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Papers authored by Doyu M

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Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis.

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Sone J, Niwa J, Kawai K, Ishigaki S, Yamada S, Adachi H, Katsuno M, Tanaka F, Doyu M, and Sobue G

Journal of neuroscience research 88(1):123-35, 2010 Jan - Who cited this? | PubMed ID: 19610091 | Fulltext

Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy.

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Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N,

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Annals of neurology 65(2):140-50, 2009 Feb - Who cited this? | PubMed ID: 19259967 | Fulltext

Neuropathic pain correlates with myelinated fibre loss and cytokine profile in POEMS syndrome.

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Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Watanabe H, Tanaka F, Doyu M, and Sobue G

Journal of neurology, neurosurgery, and psychiatry 79(10):1171-9, 2008 Oct - Who cited this? | PubMed ID: 18356256 | Fulltext

Nonmyelinating Schwann cell involvement with well-preserved unmyelinated axons in Charcot-Marie-Tooth disease type 1A.

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Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Katsuno M, Tanaka F, Watanabe H, Doyu M, Yoshikawa H, and Sobue G

Journal of neuropathology and experimental neurology 66(11):1027-36, 2007 Nov - Who cited this? | PubMed ID: 17984684 | Fulltext

Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.

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Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, and Sobue G

The Journal of biological chemistry 282(38):28087-95, 2007 Sep 21 - Who cited this? | PubMed ID: 17666395 | Fulltext

Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis.

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Jiang YM, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwa J, Doyu M, Yoshida M, Hashizume Y, and Sobue G

Journal of neuropathology and experimental neurology 66(7):617-27, 2007 Jul - Who cited this? | PubMed ID: 17620987 | Fulltext

CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

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Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, and Sobue G

The Journal of neuroscience : the official journal of the Society for Neuroscience 27(19):5115-26, 2007 May 9 - Who cited this? | PubMed ID: 17494697 | Fulltext

Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy.

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Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, and Sobue G

Neuropathology and applied neurobiology 33(2):135, 2007 Apr - Who cited this? | PubMed ID: 17359355 | Fulltext

Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity.

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Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, and Sobue G

Neurobiology of disease 25(2):331, 2007 Feb - Who cited this? | PubMed ID: 17157513 | Fulltext

Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration.

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Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, and Sobue G

The Journal of neuroscience : the official journal of the Society for Neuroscience 26(47):12106, 2006 Nov 22 - Who cited this? | PubMed ID: 17122035 | Fulltext

Gene expression profiling toward understanding of ALS pathogenesis.

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Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, and Sobue G

Annals of the New York Academy of Sciences 1086:1-10, 2006 Nov - Who cited this? | PubMed ID: 17185501 | Fulltext

Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells.

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Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, and Sobue G

The Journal of biological chemistry 281(33):23842-51, 2006 Aug 18 - Who cited this? | PubMed ID: 16793767 | Fulltext

Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein.

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Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, and Sobue G

Journal of molecular medicine (Berlin, Germany) 84(8):635-46, 2006 Aug - Who cited this? | PubMed ID: 16741751 | Fulltext

Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).

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Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, and Sobue G

Experimental neurology 200(1):8-18, 2006 Jul - Who cited this? | PubMed ID: 16513111 | Fulltext

Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: a pathogenic marker.

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Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, and Sobue G

Annals of neurology 59(3):520-6, 2006 Mar - Who cited this? | PubMed ID: 16358333 | Fulltext

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.

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Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, and Sobue G

Proceedings of the National Academy of Sciences of the United States of America 102(46):16801-6, 2005 Nov 15 - Who cited this? | PubMed ID: 16260738 | Fulltext

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.

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Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, and Sobue G

Nature medicine 11(10):1088-95, 2005 Oct - Who cited this? | PubMed ID: 16155577 | Fulltext

Intraventricular chordoid meningioma presenting with Castleman disease due to overproduction of interleukin-6. Case report.

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Arima T, Natsume A, Hatano H, Nakahara N, Fujita M, Ishii D, Wakabayashi T, Doyu M, Nagasaka T, and Yoshida J

Journal of neurosurgery 102(4):733-7, 2005 Apr - Who cited this? | PubMed ID: 15871519 | Fulltext

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

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Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, and Sobue G

Brain : a journal of neurology 128(Pt 3):659-70, 2005 Mar - Who cited this? | PubMed ID: 15659427 | Fulltext

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis.

