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Papers authored by Flatt PR

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Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

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Bender K, Maechler P, McClenaghan NH, Flatt PR, and Newsholme P

Clinical science (London, England : 1979) 117(9):321-30, 2009 Nov - Who cited this? | PubMed ID: 19344310 | Fulltext

Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties.

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Kerr BD, Irwin N, O'Harte FP, Bailey CJ, Flatt PR, and Gault VA

Biochemical pharmacology 78(8):1008-16, 2009 Oct 15 - Who cited this? | PubMed ID: 19523458 | Fulltext

Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.

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Irwin N and Flatt PR

Diabetologia 52(9):1724-31, 2009 Sep - Who cited this? | PubMed ID: 19533083 | Fulltext

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction.

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Kiely A, Robinson A, McClenaghan NH, Flatt PR, and Newsholme P

The Journal of endocrinology 202(3):365-73, 2009 Sep - Who cited this? | PubMed ID: 19553279 | Fulltext

Therapeutic potential for GIP receptor agonists and antagonists.

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Irwin N and Flatt PR

Best practice & research. Clinical endocrinology & metabolism 23(4):499-512, 2009 Aug - Who cited this? | PubMed ID: 19748067 | Fulltext

Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice.

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Irwin N, McClean PL, Hunter K, and Flatt PR

Diabetes, obesity & metabolism 11(6):603-10, 2009 Jun - Who cited this? | PubMed ID: 19515180 | Fulltext

A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae).

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Conlon JM, Abdel-Wahab YH, Flatt PR, Leprince J, Vaudry H, Jouenne T, and Condamine E

Peptides 30(5):888-92, 2009 May - Who cited this? | PubMed ID: 19428765 | Fulltext

Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice.

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Irwin N, Hunter K, Frizzell N, and Flatt PR

Regulatory peptides 153(1-3):70-6, 2009 Feb 25 - Who cited this? | PubMed ID: 19073224 | Fulltext

Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance.

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Kerr BD, Irwin N, Flatt PR, and Gault VA

Peptides 30(2):219-25, 2009 Feb - Who cited this? | PubMed ID: 19026698 | Fulltext

Recent advances in antidiabetic drug therapies targeting the enteroinsular axis.

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Flatt PR, Bailey CJ, and Green BD

Current drug metabolism 10(2):125-37, 2009 Feb - Who cited this? | PubMed ID: 19275548 | Fulltext

Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes.

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Irwin N, McClean PL, Patterson S, Hunter K, and Flatt PR

Biological chemistry 390(1):75-80, 2009 Jan - Who cited this? | PubMed ID: 18937625 | Fulltext

A peptide of the phylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and in vivo insulin-releasing activity.

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Abdel-Wahab YH, Power GJ, Flatt PR, Woodhams DC, Rollins-Smith LA, and Conlon JM

Peptides 29(12):2136-43, 2008 Dec - Who cited this? | PubMed ID: 18848963 | Fulltext

A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae).

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Conlon JM, Power GJ, Abdel-Wahab YH, Flatt PR, Jiansheng H, Coquet L, Leprince J, Jouenne T, and Vaudry H

Regulatory peptides 151(1-3):153-9, 2008 Nov 29 - Who cited this? | PubMed ID: 18501981 | Fulltext

Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta-cells.

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McClenaghan NH, Scullion SM, Mion B, Hewage C, Malthouse JP, Flatt PR, Newsholme P, and Brennan L

Clinical science (London, England : 1979), 2008 Aug 14 - Who cited this? | PubMed ID: 18702613 | Fulltext

(Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy.

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McClean PL, Irwin N, Hunter K, Gault VA, and Flatt PR

British journal of pharmacology, 2008 Aug 11 - Who cited this? | PubMed ID: 18695644 | Fulltext

Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes?.

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Flatt PR

Diabetic medicine : a journal of the British Diabetic Association 25(7):759-64, 2008 Jul - Who cited this? | PubMed ID: 18513308 | Fulltext

C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes.

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Gault VA, Kerr BD, Irwin N, and Flatt PR

Biochemical pharmacology 75(12):2325, 2008 Jun 15 - Who cited this? | PubMed ID: 18455149 | Fulltext

Comparison of independent and combined chronic metabolic effects of GIP and CB(1) receptor blockade in high-fat fed mice.

