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Papers authored by Copeland NG

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Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.

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Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA,

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Cancer research 69(21):8429-37, 2009 Nov 1 - Who cited this? | PubMed ID: 19843846 | Fulltext

Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells.

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Bosticardo M, Ghosh A, Du Y, Jenkins NA, Copeland NG, and Candotti F

Molecular therapy : the journal of the American Society of Gene Therapy 17(11):1910-8, 2009 Nov - Who cited this? | PubMed ID: 19638958 | Fulltext

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.

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Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, and Copeland NG

Cancer research 69(20):8150-6, 2009 Oct 15 - Who cited this? | PubMed ID: 19808965 | Fulltext

Deciphering the genetic landscape of cancer - from genes to pathways.

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Copeland NG and Jenkins NA

Trends in genetics : TIG 25(10):455-62, 2009 Oct - Who cited this? | PubMed ID: 19818523 | Fulltext

The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue.

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Bauer GL, Praetorius C, Bergsteinsdóttir K, Hallsson JH, Gísladóttir BK, Schepsky A, Swing DA, O'Sullivan TN, Arnheiter H, Bismuth K, Debbache J, Fletcher C, Warming S, Copeland NG, Jenkins NA, and Steingrímsson E

Genetics 183(2):581-94, 2009 Oct - Who cited this? | PubMed ID: 19635938 | Fulltext

The RNA-binding Motif Protein 15B (RBM15B/OTT3) Acts as Cofactor of the Nuclear Export Receptor NXF1.

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Uranishi H, Zolotukhin AS, Lindtner S, Warming S, Zhang GM, Bear J, Copeland NG, Jenkins NA, Pavlakis GN, and Felber BK

The Journal of biological chemistry 284(38):26106-16, 2009 Sep 18 - Who cited this? | PubMed ID: 19586903 | Fulltext

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.

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Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP,

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Nature 461(7262):411-4, 2009 Sep 17 - Who cited this? | PubMed ID: 19727076 | Fulltext

Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.

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Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y, Kitaura J, Honda Z, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura T, and Honda H

Blood 113(19):4702-10, 2009 May 7 - Who cited this? | PubMed ID: 19234145 | Fulltext

Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy.

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Davé UP, Akagi K, Tripathi R, Cleveland SM, Thompson MA, Yi M, Stephens R, Downing JR, Jenkins NA, and Copeland NG

PLoS genetics 5(5):e1000491, 2009 May - Who cited this? | PubMed ID: 19440365 | Fulltext

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.

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Davé UP, Akagi K, Tripathi R, Cleveland SM, Thompson MA, Yi M, Stephens R, Downing JR, Jenkins NA, and Copeland NG

PLoS genetics 5(5):e1000491, 2009 May - Who cited this? | PubMed ID: 19461887 | Fulltext

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.

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Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, Tessarollo L,

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Science (New York, N.Y.) 323(5922):1747-50, 2009 Mar 27 - Who cited this? | PubMed ID: 19251594 | Fulltext

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

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Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, Copeland NG,

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Nature biotechnology 27(3):264-74, 2009 Mar - Who cited this? | PubMed ID: 19234449 | Fulltext

Visualization and Identification of IL-7 Producing Cells in Reporter Mice.

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Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J,

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PLoS ONE 4(11):e7637, 2009 - Who cited this? | PubMed ID: 19907640 | Fulltext

A DNA transposon-based approach to validate oncogenic mutations in the mouse.

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Su Q, Prosser HM, Campos LS, Ortiz M, Nakamura T, Warren M, Dupuy AJ, Jenkins NA, Copeland NG, Bradley A, and Liu P

Proceedings of the National Academy of Sciences of the United States of America 105(50):19904-9, 2008 Dec 16 - Who cited this? | PubMed ID: 19064922 | Fulltext

Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

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Stankunas K, Shang C, Twu KY, Kao SC, Jenkins NA, Copeland NG, Sanyal M, Selleri L, Cleary ML, and Chang CP

Circulation research 103(7):702-9, 2008 Sep 26 - Who cited this? | PubMed ID: 18723445 | Fulltext

Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti.

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Chen Z, Montcouquiol M, Calderon R, Jenkins NA, Copeland NG, Kelley MW, and Noben-Trauth K

The Journal of neuroscience : the official journal of the Society for Neuroscience 28(26):6633, 2008 Jun 25 - Who cited this? | PubMed ID: 18579736 | Fulltext

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.

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Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, and Harhaj EW

Nature immunology 9(3):254-62, 2008 Mar - Who cited this? | PubMed ID: 18246070 | Fulltext

BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

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Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Hu XZ, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, and Lipsky RH

The Journal of neuroscience : the official journal of the Society for Neuroscience 28(5):1118-30, 2008 Jan 30 - Who cited this? | PubMed ID: 18234890 | Fulltext

Itchy mice: the identification of a new pathway for the development of autoimmunity.

