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Papers authored by Flinois JP

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Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.

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Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottée L, Bièche I, Ingelman-Sundberg M, Flinois JP, de Waziers I, Beaune P, Declèves X, Duyckaerts C, and Loriot MA

Drug metabolism and disposition: the biological fate of chemicals 37(7):1528-38, 2009 Jul - Who cited this? | PubMed ID: 19359404 | Fulltext

Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death.

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Bouvier N, Flinois JP, Gilleron J, Sauvage FL, Legendre C, Beaune P, Thervet E, Anglicheau D, and Pallet N

American journal of physiology. Renal physiology 296(1):F160-9, 2009 Jan - Who cited this? | PubMed ID: 18987109 | Fulltext

Cyclosporine-Induced Endoplasmic Reticulum Stress Triggers Tubular Phenotypic Changes and Death.

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Pallet N, Bouvier N, Bendjallabah A, Rabant M, Flinois JP, Hertig A, Legendre C, Beaune P, Thervet E, and Anglicheau D

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2008 Sep 9 - Who cited this? | PubMed ID: 18785955 | Fulltext

Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatran.

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Kenne K, Skanberg I, Glinghammar B, Berson A, Pessayre D, Flinois JP, Beaune P, Edebert I, Pohl CD, Carlsson S, and Andersson TB

Toxicology in vitro : an international journal published in association with BIBRA 22(3):730-46, 2008 Apr - Who cited this? | PubMed ID: 18191936 | Fulltext

Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo.

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Nguyen TA, Tychopoulos M, Bichat F, Zimmermann C, Flinois JP, Diry M, Ahlberg E, Delaforge M, Corcos L, Beaune P, Dansette P, André F, and de Waziers I

Molecular pharmacology 73(4):1122-33, 2008 Apr - Who cited this? | PubMed ID: 18212249 | Fulltext

Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability.

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Pallet N, Thervet E, Le Corre D, Knebelmann B, Nusbaum P, Tomkiewicz C, Meria P, Flinois JP, Beaune P, Legendre C, and Anglicheau D

Kidney international 67(6):2422-33, 2005 Jun - Who cited this? | PubMed ID: 15882288 | Fulltext

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

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Projean D, Baune B, Farinotti R, Flinois JP, Beaune P, Taburet AM, and Ducharme J

Drug metabolism and disposition: the biological fate of chemicals 31(6):748-54, 2003 Jun - Who cited this? | PubMed ID: 12756207 | Fulltext

The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats.

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Lhoste EF, Ouriet V, Bruel S, Flinois JP, Brézillon C, Magdalou J, Chèze C, and Nugon-Baudon L

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 41(5):695-702, 2003 May - Who cited this? | PubMed ID: 12659723 | Fulltext

Constitutive overexpression of immunoidentical forms of PCP-induced Euglena gracilis CYP-450.

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Barque JP, Abahamid A, Flinois JP, Beaune P, and Bonaly J

Biochemical and biophysical research communications 298(2):277-81, 2002 Oct 25 - Who cited this? | PubMed ID: 12387828 | Fulltext

Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes.

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Thijssen HH, Flinois JP, and Beaune PH

Drug metabolism and disposition: the biological fate of chemicals 28(11):1284, 2000 Nov - Who cited this? | PubMed ID: 11038154 | Fulltext

In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes.

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Nielsen TL, Rasmussen BB, Flinois JP, Beaune P, and Brosen K

The Journal of pharmacology and experimental therapeutics 289(1):31-7, 1999 Apr - Who cited this? | PubMed ID: 10086984 | Fulltext

Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.

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Baune B, Flinois JP, Furlan V, Gimenez F, Taburet AM, Becquemont L, and Farinotti R

The Journal of pharmacy and pharmacology 51(4):419-26, 1999 Apr - Who cited this? | PubMed ID: 10385214 | Fulltext

High yield purification and characterization of engineered human P450 1A2 and generation of immuno-inhibitor antibodies.

