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Papers authored by Demuth HU

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Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates.

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Seifert F, Schulz K, Koch B, Manhart S, Demuth HU, and Schilling S

Biochemistry 48(50):11831-3, 2009 Dec 22 - Who cited this? | PubMed ID: 19921850 | Fulltext

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.

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Hartlage-Rübsamen M, Staffa K, Waniek A, Wermann M, Hoffmann T, Cynis H, Schilling S, Demuth HU, and Rossner S

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 27(8):825-35, 2009 Dec - Who cited this? | PubMed ID: 19699792 | Fulltext

Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.

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Buchholz M, Hamann A, Aust S, Brandt W, Böhme L, Hoffmann T, Schilling S, Demuth HU, and Heiser U

Journal of medicinal chemistry 52(22):7069-80, 2009 Nov 26 - Who cited this? | PubMed ID: 19863057 | Fulltext

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.

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Stephan A, Wermann M, von Bohlen A, Koch B, Cynis H, Demuth HU, and Schilling S

The FEBS journal 276(22):6522-36, 2009 Nov - Who cited this? | PubMed ID: 19804409 | Fulltext

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.

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Wirths O, Breyhan H, Cynis H, Schilling S, Demuth HU, and Bayer TA

Acta neuropathologica 118(4):487-96, 2009 Oct - Who cited this? | PubMed ID: 19547991 | Fulltext

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.

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Schlenzig D, Manhart S, Cinar Y, Kleinschmidt M, Hause G, Willbold D, Funke SA, Schilling S, and Demuth HU

Biochemistry 48(29):7072-8, 2009 Jul 28 - Who cited this? | PubMed ID: 19518051 | Fulltext

Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.

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Frerker N, Raber K, Bode F, Skripuletz T, Nave H, Klemann C, Pabst R, Stephan M, Schade J, Brabant G, Wedekind D, Jacobs R, Jörns A, Forssmann U, Straub RH, Johannes S,

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Clinical chemistry and laboratory medicine : CCLM / FESCC 47(3):275-87, 2009 - Who cited this? | PubMed ID: 19327106 | Fulltext

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

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Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H,

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Nature medicine, 2008 Sep 28 - Who cited this? | PubMed ID: 18836460 | Fulltext

Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance.

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Augstein P, Berg S, Heinke P, Altmann S, Salzsieder E, Demuth HU, and Freyse EJ

Diabetes, obesity & metabolism 10(10):850-61, 2008 Sep - Who cited this? | PubMed ID: 17970756 | Fulltext

Isoaspartate residues dramatically influence substrate recognition and turnover by proteases.

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Böhme L, Bär JW, Hoffmann T, Manhart S, Ludwig HH, Rosche F, and Demuth HU

Biological chemistry, 2008 Aug 8 - Who cited this? | PubMed ID: 18690782 | Fulltext

Isoaspartate containing amyloid precursor protein derived peptides alter efficacy and specificity of potential beta-secretases.

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Böhme L, Hoffmann T, Manhart S, Wolf R, and Demuth HU

Biological chemistry, 2008 Aug 8 - Who cited this? | PubMed ID: 18690784 | Fulltext

Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease.

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Hook V, Schechter I, Demuth HU, and Hook G

Biological chemistry, 2008 Aug 8 - Who cited this? | PubMed ID: 18690783 | Fulltext

Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution.

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Schilling S, Wasternack C, and Demuth HU

Biological chemistry, 2008 Aug 8 - Who cited this? | PubMed ID: 18690772 | Fulltext

Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution.

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Schilling S, Wasternack C, and Demuth HU

Biological chemistry 389(8):983-91, 2008 Aug - Who cited this? | PubMed ID: 18979624 | Fulltext

Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease.

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Hook V, Schechter I, Demuth HU, and Hook G

Biological chemistry 389(8):993-1006, 2008 Aug - Who cited this? | PubMed ID: 18979625 | Fulltext

Isoaspartate residues dramatically influence substrate recognition and turnover by proteases.

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Böhme L, Bär JW, Hoffmann T, Manhart S, Ludwig HH, Rosche F, and Demuth HU

Biological chemistry 389(8):1043-53, 2008 Aug - Who cited this? | PubMed ID: 18979629 | Fulltext

Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases.

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Böhme L, Hoffmann T, Manhart S, Wolf R, and Demuth HU

Biological chemistry 389(8):1055-66, 2008 Aug - Who cited this? | PubMed ID: 18979630 | Fulltext

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

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Schilling S, Appl T, Hoffmann T, Cynis H, Schulz K, Jagla W, Friedrich D, Wermann M, Buchholz M, Heiser U, von Hörsten S, and Demuth HU

Journal of neurochemistry, 2008 Jul 4 - Who cited this? | PubMed ID: 18627432 | Fulltext

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-beta.

