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Papers authored by Farmer BT

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Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.

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Heim-Riether A, Taylor SJ, Liang S, Gao DA, Xiong Z, Michael August E, Collins BK, Farmer BT, Haverty K, Hill-Drzewi M, Junker HD, Mariana Margarit S, Moss N, Neumann T, Proudfoot JR, Keenan LS,

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Bioorganic & medicinal chemistry letters 19(18):5321-4, 2009 Sep 15 - Who cited this? | PubMed ID: 19692239 | Fulltext

Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode (dagger).

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Qian K, Wang L, Cywin CL, Farmer BT, Hickey E, Homon C, Jakes S, Kashem MA, Lee G, Leonard S, Li J, Magboo R, Mao W, Pack E, Peng C, Prokopowicz A,

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Journal of medicinal chemistry 52(7):1814-27, 2009 Apr 9 - Who cited this? | PubMed ID: 19256503 | Fulltext

Molecular basis of MAPK-activated protein kinase 2:p38 assembly.

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White A, Pargellis CA, Studts JM, Werneburg BG, and Farmer BT

Proceedings of the National Academy of Sciences of the United States of America 104(15):6353-8, 2007 Apr 10 - Who cited this? | PubMed ID: 17395714 | Fulltext

NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

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McDonnell PA, Constantine KL, Goldfarb V, Johnson SR, Sulsky R, Magnin DR, Robl JA, Caulfield TJ, Parker RA, Taylor DS, Adam LP, Metzler WJ, Mueller L, and Farmer BT

Journal of medicinal chemistry 49(16):5013-7, 2006 Aug 10 - Who cited this? | PubMed ID: 16884313 | Fulltext

Structural and functional characterization of CFE88: evidence that a conserved and essential bacterial protein is a methyltransferase.

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Constantine KL, Krystek SR, Healy MD, Doyle ML, Siemers NO, Thanassi J, Yan N, Xie D, Goldfarb V, Yanchunas J, Tao L, Dougherty BA, and Farmer BT

Protein science : a publication of the Protein Society 14(6):1472-84, 2005 Jun - Who cited this? | PubMed ID: 15929997 | Fulltext

Backbone and side chain dynamics of uncomplexed human adipocyte and muscle fatty acid-binding proteins.

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Constantine KL, Friedrichs MS, Wittekind M, Jamil H, Chu CH, Parker RA, Goldfarb V, Mueller L, and Farmer BT

Biochemistry 37(22):7965-80, 1998 Jun 2 - Who cited this? | PubMed ID: 9609689 | Fulltext

Characterization of NADP+ binding to perdeuterated MurB: backbone atom NMR assignments and chemical-shift changes.

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Constantine KL, Mueller L, Goldfarb V, Wittekind M, Metzler WJ, Yanchunas J, Robertson JG, Malley MF, Friedrichs MS, and Farmer BT

Journal of molecular biology 267(5):1223-46, 1997 Apr 18 - Who cited this? | PubMed ID: 9150408 | Fulltext

Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II.

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Venters RA, Farmer BT, Fierke CA, and Spicer LD

Journal of molecular biology 264(5):1101-16, 1996 Dec 20 - Who cited this? | PubMed ID: 9000633 | Fulltext

Localizing the NADP+ binding site on the MurB enzyme by NMR.

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Farmer BT, Constantine KL, Goldfarb V, Friedrichs MS, Wittekind M, Yanchunas J, Robertson JG, and Mueller L

Nature structural biology 3(12):995-7, 1996 Dec - Who cited this? | PubMed ID: 8946851 | Fulltext

The three-dimensional solution structure of the SH2 domain from p55blk kinase.

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Metzler WJ, Leiting B, Pryor K, Mueller L, and Farmer BT

Biochemistry 35(20):6201-11, 1996 May 21 - Who cited this? | PubMed ID: 8639560 | Fulltext

Assignment of aliphatic side-chain 1HN/15N resonances in perdeuterated proteins.

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Farmer BT and Venters RA

Journal of biomolecular NMR 7(1):59-71, 1996 Jan - Who cited this? | PubMed ID: 8720832 | Fulltext

Triple resonance HNCCCH experiments for correlating exchangeable and nonexchangeable cytidine and uridine base protons in RNA.

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Simorre JP, Zimmermann GR, Pardi A, Farmer BT, and Mueller L

Journal of biomolecular NMR 6(4):427-32, 1995 Dec - Who cited this? | PubMed ID: 8563469 | Fulltext

High-level 2H/13C/15N labeling of proteins for NMR studies.

