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Papers authored by Ewing WR

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Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.

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Haque TS, Liang N, Golla R, Seethala R, Ma Z, Ewing WR, Cooper CB, Pelleymounter MA, Poss MA, and Cheng D

Bioorganic & medicinal chemistry letters 19(20):5872-6, 2009 Oct 15 - Who cited this? | PubMed ID: 19740659 | Fulltext

(d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues.

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Li J, Chen SY, Murphy BJ, Flynn N, Seethala R, Slusarchyk D, Yan M, Sleph P, Zhang H, Humphreys WG, Ewing WR, Robl JA, Gordon D, and Tino JA

Bioorganic & medicinal chemistry letters 18(14):4072-4, 2008 Jul 15 - Who cited this? | PubMed ID: 18554903 | Fulltext

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

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Li J, Chen SY, Tao S, Wang H, Li JJ, Swartz S, Musial C, Hernandez AA, Flynn N, Murphy BJ, Beehler B, Dickinson KE, Giupponi L, Grover G, Seethala R, Sleph P,

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Bioorganic & medicinal chemistry letters 18(6):1825-9, 2008 Mar 15 - Who cited this? | PubMed ID: 18295486 | Fulltext

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.

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Hangeland JJ, Cheney DL, Friends TJ, Swartz S, Levesque PC, Rich AJ, Sun L, Bridal TR, Adam LP, Normandin DE, Murugesan N, and Ewing WR

Bioorganic & medicinal chemistry letters 18(2):474-8, 2008 Jan 15 - Who cited this? | PubMed ID: 18160281 | Fulltext

Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180).

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Li J, Chen SY, Li JJ, Wang H, Hernandez AS, Tao S, Musial CM, Qu F, Swartz S, Chao ST, Flynn N, Murphy BJ, Slusarchyk DA, Seethala R, Yan M, Sleph P,

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Journal of medicinal chemistry 50(24):5890-3, 2007 Nov 29 - Who cited this? | PubMed ID: 17973363 | Fulltext

Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.

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Ellsworth BA, Wang Y, Zhu Y, Pendri A, Gerritz SW, Sun C, Carlson KE, Kang L, Baska RA, Yang Y, Huang Q, Burford NT, Cullen MJ, Johnghar S, Behnia K, Pelleymounter MA,

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Bioorganic & medicinal chemistry letters 17(14):3978-82, 2007 Jul 15 - Who cited this? | PubMed ID: 17513109 | Fulltext

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

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Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL,

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Bioorganic & medicinal chemistry letters 17(12):3511-5, 2007 Jun 15 - Who cited this? | PubMed ID: 17502136 | Fulltext

Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys.

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Zhang H, Zhang D, Li W, Yao M, D'Arienzo C, Li YX, Ewing WR, Gu Z, Zhu Y, Murugesan N, Shyu WC, and Humphreys WG

Drug metabolism and disposition: the biological fate of chemicals 35(5):795, 2007 May - Who cited this? | PubMed ID: 17303626 | Fulltext

Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.

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Murugesan N, Gu Z, Fadnis L, Tellew JE, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Valentine MT, Humphreys WG, Lan SJ, Ewing WR, Carlson KE, Kowala MC, Zahler R,

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Journal of medicinal chemistry 48(1):171-9, 2005 Jan 13 - Who cited this? | PubMed ID: 15634011 | Fulltext

Discovery of a potent and novel motilin agonist.

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Li JJ, Chao HG, Wang H, Tino JA, Lawrence RM, Ewing WR, Ma Z, Yan M, Slusarchyk D, Seethala R, Sun H, Li D, Burford NT, Stoffel RH, Salyan ME, Li CY,

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Journal of medicinal chemistry 47(7):1704-8, 2004 Mar 25 - Who cited this? | PubMed ID: 15027861 | Fulltext

Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.

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Maignan S, Guilloteau JP, Choi-Sledeski YM, Becker MR, Ewing WR, Pauls HW, Spada AP, and Mikol V

Journal of medicinal chemistry 46(5):685-90, 2003 Feb 27 - Who cited this? | PubMed ID: 12593649 | Fulltext

The design of competitive, small-molecule inhibitors of coagulation factor Xa.

