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Papers authored by Fikrig E

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Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response.

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Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, and Shaw AC

Journal of immunology (Baltimore, Md. : 1950) 184(5):2518-27, 2010 Mar 1 - Who cited this? | PubMed ID: 20100933 | Fulltext

Passage through Ixodes scapularis Ticks Enhances the Virulence of a Weakly Pathogenic Isolate of Borrelia burgdorferi.

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Adusumilli S, Booth CJ, Anguita J, and Fikrig E

Infection and immunity 78(1):138-44, 2010 Jan - Who cited this? | PubMed ID: 19822652 | Fulltext

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

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Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, and Elledge SJ

Cell 139(7):1243-54, 2009 Dec 24 - Who cited this? | PubMed ID: 20064371 | Fulltext

Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease Agent.

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Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, and Fikrig E

Cell host & microbe 6(5):482-92, 2009 Nov 19 - Who cited this? | PubMed ID: 19917502 | Fulltext

Toll-Like Receptors 1 and 2 Heterodimers Alter Borrelia burgdorferi Gene Expression in Mice and Ticks.

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Fikrig E, Narasimhan S, Neelakanta G, Pal U, Chen M, and Flavell R

The Journal of infectious diseases 200(8):1331-40, 2009 Oct 15 - Who cited this? | PubMed ID: 19754309 | Fulltext

IL-10 signaling blockade controls murine west nile virus infection.

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Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, and Fikrig E

PLoS pathogens 5(10):e1000610, 2009 Oct - Who cited this? | PubMed ID: 19816558 | Fulltext

Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody.

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Sultana H, Foellmer HG, Neelakanta G, Oliphant T, Engle M, Ledizet M, Krishnan MN, Bonafé N, Anthony KG, Marasco WA, Kaplan P, Montgomery RR, Diamond MS, Koski RA, and Fikrig E

Journal of immunology (Baltimore, Md. : 1950) 183(1):650-60, 2009 Jul 1 - Who cited this? | PubMed ID: 19535627 | Fulltext

Human innate immunosenescence: causes and consequences for immunity in old age.

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Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, and Shaw AC

Trends in immunology 30(7):325-33, 2009 Jul - Who cited this? | PubMed ID: 19541535 | Fulltext

Effective siRNA targeting of the 3' untranslated region of the West Nile virus genome.

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Anthony KG, Bai F, Krishnan MN, Fikrig E, and Koski RA

Antiviral research 82(3):166-8, 2009 Jun - Who cited this? | PubMed ID: 19135091 | Fulltext

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy.

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Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, and Fahmy TM

Vaccine 27(23):3013-21, 2009 May 18 - Who cited this? | PubMed ID: 19428913 | Fulltext

The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi.

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Hovius JW, Bijlsma MF, van der Windt GJ, Wiersinga WJ, Boukens BJ, Coumou J, Oei A, de Beer R , de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJ, and van der Poll T

PLoS pathogens 5(5):e1000447, 2009 May - Who cited this? | PubMed ID: 19440540 | Fulltext

The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi.

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Hovius JW, Bijlsma MF, van der Windt GJ, Wiersinga WJ, Boukens BJ, Coumou J, Oei A, de Beer R , de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJ, and van der Poll T

PLoS pathogens 5(5):e1000447, 2009 May - Who cited this? | PubMed ID: 19461880 | Fulltext

Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.

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Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, and Fikrig E

Immunity 30(2):242-53, 2009 Feb - Who cited this? | PubMed ID: 19200759 | Fulltext

A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells.

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Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, and Kaplan P

Vaccine, 2008 Nov 6 - Who cited this? | PubMed ID: 18996430 | Fulltext

Preferential Protection of Borrelia burgdorferi Sensu Stricto by a Salp15 Homologue in Ixodes ricinus Saliva.

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Hovius JW, Schuijt TJ, de Groot KA, Roelofs JJ, Oei GA, Marquart JA, de Beer R , Van 't Veer C, van der Poll T, Ramamoorthi N, Fikrig E, and van Dam AP

The Journal of infectious diseases 198(8):1189-1197, 2008 Oct 15 - Who cited this? | PubMed ID: 18752445 | Fulltext

Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety.

