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Papers authored by Depinho RA

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Context-dependent transformation of adult pancreatic cells by oncogenic k-ras.

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Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, Depinho RA, and Jacks T

Cancer cell 16(5):379-89, 2009 Nov 6 - Who cited this? | PubMed ID: 19878870 | Fulltext

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.

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Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL,

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Cell stem cell 5(5):540-53, 2009 Nov 6 - Who cited this? | PubMed ID: 19896444 | Fulltext

Foxo1 integrates insulin signaling with mitochondrial function in the liver.

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Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, and White MF

Nature medicine 15(11):1307-11, 2009 Nov - Who cited this? | PubMed ID: 19838201 | Fulltext

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival.

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Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, Depinho RA, Kutok JL, Kearney JF, Otipoby KL, and Rajewsky K

Cell 139(3):573-86, 2009 Oct 30 - Who cited this? | PubMed ID: 19879843 | Fulltext

Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.

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Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, and Accili D

Diabetes 58(10):2344-54, 2009 Oct - Who cited this? | PubMed ID: 19584310 | Fulltext

FoxO4 Inhibits NF-kappaB and Protects Mice Against Colonic Injury and Inflammation.

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Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, Depinho RA, and Liu ZP

Gastroenterology 137(4):1403-14, 2009 Oct - Who cited this? | PubMed ID: 19560465 | Fulltext

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.

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Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, Depinho RA, Wardlaw SL, and Accili D

Nature medicine 15(10):1195-201, 2009 Oct - Who cited this? | PubMed ID: 19767734 | Fulltext

Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.

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Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, and Accili D

Molecular and cellular biology 29(16):4417-30, 2009 Aug - Who cited this? | PubMed ID: 19506018 | Fulltext

Brain metastasis: opportunities in basic and translational research.

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Maher EA, Mietz J, Arteaga CL, DePinho RA, and Mohla S

Cancer research 69(15):6015-20, 2009 Aug 1 - Who cited this? | PubMed ID: 19638593 | Fulltext

HDAC2 negatively regulates memory formation and synaptic plasticity.

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Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, and Tsai LH

Nature 459(7243):55-60, 2009 May 7 - Who cited this? | PubMed ID: 19424149 | Fulltext

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.

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Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, and Hedrick SM

Nature immunology 10(5):504-13, 2009 May - Who cited this? | PubMed ID: 19363483 | Fulltext

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.

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Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, and Bosenberg M

Nature genetics 41(5):544-52, 2009 May - Who cited this? | PubMed ID: 19282848 | Fulltext

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

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van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D,

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Nature genetics 41(5):521-3, 2009 May - Who cited this? | PubMed ID: 19330029 | Fulltext

Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice.

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Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, Clark K, Cai Z, Vincent S, Bottega S, Shen Q, Richardson A, Bosenburg M, Naber SP, DePinho RA, Kuperwasser C,

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Proceedings of the National Academy of Sciences of the United States of America 106(17):7022-7, 2009 Apr 28 - Who cited this? | PubMed ID: 19369208 | Fulltext

mTORC1 signaling governs hematopoietic stem cell quiescence.

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Gan B and Depinho RA

Cell cycle (Georgetown, Tex.) 8(7):1003-6, 2009 Apr 1 - Who cited this? | PubMed ID: 19270523 | Fulltext

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

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Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, Depinho RA, and Hedrick SM

Nature immunology 10(2):176-84, 2009 Feb - Who cited this? | PubMed ID: 19136962 | Fulltext

Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.

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Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, and States DJ

Cancer research 69(1):300-9, 2009 Jan 1 - Who cited this? | PubMed ID: 19118015 | Fulltext

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.

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Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP,

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Proceedings of the National Academy of Sciences of the United States of America 105(49):19372-7, 2008 Dec 9 - Who cited this? | PubMed ID: 19050074 | Fulltext

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

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Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, and Depinho RA

Proceedings of the National Academy of Sciences of the United States of America 105(49):19384-9, 2008 Dec 9 - Who cited this? | PubMed ID: 19052232 | Fulltext

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.

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Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, Depinho RA, and Rickert RC

Nature immunology, 2008 Nov 2 - Who cited this? | PubMed ID: 18978794 | Fulltext

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.

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Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA,

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Nature 455(7216):1129-33, 2008 Oct 23 - Who cited this? | PubMed ID: 18948956 | Fulltext

Codependent Activators Direct Myoblast-Specific MyoD Transcription.

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Hu P, Geles KG, Paik JH, Depinho RA, and Tjian R

Developmental cell 15(4):534-46, 2008 Oct - Who cited this? | PubMed ID: 18854138 | Fulltext

Forkhead Box, Class O Transcription Factors in Brain: Regulation and Behavioral Manifestation.

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Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, and Li X

Biological psychiatry, 2008 Sep 27 - Who cited this? | PubMed ID: 18823877 | Fulltext

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma?: A role for Bcl2L12 as a multifunctional cell death regulator.

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Stegh AH, Chin L, Louis DN, and Depinho RA

Cell cycle (Georgetown, Tex.) 7(18), 2008 Sep 11 - Who cited this? | PubMed ID: 18769159 | Fulltext

FoxOs promote apoptosis of insulin resistant macrophages during cholesterol-induced ER stress.

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Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, Depinho RA, Accili D, Tabas I, and Tall AR

Diabetes, 2008 Aug 26 - Who cited this? | PubMed ID: 18728232 | Fulltext

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.