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Irwin N, Hunter K, and Flatt PR

Peptides 29(6):1036-41, 2008 Jun - Who cited this? | PubMed ID: 18291559 | Fulltext

Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP.

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McClean PL, Gault VA, Irwin N, McCluskey JT, and Flatt PR

Diabetes, obesity & metabolism 10(4):336, 2008 Apr - Who cited this? | PubMed ID: 18333892 | Fulltext

Iterative exposure of clonal BRIN-BD11 cells to ninhydrin enables selection of robust toxin-resistant cells but with decreased gene expression of insulin secretory function.

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Liu HK, McCluskey JT, McClenghan NH, and Flatt PR

Pancreas 36(3):294-301, 2008 Apr - Who cited this? | PubMed ID: 18362844 | Fulltext

Sub-chronic administration of the 11beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity.

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Taylor A, Irwin N, McKillop AM, Flatt PR, and Gault VA

Biological chemistry 389(4):441-5, 2008 Apr - Who cited this? | PubMed ID: 18225986 | Fulltext

Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.

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Irwin N, Hunter K, Frizzell N, and Flatt PR

European journal of pharmacology 581(1-2):226, 2008 Feb 26 - Who cited this? | PubMed ID: 18191122 | Fulltext

Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets.

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Cassidy RS, Irwin N, and Flatt PR

Biological chemistry 389(2):189-93, 2008 Feb - Who cited this? | PubMed ID: 18163884 | Fulltext

Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys(18)]-substituted analogue.

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Abdel-Wahab YH, Power GJ, Ng MT, Flatt PR, and Conlon JM

Biological chemistry 389(2):143-8, 2008 Feb - Who cited this? | PubMed ID: 18163889 | Fulltext

Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.

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Flatt PR, Bailey CJ, and Green BD

Frontiers in bioscience : a journal and virtual library 13:3648, 2008 - Who cited this? | PubMed ID: 18508462 | Fulltext

Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects.

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McKillop AM, Duffy NA, Lindsay JR, O'Harte FP, Bell PM, and Flatt PR

Diabetes research and clinical practice 79(1):79-85, 2008 Jan - Who cited this? | PubMed ID: 17904681 | Fulltext

Incretin hormone mimetics and analogues in diabetes therapeutics.

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Green BD and Flatt PR

Best practice & research. Clinical endocrinology & metabolism 21(4):497-516, 2007 Dec - Who cited this? | PubMed ID: 18054732 | Fulltext

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.

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McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, and Flatt PR

American journal of physiology. Endocrinology and metabolism 293(6):E1746-55, 2007 Dec - Who cited this? | PubMed ID: 17848629 | Fulltext

Comparison of the metabolic effects of GIP receptor antagonism and PYY(3-36) receptor activation in high fat fed mice.

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Irwin N, Hunter K, and Flatt PR

Peptides 28(11):2192-8, 2007 Nov - Who cited this? | PubMed ID: 17884253 | Fulltext

Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide.

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Irwin N, McClean PL, Cassidy RS, O'harte FP, Green BD, Gault VA, Harriott P, and Flatt PR

Diabetes/metabolism research and reviews 23(7):572-9, 2007 Oct - Who cited this? | PubMed ID: 17315241 | Fulltext

Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line.

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Kiely A, McClenaghan NH, Flatt PR, and Newsholme P

The Journal of endocrinology 195(1):113-23, 2007 Oct - Who cited this? | PubMed ID: 17911403 | Fulltext

Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.

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Gault VA, McClean PL, Cassidy RS, Irwin N, and Flatt PR

Diabetologia 50(8):1752-62, 2007 Aug - Who cited this? | PubMed ID: 17558485 | Fulltext

Streptozotocin-resistant BRIN-BD11 cells possess wide spectrum of toxin tolerance and enhanced insulin-secretory capacity.

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Liu HK, McCluskey JT, McClenghan NH, and Flatt PR

Endocrine 32(1):20-9, 2007 Aug - Who cited this? | PubMed ID: 17992598 | Fulltext

Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1.

