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Papers authored by Carling D

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

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Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G,

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Science (New York, N.Y.) 326(5949):140-4, 2009 Oct 2 - Who cited this? | PubMed ID: 19797661 | Fulltext

Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: A cautionary tale.

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Renz B, Davies JK, Carling D, Watkins H, and Redwood C

Protein expression and purification 66(2):181-4, 2009 Aug - Who cited this? | PubMed ID: 19269329 | Fulltext

The regulation and function of mammalian AMPK-related kinases.

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Bright NJ, Thornton C, and Carling D

Acta physiologica (Oxford, England) 196(1):15-26, 2009 May - Who cited this? | PubMed ID: 19245655 | Fulltext

Taking the Stress out of Melanoma.

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Martin MJ, Carling D, and Marais R

Cancer cell 15(3):163-4, 2009 Mar 3 - Who cited this? | PubMed ID: 19249673 | Fulltext

Branching out on AMPK Regulation.

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Carling D

Cell metabolism 9(1):7-8, 2009 Jan 7 - Who cited this? | PubMed ID: 19117541 | Fulltext

Characterization of an Alternative Splice Variant of LKB1.

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Denison FC, Hiscock NJ, Carling D, and Woods A

The Journal of biological chemistry 284(1):67-76, 2009 Jan 2 - Who cited this? | PubMed ID: 18854309 | Fulltext

Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype.

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Sag D, Carling D, Stout RD, and Suttles J

Journal of immunology (Baltimore, Md. : 1950) 181(12):8633-41, 2008 Dec 15 - Who cited this? | PubMed ID: 19050283 | Fulltext

The regulation of AMP-activated protein kinase by upstream kinases.

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Carling D, Sanders MJ, and Woods A

International journal of obesity (2005) 32 Suppl 4, 2008 Sep - Who cited this? | PubMed ID: 18719600 | Fulltext

Muscarinic Receptor Activation of AMP-activated Protein Kinase Inhibits Orexigenic Neuropeptide mRNA Expression.

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Thornton C, Sardini A, and Carling D

The Journal of biological chemistry 283(25):17116, 2008 Jun 20 - Who cited this? | PubMed ID: 18436530 | Fulltext

Investigating the Regulation of Brain-specific Kinases 1 and 2 by Phosphorylation.

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Bright NJ, Carling D, and Thornton C

The Journal of biological chemistry 283(22):14946-54, 2008 May 30 - Who cited this? | PubMed ID: 18339622 | Fulltext

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

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López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW,

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Cell metabolism 7(5):389, 2008 May - Who cited this? | PubMed ID: 18460330 | Fulltext

Low utilization of circulating glucose after food withdrawal in Snell dwarf mice.

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Brooks NL, Trent CM, Raetzsch CF, Flurkey K, Boysen G, Perfetti MT, Jeong YC, Klebanov S, Patel KB, Khodush VR, Kupper LL, Carling D, Swenberg JA, Harrison DE, and Combs TP

The Journal of biological chemistry 282(48):35069, 2007 Nov 30 - Who cited this? | PubMed ID: 17905742 | Fulltext

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

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Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, and Carling D

The Journal of biological chemistry 282(45):32539-48, 2007 Nov 9 - Who cited this? | PubMed ID: 17728241 | Fulltext

Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses.

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Dranchak PK, Leiper FC, Valberg SJ, Piercy RJ, Carling D, McCue ME, and Mickelson JR

American journal of veterinary research 68(10):1079-84, 2007 Oct - Who cited this? | PubMed ID: 17916014 | Fulltext

Structural basis for AMP binding to mammalian AMP-activated protein kinase.

