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Papers authored by Downing JR

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Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression.

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Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C,

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Molecular and cellular biology 29(21):5911-22, 2009 Nov - Who cited this? | PubMed ID: 19704007 | Fulltext

Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.

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Mullighan CG, Collins-Underwood JR, Phillips LA, Loudin MG, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Meyer J, Carroll AJ, Williams RT, Cheng J, Heerema NA,

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Nature genetics 41(11):1243-6, 2009 Nov - Who cited this? | PubMed ID: 19838194 | Fulltext

Can Treating the SYK Cell Cure Leukemia?.

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Downing JR

Cancer cell 16(4):270-1, 2009 Oct 6 - Who cited this? | PubMed ID: 19800569 | Fulltext

Cancer genomes -- continuing progress.

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Downing JR

The New England journal of medicine 361(11):1111-2, 2009 Sep 10 - Who cited this? | PubMed ID: 19657111 | Fulltext

PROMISE: a tool to identify genomic features with a specific biologically interesting pattern of associations with multiple endpoint variables.

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Pounds S, Cheng C, Cao X, Crews KR, Plunkett W, Gandhi V, Rubnitz J, Ribeiro RC, Downing JR, and Lamba J

Bioinformatics (Oxford, England) 25(16):2013-9, 2009 Aug 15 - Who cited this? | PubMed ID: 19528086 | Fulltext

Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder.

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Oravecz-Wilson KI, Philips ST, Yilmaz OH, Ames HM, Li L, Crawford BD, Gauvin AM, Lucas PC, Sitwala K, Downing JR, Morrison SJ, and Ross TS

Cancer cell 16(2):137-48, 2009 Aug 4 - Who cited this? | PubMed ID: 19647224 | Fulltext

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia.

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Radtke I, Mullighan CG, Ishii M, Su X, Cheng J, Ma J, Ganti R, Cai Z, Goorha S, Pounds SB, Cao X, Obert C, Armstrong J, Zhang J, Song G, Ribeiro RC,

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Proceedings of the National Academy of Sciences of the United States of America 106(31):12944-9, 2009 Aug 4 - Who cited this? | PubMed ID: 19651601 | Fulltext

Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial.

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Rubnitz JE, Crews KR, Pounds S, Yang S, Campana D, Gandhi VV, Raimondi SC, Downing JR, Razzouk BI, Pui CH, and Ribeiro RC

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 23(8):1410-6, 2009 Aug - Who cited this? | PubMed ID: 19242495 | Fulltext

Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.

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Jeha S, Pei D, Raimondi SC, Onciu M, Campana D, Cheng C, Sandlund JT, Ribeiro RC, Rubnitz JE, Howard SC, Downing JR, Evans WE, Relling MV, and Pui CH

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 23(8):1406-9, 2009 Aug - Who cited this? | PubMed ID: 19282835 | Fulltext

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.

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Mullighan CG and Downing JR

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 23(7):1209-18, 2009 Jul - Who cited this? | PubMed ID: 19242497 | Fulltext

Treating childhood acute lymphoblastic leukemia without cranial irradiation.

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Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V,

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The New England journal of medicine 360(26):2730-41, 2009 Jun 25 - Who cited this? | PubMed ID: 19553647 | Fulltext

JAK mutations in high-risk childhood acute lymphoblastic leukemia.

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Mullighan CG, Zhang J, Harvey RC, Collins-Underwood JR, Schulman BA, Phillips LA, Tasian SK, Loh ML, Su X, Liu W, Devidas M, Atlas SR, Chen IM, Clifford RJ, Gerhard DS, Carroll WL,

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Proceedings of the National Academy of Sciences of the United States of America 106(23):9414-8, 2009 Jun 9 - Who cited this? | PubMed ID: 19470474 | Fulltext

Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital.

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Rubnitz JE, Onciu M, Pounds S, Shurtleff S, Cao X, Raimondi SC, Behm FG, Campana D, Razzouk BI, Ribeiro RC, Downing JR, and Pui CH

Blood 113(21):5083-9, 2009 May 21 - Who cited this? | PubMed ID: 19131545 | Fulltext

Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.

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French D, Yang W, Cheng C, Raimondi SC, Mullighan CG, Downing JR, Evans WE, Pui CH, and Relling MV

Blood 113(19):4512-20, 2009 May 7 - Who cited this? | PubMed ID: 19066393 | Fulltext

Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy.

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Davé UP, Akagi K, Tripathi R, Cleveland SM, Thompson MA, Yi M, Stephens R, Downing JR, Jenkins NA, and Copeland NG

PLoS genetics 5(5):e1000491, 2009 May - Who cited this? | PubMed ID: 19440365 | Fulltext

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.

