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Papers authored by Downing KH

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Survey of large protein complexes in D. vulgaris reveals great structural diversity.

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Han BG, Dong M, Liu H, Camp L, Geller J, Singer M, Hazen TC, Choi M, Witkowska HE, Ball DA, Typke D, Downing KH, Shatsky M, Brenner SE, Chandonia JM, Biggin MD,

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Proceedings of the National Academy of Sciences of the United States of America 106(39):16580-5, 2009 Sep 29 - Who cited this? | PubMed ID: 19805340 | Fulltext

Real-time molecular monitoring of chemical environment in obligate anaerobes during oxygen adaptive response.

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Holman HY, Wozei E, Lin Z, Comolli LR, Ball DA, Borglin S, Fields MW, Hazen TC, and Downing KH

Proceedings of the National Academy of Sciences of the United States of America 106(31):12599-604, 2009 Aug 4 - Who cited this? | PubMed ID: 19541631 | Fulltext

Effect of ion distribution on conductivity of block copolymer electrolytes.

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Gomez ED, Panday A, Feng EH, Chen V, Stone GM, Minor AM, Kisielowski C, Downing KH, Borodin O, Smith GD, and Balsara NP

Nano letters 9(3):1212-6, 2009 Mar - Who cited this? | PubMed ID: 19193125 | Fulltext

Three-dimensional analysis of the structure and ecology of a novel, ultra-small archaeon.

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Comolli LR, Baker BJ, Downing KH, Siegerist CE, and Banfield JF

The ISME journal 3(2):159-67, 2009 Feb - Who cited this? | PubMed ID: 18946497 | Fulltext

A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole.

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Bowman GR, Comolli LR, Zhu J, Eckart M, Koenig M, Downing KH, Moerner WE, Earnest T, and Shapiro L

Cell 134(6):945, 2008 Sep 19 - Who cited this? | PubMed ID: 18805090 | Fulltext

Restoration of weak phase-contrast images recorded with a high degree of defocus: The "twin image" problem associated with CTF correction.

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Downing KH and Glaeser RM

Ultramicroscopy 108(9):921-8, 2008 Aug - Who cited this? | PubMed ID: 18508199 | Fulltext

Aspects of using a boersch type phase shifting device for contrast enhancement in macromolecular electron microscopy.

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Typke D, Glaeser R, Downing Kh, Tiemeijer P, Cambie R, and Jin J

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 14 Suppl 2:74-5, 2008 Aug - Who cited this? | PubMed ID: 18673620 | Fulltext

Structural study of multiple microtubule types by cryo-electron microscopy.

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Sui H and Downing Kh

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 14 Suppl 2:1478-9, 2008 Aug - Who cited this? | PubMed ID: 18674322 | Fulltext

The kinesin-1 motor protein is regulated by a direct interaction of its head and tail.

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Dietrich KA, Sindelar CV, Brewer PD, Downing KH, Cremo CR, and Rice SE

Proceedings of the National Academy of Sciences of the United States of America 105(26):8938-43, 2008 Jul 1 - Who cited this? | PubMed ID: 18579780 | Fulltext

A charge coupled device camera with electron decelerator for intermediate voltage electron microscopy.

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Downing KH and Mooney PE

The Review of scientific instruments 79(4):043702, 2008 Apr - Who cited this? | PubMed ID: 18447528 | Fulltext

Markov random field based automatic image alignment for electron tomography.

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Amat F, Moussavi F, Comolli LR, Elidan G, Downing KH, and Horowitz M

Journal of structural biology 161(3):260-75, 2008 Mar - Who cited this? | PubMed ID: 17855124 | Fulltext

Three-dimensional architecture of the bacteriophage phi29 packaged genome and elucidation of its packaging process.

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Comolli LR, Spakowitz AJ, Siegerist CE, Jardine PJ, Grimes S, Anderson DL, Bustamante C, and Downing KH

Virology 371(2):267-77, 2008 Feb 20 - Who cited this? | PubMed ID: 18001811 | Fulltext

Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells.

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Killilea AN, Downing KH, and Killilea DW

Cancer letters 258(1):70-9, 2007 Dec 8 - Who cited this? | PubMed ID: 17905512 | Fulltext

Electron crystallography of the scrapie prion protein complexed with heavy metals.

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Wille H, Govaerts C, Borovinskiy A, Latawiec D, Downing KH, Cohen FE, and Prusiner SB

Archives of biochemistry and biophysics 467(2):239-48, 2007 Nov 15 - Who cited this? | PubMed ID: 17935686 | Fulltext

Electron tomography: a 3D view of the subcellular world.

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Downing KH, Sui H, and Auer M

Analytical chemistry 79(21):7949-57, 2007 Nov 1 - Who cited this? | PubMed ID: 18044021 | Fulltext

Increased water retention in polymer electrolyte membranes at elevated temperatures assisted by capillary condensation.

