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Papers authored by Farid NA

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A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.

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Hagihara K, Kazui M, Kurihara A, Yoshiike M, Honda K, Okazaki O, Farid NA, and Ikeda T

Drug metabolism and disposition: the biological fate of chemicals 37(11):2145-52, 2009 Nov - Who cited this? | PubMed ID: 19704027 | Fulltext

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.

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Nishiya Y, Hagihara K, Kurihara A, Okudaira N, Farid NA, Okazaki O, and Ikeda T

Xenobiotica; the fate of foreign compounds in biological systems 39(11):836-43, 2009 Nov - Who cited this? | PubMed ID: 19845434 | Fulltext

Pharmacokinetics and pharmacodynamics of prasugrel in subjects with moderate liver disease.

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Small DS, Farid NA, Li YG, Ernest CS, Winters KJ, Salazar DE, and Payne CD

Journal of clinical pharmacy and therapeutics 34(5):575-83, 2009 Oct - Who cited this? | PubMed ID: 19744013 | Fulltext

Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal disease.

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Small DS, Wrishko RE, Ernest CS, Ni L, Winters KJ, Farid NA, Li YG, Brandt JT, Salazar DE, Borel AG, Kles KA, and Payne CD

Journal of clinical pharmacy and therapeutics 34(5):585-94, 2009 Oct - Who cited this? | PubMed ID: 19744014 | Fulltext

Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects.

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Farid NA, Jakubowski JA, Payne CD, Li YG, Jin Y, Ernest II CS, Winters KJ, Brandt JT, Salazar DE, and Small DS

Current medical research and opinion 25(8):1821-9, 2009 Aug - Who cited this? | PubMed ID: 19530977 | Fulltext

Inhibition of platelet aggregation with prasugrel and clopidogrel: an integrated analysis in 846 subjects.

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Li YG, Ni L, Brandt JT, Small DS, Payne CD, Ernest CS, Rohatagi S, Farid NA, Jakubowski JA, and Winters KJ

Platelets 20(5):316-27, 2009 Aug - Who cited this? | PubMed ID: 19637095 | Fulltext

Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel.

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Nishiya Y, Hagihara K, Ito T, Tajima M, Miura S, Kurihara A, Farid NA, and Ikeda T

Drug metabolism and disposition: the biological fate of chemicals 37(3):589-93, 2009 Mar - Who cited this? | PubMed ID: 19047469 | Fulltext

Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.

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Hagihara K, Kazui M, Ikenaga H, Nanba T, Fusegawa K, Takahashi M, Kurihara A, Okazaki O, Farid NA, and Ikeda T

Xenobiotica; the fate of foreign compounds in biological systems 39(3):218-26, 2009 Mar - Who cited this? | PubMed ID: 19280520 | Fulltext

Effect of Age on the Pharmacokinetics and Pharmacodynamics of Prasugrel during Multiple Dosing: An Open-Label, Single-Sequence, Clinical Trial.

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Small DS, Wrishko RE, Ernest CS, Ni L, Winters KJ, Farid NA, Li YG, Salazar DE, and Payne CD

Drugs & aging 26(9):781-90, 2009 - Who cited this? | PubMed ID: 19728751 | Fulltext

Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects.

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Farid NA, Small DS, Payne CD, Jakubowski JA, Brandt JT, Li YG, Ernest CS, Salazar DE, Konkoy CS, and Winters KJ

Pharmacotherapy 28(12):1483-94, 2008 Dec - Who cited this? | PubMed ID: 19025429 | Fulltext

Quantitative determination of clopidogrel active metabolite in human plasma by LC-MS/MS.

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Takahashi M, Pang H, Kawabata K, Farid NA, and Kurihara A

Journal of pharmaceutical and biomedical analysis 48(4):1219-24, 2008 Dec 1 - Who cited this? | PubMed ID: 18829199 | Fulltext

Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.

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Small DS, Farid NA, Li YG, Ernest CS, Payne CD, Salazar DE, and Winters KJ

Current medical research and opinion 24(8):2251-7, 2008 Aug - Who cited this? | PubMed ID: 18786302 | Fulltext

The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2.

