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Papers authored by Cravatt BF

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Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling.

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Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, and Liu QS

The Journal of pharmacology and experimental therapeutics 331(2):591-7, 2009 Nov - Who cited this? | PubMed ID: 19666749 | Fulltext

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine.

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Hu SS, Bradshaw HB, Benton VM, Chen JS, Huang SM, Minassi A, Bisogno T, Masuda K, Tan B, Roskoski R, Cravatt BF, Di Marzo V, and Walker JM

Prostaglandins, leukotrienes, and essential fatty acids 81(4):291-301, 2009 Oct - Who cited this? | PubMed ID: 19570666 | Fulltext

Activity-based probes for monitoring postproline protease activity.

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Sabidó E, Tarragó T, Niessen S, Cravatt BF, and Giralt E

Chembiochem : a European journal of chemical biology 10(14):2361-6, 2009 Sep 21 - Who cited this? | PubMed ID: 19688784 | Fulltext

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.

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Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, and Lichtman AH

The Journal of pharmacology and experimental therapeutics 330(3):902-10, 2009 Sep - Who cited this? | PubMed ID: 19502530 | Fulltext

A suite of activity-based probes for human cytochrome P450 enzymes.

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Wright AT, Song JD, and Cravatt BF

Journal of the American Chemical Society 131(30):10692-700, 2009 Aug 5 - Who cited this? | PubMed ID: 19583257 | Fulltext

Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.

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Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, and Stevens RC

Journal of the American Chemical Society 131(30):10497-506, 2009 Aug 5 - Who cited this? | PubMed ID: 19722626 | Fulltext

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism.

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Long JZ, Nomura DK, and Cravatt BF

Chemistry & biology 16(7):744-53, 2009 Jul 31 - Who cited this? | PubMed ID: 19635411 | Fulltext

Comparative assessment of large-scale proteomic studies of apoptotic proteolysis.

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Simon GM, Dix MM, and Cravatt BF

ACS chemical biology 4(6):401-8, 2009 Jun 19 - Who cited this? | PubMed ID: 19415908 | Fulltext

Inhibitors of Endocannabinoid-Metabolizing Enzymes Reduce Precipitated Withdrawal Responses in THC-Dependent Mice.

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Schlosburg JE, Carlson BL, Ramesh D, Abdullah RA, Long JZ, Cravatt BF, and Lichtman AH

The AAPS journal 11(2):342-52, 2009 Jun - Who cited this? | PubMed ID: 19430909 | Fulltext

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).

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Johnson DS, Ahn K, Kesten S, Lazerwith SE, Song Y, Morris M, Fay L, Gregory T, Stiff C, Dunbar JB, Liimatta M, Beidler D, Smith S, Nomanbhoy TK, and Cravatt BF

Bioorganic & medicinal chemistry letters 19(10):2865-9, 2009 May 15 - Who cited this? | PubMed ID: 19386497 | Fulltext

Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana.

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Kaschani F, Gu C, Niessen S, Hoover H, Cravatt BF, and van der Hoorn RA

Molecular & cellular proteomics : MCP 8(5):1082-93, 2009 May - Who cited this? | PubMed ID: 19136719 | Fulltext

Erratum: Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

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Bachovchin DA, Brown SJ, Rosen H, and Cravatt BF

Nature biotechnology 27(5):485, 2009 May - Who cited this? | PubMed ID: 19430458 | Fulltext

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.

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Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S,

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Chemistry & biology 16(4):411-20, 2009 Apr 24 - Who cited this? | PubMed ID: 19389627 | Fulltext

Synergy between Enzyme Inhibitors of Fatty Acid Amide Hydrolase and Cyclooxygenase in Visceral Nociception.

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Naidu PS, Booker L, Cravatt BF, and Lichtman AH

The Journal of pharmacology and experimental therapeutics 329(1):48-56, 2009 Apr - Who cited this? | PubMed ID: 19118134 | Fulltext

Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus.

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Schlosburg JE, Boger DL, Cravatt BF, and Lichtman AH

The Journal of pharmacology and experimental therapeutics 329(1):314-23, 2009 Apr - Who cited this? | PubMed ID: 19168707 | Fulltext

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

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Bachovchin DA, Brown SJ, Rosen H, and Cravatt BF

Nature biotechnology 27(4):387-94, 2009 Apr - Who cited this? | PubMed ID: 19329999 | Fulltext

Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.

