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Papers authored by Coxon A

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Biochemical Characterization of AMG 102: A Neutralizing, Fully Human Monoclonal Antibody to Human and Nonhuman Primate Hepatocyte Growth Factor.

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Burgess TL, Sun J, Meyer S, Tsuruda TS, Sun J, Elliott G, Chen Q, Haniu M, Barron WF, Juan T, Zhang K, Coxon A, and Kendall RL

Molecular cancer therapeutics 9(2):400-9, 2010 Feb - Who cited this? | PubMed ID: 20124448 | Fulltext

Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma.

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Davis IJ, McFadden AW, Zhang Y, Coxon A, Burgess TL, Wagner AJ, and Fisher DE

Cancer research 70(2):639-45, 2010 Jan 15 - Who cited this? | PubMed ID: 20068147 | Fulltext

Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors.

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Gordon MS, Sweeney CS, Mendelson DS, Eckhardt SG, Anderson A, Beaupre DM, Branstetter D, Burgess TL, Coxon A, Deng H, Kaplan-Lefko P, Leitch IM, Oliner KS, Yan L, Zhu M, and Gore L

Clinical cancer research : an official journal of the American Association for Cancer Research 16(2):699-710, 2010 Jan 15 - Who cited this? | PubMed ID: 20068101 | Fulltext

Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels.

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Falcón BL, Hashizume H, Koumoutsakos P, Chou J, Bready JV, Coxon A, Oliner JD, and McDonald DM

The American journal of pathology 175(5):2159-70, 2009 Nov - Who cited this? | PubMed ID: 19815705 | Fulltext

Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma.

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Gao CF, Xie Q, Zhang YW, Su Y, Zhao P, Cao B, Furge K, Sun J, Rex K, Osgood T, Coxon A, Burgess TL, and Vande Woude GF

Molecular cancer therapeutics 8(10):2803-10, 2009 Oct - Who cited this? | PubMed ID: 19825800 | Fulltext

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.

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Cee VJ, Cheng AC, Romero K, Bellon S, Mohr C, Whittington DA, Bak A, Bready J, Caenepeel S, Coxon A, Deak HL, Fretland J, Gu Y, Hodous BL, Huang X, Kim JL,

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Bioorganic & medicinal chemistry letters 19(2):424-7, 2009 Jan 15 - Who cited this? | PubMed ID: 19062275 | Fulltext

Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and kit receptors.

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Coxon A, Bush T, Saffran D, Kaufman S, Belmontes B, Rex K, Hughes P, Caenepeel S, Rottman JB, Tasker A, Patel V, Kendall R, Radinsky R, and Polverino A

Clinical cancer research : an official journal of the American Association for Cancer Research 15(1):110-8, 2009 Jan 1 - Who cited this? | PubMed ID: 19118038 | Fulltext

Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors.

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D'Angelo ND, Bellon SF, Booker SK, Cheng Y, Coxon A, Dominguez C, Fellows I, Hoffman D, Hungate R, Kaplan-Lefko P, Lee MR, Li C, Liu L, Rainbeau E, Reider PJ, Rex K,

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Journal of medicinal chemistry 51(18):5766, 2008 Sep 25 - Who cited this? | PubMed ID: 18763753 | Fulltext

Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors.

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Bauer D, Whittington DA, Coxon A, Bready J, Harriman SP, Patel VF, Polverino A, and Harmange JC

Bioorganic & medicinal chemistry letters 18(17):4844-8, 2008 Sep 1 - Who cited this? | PubMed ID: 18682324 | Fulltext

Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo.

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Zhang Y, Kaplan-Lefko PJ, Rex K, Yang Y, Moriguchi J, Osgood T, Mattson B, Coxon A, Reese M, Kim TS, Lin J, Chen A, Burgess TL, and Dussault I

Cancer research 68(16):6680, 2008 Aug 15 - Who cited this? | PubMed ID: 18701492 | Fulltext

Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.

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Park Y, Kubo A, Komiya T, Coxon A, Beebe K, Neckers L, Meltzer PS, and Kaye FJ

Cell cycle (Georgetown, Tex.) 7(15):2384-91, 2008 Aug - Who cited this? | PubMed ID: 18677112 | Fulltext

The growth factor midkine antagonizes VEGF signaling in vitro and in vivo.