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Duffy NA, Green BD, Irwin N, Gault VA, McKillop AM, O'Harte FP, and Flatt PR

European journal of pharmacology 568(1-3):278-86, 2007 Jul 30 - Who cited this? | PubMed ID: 17573070 | Fulltext

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice.

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Irwin N, McClean PL, O'Harte FP, Gault VA, Harriott P, and Flatt PR

Diabetologia 50(7):1532-40, 2007 Jul - Who cited this? | PubMed ID: 17486314 | Fulltext

Effects of subchronic treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in streptozotocin-induced diabetes.

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Gault VA, McClean PL, Irwin N, Power GJ, McCluskey JT, and Flatt PR

Pancreas 35(1):73-9, 2007 Jul - Who cited this? | PubMed ID: 17575548 | Fulltext

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.

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Irwin N, McClean PL, and Flatt PR

Journal of peptide science : an official publication of the European Peptide Society 13(6):400-5, 2007 Jun - Who cited this? | PubMed ID: 17486662 | Fulltext

Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice.

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O'Harte FP, Hunter K, Gault VA, Irwin N, Green BD, Greer B, Harriott P, Bailey CJ, and Flatt PR

American journal of physiology. Endocrinology and metabolism 292(6):E1674-82, 2007 Jun - Who cited this? | PubMed ID: 17299087 | Fulltext

Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastric inhibitory polypeptide (GIP): evidence and clinical opportunity for development of new obesity-diabetes drugs?.

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Flatt PR

Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 4(2):151-3, 2007 Jun - Who cited this? | PubMed ID: 17654450 | Fulltext

Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity.

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Patterson S, Flatt PR, and McClenaghan NH

Archives of biochemistry and biophysics 461(2):287-93, 2007 May 15 - Who cited this? | PubMed ID: 17376398 | Fulltext

Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists.

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Gault VA, Hunter K, Irwin N, Green BD, Greer B, Harriott P, O'Harte FP, and Flatt PR

Archives of biochemistry and biophysics 461(2):263-74, 2007 May 15 - Who cited this? | PubMed ID: 17428436 | Fulltext

Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice.

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Green BD, Irwin N, and Flatt PR

Peptides 28(5):981-7, 2007 May - Who cited this? | PubMed ID: 17350140 | Fulltext

Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents.

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Patterson S, Scullion SM, McCluskey JT, Flatt PR, and McClenaghan NH

Diabetes/metabolism research and reviews 23(4):324-34, 2007 May - Who cited this? | PubMed ID: 17089371 | Fulltext

Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice.

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Irwin N, McClean PL, Harriott P, and Flatt PR

Experimental gerontology 42(4):296-300, 2007 Apr - Who cited this? | PubMed ID: 17184947 | Fulltext

Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action.

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Hannan JM, Ali L, Rokeya B, Khaleque J, Akhter M, Flatt PR, and Abdel-Wahab YH

The British journal of nutrition 97(3):514-21, 2007 Mar - Who cited this? | PubMed ID: 17313713 | Fulltext

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes.

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Gault VA, Hunter K, Irwin N, Greer B, Green BD, Harriott P, O'Harte FP, and Flatt PR

Biological chemistry 388(2):173-9, 2007 Feb - Who cited this? | PubMed ID: 17261080 | Fulltext

Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice.

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Parker JC, Irwin N, Lavery KS, Green BD, O'Harte FP, Gault VA, and Flatt PR

Biological chemistry 388(2):221-6, 2007 Feb - Who cited this? | PubMed ID: 17261085 | Fulltext

Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells.

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Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR, and Abdel-Wahab YH

The Journal of endocrinology 192(1):159, 2007 Jan - Who cited this? | PubMed ID: 17210753 | Fulltext

Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase.

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Patterson S, Flatt PR, and McClenaghan NH

Pancreas 34(1):144-51, 2007 Jan - Who cited this? | PubMed ID: 17198197 | Fulltext

Insulin releasing properties of the temporin family of antimicrobial peptides.

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Abdel-Wahab YH, Marenah L, Flatt PR, and Conlon JM

Protein and peptide letters 14(7):702-7, 2007 - Who cited this? | PubMed ID: 17897097 | Fulltext

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