of the apical ectodermal ridge (AER).

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Gumpel-Pinot M, Ede DA, and Flint OP

Journal of embryology and experimental morphology 80:105-25, 1984 Apr - Who cited this? | PubMed ID: 6747521 | Fulltext

Interactions between differentiating nerve and limb cells in vitro: implications for limb pattern formation.

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Flint OP

Progress in clinical and biological research 151:399-408, 1984 - Who cited this? | PubMed ID: 6473375 | Fulltext

Orientated movement of myogenic cells in the avian limb bud and its dependence on presence of the apical ectodermal ridge.

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Ede DA, Gumpel Pinot M, and Flint OP

Progress in clinical and biological research 151:427-38, 1984 - Who cited this? | PubMed ID: 6473377 | Fulltext

A micromass culture method for rat embryonic neural cells.

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Flint OP

Journal of cell science 61:247-62, 1983 May - Who cited this? | PubMed ID: 6350331 | Fulltext

Cell interactions in the developing somite: in vitro comparisons between amputated (am/am) and normal mouse embryos.

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Flint OP and Ede DA

Journal of embryology and experimental morphology 67:113-25, 1982 Feb - Who cited this? | PubMed ID: 7086329 | Fulltext

Cell behaviour and cleft palate in the mutant mouse, amputated.

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Flint OP

Journal of embryology and experimental morphology 58:131-42, 1980 Aug - Who cited this? | PubMed ID: 7441149 | Fulltext

Facial development in the mouse; a comparison between normal and mutant (amputated) mouse embryos.

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Flint OP and Ede DA

Journal of embryology and experimental morphology 48:249-67, 1978 Dec - Who cited this? | PubMed ID: 744952 | Fulltext

Cell interactions in the developing somite; in vivo comparisons between amputated (AM/AM) and normal mouse embryos.

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Flint OP and Ede DA

Journal of cell science 31:275-91, 1978 Jun - Who cited this? | PubMed ID: 670324 | Fulltext

Control of somite number in normal and amputated mutant mouse embryos: an experimental and a theoretical analysis.

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Flint OP, Ede DA, Wilby OK, and Proctor J

Journal of embryology and experimental morphology 45:189-202, 1978 Jun - Who cited this? | PubMed ID: 670860 | Fulltext

Abnormalities in the differentiation and cellular properties of hyperplastic lens epithelium from strains of chickens selected for high growth rate.

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Clayton RM, Eguchi G, Truman DE, Perry MM, Jacob J, and Flint OP

Journal of embryology and experimental morphology 35(1):1-23, 1976 Feb - Who cited this? | PubMed ID: 1270973 | Fulltext

Cell proliferation in the developing wing-bud of normal and talpid3 mutant chick embryos.

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Ede DA, Flint OP, and Teague P

Journal of embryology and experimental morphology 34(3):589-607, 1975 Dec - Who cited this? | PubMed ID: 1214111 | Fulltext

Cell movement and adhesion in the developing chick wing bud: studies on cultured mesenchyme cells from normal and talpid mutant embryos.

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Ede DA and Flint OP

Journal of cell science 18(2):301-13, 1975 Jul - Who cited this? | PubMed ID: 1171110 | Fulltext

Intercellular adhesion and formation of aggregates in normal and Talpid-3 mutant chick limb mesenchyme.

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Ede DA and Flint OP

Journal of cell science 18(1):97-111, 1975 Jun - Who cited this? | PubMed ID: 1141395 | Fulltext

Patterns of cell division, cell death and chondrogenesis in cultured aggregates of normal and talpid 3 mutant chick limb mesenchyme cells.

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Ede DA and Flint OP

Journal of embryology and experimental morphology 27(1):245-60, 1972 Feb - Who cited this? | PubMed ID: 4112065 | Fulltext

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