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van der Horst EH, Frank BT, Chinn L, Coxon A, Li S, Polesso F, Slavin A, Ruefli-Brasse A, and Wesche H

Neoplasia (New York, N.Y.) 10(4):340-6, 2008 Apr - Who cited this? | PubMed ID: 18392135 | Fulltext

Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.

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Weiss MM, Harmange JC, Polverino AJ, Bauer D, Berry L, Berry V, Borg G, Bready J, Chen D, Choquette D, Coxon A, DeMelfi T, Doerr N, Estrada J, Flynn J, Graceffa RF,

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Journal of medicinal chemistry 51(6):1668, 2008 Mar 27 - Who cited this? | PubMed ID: 18324759 | Fulltext

Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.

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La DS, Belzile J, Bready JV, Coxon A, Demelfi T, Doerr N, Estrada J, Flynn JC, Flynn SR, Graceffa RF, Harriman SP, Larrow JF, Long AM, Martin MW, Morrison MJ, Patel VF,

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Journal of medicinal chemistry 51(6):1695-705, 2008 Mar 27 - Who cited this? | PubMed ID: 18311900 | Fulltext

Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.

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Harmange JC, Weiss MM, Germain J, Polverino AJ, Borg G, Bready J, Chen D, Choquette D, Coxon A, Demelfi T, Dipietro L, Doerr N, Estrada J, Flynn J, Graceffa RF, Harriman SP,

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Journal of medicinal chemistry 51(6):1649-67, 2008 Mar 27 - Who cited this? | PubMed ID: 18324761 | Fulltext

Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors.

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Potashman MH, Bready J, Coxon A, Demelfi TM, Dipietro L, Doerr N, Elbaum D, Estrada J, Gallant P, Germain J, Gu Y, Harmange JC, Kaufman SA, Kendall R, Kim JL, Kumar GN,

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Journal of medicinal chemistry 51(3):699, 2008 Feb 14 - Who cited this? | PubMed ID: 18198824 | Fulltext

c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations.

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Bellon SF, Kaplan-Lefko P, Yang Y, Zhang Y, Moriguchi J, Rex K, Johnson CW, Rose PE, Long AM, O'Connor AB, Gu Y, Coxon A, Kim TS, Tasker A, Burgess TL, and Dussault I

The Journal of biological chemistry 283(5):2675, 2008 Feb 1 - Who cited this? | PubMed ID: 18055465 | Fulltext

AMG 102, A Fully Human Anti-Hepatocyte Growth Factor/Scatter Factor Neutralizing Antibody, Enhances the Efficacy of Temozolomide or Docetaxel in U-87 MG Cells and Xenografts.

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Jun HT, Sun J, Rex K, Radinsky R, Kendall R, Coxon A, and Burgess TL

Clinical cancer research : an official journal of the American Association for Cancer Research 13(22):6735-42, 2007 Nov 15 - Who cited this? | PubMed ID: 18006775 | Fulltext

Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr.

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Dominguez C, Smith L, Huang Q, Yuan C, Ouyang X, Cai L, Chen P, Kim J, Harvey T, Syed R, Kim TS, Tasker A, Wang L, Zhang M, Coxon A, Bready J,

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Bioorganic & medicinal chemistry letters 17(21):6003, 2007 Nov 1 - Who cited this? | PubMed ID: 17869515 | Fulltext

Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors.

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Potashman MH, Bready J, Coxon A, DeMelfi TM, DiPietro L, Doerr N, Elbaum D, Estrada J, Gallant P, Germain J, Gu Y, Harmange JC, Kaufman SA, Kendall R, Kim JL, Kumar GN,

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Journal of medicinal chemistry 50(18):4351-73, 2007 Sep 6 - Who cited this? | PubMed ID: 17696416 | Fulltext

Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

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Hodous BL, Geuns-Meyer SD, Hughes PE, Albrecht BK, Bellon S, Bready J, Caenepeel S, Cee VJ, Chaffee SC, Coxon A, Emery M, Fretland J, Gallant P, Gu Y, Hoffman D, Johnson RE,

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Journal of medicinal chemistry 50(4):611-26, 2007 Feb 22 - Who cited this? | PubMed ID: 17253678 | Fulltext

Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.