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Park MJ, Downing KH, Jackson A, Gomez ED, Minor AM, Cookson D, Weber AZ, and Balsara NP

Nano letters 7(11):3547-52, 2007 Nov - Who cited this? | PubMed ID: 17960948 | Fulltext

The beginning of kinesin's force-generating cycle visualized at 9-A resolution.

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Sindelar CV and Downing KH

The Journal of cell biology 177(3):377-85, 2007 May 7 - Who cited this? | PubMed ID: 17470637 | Fulltext

Structural insights into microtubule doublet interactions in axonemes.

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Downing KH and Sui H

Current opinion in structural biology 17(2):253-9, 2007 Apr - Who cited this? | PubMed ID: 17387011 | Fulltext

Stroboscopic image capture: reducing the dose per frame by a factor of 30 does not prevent beam-induced specimen movement in paraffin.

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Typke D, Gilpin CJ, Downing KH, and Glaeser RM

Ultramicroscopy 107(2-3):106-15, 2007 - Who cited this? | PubMed ID: 16905258 | Fulltext

Design of a microfabricated, two-electrode phase-contrast element suitable for electron microscopy.

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Cambie R, Downing KH, Typke D, Glaeser RM, and Jin J

Ultramicroscopy 107(4-5):329-39, 2007 - Who cited this? | PubMed ID: 17079082 | Fulltext

Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography.

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Sui H and Downing KH

Nature 442(7101):475-8, 2006 Jul 27 - Who cited this? | PubMed ID: 16738547 | Fulltext

Characterization of intact subcellular bodies in whole bacteria by cryo-electron tomography and spectroscopic imaging.

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Comolli LR, Kundmann M, and Downing KH

Journal of microscopy 223(Pt 1):40-52, 2006 Jul - Who cited this? | PubMed ID: 16872430 | Fulltext

Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II.

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Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, and Kuriyan J

The FEBS journal 273(4):682, 2006 Feb - Who cited this? | PubMed ID: 16441656 | Fulltext

Dose tolerance at helium and nitrogen temperatures for whole cell electron tomography.

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Comolli LR and Downing KH

Journal of structural biology 152(3):149-56, 2005 Dec - Who cited this? | PubMed ID: 16198601 | Fulltext

Distinct constrictive processes, separated in time and space, divide caulobacter inner and outer membranes.

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Judd EM, Comolli LR, Chen JC, Downing KH, Moerner WE, and McAdams HH

Journal of bacteriology 187(20):6874, 2005 Oct - Who cited this? | PubMed ID: 16199556 | Fulltext

High-throughput film-densitometry: an efficient approach to generate large data sets.

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Typke D, Nordmeyer RA, Jones A, Lee J, Avila-Sakar A, Downing KH, and Glaeser RM

Journal of structural biology 149(1):17-29, 2005 Jan - Who cited this? | PubMed ID: 15629654 | Fulltext

Experimental characterization and mitigation of specimen charging on thin films with one conducting layer.

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Downing KH, McCartney MR, and Glaeser RM

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 10(6):783-9, 2004 Dec - Who cited this? | PubMed ID: 19780320 | Fulltext

Specimen charging on thin films with one conducting layer: discussion of physical principles.

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Glaeser RM and Downing KH

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 10(6):790-6, 2004 Dec - Who cited this? | PubMed ID: 19780321 | Fulltext

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.

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Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, and Downing KH

Science (New York, N.Y.) 305(5685):866-9, 2004 Aug 6 - Who cited this? | PubMed ID: 15297674 | Fulltext

Meiosis-specific failure of cell cycle progression in fission yeast by mutation of a conserved beta-tubulin residue.

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Paluh JL, Killilea AN, Detrich HW, and Downing KH

Molecular biology of the cell 15(3):1160-71, 2004 Mar - Who cited this? | PubMed ID: 14657251 | Fulltext

Electron microscopy of biological macromolecules: bridging the gap between what physics allows and what we currently can get.

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Typke D, Downing KH, and Glaeser RM

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 10(1):21-7, 2004 Feb - Who cited this? | PubMed ID: 15306063 | Fulltext

Three-dimensional diffractive imaging for crystalline monolayers with one-dimensional compact support.

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Spence JC, Weierstall U, Fricke TT, Glaeser RM, and Downing KH

Journal of structural biology 144(1-2):209-18, 2003 - Who cited this? | PubMed ID: 14643223 | Fulltext

Microtubule structure at 8 A resolution.

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Li H, DeRosier DJ, Nicholson WV, Nogales E, and Downing KH

Structure (London, England : 1993) 10(10):1317-28, 2002 Oct - Who cited this? | PubMed ID: 12377118 | Fulltext

Modeling chemical bonding effects for protein electron crystallography: the transferable fragmental electrostatic potential (TFESP) method.