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Matesic LE, Copeland NG, and Jenkins NA

Current topics in microbiology and immunology 321:185, 2008 - Who cited this? | PubMed ID: 18727493 | Fulltext

BCL11B is required for positive selection and survival of double-positive thymocytes.

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Albu DI, Feng D, Bhattacharya D, Jenkins NA, Copeland NG, Liu P, and Avram D

The Journal of experimental medicine 204(12):3003-15, 2007 Nov 26 - Who cited this? | PubMed ID: 17998389 | Fulltext

A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.

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Colomer Gould VF, Goti D, Pearce D, Gonzalez GA, Gao H, Bermudez de Leon M, Jenkins NA, Copeland NG, Ross CA, and Brown DR

Neurobiology of disease 27(3):362-9, 2007 Sep - Who cited this? | PubMed ID: 17632007 | Fulltext

The tetraspanin protein peripherin-2 forms a complex with melanoregulin, a putative membrane fusion regulator.

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Boesze-Battaglia K, Song H, Sokolov M, Lillo C, Pankoski-Walker L, Gretzula C, Gallagher B, Rachel RA, Jenkins NA, Copeland NG, Morris F, Jacob J, Yeagle P, Williams DS, and Damek-Poprawa M

Biochemistry 46(5):1256-72, 2007 Feb 6 - Who cited this? | PubMed ID: 17260955 | Fulltext

Itch genetically interacts with Notch1 in a mouse autoimmune disease model.

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Matesic LE, Haines DC, Copeland NG, and Jenkins NA

Human molecular genetics 15(24):3485, 2006 Dec 15 - Who cited this? | PubMed ID: 17095521 | Fulltext

Mouse coat color mutations: from fancy mice to functional genomics.

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Steingrímsson E, Copeland NG, and Jenkins NA

Developmental dynamics : an official publication of the American Association of Anatomists 235(9):2401-11, 2006 Sep - Who cited this? | PubMed ID: 16691561 | Fulltext

Zfp423 is required for normal cerebellar development.

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Warming S, Rachel RA, Jenkins NA, and Copeland NG

Molecular and cellular biology 26(18):6913-22, 2006 Sep - Who cited this? | PubMed ID: 16943432 | Fulltext

Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice.

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Suzuki T, Minehata K, Akagi K, Jenkins NA, and Copeland NG

The EMBO journal 25(14):3422, 2006 Jul 26 - Who cited this? | PubMed ID: 16858412 | Fulltext

Onset and progression in inherited ALS determined by motor neurons and microglia.

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Boillée S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, and Cleveland DW

Science (New York, N.Y.) 312(5778):1389, 2006 Jun 2 - Who cited this? | PubMed ID: 16741123 | Fulltext

Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.

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Montcouquiol M, Sans N, Huss D, Kach J, Dickman JD, Forge A, Rachel RA, Copeland NG, Jenkins NA, Bogani D, Murdoch J, Warchol ME, Wenthold RJ, and Kelley MW

The Journal of neuroscience : the official journal of the Society for Neuroscience 26(19):5265-75, 2006 May 10 - Who cited this? | PubMed ID: 16687519 | Fulltext

Sleeping beauty: a novel cancer gene discovery tool.

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Dupuy AJ, Jenkins NA, and Copeland NG

Human molecular genetics 15 Spec No 1, 2006 Apr 15 - Who cited this? | PubMed ID: 16651372 | Fulltext

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

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Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, Glimm H, Kühlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I,

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Nature medicine 12(4):401-9, 2006 Apr - Who cited this? | PubMed ID: 16582916 | Fulltext

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

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Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, and Ellerby LM

Neurobiology of disease 21(2):381-91, 2006 Feb - Who cited this? | PubMed ID: 16150600 | Fulltext

Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR.

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Boyd KE, Xiao YY, Fan K, Poholek A, Copeland NG, Jenkins NA, and Perkins AS

Blood 107(2):733-41, 2006 Jan 15 - Who cited this? | PubMed ID: 16204320 | Fulltext

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

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Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, and Lee MK

The Journal of neuroscience : the official journal of the Society for Neuroscience 26(1):41-50, 2006 Jan 4 - Who cited this? | PubMed ID: 16399671 | Fulltext

Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells.

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Du Y, Jenkins NA, and Copeland NG

Blood 106(12):3932, 2005 Dec 1 - Who cited this? | PubMed ID: 16109773 | Fulltext

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.

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Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, and Borchelt DR

PLoS medicine 2(12), 2005 Dec - Who cited this? | PubMed ID: 16279840 | Fulltext

Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA.