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Louërat-Oriou B, Flinois JP, Beaune PH, and Pompon D

Pharmacogenetics 9(1):61-70, 1999 Feb - Who cited this? | PubMed ID: 10208644 | Fulltext

Effects of the bacterial status of rats on the changes in some liver cytochrome P450 (EC 1.14.14.1) apoproteins consequent to a glucosinolate-rich diet.

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Nugon-Baudon L, Rabot S, Flinois JP, Lory S, and Beaune P

The British journal of nutrition 80(3):231-4, 1998 Sep - Who cited this? | PubMed ID: 9875062 | Fulltext

Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol.

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Guitton J, Buronfosse T, Desage M, Flinois JP, Perdrix JP, Brazier JL, and Beaune P

British journal of anaesthesia 80(6):788-95, 1998 Jun - Who cited this? | PubMed ID: 9771309 | Fulltext

Pregnenolone-7beta-hydroxylating activity of human cytochrome P450-1A1.

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Doostzadeh J, Flinois JP, Beaune P, and Morfin R

The Journal of steroid biochemistry and molecular biology 60(1-2):147-52, 1997 Jan - Who cited this? | PubMed ID: 9182869 | Fulltext

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.

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Nielsen KK, Flinois JP, Beaune P, and Brøsen K

The Journal of pharmacology and experimental therapeutics 277(3):1659-64, 1996 Jun - Who cited this? | PubMed ID: 8667235 | Fulltext

Hepatic cytochrome P450 and UDP-glucuronosyl transferase are affected by five sources of dietary fiber in germ-free rats.

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Nugon-Baudon L, Roland N, Flinois JP, and Beaune P

The Journal of nutrition 126(2):403-9, 1996 Feb - Who cited this? | PubMed ID: 8632212 | Fulltext

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies.

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Belloc C, Baird S, Cosme J, Lecoeur S, Gautier JC, Challine D, de Waziers I, Flinois JP, and Beaune PH

Toxicology 106(1-3):207-19, 1996 Jan 8 - Who cited this? | PubMed ID: 8571393 | Fulltext

Hepatic and intestinal cytochrome P-450, glutathione-S-transferase and UDP-glucuronosyl transferase are affected by six types of dietary fiber in rats inoculated with human whole fecal flora.

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Roland N, Nugon-Baudon L, Flinois JP, and Beaune P

The Journal of nutrition 124(9):1581-7, 1994 Sep - Who cited this? | PubMed ID: 8089725 | Fulltext

Overexpression of glutamine synthetase in human primary liver cancer.

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Christa L, Simon MT, Flinois JP, Gebhardt R, Brechot C, and Lasserre C

Gastroenterology 106(5):1312-20, 1994 May - Who cited this? | PubMed ID: 7909780 | Fulltext

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide.

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Walker D, Flinois JP, Monkman SC, Beloc C, Boddy AV, Cholerton S, Daly AK, Lind MJ, Pearson AD, and Beaune PH

Biochemical pharmacology 47(7):1157-63, 1994 Mar 29 - Who cited this? | PubMed ID: 8161344 | Fulltext

Presence of proteins recognized by mammalian cytochrome P-450 antibodies in Euglena gracilis.

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Briand J, Julistiono H, Beaune P, Flinois JP, de Waziers I, and Leroux JP

Biochimica et biophysica acta 1203(2):199-204, 1993 Dec 8 - Who cited this? | PubMed ID: 8268200 | Fulltext

Metabolism rate of oxodipine in rats and humans: comparison of in vivo and in vitro data.

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Flinois JP, Chabin M, Egros F, Dufour A, de Waziers I, Mas-Chamberlin C, and Beaune PH

The Journal of pharmacology and experimental therapeutics 261(1):381-6, 1992 Apr - Who cited this? | PubMed ID: 1560383 | Fulltext

Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age.

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Ratanasavanh D, Beaune P, Morel F, Flinois JP, Guengerich FP, and Guillouzo A

Hepatology (Baltimore, Md.) 13(6):1142-51, 1991 Jun - Who cited this? | PubMed ID: 1904834 | Fulltext

Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.

