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Papers authored by Eckhart AD

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[Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration].

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Ma YB, Li BY, Gao HQ, Yao M, Koch WJ, Eckhart AD, and Zhou RH

Zhonghua bing li xue za zhi Chinese journal of pathology 38(1):50-4, 2009 Jan - Who cited this? | PubMed ID: 19489226 | Fulltext

Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances {alpha}1D-adrenergic receptor constriction.

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Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, Dorn GW, and Eckhart AD

American journal of physiology. Heart and circulatory physiology 295(4):H1695-704, 2008 Oct - Who cited this? | PubMed ID: 18723764 | Fulltext

Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure.

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Harris DM, Chen X, Pesant S, Cohn HI, Macdonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, and Eckhart AD

Journal of molecular and cellular cardiology, 2008 Sep 30 - Who cited this? | PubMed ID: 18930063 | Fulltext

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

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Martini JS, Raake P, Vinge LE, Degeorge B, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, and Koch WJ

Proceedings of the National Academy of Sciences of the United States of America 105(34):12457-62, 2008 Aug 26 - Who cited this? | PubMed ID: 18711143 | Fulltext

GPCR signalling in hypertension: role of GRKs.

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Harris DM, Cohn HI, Pesant S, and Eckhart AD

Clinical science (London, England : 1979) 115(3):79, 2008 Aug - Who cited this? | PubMed ID: 18593382 | Fulltext

G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure.

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Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, and Koch WJ

Circulation research, 2008 Jul 17 - Who cited this? | PubMed ID: 18635825 | Fulltext

Central Role of Gq in the Hypertrophic Signal Transduction of Angiotensin II in Vascular Smooth Muscle Cells.

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Ohtsu H, Higuchi S, Shirai H, Eguchi K, Suzuki H, Hinoki A, Brailoiu E, Eckhart AD, Frank GD, and Eguchi S

Endocrinology 149(7):3569, 2008 Jul - Who cited this? | PubMed ID: 18356277 | Fulltext

Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells.

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Mahadev K, Wu X, Donnelly S, Ouedraogo R, Eckhart AD, and Goldstein BJ

Cardiovascular research 78(2):376-84, 2008 May 1 - Who cited this? | PubMed ID: 18267956 | Fulltext

Endothelial S100A1 Modulates Vascular Function via Nitric Oxide.

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Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Völkers M, Heierhorst J, Oie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ,

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Circulation research 102(7):786-94, 2008 Apr 11 - Who cited this? | PubMed ID: 18292599 | Fulltext

Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.

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DeGeorge BR, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, and Koch WJ

Circulation 117(11):1378, 2008 Mar 18 - Who cited this? | PubMed ID: 18316484 | Fulltext

Enhanced sterol response element-binding protein in postintervention restenotic blood vessels plays an important role in vascular smooth muscle proliferation.

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Zhou RH, Pesant S, Cohn HI, and Eckhart AD

Life sciences 82(3-4):174-81, 2008 Jan 16 - Who cited this? | PubMed ID: 18068195 | Fulltext

Vascular smooth muscle G(q) signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension.

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Harris DM, Cohn HI, Pesant S, Zhou RH, and Eckhart AD

American journal of physiology. Heart and circulatory physiology 293(5):H3072-9, 2007 Nov - Who cited this? | PubMed ID: 17873012 | Fulltext

Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.

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Giangrande PH, Zhang J, Tanner A, Eckhart AD, Rempel RE, Andrechek ER, Layzer JM, Keys JR, Hagen PO, Nevins JR, Koch WJ, and Sullenger BA

Proceedings of the National Academy of Sciences of the United States of America 104(32):12988, 2007 Aug 7 - Who cited this? | PubMed ID: 17652516 | Fulltext

Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart.

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Gao E, Boucher M, Chuprun JK, Zhou RH, Eckhart AD, and Koch WJ

American journal of physiology. Heart and circulatory physiology 293(1):H60-8, 2007 Jul - Who cited this? | PubMed ID: 17384131 | Fulltext

Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.

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Pleger ST, Most P, Boucher M, Soltys S, Chuprun JK, Pleger W, Gao E, Dasgupta A, Rengo G, Remppis A, Katus HA, Eckhart AD, Rabinowitz JE, and Koch WJ

Circulation 115(19):2506-15, 2007 May 15 - Who cited this? | PubMed ID: 17470693 | Fulltext

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.

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Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, and Koch WJ

Nature medicine 13(3):315-23, 2007 Mar - Who cited this? | PubMed ID: 17322894 | Fulltext

Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq.

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Kim J, Keys JR, and Eckhart AD

Cellular signalling 18(10):1695-701, 2006 Oct - Who cited this? | PubMed ID: 16504475 | Fulltext

Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.

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Most P, Seifert H, Gao E, Funakoshi H, Völkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR, Eckhart AD, Feldman AM, and Koch WJ

Circulation 114(12):1258, 2006 Sep 19 - Who cited this? | PubMed ID: 16952982 | Fulltext

Galphaq and its Aktions.

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Harris DM, Eckhart AD, and Koch WJ

Journal of molecular and cellular cardiology 40(5):589-92, 2006 May - Who cited this? | PubMed ID: 16630627 | Fulltext

S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.

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Pleger ST, Remppis A, Heidt B, Völkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, Müller OJ, Eckhart AD, Katus HA, Koch WJ, and Most P

Molecular therapy : the journal of the American Society of Gene Therapy 12(6):1120-9, 2005 Dec - Who cited this? | PubMed ID: 16168714 | Fulltext

Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1).

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Tevaearai HT, Walton GB, Keys JR, Koch WJ, and Eckhart AD

The journal of gene medicine 7(9):1172-7, 2005 Sep - Who cited this? | PubMed ID: 15880449 | Fulltext

Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling.