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Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, Louis DN, Chin L, and Depinho RA

Proceedings of the National Academy of Sciences of the United States of America 105(31):10703, 2008 Aug 5 - Who cited this? | PubMed ID: 18669646 | Fulltext

Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.

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Jeon HM, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, Depinho RA, Chin L, and Kim H

Genes & development 22(15):2028, 2008 Aug 1 - Who cited this? | PubMed ID: 18676808 | Fulltext

Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.

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Aghi M, Visted T, Depinho RA, and Chiocca EA

Oncogene 27(30):4249-54, 2008 Jul 10 - Who cited this? | PubMed ID: 18345032 | Fulltext

Inactivation of hepatic foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

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Dong XC, Copps KD, Guo S, Li Y, Kollipara R, Depinho RA, and White MF

Cell metabolism 8(1):65, 2008 Jul - Who cited this? | PubMed ID: 18590693 | Fulltext

A mouse to human search for plasma proteome changes associated with pancreatic tumor development.

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Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE,

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PLoS medicine 5(6), 2008 Jun 10 - Who cited this? | PubMed ID: 18547137 | Fulltext

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.

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Herzog S, Hug E, Meixlsperger S, Paik JH, Depinho RA, Reth M, and Jumaa H

Nature immunology 9(6):623, 2008 Jun - Who cited this? | PubMed ID: 18488031 | Fulltext

Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.

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Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, and Weissleder R

PLoS medicine 5(4):0, 2008 Apr 15 - Who cited this? | PubMed ID: 18416599 | Fulltext

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.

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Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, Depinho RA, and Mäkelä TP

Nature genetics 40(4):455, 2008 Apr - Who cited this? | PubMed ID: 18311138 | Fulltext

Pancreatic lkb1 deletion leads to acinar polarity defects and cystic neoplasms.

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Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, and Depinho RA

Molecular and cellular biology 28(7):2414-25, 2008 Apr - Who cited this? | PubMed ID: 18227155 | Fulltext

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.

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Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, and Wong KK

Carcinogenesis 29(4):747-53, 2008 Apr - Who cited this? | PubMed ID: 18283039 | Fulltext

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation.

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David G, Grandinetti KB, Finnerty PM, Simpson N, Chu GC, and Depinho RA

Proceedings of the National Academy of Sciences of the United States of America 105(11):4168-72, 2008 Mar 18 - Who cited this? | PubMed ID: 18332431 | Fulltext

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.

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de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, and Bonni A

Genes & development 22(4):449, 2008 Feb 15 - Who cited this? | PubMed ID: 18258752 | Fulltext

A mouse plasma peptide atlas as a resource for disease proteomics.

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Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS,

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Genome biology 9(6), 2008 - Who cited this? | PubMed ID: 18522751 | Fulltext

Pten and p53 Converge on c-Myc to Control Differentiation, Self-renewal, and Transformation of Normal and Neoplastic Stem Cells in Glioblastoma.

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Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA,

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Cold Spring Harbor symposia on quantitative biology 73:427-37, 2008 - Who cited this? | PubMed ID: 19150964 | Fulltext

Alu elements mediate MYB gene tandem duplication in human T-ALL.

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O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA,

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The Journal of experimental medicine 204(13):3059-66, 2007 Dec 24 - Who cited this? | PubMed ID: 18070937 | Fulltext

Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.

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Kim TK, Lee JS, Oh SY, Jin X, Choi YJ, Lee TH, Lee E, Choi YK, You S, Chung YG, Lee JB, DePinho RA, Chin L, and Kim H

Cancer research 67(23):11133-40, 2007 Dec 1 - Who cited this? | PubMed ID: 18056437 | Fulltext

Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.

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Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, and DePinho RA

Cancer research 67(22):10736-43, 2007 Nov 15 - Who cited this? | PubMed ID: 18006816 | Fulltext

Malignant astrocytic glioma: genetics, biology, and paths to treatment.

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Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, Depinho RA, and Cavenee WK

Genes & development 21(21):2683, 2007 Nov 1 - Who cited this? | PubMed ID: 17974913 | Fulltext

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.

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Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, and DePinho RA

Science (New York, N.Y.) 318(5848):287-90, 2007 Oct 12 - Who cited this? | PubMed ID: 17872411 | Fulltext

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

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Matsumoto M, Pocai A, Rossetti L, Depinho RA, and Accili D

Cell metabolism 6(3):208, 2007 Sep - Who cited this? | PubMed ID: 17767907 | Fulltext

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.

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Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, Depinho RA, Kitajewski J, and Accili D

The Journal of clinical investigation 117(9):2477, 2007 Sep - Who cited this? | PubMed ID: 17717603 | Fulltext

How stem cells age and why this makes us grow old.

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Sharpless NE and DePinho RA

Nature reviews. Molecular cell biology 8(9):703-13, 2007 Sep - Who cited this? | PubMed ID: 17717515 | Fulltext

Stromal biology of pancreatic cancer.

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Chu GC, Kimmelman AC, Hezel AF, and DePinho RA

Journal of cellular biochemistry 101(4):887-907, 2007 Jul 1 - Who cited this? | PubMed ID: 17266048 | Fulltext

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.

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Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, and Merlino G

Proceedings of the National Academy of Sciences of the United States of America 104(26):10968, 2007 Jun 26 - Who cited this? | PubMed ID: 17576930 | Fulltext

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

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Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S,

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Nature 447(7147):966, 2007 Jun 21 - Who cited this? | PubMed ID: 17515920 | Fulltext

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