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Cee VJ, Albrecht BK, Geuns-Meyer S, Hughes P, Bellon S, Bready J, Caenepeel S, Chaffee SC, Coxon A, Emery M, Fretland J, Gallant P, Gu Y, Hodous BL, Hoffman D, Johnson RE,

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Journal of medicinal chemistry 50(4):627-40, 2007 Feb 22 - Who cited this? | PubMed ID: 17253679 | Fulltext

Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation.

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Komiya T, Park Y, Modi S, Coxon AB, Oh H, and Kaye FJ

Oncogene 25(45):6128-32, 2006 Oct 5 - Who cited this? | PubMed ID: 16652146 | Fulltext

AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.

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Polverino A, Coxon A, Starnes C, Diaz Z, DeMelfi T, Wang L, Bready J, Estrada J, Cattley R, Kaufman S, Chen D, Gan Y, Kumar G, Meyer J, Neervannan S, Alva G,

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Cancer research 66(17):8715-21, 2006 Sep 1 - Who cited this? | PubMed ID: 16951187 | Fulltext

c-Met ectodomain shedding rate correlates with malignant potential.

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Athauda G, Giubellino A, Coleman JA, Horak C, Steeg PS, Lee MJ, Trepel J, Wimberly J, Sun J, Coxon A, Burgess TL, and Bottaro DP

Clinical cancer research : an official journal of the American Association for Cancer Research 12(14 Pt 1):4154, 2006 Jul 15 - Who cited this? | PubMed ID: 16857786 | Fulltext

Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors.

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Burgess T, Coxon A, Meyer S, Sun J, Rex K, Tsuruda T, Chen Q, Ho SY, Li L, Kaufman S, McDorman K, Cattley RC, Sun J, Elliott G, Zhang K, Feng X,

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Cancer research 66(3):1721-9, 2006 Feb 1 - Who cited this? | PubMed ID: 16452232 | Fulltext

Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.

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Coxon A, Rozenblum E, Park YS, Joshi N, Tsurutani J, Dennis PA, Kirsch IR, and Kaye FJ

Cancer research 65(16):7137-44, 2005 Aug 15 - Who cited this? | PubMed ID: 16103063 | Fulltext

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.

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Oliner J, Min H, Leal J, Yu D, Rao S, You E, Tang X, Kim H, Meyer S, Han SJ, Hawkins N, Rosenfeld R, Davy E, Graham K, Jacobsen F, Stevenson S,

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Cancer cell 6(5):507-16, 2004 Nov - Who cited this? | PubMed ID: 15542434 | Fulltext

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.

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Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, and Kaye FJ

Nature genetics 33(2):208-13, 2003 Feb - Who cited this? | PubMed ID: 12539049 | Fulltext

Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis.

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Coxon A, Bolon B, Estrada J, Kaufman S, Scully S, Rattan A, Duryea D, Hu YL, Rex K, Pacheco E, Van G, Zack D, and Feige U

Arthritis and rheumatism 46(10):2604-12, 2002 Oct - Who cited this? | PubMed ID: 12384918 | Fulltext

How many samples from a drug seizure need to be analyzed?.

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Coulson SA, Coxon A, and Buckleton JS

Journal of forensic sciences 46(6):1456-61, 2001 Nov - Who cited this? | PubMed ID: 11714159 | Fulltext

Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation.

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Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, Luscinskas FW, and Mayadas TN

Immunity 14(6):693, 2001 Jun - Who cited this? | PubMed ID: 11420040 | Fulltext

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

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Modi S, Kubo A, Oie H, Coxon AB, Rehmatulla A, and Kaye FJ

Oncogene 19(40):4632-9, 2000 Sep 21 - Who cited this? | PubMed ID: 11030152 | Fulltext

Cytokine-activated endothelial cells delay neutrophil apoptosis in vitro and in vivo. A role for granulocyte/macrophage colony-stimulating factor.

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Coxon A, Tang T, and Mayadas TN

The Journal of experimental medicine 190(7):923-34, 1999 Oct 4 - Who cited this? | PubMed ID: 10510082 | Fulltext

Temperature-sensitive RB mutations linked to incomplete penetrance of familial retinoblastoma in 12 families.