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Wang J, Xu G, Slunt HH, Gonzales V, Coonfield M, Fromholt D, Copeland NG, Jenkins NA, and Borchelt DR

Neurobiology of disease 20(3):943-52, 2005 Dec - Who cited this? | PubMed ID: 16046140 | Fulltext

Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis.

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Du Y, Spence SE, Jenkins NA, and Copeland NG

Blood 106(7):2498-505, 2005 Oct 1 - Who cited this? | PubMed ID: 15961513 | Fulltext

Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system.

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Keng VW, Yae K, Hayakawa T, Mizuno S, Uno Y, Yusa K, Kokubu C, Kinoshita T, Akagi K, Jenkins NA, Copeland NG, Horie K, and Takeda J

Nature methods 2(10):763-9, 2005 Oct - Who cited this? | PubMed ID: 16179923 | Fulltext

Transgenic mice expressing Cre-recombinase specifically in retinal rod bipolar neurons.

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Zhang XM, Chen BY, Ng AH, Tanner JA, Tay D, So KF, Rachel RA, Copeland NG, Jenkins NA, and Huang JD

Investigative ophthalmology & visual science 46(10):3515-20, 2005 Oct - Who cited this? | PubMed ID: 16186328 | Fulltext

Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation.

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Wang J, Xu G, Li H, Gonzales V, Fromholt D, Karch C, Copeland NG, Jenkins NA, and Borchelt DR

Human molecular genetics 14(16):2335-47, 2005 Aug 15 - Who cited this? | PubMed ID: 16000321 | Fulltext

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

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Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, and Jenkins NA

Nature 436(7048):221-6, 2005 Jul 14 - Who cited this? | PubMed ID: 16015321 | Fulltext

A comprehensive SNP-based genetic analysis of inbred mouse strains.

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Tsang S, Sun Z, Luke B, Stewart C, Lum N, Gregory M, Wu X, Subleski M, Jenkins NA, Copeland NG, and Munroe DJ

Mammalian genome : official journal of the International Mammalian Genome Society 16(7):476-80, 2005 Jul - Who cited this? | PubMed ID: 16151692 | Fulltext

Myosin-1a is critical for normal brush border structure and composition.

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Tyska MJ, Mackey AT, Huang JD, Copeland NG, Jenkins NA, and Mooseker MS

Molecular biology of the cell 16(5):2443-57, 2005 May - Who cited this? | PubMed ID: 15758024 | Fulltext

Melanocyte stem cell maintenance and hair graying.

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Steingrímsson E, Copeland NG, and Jenkins NA

Cell 121(1):9, 2005 Apr 8 - Who cited this? | PubMed ID: 15820674 | Fulltext

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.

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Iwasaki M, Kuwata T, Yamazaki Y, Jenkins NA, Copeland NG, Osato M, Ito Y, Kroon E, Sauvageau G, and Nakamura T

Blood 105(2):784-93, 2005 Jan 15 - Who cited this? | PubMed ID: 15454493 | Fulltext

Simple and highly efficient BAC recombineering using galK selection.

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Warming S, Costantino N, Court DL, Jenkins NA, and Copeland NG

Nucleic acids research 33(4):e36, 2005 - Who cited this? | PubMed ID: 15731329 | Fulltext

dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice.

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O'Sullivan TN, Wu XS, Rachel RA, Huang JD, Swing DA, Matesic LE, Hammer JA, Copeland NG, and Jenkins NA

Proceedings of the National Academy of Sciences of the United States of America 101(48):16831-6, 2004 Nov 30 - Who cited this? | PubMed ID: 15550542 | Fulltext

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

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Goti D, Katzen SM, Mez J, Kurtis N, Kiluk J, Ben-Haïem L, Jenkins NA, Copeland NG, Kakizuka A, Sharp AH, Ross CA, Mouton PR, and Colomer V

The Journal of neuroscience : the official journal of the Society for Neuroscience 24(45):10266-79, 2004 Nov 10 - Who cited this? | PubMed ID: 15537899 | Fulltext

Highly restricted expression of Cre recombinase in cerebellar Purkinje cells.

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Zhang XM, Ng AH, Tanner JA, Wu WT, Copeland NG, Jenkins NA, and Huang JD

Genesis (New York, N.Y. : 2000) 40(1):45-51, 2004 Sep - Who cited this? | PubMed ID: 15354293 | Fulltext

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.

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Schilling G, Savonenko AV, Klevytska A, Morton JL, Tucker SM, Poirier M, Gale A, Chan N, Gonzales V, Slunt HH, Coonfield ML, Jenkins NA, Copeland NG, Ross CA, and Borchelt DR

Human molecular genetics 13(15):1599, 2004 Aug 1 - Who cited this? | PubMed ID: 15190011 | Fulltext

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