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Papers authored by Clevers H

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The kinase TNIK is an essential activator of Wnt target genes.

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Mahmoudi T, Li VS, Ng SS, Taouatas N, Vries RG, Mohammed S, Heck AJ, and Clevers H

The EMBO journal 28(21):3329-40, 2009 Nov 4 - Who cited this? | PubMed ID: 19816403 | Fulltext

Eyeing up new wnt pathway players.

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Clevers H

Cell 139(2):227-9, 2009 Oct 16 - Who cited this? | PubMed ID: 19837026 | Fulltext

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

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Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B, Schirmacher P, Kestler H, Danenberg E, Barker N, Clevers H, Speicher MR, and Rudolph KL

Nature genetics 41(10):1138-43, 2009 Oct - Who cited this? | PubMed ID: 19718028 | Fulltext

The ets-domain transcription factor spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

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Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, and Clevers H

Gastroenterology 137(4):1333-1345.e3, 2009 Oct - Who cited this? | PubMed ID: 19549527 | Fulltext

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

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Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, and Whitsett JA

The Journal of clinical investigation 119(10):2914-24, 2009 Oct - Who cited this? | PubMed ID: 19759516 | Fulltext

A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.

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Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, and Stiles CD

The Journal of neuroscience : the official journal of the Society for Neuroscience 29(36):11399-408, 2009 Sep 9 - Who cited this? | PubMed ID: 19741146 | Fulltext

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.

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Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, and Lu QR

Nature neuroscience 12(7):829-38, 2009 Jul - Who cited this? | PubMed ID: 19503085 | Fulltext

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.

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van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, and Clevers H

Gastroenterology 137(1):15-7, 2009 Jul - Who cited this? | PubMed ID: 19450592 | Fulltext

LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism.

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Jansen M, Ten Klooster JP, Offerhaus GJ, and Clevers H

Physiological reviews 89(3):777-98, 2009 Jul - Who cited this? | PubMed ID: 19584313 | Fulltext

Prominin-1/CD133 Marks Stem Cells and Early Progenitors in Mouse Small Intestine.

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Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, and Clevers H

Gastroenterology 136(7):2187-2194.e1, 2009 Jun - Who cited this? | PubMed ID: 19324043 | Fulltext

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

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Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, and Clevers H

Nature 459(7244):262-5, 2009 May 14 - Who cited this? | PubMed ID: 19329995 | Fulltext

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.

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Medina PP, Castillo SD, Blanco S, Sanz-Garcia M, Largo C, Alvarez S, Yokota J, Gonzalez-Neira A, Benitez J, Clevers HC, Cigudosa JC, Lazo PA, and Sanchez-Cespedes M

Human molecular genetics 18(7):1343-52, 2009 Apr 1 - Who cited this? | PubMed ID: 19153074 | Fulltext

MafB oncoprotein detected by immunohistochemistry as a highly sensitive and specific marker for the prognostic unfavorable t(14;20) (q32;q12) in multiple myeloma patients.

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Stralen E, Leguit RJ, Begthel H, Michaux L, Buijs A, Lemmens H, Scheiff JM, Doyen C, Pierre P, Forget F, Clevers HC, and Bast B

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 23(4):801-3, 2009 Apr - Who cited this? | PubMed ID: 18830254 | Fulltext

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

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ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, and Clevers H

Developmental cell 16(4):551-62, 2009 Apr - Who cited this? | PubMed ID: 19386264 | Fulltext

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

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van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, and Clevers H

Cell 136(5):903-12, 2009 Mar 6 - Who cited this? | PubMed ID: 19269367 | Fulltext

Wnt signaling, lgr5, and stem cells in the intestine and skin.

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Haegebarth A and Clevers H

The American journal of pathology 174(3):715-21, 2009 Mar - Who cited this? | PubMed ID: 19197002 | Fulltext

T-Cell Factor 4 (tcf7l2) Is the Main Effector of Wnt Signaling During Zebrafish Intestine Organogenesis.

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Faro A, Boj SF, Ambrósio R, van den Broek O, Korving J, and Clevers H

Zebrafish 6(1):59-68, 2009 Mar - Who cited this? | PubMed ID: 19374549 | Fulltext

Inflammatory bowel disease, stress, and the endoplasmic reticulum.