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Xiao B, Heath R, Saiu P, Leiper FC, Leone P, Jing C, Walker PA, Haire L, Eccleston JF, Davis CT, Martin SR, Carling D, and Gamblin SJ

Nature 449(7161):496-500, 2007 Sep 27 - Who cited this? | PubMed ID: 17851531 | Fulltext

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

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Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D,

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The Journal of clinical investigation 117(8):2325-36, 2007 Aug - Who cited this? | PubMed ID: 17671657 | Fulltext

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

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Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, and Sanz P

The Journal of biological chemistry 282(22):16117-25, 2007 Jun 1 - Who cited this? | PubMed ID: 17403675 | Fulltext

S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase.

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Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y, Djouadi F, Miraux S, Thiaudière E, Foretz M, Viollet B, Diolez P, Bastin J, Benit P, Rustin P, Carling D, Sandri M,

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Cell metabolism 5(6):476-87, 2007 Jun - Who cited this? | PubMed ID: 17550782 | Fulltext

Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.

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Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, and Xu A

Diabetes 56(5):1387-94, 2007 May - Who cited this? | PubMed ID: 17287464 | Fulltext

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade.

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Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, and Carling D

The Biochemical journal 403(1):139-48, 2007 Apr 1 - Who cited this? | PubMed ID: 17147517 | Fulltext

Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase.

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Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, Cooper E,

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Neuron 53(2):233, 2007 Jan 18 - Who cited this? | PubMed ID: 17224405 | Fulltext

The role of the AMP-activated protein kinase in the regulation of energy homeostasis.

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Carling D

Novartis Foundation symposium 286:72-81; discussion 81-5, 162-3, 196-203, 2007 - Who cited this? | PubMed ID: 18269175 | Fulltext

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

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Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, and Kemp BE

Cell metabolism 4(6):465, 2006 Dec - Who cited this? | PubMed ID: 17141630 | Fulltext

Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart.

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Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, and Young LH

American journal of physiology. Heart and circulatory physiology 291(4):H1927-34, 2006 Oct - Who cited this? | PubMed ID: 16648175 | Fulltext

Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta.

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Stahmann N, Woods A, Carling D, and Heller R

Molecular and cellular biology 26(16):5933, 2006 Aug - Who cited this? | PubMed ID: 16880506 | Fulltext

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

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Watt MJ, Dzamko N, Thomas WG, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio MA, and Steinberg GR

Nature medicine 12(5):541, 2006 May - Who cited this? | PubMed ID: 16604088 | Fulltext

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.

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Davies JK, Wells DJ, Liu K, Whitrow HR, Daniel TD, Grignani R, Lygate CA, Schneider JE, Noël G, Watkins H, and Carling D

American journal of physiology. Heart and circulatory physiology 290(5), 2006 May - Who cited this? | PubMed ID: 16339829 | Fulltext

LKB1: a sweet side to Peutz-Jeghers syndrome?.

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Carling D

Trends in molecular medicine 12(4):144-7, 2006 Apr - Who cited this? | PubMed ID: 16530014 | Fulltext

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

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Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Wallimann T, Carling D, Hue L, and Rider MH

The Journal of biological chemistry 281(9):5335, 2006 Mar 3 - Who cited this? | PubMed ID: 16340011 | Fulltext

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

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Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, and Carling D

Cell metabolism 2(1):21, 2005 Jul - Who cited this? | PubMed ID: 16054096 | Fulltext

Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity.

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Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, Small CJ, Carling D, and Richter EA

Biochemical and biophysical research communications 329(2):719-25, 2005 Apr 8 - Who cited this? | PubMed ID: 15737645 | Fulltext

AMP-activated protein kinase and the metabolic syndrome.

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Fryer LG and Carling D

Biochemical Society transactions 33(Pt 2):362, 2005 Apr - Who cited this? | PubMed ID: 15787607 | Fulltext

Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.

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Sidhu JS, Rajawat YS, Rami TG, Gollob MH, Wang Z, Yuan R, Marian AJ, DeMayo FJ, Weilbacher D, Taffet GE, Davies JK, Carling D, Khoury DS, and Roberts R

Circulation 111(1):21, 2005 Jan 4 - Who cited this? | PubMed ID: 15611370 | Fulltext

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

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Kahn BB, Alquier T, Carling D, and Hardie DG

Cell metabolism 1(1):15, 2005 Jan - Who cited this? | PubMed ID: 16054041 | Fulltext

AMP-activated protein kinase: balancing the scales.