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Otterson GA, Modi S, Nguyen K, Coxon AB, and Kaye FJ

American journal of human genetics 65(4):1040-6, 1999 Oct - Who cited this? | PubMed ID: 10486322 | Fulltext

Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18).

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Yan J, Vetvicka V, Xia Y, Coxon A, Carroll MC, Mayadas TN, and Ross GD

Journal of immunology (Baltimore, Md. : 1950) 163(6):3045-52, 1999 Sep 15 - Who cited this? | PubMed ID: 10477568 | Fulltext

Parallel accounts? Discrepancies between self-report (diary) and recall (questionnaire) measures of the same sexual behaviour.

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Coxon AP

AIDS care 11(2):221-34, 1999 Apr - Who cited this? | PubMed ID: 10474624 | Fulltext

Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury.

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Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, Hickey PR, and Mayadas TN

Stroke; a journal of cerebral circulation 30(1):134-9, 1999 Jan - Who cited this? | PubMed ID: 9880401 | Fulltext

Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice.

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Rosenkranz AR, Coxon A, Maurer M, Gurish MF, Austen KF, Friend DS, Galli SJ, and Mayadas TN

Journal of immunology (Baltimore, Md. : 1950) 161(12):6463-7, 1998 Dec 15 - Who cited this? | PubMed ID: 9862668 | Fulltext

RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.

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Coxon AB, Ward JM, Geradts J, Otterson GA, Zajac-Kaye M, and Kaye FJ

Oncogene 17(12):1625-8, 1998 Sep 24 - Who cited this? | PubMed ID: 9794240 | Fulltext

Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function.

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Otterson GA, Chen W, Coxon AB, Khleif SN, and Kaye FJ

Proceedings of the National Academy of Sciences of the United States of America 94(22):12036-40, 1997 Oct 28 - Who cited this? | PubMed ID: 9342358 | Fulltext

A new class of obesity genes encodes leukocyte adhesion receptors.

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Dong ZM, Gutierrez-Ramos JC, Coxon A, Mayadas TN, and Wagner DD

Proceedings of the National Academy of Sciences of the United States of America 94(14):7526-30, 1997 Jul 8 - Who cited this? | PubMed ID: 9207125 | Fulltext

Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding.

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Chen WD, Otterson GA, Lipkowitz S, Khleif SN, Coxon AB, and Kaye FJ

Oncogene 14(10):1243-8, 1997 Mar 13 - Who cited this? | PubMed ID: 9121775 | Fulltext

A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation.

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Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Arnaout MA, and Mayadas TN

Immunity 5(6):653-66, 1996 Dec - Who cited this? | PubMed ID: 8986723 | Fulltext

Sexual behaviour of men. Review mis-stated prevalence of anal intercourse.

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McManus TJ and Coxon AP

BMJ (Clinical research ed.) 311(7013):1163, 1995 Oct 28 - Who cited this? | PubMed ID: 7580722 | Fulltext

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.

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Otterson GA, Khleif SN, Chen W, Coxon AB, and Kaye FJ

Oncogene 11(6):1211-6, 1995 Sep 21 - Who cited this? | PubMed ID: 7566983 | Fulltext

Proteins that glow in green and blue.

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Coxon A and Bestor TH

Chemistry & biology 2(3):119-21, 1995 Mar - Who cited this? | PubMed ID: 9383412 | Fulltext

Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.

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Kim YW, Otterson GA, Kratzke RA, Coxon AB, and Kaye FJ

Molecular and cellular biology 14(11):7256-64, 1994 Nov - Who cited this? | PubMed ID: 7935440 | Fulltext

Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB.

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Otterson GA, Kratzke RA, Coxon A, Kim YW, and Kaye FJ

Oncogene 9(11):3375-8, 1994 Nov - Who cited this? | PubMed ID: 7936665 | Fulltext

RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma.

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Shimizu E, Coxon A, Otterson GA, Steinberg SM, Kratzke RA, Kim YW, Fedorko J, Oie H, Johnson BE, and Mulshine JL

Oncogene 9(9):2441-8, 1994 Sep - Who cited this? | PubMed ID: 8058306 | Fulltext

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