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Papers authored by Cantley LC

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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

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Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, and Alessi DR

The Biochemical journal 424(1):47-60, 2009 Nov 15 - Who cited this? | PubMed ID: 19740074 | Fulltext

Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?.

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Myers AP, Meyerhardt JA, and Cantley LC

Clinical cancer research : an official journal of the American Association for Cancer Research 15(22):6748-50, 2009 Nov 15 - Who cited this? | PubMed ID: 19903790 | Fulltext

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

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Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, and Elmquist JK

Endocrinology 150(11):4874-82, 2009 Nov - Who cited this? | PubMed ID: 19819947 | Fulltext

Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.

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Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, and Vary CP

Developmental dynamics : an official publication of the American Association of Anatomists 238(10):2670-9, 2009 Oct - Who cited this? | PubMed ID: 19705443 | Fulltext

Cancer's insatiable appetite.

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Locasale JW, Cantley LC, and Heiden MG

Nature biotechnology 27(10):916-7, 2009 Oct - Who cited this? | PubMed ID: 19816448 | Fulltext

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling.

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Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, and Cantley LC

Cancer cell 16(2):115-25, 2009 Aug 4 - Who cited this? | PubMed ID: 19647222 | Fulltext

Lewis C. Cantley.

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Cantley LC

Current biology : CB 19(14):R540-1, 2009 Jul 28 - Who cited this? | PubMed ID: 19655422 | Fulltext

The antiproliferative cytostatic effects of a self-activating viridin prodrug.

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Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, and Josephson L

Molecular cancer therapeutics 8(6):1666-75, 2009 Jun - Who cited this? | PubMed ID: 19509266 | Fulltext

Understanding the Warburg effect: the metabolic requirements of cell proliferation.

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Vander Heiden MG, Cantley LC, and Thompson CB

Science (New York, N.Y.) 324(5930):1029-33, 2009 May 22 - Who cited this? | PubMed ID: 19460998 | Fulltext

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

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Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, and Cantley LC

Molecular cell 34(4):461-72, 2009 May 14 - Who cited this? | PubMed ID: 19481526 | Fulltext

Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis.

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Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, and Asara JM

Science (New York, N.Y.) 324(5927):626-31, 2009 May 1 - Who cited this? | PubMed ID: 19407199 | Fulltext

PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.

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Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, and Fuchs CS

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27(9):1477-84, 2009 Mar 20 - Who cited this? | PubMed ID: 19237633 | Fulltext

Bidirectional transport of amino acids regulates mTOR and autophagy.

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Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM,

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Cell 136(3):521-34, 2009 Feb 6 - Who cited this? | PubMed ID: 19203585 | Fulltext

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation.

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Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, and Cantley LC

Molecular cell 33(2):237-47, 2009 Jan 30 - Who cited this? | PubMed ID: 19187764 | Fulltext

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

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Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF,

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Nature medicine 14(12):1351-6, 2008 Dec - Who cited this? | PubMed ID: 19029981 | Fulltext

PI3K pathway alterations in cancer: variations on a theme.

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Yuan TL and Cantley LC

Oncogene 27(41):5497-510, 2008 Sep 18 - Who cited this? | PubMed ID: 18794884 | Fulltext

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

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Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, and Pandolfi PP

The Journal of clinical investigation 118(9):3065, 2008 Sep 2 - Who cited this? | PubMed ID: 18725988 | Fulltext

PI3K enters beta-testing.

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Shaywitz AJ, Courtney KD, Patnaik A, and Cantley LC

Cell metabolism 8(3):179, 2008 Sep - Who cited this? | PubMed ID: 18762017 | Fulltext

Slow self-activation enhances the potency of viridin prodrugs.

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Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, and Josephson L

Journal of medicinal chemistry 51(15):4699, 2008 Aug 14 - Who cited this? | PubMed ID: 18630894 | Fulltext

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

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Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, and Cantley LC

Proceedings of the National Academy of Sciences of the United States of America 105(28):9739, 2008 Jul 15 - Who cited this? | PubMed ID: 18621722 | Fulltext

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

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Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, and Elmquist JK

The Journal of clinical investigation 118(5):1796, 2008 May - Who cited this? | PubMed ID: 18382766 | Fulltext

A sweet new role for EGFR in cancer.

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Engelman JA and Cantley LC

Cancer cell 13(5):375, 2008 May - Who cited this? | PubMed ID: 18455118 | Fulltext

Molecular phylogenetics of mastodon and Tyrannosaurus rex.

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Organ CL, Schweitzer MH, Zheng W, Freimark LM, Cantley LC, and Asara JM

Science (New York, N.Y.) 320(5875):499, 2008 Apr 25 - Who cited this? | PubMed ID: 18436782 | Fulltext

Pyruvate kinase M2 is a phosphotyrosine-binding protein.