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Berthou F, Flinois JP, Ratanasavanh D, Beaune P, Riche C, and Guillouzo A

Drug metabolism and disposition: the biological fate of chemicals 19(3):561-7, 1991 - Who cited this? | PubMed ID: 1680620 | Fulltext

Expression of cytochrome P-450 enzymes in cultured human hepatocytes.

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Morel F, Beaune PH, Ratanasavanh D, Flinois JP, Yang CS, Guengerich FP, and Guillouzo A

European journal of biochemistry / FEBS 191(2):437-44, 1990 Jul 31 - Who cited this? | PubMed ID: 2200675 | Fulltext

Hydrophobic chromatography: a one-step method for the purification of human liver microsomal epoxide hydrolase.

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Beaune PH, Cresteil T, Flinois JP, and Leroux JP

Journal of chromatography 426(1):169-76, 1988 Apr 8 - Who cited this? | PubMed ID: 3384870 | Fulltext

Purification of a new cytochrome P-450 from human liver microsomes.

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Beaune P, Flinois JP, Kiffel L, Kremers P, and Leroux JP

Biochimica et biophysica acta 840(3):364-70, 1985 Jul 5 - Who cited this? | PubMed ID: 4005291 | Fulltext

Induction of drug-metabolizing enzymes by tricyclic antidepressants in human liver: characterization and partial resolution of cytochromes P-450.

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Cresteil T, Célier C, Kremers P, Flinois JP, Beaune P, and Leroux JP

British journal of clinical pharmacology 16(6):651-7, 1983 Dec - Who cited this? | PubMed ID: 6661349 | Fulltext

Influence of ethanol and benzene on cytochrome P-450 fractions in rat liver microsomes.

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Beaune P, Flinois JP, Le Provost E, and Leroux JP

Drug metabolism and disposition: the biological fate of chemicals 11(5):499-506, 1983 - Who cited this? | PubMed ID: 6138238 | Fulltext

Enzymatic and immunological evidences that phenobarbital induces cytochrome P 450 in fetal and neonatal rat liver.

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Cresteil T, Le Provost E, Flinois JP, and Leroux JP

Biochemical and biophysical research communications 106(3):823-30, 1982 Jun 15 - Who cited this? | PubMed ID: 7115377 | Fulltext

Drug-metabolizing enzymes in human foetal liver: partial resolution of multiple cytochromes P 450.

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Cresteil T, Beaune P, Kremers P, Flinois JP, and Leroux JP

Pediatric pharmacology (New York, N.Y.) 2(3):199-207, 1982 - Who cited this? | PubMed ID: 7162874 | Fulltext

Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: partial purificaton and properties of cytochrome P-450-troleandomycin metabolite complexes.

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Mansuy D, Delaforge M, LeProvost E, Flinois JP, Columelli S, and Beaune P

Biochemical and biophysical research communications 103(4):1201-8, 1981 Dec 31 - Who cited this? | PubMed ID: 6977361 | Fulltext

Immunochemical characterization of some monooxygenase activities in liver microsomes from untreated and phenobarbital-treated rats.

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Le Provost E, Flinois JP, Beaune P, and Leroux JP

Biochemical and biophysical research communications 101(2):547-54, 1981 Jul 30 - Who cited this? | PubMed ID: 6796075 | Fulltext

Effect of microsomal preparations and induction on cytochrome P-450-dependent monooxygenases in fetal and neonatal rat liver.

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Cresteil T, Flinois JP, Pfister A, and Leroux JP

Biochemical pharmacology 28(13):2057-63, 1979 Jul 1 - Who cited this? | PubMed ID: 224884 | Fulltext

Partial purification of human liver cytochrome P 450.

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Beaune P, Dansette P, Flinois JP, Columelli S, Mansuy D, and Leroux JP

Biochemical and biophysical research communications 88(3):826-32, 1979 Jun 13 - Who cited this? | PubMed ID: 465082 | Fulltext

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