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Carling D

Biochimie 87(1):87-91, 2005 Jan - Who cited this? | PubMed ID: 15733742 | Fulltext

Cellular energy sensor balances the scales.

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Small CJ, Carling D, and Bloom SR

Nature medicine 10(7):681-2, 2004 Jul - Who cited this? | PubMed ID: 15229514 | Fulltext

Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids.

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Clark H, Carling D, and Saggerson D

European journal of biochemistry / FEBS 271(11):2215-24, 2004 Jun - Who cited this? | PubMed ID: 15153111 | Fulltext

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.

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Cheng SW, Fryer LG, Carling D, and Shepherd PR

The Journal of biological chemistry 279(16):15719-22, 2004 Apr 16 - Who cited this? | PubMed ID: 14970221 | Fulltext

AMP-activated protein kinase plays a role in the control of food intake.

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Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, and Small CJ

The Journal of biological chemistry 279(13):12005, 2004 Mar 26 - Who cited this? | PubMed ID: 14742438 | Fulltext

Neuregulin signaling on glucose transport in muscle cells.

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Cantó C, Suárez E, Lizcano JM, Griñó E, Shepherd PR, Fryer LG, Carling D, Bertran J, Palacín M, Zorzano A, and Gumà A

The Journal of biological chemistry 279(13):12260-8, 2004 Mar 26 - Who cited this? | PubMed ID: 14711829 | Fulltext

AMPK.

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Carling D

Current biology : CB 14(6):R220, 2004 Mar 23 - Who cited this? | PubMed ID: 15043827 | Fulltext

Effects of nematicides on cotton root mycobiota.

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Baird RE, Carling DE, Watson CE, Scruggs ML, and Hightower P

Mycopathologia 157(2):191-9, 2004 Feb - Who cited this? | PubMed ID: 15119856 | Fulltext

The AMP-activated protein kinase cascade--a unifying system for energy control.

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Carling D

Trends in biochemical sciences 29(1):18-24, 2004 Jan - Who cited this? | PubMed ID: 14729328 | Fulltext

Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase.

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Carling D, Fryer LG, Woods A, Daniel T, Jarvie SL, and Whitrow H

Biochemical Society transactions 31(Pt 6):1157, 2003 Dec - Who cited this? | PubMed ID: 14641016 | Fulltext

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.

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Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, and Carling D

Current biology : CB 13(22):2004-8, 2003 Nov 11 - Who cited this? | PubMed ID: 14614828 | Fulltext

Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli.

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Neumann D, Woods A, Carling D, Wallimann T, and Schlattner U

Protein expression and purification 30(2):230-7, 2003 Aug - Who cited this? | PubMed ID: 12880772 | Fulltext

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.

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Woods A, Vertommen D, Neumann D, Turk R, Bayliss J, Schlattner U, Wallimann T, Carling D, and Rider MH

The Journal of biological chemistry 278(31):28434-42, 2003 Aug 1 - Who cited this? | PubMed ID: 12764152 | Fulltext

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.

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Hong SP, Leiper FC, Woods A, Carling D, and Carlson M

Proceedings of the National Academy of Sciences of the United States of America 100(15):8839-43, 2003 Jul 22 - Who cited this? | PubMed ID: 12847291 | Fulltext

Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.

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Wang W, Yang X, López de Silanes I, Carling D, and Gorospe M

The Journal of biological chemistry 278(29):27016-23, 2003 Jul 18 - Who cited this? | PubMed ID: 12730239 | Fulltext

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes.

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Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, and Ido Y

Biochemical Society transactions 31(Pt 1):202-6, 2003 Feb - Who cited this? | PubMed ID: 12546685 | Fulltext

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