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Pauls HW and Ewing WR

Current topics in medicinal chemistry 1(2):83-100, 2001 Jun - Who cited this? | PubMed ID: 11899252 | Fulltext

Crystal structures of human factor Xa complexed with potent inhibitors.

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Maignan S, Guilloteau JP, Pouzieux S, Choi-Sledeski YM, Becker MR, Klein SI, Ewing WR, Pauls HW, Spada AP, and Mikol V

Journal of medicinal chemistry 43(17):3226-32, 2000 Aug 24 - Who cited this? | PubMed ID: 10966741 | Fulltext

Pharmacodynamic activity and antithrombotic efficacy of RPR120844, a novel inhibitor of coagulation factor Xa.

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Leadley RJ, Morgan SR, Bentley R, Bostwick JS, Kasiewski CJ, Heran C, Chu V, Brown K, Moxey P, Ewing WR, Pauls H, Spada AP, Perrone MH, and Dunwiddie CT

Journal of cardiovascular pharmacology 34(6):791-9, 1999 Dec - Who cited this? | PubMed ID: 10598121 | Fulltext

Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors.

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Becker MR, Ewing WR, Davis RS, Pauls HW, Ly C, Li A, Mason HJ, Choi-Sledeski YM, Spada AP, Chu V, Brown KD, Colussi DJ, Leadley RJ, Bentley R, Bostwick J, Kasiewski C,

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Bioorganic & medicinal chemistry letters 9(18):2753-8, 1999 Sep 20 - Who cited this? | PubMed ID: 10509929 | Fulltext

Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa.

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Ewing WR, Becker MR, Manetta VE, Davis RS, Pauls HW, Mason H, Choi-Sledeski YM, Green D, Cha D, Spada AP, Cheney DL, Mason JS, Maignan S, Guilloteau JP, Brown K, Colussi D,

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Journal of medicinal chemistry 42(18):3557-71, 1999 Sep 9 - Who cited this? | PubMed ID: 10479288 | Fulltext

Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization.

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Choi-Sledeski YM, McGarry DG, Green DM, Mason HJ, Becker MR, Davis RS, Ewing WR, Dankulich WP, Manetta VE, Morris RL, Spada AP, Cheney DL, Brown KD, Colussi DJ, Chu V, Heran CL,

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Journal of medicinal chemistry 42(18):3572-87, 1999 Sep 9 - Who cited this? | PubMed ID: 10479289 | Fulltext

Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA.

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Choi-Sledeski YM, Becker MR, Green DM, Davis R, Ewing WR, Mason HJ, Ly C, Spada A, Liang G, Cheney D, Barton J, Chu V, Brown K, Colussi D, Bentley R, Leadley R,

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Bioorganic & medicinal chemistry letters 9(17):2539-44, 1999 Sep 6 - Who cited this? | PubMed ID: 10498204 | Fulltext

RPR120844, a novel, specific inhibitor of coagulation factor Xa inhibits venous thrombosis in the rabbit.

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Bostwick JS, Bentley R, Morgan S, Brown K, Chu V, Ewing WR, Spada AP, Pauls H, Perrone MH, Dunwiddie CT, and Leadley RJ

Thrombosis and haemostasis 81(1):157-60, 1999 Jan - Who cited this? | PubMed ID: 10348709 | Fulltext

Affinity of fibroblast growth factors for beta-cyclodextrin tetradecasulfate.

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Yuen SN, Folkman J, Weisz PB, Joullie MM, and Ewing WR

Analytical biochemistry 185(1):108-11, 1990 Feb 15 - Who cited this? | PubMed ID: 2344037 | Fulltext

Control of angiogenesis with synthetic heparin substitutes.

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Folkman J, Weisz PB, Joullié MM, Li WW, and Ewing WR

Science (New York, N.Y.) 243(4897):1490-3, 1989 Mar 17 - Who cited this? | PubMed ID: 2467380 | Fulltext

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