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Davé UP, Akagi K, Tripathi R, Cleveland SM, Thompson MA, Yi M, Stephens R, Downing JR, Jenkins NA, and Copeland NG

PLoS genetics 5(5):e1000491, 2009 May - Who cited this? | PubMed ID: 19461887 | Fulltext

Mouse models of human AML accurately predict chemotherapy response.

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Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, and Lowe SW

Genes & development 23(7):877-89, 2009 Apr 1 - Who cited this? | PubMed ID: 19339691 | Fulltext

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

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Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, Chang HY, Shurtleff SA, Downing JR, and Cleary ML

Cell stem cell 4(2):129-40, 2009 Feb 6 - Who cited this? | PubMed ID: 19200802 | Fulltext

Reference alignment of SNP microarray signals for copy number analysis of tumors.

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Pounds S, Cheng C, Mullighan C, Raimondi SC, Shurtleff S, and Downing JR

Bioinformatics (Oxford, England) 25(3):315-21, 2009 Feb 1 - Who cited this? | PubMed ID: 19052058 | Fulltext

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.

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Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, Cheng C, Su X, Rubnitz JE, Basso G, Biondi A, Pui CH, Downing JR, and Campana D

The lancet oncology 10(2):147-56, 2009 Feb - Who cited this? | PubMed ID: 19147408 | Fulltext

Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.

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Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB, Ma J, Liu W, Cheng C, Schulman BA, Harvey RC, Chen IM, Clifford RJ, Carroll WL, Reaman G, Bowman WP,

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The New England journal of medicine 360(5):470-80, 2009 Jan 29 - Who cited this? | PubMed ID: 19129520 | Fulltext

Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.

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Yang JJ, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds SB, Neale G, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui CH, Devidas M, Bowman WP,

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JAMA : the journal of the American Medical Association 301(4):393-403, 2009 Jan 28 - Who cited this? | PubMed ID: 19176441 | Fulltext

Global genomic characterization of acute lymphoblastic leukemia.

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Mullighan CG and Downing JR

Seminars in hematology 46(1):3-15, 2009 Jan - Who cited this? | PubMed ID: 19100363 | Fulltext

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

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Mullighan CG, Phillips LA, Su X, Ma J, Miller CB, Shurtleff SA, and Downing JR

Science (New York, N.Y.) 322(5906):1377-80, 2008 Nov 28 - Who cited this? | PubMed ID: 19039135 | Fulltext

Coding polymorphisms in CD33 and response to gemtuzumab ozogamicin in pediatric patients with AML: a pilot study.

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Lamba JK, Pounds S, Cao X, Downing JR, Campana D, Ribeiro RC, Pui CH, and Rubnitz JE

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008 Jul 10 - Who cited this? | PubMed ID: 18615103 | Fulltext

An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase.

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Kohlmann A, Kipps TJ, Rassenti LZ, Downing JR, Shurtleff SA, Mills KI, Gilkes AF, Hofmann WK, Basso G, Dell'orto MC, Foà R, Chiaretti S, De Vos J, Rauhut S, Papenhausen PR, Hernández JM,

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British journal of haematology, 2008 Jun 20 - Who cited this? | PubMed ID: 18573112 | Fulltext

Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.

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Mullighan CG, Williams RT, Downing JR, and Sherr CJ

Genes & development 22(11):1411-5, 2008 Jun 1 - Who cited this? | PubMed ID: 18519632 | Fulltext

BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.

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Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH, Relling MV, Shurtleff SA, and Downing JR

Nature 453(7191):110, 2008 May 1 - Who cited this? | PubMed ID: 18408710 | Fulltext

Targeted therapy in leukemia.

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Downing JR

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 21 Suppl 2:S2-7, 2008 May - Who cited this? | PubMed ID: 18437169 | Fulltext

Response: Genes associated with response to therapy in childhood acute lymphoblastic leukemia.

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Flotho C, Coustan-Smith E, Pei D, Cheng C, Song G, Pui CH, Downing JR, and Campana D

Blood 111(4):2487-8, 2008 Feb 15 - Who cited this? | PubMed ID: 18263788 | Fulltext

Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.

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French D, Yang W, Hamilton LH, Neale G, Fan Y, Downing JR, Cox NJ, Pui CH, Evans WE, and Relling MV

PLoS ONE 3(5), 2008 - Who cited this? | PubMed ID: 18478092 | Fulltext

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias.

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Mullighan CG, Kennedy A, Zhou X, Radtke I, Phillips LA, Shurtleff SA, and Downing JR

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 21(9):2000-9, 2007 Sep - Who cited this? | PubMed ID: 17597811 | Fulltext

Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.

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Flotho C, Steinemann D, Mullighan CG, Neale G, Mayer K, Kratz CP, Schlegelberger B, Downing JR, and Niemeyer CM

Oncogene 26(39):5816-21, 2007 Aug 23 - Who cited this? | PubMed ID: 17353900 | Fulltext

A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia.