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Zhong S, Dadarlat VM, Glaeser RM, Head-Gordon T, and Downing KH

Acta crystallographica. Section A, Foundations of crystallography 58(Pt 2):162-70, 2002 Mar - Who cited this? | PubMed ID: 11832586 | Fulltext

Cryoelectron microscopy of lambda phage DNA condensates in vitreous ice: the fine structure of DNA toroids.

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Hud NV and Downing KH

Proceedings of the National Academy of Sciences of the United States of America 98(26):14925-30, 2001 Dec 18 - Who cited this? | PubMed ID: 11734630 | Fulltext

Structure of an early intermediate in the M-state phase of the bacteriorhodopsin photocycle.

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Facciotti MT, Rouhani S, Burkard FT, Betancourt FM, Downing KH, Rose RB, McDermott G, and Glaeser RM

Biophysical journal 81(6):3442-55, 2001 Dec - Who cited this? | PubMed ID: 11721006 | Fulltext

Refined structure of alpha beta-tubulin at 3.5 A resolution.

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Löwe J, Li H, Downing KH, and Nogales E

Journal of molecular biology 313(5):1045-57, 2001 Nov 9 - Who cited this? | PubMed ID: 11700061 | Fulltext

Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump.

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Avila-Sakar AJ, Misaghi S, Wilson-Kubalek EM, Downing KH, Zgurskaya H, Nikaido H, and Nogales E

Journal of structural biology 136(1):81-8, 2001 Oct - Who cited this? | PubMed ID: 11858709 | Fulltext

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density.

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Snyder JP, Nettles JH, Cornett B, Downing KH, and Nogales E

Proceedings of the National Academy of Sciences of the United States of America 98(9):5312, 2001 Apr 24 - Who cited this? | PubMed ID: 11309480 | Fulltext

Dinitroaniline herbicides against protozoan parasites: the case of Trypanosoma cruzi.

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Traub-Cseko YM, Ramalho-Ortigão JM, Dantas AP, de Castro SL, Barbosa HS, and Downing KH

Trends in parasitology 17(3):136-41, 2001 Mar - Who cited this? | PubMed ID: 11286798 | Fulltext

Cold adaptation of microtubule assembly and dynamics. Structural interpretation of primary sequence changes present in the alpha- and beta-tubulins of Antarctic fishes.

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Detrich HW, Parker SK, Williams RC, Nogales E, and Downing KH

The Journal of biological chemistry 275(47):37038-47, 2000 Nov 24 - Who cited this? | PubMed ID: 10956651 | Fulltext

Structure-function relationships in yeast tubulins.

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Richards KL, Anders KR, Nogales E, Schwartz K, Downing KH, and Botstein D

Molecular biology of the cell 11(5):1887, 2000 May - Who cited this? | PubMed ID: 10793159 | Fulltext

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.

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Giannakakou P, Gussio R, Nogales E, Downing KH, Zaharevitz D, Bollbuck B, Poy G, Sackett D, Nicolaou KC, and Fojo T

Proceedings of the National Academy of Sciences of the United States of America 97(6):2904-9, 2000 Mar 14 - Who cited this? | PubMed ID: 10688884 | Fulltext

Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics.

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Downing KH

Annual review of cell and developmental biology 16:89-111, 2000 - Who cited this? | PubMed ID: 11031231 | Fulltext

Visualizing a new binding site of ncd-motor domain on tubulin.

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Han Y, Sablin EP, Nogales E, Fletterick RJ, and Downing KH

Journal of structural biology 128(1):26-33, 1999 Dec 1 - Who cited this? | PubMed ID: 10600555 | Fulltext

Crystallographic structure of tubulin: implications for dynamics and drug binding.

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Downing KH and Nogales E

Cell structure and function 24(5):269-75, 1999 Oct - Who cited this? | PubMed ID: 15216882 | Fulltext

Chemical bonding effects in the determination of protein structures by electron crystallography.

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Chang S, Head-Gordon T, Glaeser RM, and Downing KH

Acta crystallographica. Section A, Foundations of crystallography 55 ( Pt 2 Pt 2):305-13, 1999 Mar 1 - Who cited this? | PubMed ID: 10927261 | Fulltext

Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin.

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Feierbach B, Nogales E, Downing KH, and Stearns T

The Journal of cell biology 144(1):113-24, 1999 Jan 11 - Who cited this? | PubMed ID: 9885248 | Fulltext

High-resolution model of the microtubule.

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Nogales E, Whittaker M, Milligan RA, and Downing KH

Cell 96(1):79-88, 1999 Jan 8 - Who cited this? | PubMed ID: 9989499 | Fulltext

Cryo-electron microscopy of GDP-tubulin rings.

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Nicholson WV, Lee M, Downing KH, and Nogales E

Cell biochemistry and biophysics 31(2):175-83, 1999 - Who cited this? | PubMed ID: 10593258 | Fulltext

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