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Williams ET, Jones KO, Ponsler GD, Lowery SM, Perkins EJ, Wrighton SA, Ruterbories KJ, Kazui M, and Farid NA

Drug metabolism and disposition: the biological fate of chemicals 36(7):1227, 2008 Jul - Who cited this? | PubMed ID: 18372401 | Fulltext

Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects.

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Payne CD, Li YG, Brandt JT, Jakubowski JA, Small DS, Farid NA, Salazar DE, and Winters KJ

Platelets 19(4):275-81, 2008 Jun - Who cited this? | PubMed ID: 18569863 | Fulltext

Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.

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Small DS, Farid NA, Payne CD, Weerakkody GJ, Li YG, Brandt JT, Salazar DE, and Winters KJ

Journal of clinical pharmacology 48(4):475-84, 2008 Apr - Who cited this? | PubMed ID: 18303127 | Fulltext

The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y(12) inhibition levels following prasugrel and clopidogrel administration.

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Jakubowski JA, Payne CD, Li YG, Brandt JT, Small DS, Farid NA, Salazar DE, and Winters KJ

Thrombosis and haemostasis 99(2):409-15, 2008 Feb - Who cited this? | PubMed ID: 18278193 | Fulltext

Prasugrel, a New Thienopyridine Antiplatelet Drug, Weakly Inhibits Cytochrome P450 2B6 in Humans.

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Farid NA, Payne CD, Ernest CS, Li YG, Winters KJ, Salazar DE, and Small DS

Journal of clinical pharmacology 48(1):53-9, 2008 Jan - Who cited this? | PubMed ID: 18094219 | Fulltext

A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry.

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Jakubowski JA, Payne CD, Li YG, Farid NA, Brandt JT, Small DS, Salazar DE, and Winters KJ

Thrombosis and haemostasis 99(1):215-22, 2008 Jan - Who cited this? | PubMed ID: 18217157 | Fulltext

Comparison of human cytochrome p450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine.

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Hagihara K, Nishiya Y, Kurihara A, Kazui M, Farid NA, and Ikeda T

Drug metabolism and pharmacokinetics 23(6):412-20, 2008 - Who cited this? | PubMed ID: 19122335 | Fulltext

Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.

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Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest CS, Lachno DR, Salazar D, and Winters KJ

Journal of thrombosis and haemostasis : JTH 5(12):2429-36, 2007 Dec - Who cited this? | PubMed ID: 17900275 | Fulltext

Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel.

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Payne CD, Li YG, Small DS, Ernest CS, Farid NA, Jakubowski JA, Brandt JT, Salazar DE, and Winters KJ

Journal of cardiovascular pharmacology 50(5):555-62, 2007 Nov - Who cited this? | PubMed ID: 18030066 | Fulltext

Disposition and metabolic fate of prasugrel in mice, rats, and dogs.

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Smith RL, Gillespie TA, Rash TJ, Kurihara A, and Farid NA

Xenobiotica; the fate of foreign compounds in biological systems 37(8):884-901, 2007 Aug - Who cited this? | PubMed ID: 17701835 | Fulltext

Comparison of speed of onset of platelet inhibition after loading doses of clopidogrel versus prasugrel in healthy volunteers and correlation with responder status.

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Weerakkody GJ, Jakubowski JA, Brandt JT, Farid NA, Payne CD, Zhu J, Warner MR, Naganuma H, and Winters KJ

The American journal of cardiology 100(2):331-6, 2007 Jul 15 - Who cited this? | PubMed ID: 17631093 | Fulltext

The disposition of prasugrel, a novel thienopyridine, in humans.

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Farid NA, Smith RL, Gillespie TA, Rash TJ, Blair PE, Kurihara A, and Goldberg MJ

Drug metabolism and disposition: the biological fate of chemicals 35(7):1096-104, 2007 Jul - Who cited this? | PubMed ID: 17403916 | Fulltext

Absorption, distribution and excretion of the new thienopyridine agent prasugrel in rats.

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Hagihara K, Kurihara A, Kawai K, Kazui M, Takahashi M, Kawabata K, Farid NA, and Ikeda T

Xenobiotica; the fate of foreign compounds in biological systems 37(7):788-801, 2007 Jul - Who cited this? | PubMed ID: 17620223 | Fulltext

Stereoselective metabolism of prasugrel in humans using a novel chiral liquid chromatography-tandem mass spectrometry method.