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Yang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, and Pal U

Microbes and infection / Institut Pasteur 10(12-13):1300-8, 2008 Oct - Who cited this? | PubMed ID: 18725314 | Fulltext

Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function.

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Thomas V, Samanta S, and Fikrig E

Infection and immunity, 2008 Sep 2 - Who cited this? | PubMed ID: 18765732 | Fulltext

RNA interference screen for human genes associated with West Nile virus infection.

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Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ,

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Nature, 2008 Aug 6 - Who cited this? | PubMed ID: 18690214 | Fulltext

Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly.

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Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, and Montgomery RR

Journal of virology 82(15):7613, 2008 Aug - Who cited this? | PubMed ID: 18508883 | Fulltext

Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis.

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Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, and Wang T

Journal of immunology (Baltimore, Md. : 1950) 181(3):2084, 2008 Aug 1 - Who cited this? | PubMed ID: 18641347 | Fulltext

Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain.

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Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, and Fikrig E

Journal of virology, 2008 Jul 16 - Who cited this? | PubMed ID: 18632868 | Fulltext

The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates.

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Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, and van Dam AP

Infection and immunity 76(7):2888-94, 2008 Jul - Who cited this? | PubMed ID: 18426890 | Fulltext

Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae).

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Anderson JF, Main AJ, Delroux K, and Fikrig E

Journal of medical entomology 45(3):445-51, 2008 May - Who cited this? | PubMed ID: 18533438 | Fulltext

Icam-1 participates in the entry of west nile virus into the central nervous system.

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Dai J, Wang P, Bai F, Town T, and Fikrig E

Journal of virology 82(8):4164-8, 2008 Apr - Who cited this? | PubMed ID: 18256150 | Fulltext

West nile virus attenuates activation of primary human macrophages.

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Kong KF, Wang X, Anderson JF, Fikrig E, and Montgomery RR

Viral immunology 21(1):78, 2008 Mar - Who cited this? | PubMed ID: 18355125 | Fulltext

Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization.

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Hovius JW, de Jong MA, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, and Geijtenbeek TB

PLoS pathogens 4(2):e31, 2008 Feb 8 - Who cited this? | PubMed ID: 18282094 | Fulltext

Salivating for knowledge: potential pharmacological agents in tick saliva.

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Hovius JW, Levi M, and Fikrig E

PLoS medicine 5(2):e43, 2008 Feb - Who cited this? | PubMed ID: 18271624 | Fulltext

Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis.

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Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, and Fikrig E

The Journal of experimental medicine 205(1):133-41, 2008 Jan 21 - Who cited this? | PubMed ID: 18166585 | Fulltext

c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.

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Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, and Fikrig E

Infection and immunity 76(1):308-16, 2008 Jan - Who cited this? | PubMed ID: 17998313 | Fulltext

A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks.

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Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, and Fikrig E

The Journal of infectious diseases 197(1):148-55, 2008 Jan 1 - Who cited this? | PubMed ID: 18171298 | Fulltext

West Nile Virus Envelope Protein Inhibits dsRNA-Induced Innate Immune Responses.

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Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, and Fikrig E

Journal of immunology (Baltimore, Md. : 1950) 179(12):8403-9, 2007 Dec 15 - Who cited this? | PubMed ID: 18056386 | Fulltext

Antibodies Targeting Linear Determinants of the Envelope Protein Protect Mice against West Nile Virus.

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Ledizet M, Kar K, Foellmer HG, Bonafé N, Anthony KG, Gould LH, Bushmich SL, Fikrig E, and Koski RA

The Journal of infectious diseases 196(12):1741-8, 2007 Dec 15 - Who cited this? | PubMed ID: 18190253 | Fulltext

ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection.

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Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, and Fikrig E

Journal of immunology (Baltimore, Md. : 1950) 179(7):4783-91, 2007 Oct 1 - Who cited this? | PubMed ID: 17878377 | Fulltext

Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion.

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Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, and Bucala R

The Journal of clinical investigation 117(10):3059-66, 2007 Oct - Who cited this? | PubMed ID: 17909632 | Fulltext

Role of outer surface protein D in the Borrelia burgdorferi life cycle.

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Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, and Fikrig E

Infection and immunity 75(9):4237-44, 2007 Sep - Who cited this? | PubMed ID: 17620358 | Fulltext

Tick-host-pathogen interactions in Lyme borreliosis.