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Lever IJ, Robinson M, Cibelli M, Paule C, Santha P, Yee L, Hunt SP, Cravatt BF, Elphick MR, Nagy I, and Rice AS

The Journal of neuroscience : the official journal of the Society for Neuroscience 29(12):3766-80, 2009 Mar 25 - Who cited this? | PubMed ID: 19321773 | Fulltext

Large-scale profiling of protein palmitoylation in mammalian cells.

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Martin BR and Cravatt BF

Nature methods 6(2):135-8, 2009 Feb - Who cited this? | PubMed ID: 19137006 | Fulltext

Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study.

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Nakai R, Salisbury CM, Rosen H, and Cravatt BF

Bioorganic & medicinal chemistry 17(3):1101-8, 2009 Feb 1 - Who cited this? | PubMed ID: 18364257 | Fulltext

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.

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Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, and Cravatt BF

Nature chemical biology 5(1):37-44, 2009 Jan - Who cited this? | PubMed ID: 19029917 | Fulltext

The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.

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Bradshaw HB, Rimmerman N, Hu SS, Benton VM, Stuart JM, Masuda K, Cravatt BF, O'Dell DK, and Walker JM

BMC biochemistry 10:14, 2009 - Who cited this? | PubMed ID: 19460156 | Fulltext

Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes (dagger) (double dagger).

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Barglow KT, Saikatendu KS, Bracey MH, Huey R, Morris GM, Olson AJ, Stevens RC, and Cravatt BF

Biochemistry 47(51):13514-23, 2008 Dec 23 - Who cited this? | PubMed ID: 19053248 | Fulltext

Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.

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DeMartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, and Boger DL

Bioorganic & medicinal chemistry letters 18(22):5842-6, 2008 Nov 15 - Who cited this? | PubMed ID: 18639454 | Fulltext

Tetrahedron young investigator award 2008.

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Cravatt BF

Bioorganic & medicinal chemistry letters 18(22):5837, 2008 Nov 15 - Who cited this? | PubMed ID: 18995172 | Fulltext

Challenges for the 'chemical-systems' biologist.

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Simon GM and Cravatt BF

Nature chemical biology 4(11):639-42, 2008 Nov - Who cited this? | PubMed ID: 18936742 | Fulltext

Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation.

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Conn EM, Madsen MA, Cravatt BF, Ruf W, Deryugina EI, and Quigley JP

The Journal of biological chemistry 283(39):26518-27, 2008 Sep 26 - Who cited this? | PubMed ID: 18658134 | Fulltext

Structure-guided inhibitor design for human FAAH by interspecies active site conversion.

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Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, and Stevens RC

Proceedings of the National Academy of Sciences of the United States of America, 2008 Aug 27 - Who cited this? | PubMed ID: 18753625 | Fulltext

Global mapping of the topography and magnitude of proteolytic events in apoptosis.

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Dix MM, Simon GM, and Cravatt BF

Cell 134(4):679, 2008 Aug 22 - Who cited this? | PubMed ID: 18724940 | Fulltext

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.

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Hoover HS, Blankman JL, Niessen S, and Cravatt BF

Bioorganic & medicinal chemistry letters, 2008 Jul 2 - Who cited this? | PubMed ID: 18657971 | Fulltext

Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells.

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Hegde VL, Hegde S, Cravatt BF, Hofseth LJ, Nagarkatti M, and Nagarkatti PS

Molecular pharmacology 74(1):20, 2008 Jul - Who cited this? | PubMed ID: 18388242 | Fulltext

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.

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Rimmerman N, Bradshaw HB, Hughes HV, Chen JS, Hu SS, McHugh D, Vefring E, Jahnsen JA, Thompson EL, Masuda K, Cravatt BF, Burstein S, Vasko MR, Prieto AL, O'Dell DK, and Walker JM

Molecular pharmacology 74(1):213, 2008 Jul - Who cited this? | PubMed ID: 18424551 | Fulltext

Disparate proteome reactivity profiles of carbon electrophiles.

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Weerapana E, Simon GM, and Cravatt BF

Nature chemical biology 4(7):405, 2008 Jul - Who cited this? | PubMed ID: 18488014 | Fulltext

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.