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Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, and Sobue G

Annals of neurology 57(2):236, 2005 Feb - Who cited this? | PubMed ID: 15668976 | Fulltext

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.

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Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, and Sobue G

Human molecular genetics 13(11):1183-92, 2004 Jun 1 - Who cited this? | PubMed ID: 15102712 | Fulltext

Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis.

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Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, and Sobue G

Journal of neurochemistry 89(1):64-72, 2004 Apr - Who cited this? | PubMed ID: 15030390 | Fulltext

Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.

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Hishikawa N, Niwa J, Doyu M, Ito T, Ishigaki S, Hashizume Y, and Sobue G

The American journal of pathology 163(2):609-19, 2003 Aug - Who cited this? | PubMed ID: 12875980 | Fulltext

Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.

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Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, and Sobue G

The Journal of biological chemistry 278(31):29106-14, 2003 Aug 1 - Who cited this? | PubMed ID: 12750386 | Fulltext

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy.

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Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, and Sobue G

Nature medicine 9(6):768, 2003 Jun - Who cited this? | PubMed ID: 12754502 | Fulltext

Caspase-1 and -3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study using laser microdissection and real-time RT-PCR.

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Ando Y, Liang Y, Ishigaki S, Niwa J, Jiang Y, Kobayashi Y, Yamamoto M, Doyu M, and Sobue G

Neurochemical research 28(6):839-46, 2003 Jun - Who cited this? | PubMed ID: 12718436 | Fulltext

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein.

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Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, and Sobue G

The Journal of neuroscience : the official journal of the Society for Neuroscience 23(6):2203-11, 2003 Mar 15 - Who cited this? | PubMed ID: 12657679 | Fulltext

Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis.

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Takeuchi H, Kobayashi Y, Ishigaki S, Doyu M, and Sobue G

The Journal of biological chemistry 277(52):50966-72, 2002 Dec 27 - Who cited this? | PubMed ID: 12393885 | Fulltext

c-Jun N-terminal kinase pathway mediates Lactacystin-induced cell death in a neuronal differentiated Neuro2a cell line.

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Sang C, Kobayashi Y, Du J, Katsumo M, Adachi H, Doyu M, and Sobue G

Brain research. Molecular brain research 108(1-2):7-17, 2002 Dec - Who cited this? | PubMed ID: 12480174 | Fulltext

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis.

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Ishigaki S, Niwa J, Ando Y, Yoshihara T, Sawada K, Doyu M, Yamamoto M, Kato K, Yotsumoto Y, and Sobue G

FEBS letters 531(2):354-8, 2002 Nov 6 - Who cited this? | PubMed ID: 12417341 | Fulltext

Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.

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Niwa J, Ishigaki S, Hishikawa N, Yamamoto M, Doyu M, Murata S, Tanaka K, Taniguchi N, and Sobue G

The Journal of biological chemistry 277(39):36793-8, 2002 Sep 27 - Who cited this? | PubMed ID: 12145308 | Fulltext

Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1.

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Takeuchi H, Kobayashi Y, Yoshihara T, Niwa J, Doyu M, Ohtsuka K, and Sobue G

Brain research 949(1-2):11-22, 2002 Sep 13 - Who cited this? | PubMed ID: 12213295 | Fulltext

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.

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Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi Y, Doyu M, and Sobue G

Neuron 35(5):843-54, 2002 Aug 29 - Who cited this? | PubMed ID: 12372280 | Fulltext

X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration.

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Ishigaki S, Liang Y, Yamamoto M, Niwa J, Ando Y, Yoshihara T, Takeuchi H, Doyu M, and Sobue G

Journal of neurochemistry 82(3):576-84, 2002 Aug - Who cited this? | PubMed ID: 12153481 | Fulltext

Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients.

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Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, Aiba I, Abe Y, Tamakoshi A, Doyu M, Hirayama M, and Sobue G

Brain : a journal of neurology 125(Pt 5):1070-83, 2002 May - Who cited this? | PubMed ID: 11960896 | Fulltext

ABO-incompatible auxiliary partial orthotopic liver transplant for late-onset familial amyloid polyneuropathy.

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Watanabe H, Misu K, Kobayashi T, Hattori N, Doyu M, Yokoyama I, Ando Y, Nakao A, and Sobue G

Journal of the neurological sciences 195(1):63-6, 2002 Mar 15 - Who cited this? | PubMed ID: 11867075 | Fulltext

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.