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Venters RA, Huang CC, Farmer BT, Trolard R, Spicer LD, and Fierke CA

Journal of biomolecular NMR 5(4):339-44, 1995 Jun - Who cited this? | PubMed ID: 7647552 | Fulltext

Refined solution structure of human profilin I.

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Metzler WJ, Farmer BT, Constantine KL, Friedrichs MS, Lavoie T, and Mueller L

Protein science : a publication of the Protein Society 4(3):450-9, 1995 Mar - Who cited this? | PubMed ID: 7795529 | Fulltext

Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy.

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Wittekind M, Mapelli C, Farmer BT, Suen KL, Goldfarb V, Tsao J, Lavoie T, Barbacid M, Meyers CA, and Mueller L

Biochemistry 33(46):13531-9, 1994 Nov 22 - Who cited this? | PubMed ID: 7947763 | Fulltext

Simultaneous acquisition of [13C,15N]- and [15N,15N]-separated 4D gradient-enhanced NOESY spectra in proteins.

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Farmer BT and Mueller L

Journal of biomolecular NMR 4(5):673-87, 1994 Sep - Who cited this? | PubMed ID: 7919953 | Fulltext

Unambiguous through-bond sugar-to-base correlations for purines in 13C,15N-labeled nucleic acids: the HsCsNb,HsCs(N)bCb, and HbNbCb experiments.

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Farmer BT, Müller L, Nikonowicz EP, and Pardi A

Journal of biomolecular NMR 4(1):129-33, 1994 Jan - Who cited this? | PubMed ID: 7510555 | Fulltext

Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR.

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Warren WS, Richter W, Andreotti AH, and Farmer BT

Science (New York, N.Y.) 262(5142):2005-9, 1993 Dec 24 - Who cited this? | PubMed ID: 8266096 | Fulltext

A refocused and optimized HNCA: increased sensitivity and resolution in large macromolecules.

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Farmer BT, Venters RA, Spicer LD, Wittekind MG, and Müller L

Journal of biomolecular NMR 2(2):195-202, 1992 Mar - Who cited this? | PubMed ID: 1422152 | Fulltext

Protein hydration studied with homonuclear 3D 1H NMR experiments.

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Otting G, Liepinsh E, Farmer BT, and Wüthrich K

Journal of biomolecular NMR 1(2):209-15, 1991 Jul - Who cited this? | PubMed ID: 1726782 | Fulltext

Rotating-frame nuclear Overhauser effect.

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Brown LR and Farmer BT

Methods in enzymology 176:199-216, 1989 - Who cited this? | PubMed ID: 2811687 | Fulltext

ESR studies of the erythrocyte membrane skeletal protein network: influence of the state of aggregation of spectrin on the physical state of membrane proteins, bilayer lipids, and cell surface carbohydrates.

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Farmer BT, Harmon TM, and Butterfield DA

Biochimica et biophysica acta 821(3):420-30, 1985 Dec 19 - Who cited this? | PubMed ID: 3000446 | Fulltext

Alzheimer's disease: no alteration in the physical state of erythrocyte membrane glycoconjugates.

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Butterfield DA, Farmer BT, and Markesbery WR

Annals of neurology 18(1):104-5, 1985 Jul - Who cited this? | PubMed ID: 4037746 | Fulltext

The alteration of membrane proteins in human erythrocyte membranes induced by quinolinic acid, an endogenous neurotoxin. Correlation of effect with structure.

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Farmer BT, Nicholas MM, and Butterfield DA

Biochimica et biophysica acta 778(2):260-8, 1984 Dec 5 - Who cited this? | PubMed ID: 6093884 | Fulltext

Selective spin labeling of terminal galactose and N-acetylgalactosamine residues on the membrane surface of erythrocytes.

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Farmer BT and Butterfield DA

Journal of biochemical and biophysical methods 10(1-2):111-20, 1984 Nov - Who cited this? | PubMed ID: 6097609 | Fulltext

Quinolinic acid, an endogenous metabolite with neurotoxic properties, alters the physical state of membrane proteins in human erythrocytes.

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Farmer BT and Butterfield DA

Life sciences 35(5):501-9, 1984 Jul 30 - Who cited this? | PubMed ID: 6087067 | Fulltext

Induced alterations in the physical state of sialic acid and membrane proteins in human erythrocyte ghosts: implications for the topology of the major sialoglycoprotein.

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Butterfield DA, Farmer BT, and Feix JB

Annals of the New York Academy of Sciences 414:169-79, 1983 - Who cited this? | PubMed ID: 6322653 | Fulltext

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