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Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, and Stevens RC

Bioorganic & medicinal chemistry letters, 2008 Jun 28 - Who cited this? | PubMed ID: 18644727 | Fulltext

Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei.

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Suárez J, Bermúdez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravatt BF, and de Fonseca FR

The Journal of comparative neurology 509(4):400, 2008 Jun 2 - Who cited this? | PubMed ID: 18521853 | Fulltext

Activation of the endocannabinoid system by organophosphorus nerve agents.

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Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, and Casida JE

Nature chemical biology 4(6):373, 2008 Jun - Who cited this? | PubMed ID: 18438404 | Fulltext

Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.

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Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, and Gonias SL

Blood 111(11):5316, 2008 Jun 1 - Who cited this? | PubMed ID: 18369152 | Fulltext

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.

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Ahn K, McKinney MK, and Cravatt BF

Chemical reviews 108(5):1687-707, 2008 May - Who cited this? | PubMed ID: 18429637 | Fulltext

Anandamide Biosynthesis Catalyzed by the Phosphodiesterase GDE1 and Detection of Glycerophospho-N-acyl Ethanolamine Precursors in Mouse Brain.

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Simon GM and Cravatt BF

The Journal of biological chemistry 283(14):9341-9, 2008 Apr 4 - Who cited this? | PubMed ID: 18227059 | Fulltext

Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification.

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Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, and Casida JE

Toxicology and applied pharmacology 228(1):42-8, 2008 Apr 1 - Who cited this? | PubMed ID: 18164358 | Fulltext

Oxidative metabolism of a Fatty Acid amide hydrolase-regulated lipid, arachidonoyltaurine.

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Turman MV, Kingsley PJ, Rouzer CA, Cravatt BF, and Marnett LJ

Biochemistry 47(12):3917-25, 2008 Mar 25 - Who cited this? | PubMed ID: 18311922 | Fulltext

Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes.

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Salisbury CM and Cravatt BF

Journal of the American Chemical Society 130(7):2184, 2008 Feb 20 - Who cited this? | PubMed ID: 18217751 | Fulltext

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum.

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Maccarrone M, Rossi S, Bari M, De Chiara V, Fezza F, Musella A, Gasperi V, Prosperetti C, Bernardi G, Finazzi-Agrò A, Cravatt BF, and Centonze D

Nature neuroscience 11(2):152, 2008 Feb - Who cited this? | PubMed ID: 18204441 | Fulltext

Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules.

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Egertová M, Simon GM, Cravatt BF, and Elphick MR

The Journal of comparative neurology 506(4):604-15, 2008 Feb 1 - Who cited this? | PubMed ID: 18067139 | Fulltext

Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals.

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Nyilas R, Dudok B, Urbán GM, Mackie K, Watanabe M, Cravatt BF, Freund TF, and Katona I

The Journal of neuroscience : the official journal of the Society for Neuroscience 28(5):1058, 2008 Jan 30 - Who cited this? | PubMed ID: 18234884 | Fulltext

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

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Ortega-Gutiérrez S, Leung D, Ficarro S, Peters EC, and Cravatt BF

PLoS ONE 3(7), 2008 - Who cited this? | PubMed ID: 18596935 | Fulltext

Evaluation of fatty acid amides in the carrageenan-induced paw edema model.

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Wise LE, Cannavacciulo R, Cravatt BF, Martin BF, and Lichtman AH

Neuropharmacology 54(1):181-8, 2008 Jan - Who cited this? | PubMed ID: 17675189 | Fulltext

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry.

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Cravatt BF, Wright AT, and Kozarich JW

Annual review of biochemistry 77:383-414, 2008 - Who cited this? | PubMed ID: 18366325 | Fulltext

Enrichment tags for enhanced-resolution profiling of the polar metabolome.

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Carlson EE and Cravatt BF

Journal of the American Chemical Society 129(51):15780-2, 2007 Dec 26 - Who cited this? | PubMed ID: 18052286 | Fulltext

Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.

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List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, and Bugge TH

The Journal of biological chemistry 282(50):36714, 2007 Dec 14 - Who cited this? | PubMed ID: 17940283 | Fulltext

The biological impact of mass-spectrometry-based proteomics.

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Cravatt BF, Simon GM, and Yates JR

Nature 450(7172):991, 2007 Dec 13 - Who cited this? | PubMed ID: 18075578 | Fulltext

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