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Yoshihara T, Ishigaki S, Yamamoto M, Liang Y, Niwa J, Takeuchi H, Doyu M, and Sobue G

Journal of neurochemistry 80(1):158, 2002 Jan - Who cited this? | PubMed ID: 11796754 | Fulltext

Low cardiac 123I-MIBG uptake in late-onset familial amyloid polyneuropathy type I (TTR Met30).

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Watanabe H, Misu K, Hirayama M, Hattori N, Yoshihara T, Doyu M, and Sobue G

Journal of neurology 248(7):627-9, 2001 Jul - Who cited this? | PubMed ID: 11518010 | Fulltext

Cardiac (123)I-meta-iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer's disease.

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Watanabe H, Ieda T, Katayama T, Takeda A, Aiba I, Doyu M, Hirayama M, and Sobue G

Journal of neurology, neurosurgery, and psychiatry 70(6):781-3, 2001 Jun - Who cited this? | PubMed ID: 11385013 | Fulltext

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

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Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, and Nishimoto I

Proceedings of the National Academy of Sciences of the United States of America 98(11):6336-41, 2001 May 22 - Who cited this? | PubMed ID: 11371646 | Fulltext

Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death.

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Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Do J, Sang C, Kobayashi Y, Doyu M, and Sobue G

Human molecular genetics 10(10):1039-48, 2001 May 1 - Who cited this? | PubMed ID: 11331614 | Fulltext

A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.

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Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, and Sobue G

Biochemical and biophysical research communications 281(3):706-13, 2001 Mar 2 - Who cited this? | PubMed ID: 11237715 | Fulltext

Gene expression profile in Alzheimer's brain screened by molecular indexing.

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Doyu M, Sawada K, Mitsuma N, Niwa J, Yoshimoto M, Fujii Y, Sobue G, and Kato K

Brain research. Molecular brain research 87(1):1-11, 2001 Feb 19 - Who cited this? | PubMed ID: 11223154 | Fulltext

Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells.

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Ishigaki S, Niwa J, Yoshihara T, Mitsuma N, Doyu M, and Sobue G

Biochemical and biophysical research communications 279(2):526-33, 2000 Dec 20 - Who cited this? | PubMed ID: 11118320 | Fulltext

Detection of triplet repeat expansion in the human genome by use of hybridization signal intensity.

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Sawada K, Doyu M, Tanaka F, Sobue G, and Kato K

Analytical biochemistry 286(1):59-66, 2000 Nov 1 - Who cited this? | PubMed ID: 11038274 | Fulltext

The role of lymphotoxin in pathogenesis of polymyositis.

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Liang Y, Inukai A, Kuru S, Kato T, Doyu M, and Sobue G

Acta neuropathologica 100(5):521-7, 2000 Nov - Who cited this? | PubMed ID: 11045674 | Fulltext

Differential somatic CAG repeat instability in variable brain cell lineage in dentatorubral pallidoluysian atrophy (DRPLA): a laser-captured microdissection (LCM)-based analysis.

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Watanabe H, Tanaka F, Doyu M, Riku S, Yoshida M, Hashizume Y, and Sobue G

Human genetics 107(5):452-7, 2000 Nov - Who cited this? | PubMed ID: 11140942 | Fulltext

Reduced expression of DMAHP/SIX5 gene in myotonic dystrophy muscle.

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Inukai A, Doyu M, Kato T, Liang Y, Kuru S, Yamamoto M, Kobayashi Y, and Sobue G

Muscle & nerve 23(9):1421-6, 2000 Sep - Who cited this? | PubMed ID: 10951446 | Fulltext

Mutations in the peripheral myelin protein zero and connexin32 genes detected by non-isotopic RNase cleavage assay and their phenotypes in Japanese patients with Charcot-Marie-Tooth disease.

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Yoshihara T, Yamamoto M, Doyu M, Mis KI, Hattori N, Hasegawa Y, Mokuno K, Mitsuma T, and Sobue G

Human mutation 16(2):177-8, 2000 Aug - Who cited this? | PubMed ID: 10923043 | Fulltext

Temporal expression of mRNAs for neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11Ralpha and OSMRbeta) in peripheral nerve injury.

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Ito Y, Yamamoto M, Li M, Mitsuma N, Tanaka F, Doyu M, Suzumura A, Mitsuma T, and Sobue G

Neurochemical research 25(8):1113-8, 2000 Aug - Who cited this? | PubMed ID: 11055749 | Fulltext

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