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Keys JR, Zhou RH, Harris DM, Druckman CA, and Eckhart AD

Circulation 112(8):1145-53, 2005 Aug 23 - Who cited this? | PubMed ID: 16103237 | Fulltext

G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.

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Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, and Eguchi S

The Journal of biological chemistry 280(28):26592-9, 2005 Jul 15 - Who cited this? | PubMed ID: 15905175 | Fulltext

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.

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Most P, Pleger ST, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, and Koch WJ

The Journal of clinical investigation 114(11):1550-63, 2004 Dec - Who cited this? | PubMed ID: 15578088 | Fulltext

Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts.

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Tevaearai HT, Walton GB, Eckhart AD, Keys JR, and Koch WJ

The Journal of thoracic and cardiovascular surgery 124(6):1149-56, 2002 Dec - Who cited this? | PubMed ID: 12447181 | Fulltext

Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature.

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Keys JR, Greene EA, Koch WJ, and Eckhart AD

Hypertension 40(5):660-6, 2002 Nov - Who cited this? | PubMed ID: 12411459 | Fulltext

Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation.

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Tevaearai HT, Walton GB, Eckhart AD, Keys JR, and Koch WJ

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 22(5):733-7, 2002 Nov - Who cited this? | PubMed ID: 12414039 | Fulltext

Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.

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Kim J, Eckhart AD, Eguchi S, and Koch WJ

The Journal of biological chemistry 277(35):32116-23, 2002 Aug 30 - Who cited this? | PubMed ID: 12048215 | Fulltext

Myocardial gene transfer and overexpression of beta2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts.

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Tevaearai HT, Eckhart AD, Walton GB, Keys JR, Wilson K, and Koch WJ

Circulation 106(1):124-9, 2002 Jul 2 - Who cited this? | PubMed ID: 12093781 | Fulltext

Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.

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Eckhart AD, Fentzke RC, Lepore J, Lang R, Lin H, Lefkowitz RJ, Koch WJ, and Leiden JM

Journal of molecular and cellular cardiology 34(6):669-77, 2002 Jun - Who cited this? | PubMed ID: 12054854 | Fulltext

Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure.

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Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, and Koch WJ

Molecular pharmacology 61(4):749-58, 2002 Apr - Who cited this? | PubMed ID: 11901213 | Fulltext

Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes.

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Eckhart AD and Koch WJ

Molecular therapy : the journal of the American Society of Gene Therapy 5(1):74-9, 2002 Jan - Who cited this? | PubMed ID: 11786048 | Fulltext

Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure.

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Tevaearai HT, Eckhart AD, and Koch WJ

Minerva cardioangiologica 49(6):389-94, 2001 Dec - Who cited this? | PubMed ID: 11733734 | Fulltext

Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor.

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Tevaearai HT, Eckhart AD, Shotwell KF, Wilson K, and Koch WJ

Circulation 104(17):2069-74, 2001 Oct 23 - Who cited this? | PubMed ID: 11673348 | Fulltext

Transgenic studies of cardiac adrenergic receptor regulation.

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Eckhart AD and Koch WJ

The Journal of pharmacology and experimental therapeutics 299(1):1-5, 2001 Oct - Who cited this? | PubMed ID: 11561056 | Fulltext

Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging.

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Gaballa MA, Eckhart AD, Koch WJ, and Goldman S

Journal of molecular and cellular cardiology 32(9):1745-55, 2000 Sep - Who cited this? | PubMed ID: 10966835 | Fulltext

Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.

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Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, and Koch WJ

Circulation research 86(1):43-50, 2000 - Who cited this? | PubMed ID: 10625304 | Fulltext

In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.

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Akhter SA, Eckhart AD, Rockman HA, Shotwell K, Lefkowitz RJ, and Koch WJ

Circulation 100(6):648-53, 1999 Aug 10 - Who cited this? | PubMed ID: 10441103 | Fulltext

The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats.

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Anderson KM, Eckhart AD, Willette RN, and Koch WJ

Hypertension 33(1 Pt 2):402-7, 1999 Jan - Who cited this? | PubMed ID: 9931137 | Fulltext

Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle.

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Eckhart AD, Yang N, Xin X, and Faber JE

Proceedings of the National Academy of Sciences of the United States of America 94(17):9487-92, 1997 Aug 19 - Who cited this? | PubMed ID: 9256509 | Fulltext

CRE-like response element regulates expression of rat alpha 2D-adrenergic receptor gene in vascular smooth muscle.

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Yang N, Eckhart AD, Xin X, and Faber JE

The American journal of physiology 273(1 Pt 2):H85-95, 1997 Jul - Who cited this? | PubMed ID: 9249478 | Fulltext

Alpha1D-adrenergic receptors and mitogen-activated protein kinase mediate increased protein synthesis by arterial smooth muscle.

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Xin X, Yang N, Eckhart AD, and Faber JE

Molecular pharmacology 51(5):764-75, 1997 May - Who cited this? | PubMed ID: 9145914 | Fulltext

Oxygen modulates alpha 1B-adrenergic receptor gene expression by arterial but not venous vascular smooth muscle.

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Eckhart AD, Zhu Z, Arendshorst WJ, and Faber JE

The American journal of physiology 271(4 Pt 2):H1599-608, 1996 Oct - Who cited this? | PubMed ID: 8897957 | Fulltext

Regulation of vascular smooth muscle growth by alpha 1-adrenoreceptor subtypes in vitro and in situ.

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Chen L, Xin X, Eckhart AD, Yang N, and Faber JE

The Journal of biological chemistry 270(52):30980-8, 1995 Dec 29 - Who cited this? | PubMed ID: 8537355 | Fulltext

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