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Hovius JW, van Dam AP, and Fikrig E

Trends in parasitology 23(9):434-8, 2007 Sep - Who cited this? | PubMed ID: 17656156 | Fulltext

IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis.

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Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, and Fikrig E

FEMS immunology and medical microbiology 50(3):401-10, 2007 Aug - Who cited this? | PubMed ID: 17521390 | Fulltext

Biochemical and functional characterization of Salp20, an Ixodes scapularis tick salivary protein that inhibits the complement pathway.

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Tyson K, Elkins C, Patterson H, Fikrig E, and de Silva A

Insect molecular biology 16(4):469-79, 2007 Aug - Who cited this? | PubMed ID: 17651236 | Fulltext

A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector.

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Narasimhan S, Sukumaran B, Bozdogan U, Thomas V, Liang X, DePonte K, Marcantonio N, Koski RA, Anderson JF, Kantor F, and Fikrig E

Cell host & microbe 2(1):7-18, 2007 Jul 12 - Who cited this? | PubMed ID: 18005713 | Fulltext

Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection.

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Thomas V and Fikrig E

Cellular microbiology 9(7):1730-7, 2007 Jul - Who cited this? | PubMed ID: 17346310 | Fulltext

A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity.

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McDonald WF, Huleatt JW, Foellmer HG, Hewitt D, Tang J, Desai P, Price A, Jacobs A, Takahashi VN, Huang Y, Nakaar V, Alexopoulou L, Fikrig E, and Powell TJ

The Journal of infectious diseases 195(11):1607, 2007 Jun 1 - Who cited this? | PubMed ID: 17471430 | Fulltext

Rab 5 is required for the cellular entry of dengue and West Nile viruses.

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Krishnan MN, Sukumaran B, Pal U, Agaisse H, Murray JL, Hodge TW, and Fikrig E

Journal of virology 81(9):4881-5, 2007 May - Who cited this? | PubMed ID: 17301152 | Fulltext

Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis.

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Hovius JW, Li X, Ramamoorthi N, van Dam AP, Barthold SW, van der Poll T, Speelman P, and Fikrig E

FEMS immunology and medical microbiology 49(2):224-34, 2007 Mar - Who cited this? | PubMed ID: 17328756 | Fulltext

Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks.

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Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, and Fikrig E

PLoS pathogens 3(3):e33, 2007 Mar - Who cited this? | PubMed ID: 17352535 | Fulltext

Antiviral peptides targeting the west nile virus envelope protein.

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Bai F, Town T, Pradhan D, Cox J, Ashish , Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, and Fikrig E

Journal of virology 81(4):2047-55, 2007 Feb - Who cited this? | PubMed ID: 17151121 | Fulltext

The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks.

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Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, and Fikrig E

Molecular microbiology 63(3):694-710, 2007 Feb - Who cited this? | PubMed ID: 17181780 | Fulltext

Age-associated defect in human TLR-1/2 function.

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van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, and Shaw AC

Journal of immunology (Baltimore, Md. : 1950) 178(2):970-5, 2007 Jan 15 - Who cited this? | PubMed ID: 17202359 | Fulltext

Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission.

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Narasimhan S, Deponte K, Marcantonio N, Liang X, Royce TE, Nelson KF, Booth CJ, Koski B, Anderson JF, Kantor F, and Fikrig E

PLoS ONE 2(5):e451, 2007 - Who cited this? | PubMed ID: 17505544 | Fulltext

Identification of Salp15 homologues in Ixodes ricinus ticks.

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Hovius JW, Ramamoorthi N, Van't Veer C, de Groot KA, Nijhof AM, Jongejan F, van Dam AP, and Fikrig E

Vector borne and zoonotic diseases (Larchmont, N.Y.) 7(3):296-303, 2007 - Who cited this? | PubMed ID: 17896872 | Fulltext

Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15.

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Garg R, Juncadella IJ, Ramamoorthi N, Ashish , Ananthanarayanan SK, Thomas V, Rincón M, Krueger JK, Fikrig E, Yengo CM, and Anguita J

Journal of immunology (Baltimore, Md. : 1950) 177(10):6579-83, 2006 Nov 15 - Who cited this? | PubMed ID: 17082567 | Fulltext

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