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Cynis H, Scheel E, Saido TC, Schilling S, and Demuth HU

Biochemistry, 2008 Jun 21 - Who cited this? | PubMed ID: 18570439 | Fulltext

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.

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Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, and Schilling S

Journal of molecular biology 379(5):966, 2008 Jun 20 - Who cited this? | PubMed ID: 18486145 | Fulltext

Regulation of Expression and Function of Dipeptidyl Peptidase 4 (DP4), DP8/9, and DP10 in Allergic Responses of the Lung in Rats.

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Schade J, Stephan M, Schmiedl A, Wagner L, Niestroj AJ, Demuth HU, Frerker N, Klemann C, Raber KA, Pabst R, and von Hörsten S

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 56(2):147-55, 2008 Feb - Who cited this? | PubMed ID: 17967935 | Fulltext

Novel Inhibitor for Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis and Details of Substrate-recognition Mechanism.

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Xu Y, Nakajima Y, Ito K, Zheng H, Oyama H, Heiser U, Hoffmann T, Gärtner UT, Demuth HU, and Yoshimoto T

Journal of molecular biology 375(3):708-19, 2008 Jan 18 - Who cited this? | PubMed ID: 18042490 | Fulltext

Inhibiting dipeptidyl peptidase activity partially ameliorates colitis in mice.

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Yazbeck R, Howarth GS, Geier MS, Demuth HU, and Abbott CA

Frontiers in bioscience : a journal and virtual library 13:6850-8, 2008 - Who cited this? | PubMed ID: 18508699 | Fulltext

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat.

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Piteau S, Olver A, Kim SJ, Winter K, Pospisilik JA, Lynn F, Manhart S, Demuth HU, Speck M, Pederson RA, and McIntosh CH

Biochemical and biophysical research communications 362(4):1007-12, 2007 Nov 3 - Who cited this? | PubMed ID: 17803965 | Fulltext

Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

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Schilling S, Lindner C, Koch B, Wermann M, Rahfeld JU, von Bohlen A, Rudolph T, Reuter G, and Demuth HU

Biochemistry 46(38):10921-30, 2007 Sep 25 - Who cited this? | PubMed ID: 17722885 | Fulltext

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

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Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghänel J, Rahfeld JU, Demuth HU, and Stubbs MT

Proceedings of the National Academy of Sciences of the United States of America 104(35):13942, 2007 Aug 28 - Who cited this? | PubMed ID: 17715056 | Fulltext

Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.

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Schilling S, Stenzel I, von Bohlen A, Wermann M, Schulz K, Demuth HU, and Wasternack C

Biological chemistry 388(2):145-53, 2007 Feb - Who cited this? | PubMed ID: 17261077 | Fulltext

Does human attractin have DP4 activity?.

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Friedrich D, Hoffmann T, Bär J, Wermann M, Manhart S, Heiser U, and Demuth HU

Biological chemistry 388(2):155-62, 2007 Feb - Who cited this? | PubMed ID: 17261078 | Fulltext

Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4.

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Frerker N, Wagner L, Wolf R, Heiser U, Hoffmann T, Rahfeld JU, Schade J, Karl T, Naim HY, Alfalah M, Demuth HU, and von Hörsten S

Peptides 28(2):257-68, 2007 Feb - Who cited this? | PubMed ID: 17223229 | Fulltext

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).

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Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Böhm G, and Demuth HU

Biochemistry 45(41):12393-9, 2006 Oct 17 - Who cited this? | PubMed ID: 17029395 | Fulltext

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.

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Cynis H, Schilling S, Bodnár M, Hoffmann T, Heiser U, Saido TC, and Demuth HU

Biochimica et biophysica acta 1764(10):1618-25, 2006 Oct - Who cited this? | PubMed ID: 17005457 | Fulltext

Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY.

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Unniappan S, McIntosh CH, Demuth HU, Heiser U, Wolf R, and Kieffer TJ

Diabetologia 49(8):1915-23, 2006 Aug - Who cited this? | PubMed ID: 16802131 | Fulltext

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

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Engel M, Hoffmann T, Manhart S, Heiser U, Chambre S, Huber R, Demuth HU, and Bode W

Journal of molecular biology 355(4):768-83, 2006 Jan 27 - Who cited this? | PubMed ID: 16330047 | Fulltext

The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship.

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Buchholz M, Heiser U, Schilling S, Niestroj AJ, Zunkel K, and Demuth HU

Journal of medicinal chemistry 49(2):664-77, 2006 Jan 26 - Who cited this? | PubMed ID: 16420052 | Fulltext

Stress and substance P but not the substance P-metabolite SP5-11 trigger murine abortion by augmenting TNF-alpha levels at the feto-maternal interface.