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Clevers H

The New England journal of medicine 360(7):726-7, 2009 Feb 12 - Who cited this? | PubMed ID: 19213688 | Fulltext

Crypt stem cells as the cells-of-origin of intestinal cancer.

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Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, and Clevers H

Nature 457(7229):608-11, 2009 Jan 29 - Who cited this? | PubMed ID: 19092804 | Fulltext

Identification of primary MAFB target genes in multiple myeloma.

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van Stralen E, van de Wetering M, Agnelli L, Neri A, Clevers HC, and Bast BJ

Experimental hematology 37(1):78-86, 2009 Jan - Who cited this? | PubMed ID: 19013005 | Fulltext

A transgenic mouse model for "lipid hang-up", or why pathologists need to be involved in genetically engineered mouse modelling.

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Offerhaus GJ, Milne AN, Oving IM, van Gijn ME, Hruban RH, and Clevers H

Gut 57(12):1739-40, 2008 Dec - Who cited this? | PubMed ID: 19022932 | Fulltext

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

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Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, and Toftgård R

Nature genetics 40(11):1291-9, 2008 Nov - Who cited this? | PubMed ID: 18849992 | Fulltext

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium.

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Van der Flier LG and Clevers H

Annual review of physiology, 2008 Sep 22 - Who cited this? | PubMed ID: 18808327 | Fulltext

The role of APC and beta-catenin in the etiology of aggressive fibromatosis (desmoid tumors).

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Lips DJ, Barker N, Clevers H, and Hennipman A

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2008 Aug 20 - Who cited this? | PubMed ID: 18722078 | Fulltext

The intestinal stem cell.

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Barker N, van de Wetering M, and Clevers H

Genes & development 22(14):1856, 2008 Jul 15 - Who cited this? | PubMed ID: 18628392 | Fulltext

Investigation of Frizzled-5 during embryonic neural development in mouse.

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Burns CJ, Zhang J, Brown EC, Van Bibber AM, Van Es J, Clevers H, Ishikawa TO, Taketo MM, Vetter ML, and Fuhrmann S

Developmental dynamics : an official publication of the American Association of Anatomists 237(6):1614, 2008 Jun - Who cited this? | PubMed ID: 18489003 | Fulltext

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.

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Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, and Zon LI

Developmental biology, 2008 May 20 - Who cited this? | PubMed ID: 18585699 | Fulltext

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.

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Hatzis P, van der Flier LG, van Driel MA, Guryev V, Nielsen F, Denissov S, Nijman IJ, Koster J, Santo EE, Welboren W, Versteeg R, Cuppen E, van de Wetering M, Clevers H, and Stunnenberg HG

Molecular and cellular biology 28(8):2732-44, 2008 Apr - Who cited this? | PubMed ID: 18268006 | Fulltext

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27(Kip1) and p57(Kip2).

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Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, Strobl LJ, Honjo T, Clevers H, and Radtke F

EMBO reports 9(4):377-83, 2008 Apr - Who cited this? | PubMed ID: 18274550 | Fulltext

Very Long-term Self-renewal of Small Intestine, Colon, and Hair Follicles from Cycling Lgr5+ve Stem Cells.

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Barker N, van Es JH, Jaks V, Kasper M, Snippert H, Toftgård R, and Clevers H

Cold Spring Harbor symposia on quantitative biology 73:351-6, 2008 - Who cited this? | PubMed ID: 19478326 | Fulltext

Transcriptome profile of human colorectal adenomas.

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Sabates-Bellver J, Van der Flier LG, de Palo M, Cattaneo E, Maake C, Rehrauer H, Laczko E, Kurowski MA, Bujnicki JM, Menigatti M, Luz J, Ranalli TV, Gomes V, Pastorelli A, Faggiani R, Anti M,

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Molecular cancer research : MCR 5(12):1263, 2007 Dec - Who cited this? | PubMed ID: 18171984 | Fulltext

Tracking down the stem cells of the intestine: strategies to identify adult stem cells.

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Barker N and Clevers H

Gastroenterology 133(6):1755-60, 2007 Dec - Who cited this? | PubMed ID: 18054544 | Fulltext

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.

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Kessler BM, Fortunati E, Melis M, Pals CE, Clevers H, and Maurice MM

Journal of proteome research 6(11):4163-72, 2007 Nov - Who cited this? | PubMed ID: 17927229 | Fulltext

Identification of stem cells in small intestine and colon by marker gene Lgr5.