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Flotho C, Coustan-Smith E, Pei D, Cheng C, Song G, Pui CH, Downing JR, and Campana D

Blood 110(4):1271-7, 2007 Aug 15 - Who cited this? | PubMed ID: 17456722 | Fulltext

MN1 overexpression is an important step in the development of inv(16) AML.

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Carella C, Bonten J, Sirma S, Kranenburg TA, Terranova S, Klein-Geltink R, Shurtleff S, Downing JR, Zwarthoff EC, Liu PP, and Grosveld GC

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 21(8):1679, 2007 Aug - Who cited this? | PubMed ID: 17525718 | Fulltext

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.

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Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, and Downing JR

Nature 446(7137):758-64, 2007 Apr 12 - Who cited this? | PubMed ID: 17344859 | Fulltext

Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase.

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Iwamoto S, Mihara K, Downing JR, Pui CH, and Campana D

The Journal of clinical investigation 117(4):1049, 2007 Apr - Who cited this? | PubMed ID: 17380207 | Fulltext

Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols.

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Holleman A, den Boer ML, Cheok MH, Kazemier KM, Pei D, Downing JR, Janka-Schaub GE, Göbel U, Graubner UB, Pui CH, Evans WE, and Pieters R

Blood 108(6):1984-90, 2006 Sep 15 - Who cited this? | PubMed ID: 16709928 | Fulltext

Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2.

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Flotho C, Coustan-Smith E, Pei D, Iwamoto S, Song G, Cheng C, Pui CH, Downing JR, and Campana D

Blood 108(3):1050-7, 2006 Aug 1 - Who cited this? | PubMed ID: 16627760 | Fulltext

Genome-wide approach to identify risk factors for therapy-related myeloid leukemia.

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Bogni A, Cheng C, Liu W, Yang W, Pfeffer J, Mukatira S, French D, Downing JR, Pui CH, and Relling MV

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 20(2):239, 2006 Feb - Who cited this? | PubMed ID: 16341039 | Fulltext

Tumor-specific genetic lesions and their influence on therapy in pediatric acute lymphoblastic leukemia.

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Downing JR and Mullighan CG

Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program:118-22, 508, 2006 - Who cited this? | PubMed ID: 17124049 | Fulltext

Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia.

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Pui CH, Pei D, Sandlund JT, Campana D, Ribeiro RC, Razzouk BI, Rubnitz JE, Howard SC, Hijiya N, Jeha S, Cheng C, Downing JR, Evans WE, Relling MV, and Hudson M

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23(31):7936, 2005 Nov 1 - Who cited this? | PubMed ID: 16258093 | Fulltext

Global gene expression as a function of germline genetic variation.

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French D, Wilkinson MR, Yang W, de Chaisemartin L, Cook EH, Das S, Ratain MJ, Evans WE, Downing JR, Pui CH, and Relling MV

Human molecular genetics 14(12):1621-9, 2005 Jun 15 - Who cited this? | PubMed ID: 15857854 | Fulltext

MicroRNA expression profiles classify human cancers.

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Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, and Golub TR

Nature 435(7043):834-8, 2005 Jun 9 - Who cited this? | PubMed ID: 15944708 | Fulltext

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.

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Kager L, Cheok M, Yang W, Zaza G, Cheng Q, Panetta JC, Pui CH, Downing JR, Relling MV, and Evans WE

The Journal of clinical investigation 115(1):110, 2005 Jan - Who cited this? | PubMed ID: 15630450 | Fulltext

Genomic assessment of pediatric acute leukemia.

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Mullighan CG, Flotho C, and Downing JR

Cancer journal (Sudbury, Mass.) 11(4):268-82, 2005 - Who cited this? | PubMed ID: 16197717 | Fulltext

Gene expression profiling of pediatric acute myelogenous leukemia.

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Ross ME, Mahfouz R, Onciu M, Liu HC, Zhou X, Song G, Shurtleff SA, Pounds S, Cheng C, Ma J, Ribeiro RC, Rubnitz JE, Girtman K, Williams WK, Raimondi SC, Liang DC,

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Blood 104(12):3679, 2004 Dec 1 - Who cited this? | PubMed ID: 15226186 | Fulltext

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors.

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Sun W and Downing JR

Blood 104(12):3565, 2004 Dec 1 - Who cited this? | PubMed ID: 15297309 | Fulltext

Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital.

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Pui CH, Sandlund JT, Pei D, Campana D, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk BI, Howard SC, Hudson MM, Cheng C, Kun LE, Raimondi SC, Behm FG, Downing JR, Relling MV,

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Blood 104(9):2690, 2004 Nov 1 - Who cited this? | PubMed ID: 15251979 | Fulltext

TGF-beta signaling, tumor suppression, and acute lymphoblastic leukemia.

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Downing JR

The New England journal of medicine 351(6):528-30, 2004 Aug 5 - Who cited this? | PubMed ID: 15295044 | Fulltext

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