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Fest S, Zenclussen AC, Joachim R, Hagen E, Demuth HU, and Hoffmann T

Scandinavian journal of immunology 63(1):42-9, 2006 Jan - Who cited this? | PubMed ID: 16398700 | Fulltext

Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus.

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McIntosh CH, Demuth HU, Kim SJ, Pospisilik JA, and Pederson RA

The international journal of biochemistry & cell biology 38(5-6):860-72, 2006 - Who cited this? | PubMed ID: 16442340 | Fulltext

Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.

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Bär JW, Rahfeld JU, Schulz I, Gans K, Ruiz-Carrillo D, Manhart S, Rosche F, and Demuth HU

Advances in experimental medicine and biology 575:103-8, 2006 - Who cited this? | PubMed ID: 16700513 | Fulltext

Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR.

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Wagner L, Hoffmann T, Rahfeld JU, and Demuth HU

Advances in experimental medicine and biology 575:109-16, 2006 - Who cited this? | PubMed ID: 16700514 | Fulltext

Dipeptidyl peptidase IV: a molecular switch of vascular actions of neuropeptide Y.

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Li L, Demuth HU, and Zukowska Z

Advances in experimental medicine and biology 575:135-40, 2006 - Who cited this? | PubMed ID: 16700516 | Fulltext

Dipeptidyl peptidases and inflammatory bowel disease.

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Abbott CA, Yazbeck R, Geier MS, Demuth HU, and Howarth GS

Advances in experimental medicine and biology 575:155-62, 2006 - Who cited this? | PubMed ID: 16700518 | Fulltext

Differential effects of N-peptidyl-O-acyl hydroxylamines on dynorphin-induced antinociception in the mouse capsaicin test.

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Tan-No K, Taira A, Nakagawasai O, Niijima F, Demuth HU, Silberring J, Terenius L, and Tadano T

Neuropeptides 39(6):569-73, 2005 Dec - Who cited this? | PubMed ID: 16271759 | Fulltext

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

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Schilling S, Cynis H, von Bohlen A, Hoffmann T, Wermann M, Heiser U, Buchholz M, Zunkel K, and Demuth HU

Biochemistry 44(40):13415-24, 2005 Oct 11 - Who cited this? | PubMed ID: 16201766 | Fulltext

Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.

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Schulz I, Zeitschel U, Rudolph T, Ruiz-Carrillo D, Rahfeld JU, Gerhartz B, Bigl V, Demuth HU, and Rossner S

Journal of neurochemistry 94(4):970, 2005 Aug - Who cited this? | PubMed ID: 16092940 | Fulltext

Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors.

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Demuth HU, McIntosh CH, and Pederson RA

Biochimica et biophysica acta 1751(1):33-44, 2005 Aug 1 - Who cited this? | PubMed ID: 15978877 | Fulltext

Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?.

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McIntosh CH, Demuth HU, Pospisilik JA, and Pederson R

Regulatory peptides 128(2):159-65, 2005 Jun 15 - Who cited this? | PubMed ID: 15780435 | Fulltext

Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.

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Wargent E, Stocker C, Augstein P, Heinke P, Meyer A, Hoffmann T, Subramanian A, Sennitt MV, Demuth HU, Arch JR, and Cawthorne MA

Diabetes, obesity & metabolism 7(2):170-81, 2005 Mar - Who cited this? | PubMed ID: 15715890 | Fulltext

Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease.

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Rossner S, Schulz I, Zeitschel U, Schliebs R, Bigl V, and Demuth HU

Neurochemical research 30(6-7):695-702, 2005 - Who cited this? | PubMed ID: 16187206 | Fulltext

Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells.

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Girardi AC, Knauf F, Demuth HU, and Aronson PS

American journal of physiology. Cell physiology 287(5):C1238-45, 2004 Nov - Who cited this? | PubMed ID: 15213057 | Fulltext

In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide.

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Hinke SA, Manhart S, Speck M, Pederson RA, Demuth HU, and McIntosh CH

Life sciences 75(15):1857-70, 2004 Aug 27 - Who cited this? | PubMed ID: 15302229 | Fulltext

A rapid in vitro screening for delivery of peptide-derived peptidase inhibitors as potential drug candidates via epithelial peptide transporters.

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Foltz M, Meyer A, Theis S, Demuth HU, and Daniel H

The Journal of pharmacology and experimental therapeutics 310(2):695-702, 2004 Aug - Who cited this? | PubMed ID: 15051798 | Fulltext

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