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Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, and Clevers H

Nature 449(7165):1003-7, 2007 Oct 25 - Who cited this? | PubMed ID: 17934449 | Fulltext

Giving APCmin tumours a SPARC.

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Gregorieff A and Clevers H

Gut 56(10):1341-3, 2007 Oct - Who cited this? | PubMed ID: 17446305 | Fulltext

Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment.

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de Leng WW, Jansen M, Keller JJ, de Gijsel M, Milne AN, Morsink FH, Weterman MA, Iacobuzio-Donahue CA, Clevers HC, Giardiello FM, and Offerhaus GJ

Gut 56(10):1475-6, 2007 Oct - Who cited this? | PubMed ID: 17872577 | Fulltext

Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools.

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van Noort M, Weerkamp F, Clevers HC, and Staal FJ

Blood 110(7):2778-9, 2007 Oct 1 - Who cited this? | PubMed ID: 17881649 | Fulltext

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.

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Muncan V, Faro A, Haramis AP, Hurlstone AF, Wienholds E, van Es J, Korving J, Begthel H, Zivkovic D, and Clevers H

EMBO reports 8(10):966-73, 2007 Oct - Who cited this? | PubMed ID: 17823612 | Fulltext

Wnt signaling mediates regional specification in the vertebrate face.

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Brugmann SA, Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, and Helms JA

Development (Cambridge, England) 134(18):3283, 2007 Sep - Who cited this? | PubMed ID: 17699607 | Fulltext

The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.

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Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, Kays RJ, Fellermann K, Burk O, Schwab M, Clevers H, Bevins CL, and Stange EF

Journal of immunology (Baltimore, Md. : 1950) 179(5):3109-18, 2007 Sep 1 - Who cited this? | PubMed ID: 17709525 | Fulltext

Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.

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Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, and Taketo MM

The Journal of biological chemistry 282(32):23532, 2007 Aug 10 - Who cited this? | PubMed ID: 17573348 | Fulltext

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

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Mori-Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, and de Crombrugghe B

Gastroenterology 133(2):539, 2007 Aug - Who cited this? | PubMed ID: 17681175 | Fulltext

Myc deletion rescues Apc deficiency in the small intestine.

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Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, and Clarke AR

Nature 446(7136):676-9, 2007 Apr 5 - Who cited this? | PubMed ID: 17377531 | Fulltext

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

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Carretero J, Medina PP, Blanco R, Smit L, Tang M, Roncador G, Maestre L, Conde E, Lopez-Rios F, Clevers HC, and Sanchez-Cespedes M

Oncogene 26(11):1616-25, 2007 Mar 8 - Who cited this? | PubMed ID: 16953221 | Fulltext

c-Myb is required for progenitor cell homeostasis in colonic crypts.

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Malaterre J, Carpinelli M, Ernst M, Alexander W, Cooke M, Sutton S, Dworkin S, Heath JK, Frampton J, McArthur G, Clevers H, Hilton D, Mantamadiotis T, and Ramsay RG

Proceedings of the National Academy of Sciences of the United States of America 104(10):3829-34, 2007 Mar 6 - Who cited this? | PubMed ID: 17360438 | Fulltext

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.

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Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, and Kopan R

Development (Cambridge, England) 134(3):535, 2007 Feb - Who cited this? | PubMed ID: 17215306 | Fulltext

The Intestinal Wnt/TCF Signature.

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Van der Flier LG, Sabates-Bellver J, Oving I, Haegebarth A, De Palo M, Anti M, Van Gijn ME, Suijkerbuijk S, Van de Wetering M, Marra G, and Clevers H

Gastroenterology 132(2):628-32, 2007 Feb - Who cited this? | PubMed ID: 17320548 | Fulltext

WNT signaling in the normal intestine and colorectal cancer.

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de Lau W, Barker N, and Clevers H

Frontiers in bioscience : a journal and virtual library 12:471-91, 2007 - Who cited this? | PubMed ID: 17127311 | Fulltext

Mining the Wnt pathway for cancer therapeutics.

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Barker N and Clevers H

Nature reviews. Drug discovery 5(12):997-1014, 2006 Dec - Who cited this? | PubMed ID: 17139285 | Fulltext

Wnt/beta-catenin signaling in development and disease.

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Clevers H

Cell 127(3):469, 2006 Nov 3 - Who cited this? | PubMed ID: 17081971 | Fulltext

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