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Wickremsinhe ER, Tian Y, Ruterbories KJ, Verburg EM, Weerakkody GJ, Kurihara A, and Farid NA

Drug metabolism and disposition: the biological fate of chemicals 35(6):917-21, 2007 Jun - Who cited this? | PubMed ID: 17353347 | Fulltext

Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently.

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Farid NA, Payne CD, Small DS, Winters KJ, Ernest CS, Brandt JT, Darstein C, Jakubowski JA, and Salazar DE

Clinical pharmacology and therapeutics 81(5):735-41, 2007 May - Who cited this? | PubMed ID: 17361128 | Fulltext

Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects.

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Jakubowski JA, Payne CD, Weerakkody GJ, Brandt JT, Farid NA, Li YG, Naganuma H, Lachno DR, and Winters KJ

Journal of cardiovascular pharmacology 49(3):167-73, 2007 Mar - Who cited this? | PubMed ID: 17414229 | Fulltext

A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.

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Brandt JT, Payne CD, Wiviott SD, Weerakkody G, Farid NA, Small DS, Jakubowski JA, Naganuma H, and Winters KJ

American heart journal 153(1):66.e9-16, 2007 Jan - Who cited this? | PubMed ID: 17174640 | Fulltext

Determination of the active and inactive metabolites of prasugrel in human plasma by liquid chromatography/tandem mass spectrometry.

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Farid NA, McIntosh M, Garofolo F, Wong E, Shwajch A, Kennedy M, Young M, Sarkar P, Kawabata K, Takahashi M, and Pang H

Rapid communications in mass spectrometry : RCM 21(2):169-79, 2007 - Who cited this? | PubMed ID: 17154350 | Fulltext

Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450.

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Rehmel JL, Eckstein JA, Farid NA, Heim JB, Kasper SC, Kurihara A, Wrighton SA, and Ring BJ

Drug metabolism and disposition: the biological fate of chemicals 34(4):600, 2006 Apr - Who cited this? | PubMed ID: 16415119 | Fulltext

The platelet inhibitory effects and pharmacokinetics of prasugrel after administration of loading and maintenance doses in healthy subjects.

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Jakubowski JA, Payne CD, Brandt JT, Weerakkody GJ, Farid NA, Small DS, Naganuma H, Li GY, and Winters KJ

Journal of cardiovascular pharmacology 47(3):377-84, 2006 Mar - Who cited this? | PubMed ID: 16633079 | Fulltext

Preclinical characterization of 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic acid metabolism: in vitro species comparison and in vivo disposition in rats.

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Perkins EJ, Cramer JW, Farid NA, Gadberry MG, Jackson DA, Mattiuz EL, O'Bannon DD, Weiss HJ, Wheeler WJ, Wood PG, and Cassidy KC

Drug metabolism and disposition: the biological fate of chemicals 31(11):1382-90, 2003 Nov - Who cited this? | PubMed ID: 14570771 | Fulltext

Disposition of LY333531, a selective protein kinase C beta inhibitor, in the Fischer 344 rat and beagle dog.

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Burkey JL, Campanale KM, O'Bannon DD, Cramer JW, and Farid NA

Xenobiotica; the fate of foreign compounds in biological systems 32(11):1045-52, 2002 Nov - Who cited this? | PubMed ID: 12487733 | Fulltext

Confidence interval criteria for assessment of dose proportionality.

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Smith BP, Vandenhende FR, DeSante KA, Farid NA, Welch PA, Callaghan JT, and Forgue ST

Pharmaceutical research 17(10):1278-83, 2000 Oct - Who cited this? | PubMed ID: 11145235 | Fulltext

Salt form selection and characterization of LY333531 mesylate monohydrate.

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Engel GL, Farid NA, Faul MM, Richardson LA, and Winneroski LL

International journal of pharmaceutics 198(2):239-47, 2000 Apr 5 - Who cited this? | PubMed ID: 10767572 | Fulltext

High-performance liquid chromatographic determination of the enantiomers of the benzoquinolinone LY191704, a human type 1 5 alpha-reductase inhibitor, in plasma.

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Farid NA and Coleman NL

Journal of chromatography. B, Biomedical sciences and applications 691(1):212-6, 1997 Mar 28 - Who cited this? | PubMed ID: 9140778 | Fulltext

Stereoselective disposition of the enantiomers of the benzoquinolinone LY191704, a human type I 5 alpha-reductase inhibitor. Differences between rats and dogs.

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Farid NA, Schreiner KM, Coleman NL, Van Lier RB, and Wrighton SA

Drug metabolism and disposition: the biological fate of chemicals 24(10):1162-5, 1996 Oct - Who cited this? | PubMed ID: 8894520 | Fulltext

Liquid chromatographic control of the identity, purity and "potency" of biomolecules used as drugs.

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Farid NA, Atkins LM, Becker GW, Dinner A, Heiney RE, Miner DJ, and Riggin RM

Journal of pharmaceutical and biomedical analysis 7(2):185-8, 1989 - Who cited this? | PubMed ID: 2488619 | Fulltext

Clinical pharmacology and pharmacokinetics of fluoxetine: a review.

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Bergstrom RF, Lemberger L, Farid NA, and Wolen RL

The British journal of psychiatry. Supplement(3):47-50, 1988 Sep - Who cited this? | PubMed ID: 3074865 | Fulltext

Pressor responses to tyramine and norepinephrine after subchronic administration of fluoxetine to man.

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Bowsher DJ, Rowe H, Farid NA, Tenbarge JB, and Lemberger L

Life sciences 42(25):2569-75, 1988 - Who cited this? | PubMed ID: 3260321 | Fulltext

Fluoxetine, pharmacology and physiologic disposition.

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Lemberger L, Farid NA, Bergstrom RF, and Wolen RL

International journal of obesity 11 Suppl 3:157-61, 1987 - Who cited this? | PubMed ID: 3501991 | Fulltext

Fluoxetine: clinical pharmacology and physiologic disposition.

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Lemberger L, Bergstrom RF, Wolen RL, Farid NA, Enas GG, and Aronoff GR

The Journal of clinical psychiatry 46(3 Pt 2):14-9, 1985 Mar - Who cited this? | PubMed ID: 3871765 | Fulltext

Single-dose and steady-state pharmacokinetics of tomoxetine in normal subjects.

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Farid NA, Bergstrom RF, Ziege EA, Parli CJ, and Lemberger L

Journal of clinical pharmacology 25(4):296-301, 1985 - Who cited this? | PubMed ID: 4008676 | Fulltext

Tc-99m labeled leukocytes: preparation and use in identification of abscess and tissue rejection.

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Farid NA, White SM, Heck LL, and Van Hove ED

Radiology 148(3):827-31, 1983 Sep - Who cited this? | PubMed ID: 6308712 | Fulltext

Determination of mexiletine and its metabolites in serum by liquid chromatography with fluorescence detection.

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Farid NA and White SM

Journal of chromatography 275(2):458-62, 1983 Jul 8 - Who cited this? | PubMed ID: 6619254 | Fulltext

Fluorescamine use in high-performance liquid chromatographic determination of aminocaproic acid in serum.

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Farid NA

Journal of pharmaceutical sciences 68(2):249-52, 1979 Feb - Who cited this? | PubMed ID: 423103 | Fulltext

Synthesis of 14C-meglumine salicylate and its disposition in humans after oral administration.

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Farid NA, Born GS, Kessler WV, Russell HT, Shaw SM, and Lange WE

Journal of pharmaceutical sciences 66(4):536-8, 1977 Apr - Who cited this? | PubMed ID: 856974 | Fulltext

Improved colorimetric determination of salicylic acid and its metabolites in urine.

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Farid NA, Born GS, Kessler WV, Shaw SM, and Lange WE

Clinical chemistry 21(8):1167-8, 1975 Jul - Who cited this? | PubMed ID: 1137922 | Fulltext

Effect of cadmium on palmitic acid metabolism by rat liver homogenate.

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Farid NA, Born GS, Kessler WV, and Anderson VL

Journal of pharmaceutical sciences 63(9):1492-4, 1974 Sep - Who cited this? | PubMed ID: 4427282 | Fulltext

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