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Christofk HR, Vander Heiden MG, Wu N, Asara JM, and Cantley LC

Nature 452(7184):181, 2008 Mar 13 - Who cited this? | PubMed ID: 18337815 | Fulltext

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

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Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, and Cantley LC

Nature 452(7184):230, 2008 Mar 13 - Who cited this? | PubMed ID: 18337823 | Fulltext

A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.

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Asara JM, Christofk HR, Freimark LM, and Cantley LC

Proteomics 8(5):994, 2008 Mar - Who cited this? | PubMed ID: 18324724 | Fulltext

Fate of a bioactive fluorescent wortmannin derivative in cells.

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Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, and Josephson L

Bioconjugate chemistry 19(1):130-7, 2008 - Who cited this? | PubMed ID: 17988080 | Fulltext

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.

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Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, and Abbott DW

Molecular and cellular biology 27(21):7451-61, 2007 Nov - Who cited this? | PubMed ID: 17709380 | Fulltext

Interpreting sequences from mastodon and T. rex.

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Asara JM, Garavelli JS, Slatter DA, Schweitzer MH, Freimark LM, Phillips M, and Cantley LC

Science (New York, N.Y.) 317(5843):1324-5, 2007 Sep 7 - Who cited this? | PubMed ID: 17823333 | Fulltext

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

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Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, and Cantley LC

Molecular and cellular biology 27(17):6012, 2007 Sep - Who cited this? | PubMed ID: 17562858 | Fulltext

Biochemistry. PI3K charges ahead.

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Lee JY, Engelman JA, and Cantley LC

Science (New York, N.Y.) 317(5835):206-7, 2007 Jul 13 - Who cited this? | PubMed ID: 17626872 | Fulltext

AKT/PKB signaling: navigating downstream.

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Manning BD and Cantley LC

Cell 129(7):1261-74, 2007 Jun 29 - Who cited this? | PubMed ID: 17604717 | Fulltext

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

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Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C,

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Science (New York, N.Y.) 316(5827):1039-43, 2007 May 18 - Who cited this? | PubMed ID: 17463250 | Fulltext

Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis.

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Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, and Cantley LC

Proceedings of the National Academy of Sciences of the United States of America 104(19):8077, 2007 May 8 - Who cited this? | PubMed ID: 17483449 | Fulltext

Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.

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Asara JM, Schweitzer MH, Freimark LM, Phillips M, and Cantley LC

Science (New York, N.Y.) 316(5822):280, 2007 Apr 13 - Who cited this? | PubMed ID: 17431180 | Fulltext

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.

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Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, and Kahn CR

Molecular and cellular biology 27(8):2830, 2007 Apr - Who cited this? | PubMed ID: 17283057 | Fulltext

AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.

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Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, and Arbiser JL

Archives of dermatology 143(4):504-6, 2007 Apr - Who cited this? | PubMed ID: 17438183 | Fulltext

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

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Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, and Fruman DA

Blood 109(7):2894-902, 2007 Apr 1 - Who cited this? | PubMed ID: 17164340 | Fulltext

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.

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Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, and Piwnica-Worms H

Proceedings of the National Academy of Sciences of the United States of America 104(13):5680, 2007 Mar 27 - Who cited this? | PubMed ID: 17372192 | Fulltext

Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis.

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Holt LJ, Hutti JE, Cantley LC, and Morgan DO

Molecular cell 25(5):689, 2007 Mar 9 - Who cited this? | PubMed ID: 17349956 | Fulltext

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase.

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Zheng B and Cantley LC

Proceedings of the National Academy of Sciences of the United States of America 104(3):819, 2007 Jan 16 - Who cited this? | PubMed ID: 17204563 | Fulltext

Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

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Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, and Fruman DA

Proceedings of the National Academy of Sciences of the United States of America 103(45):16882, 2006 Nov 7 - Who cited this? | PubMed ID: 17071741 | Fulltext

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.

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Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, and Jänne PA

The Journal of clinical investigation 116(10):2695, 2006 Oct - Who cited this? | PubMed ID: 16906227 | Fulltext

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

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Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, and Kahn CR

Proceedings of the National Academy of Sciences of the United States of America 103(32):12093, 2006 Aug 8 - Who cited this? | PubMed ID: 16880400 | Fulltext

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

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Engelman JA, Luo J, and Cantley LC

Nature reviews. Genetics 7(8):606, 2006 Aug - Who cited this? | PubMed ID: 16847462 | Fulltext

The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors.

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Engelman JA and Cantley LC

Clinical cancer research : an official journal of the American Association for Cancer Research 12(14 Pt 2):4372, 2006 Jul 15 - Who cited this? | PubMed ID: 16857813 | Fulltext

Ras, PI(3)K and mTOR signalling controls tumour cell growth.

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Shaw RJ and Cantley LC

Nature 441(7092):424, 2006 May 25 - Who cited this? | PubMed ID: 16724053 | Fulltext

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.

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Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, and Shivdasani RA

Blood 107(10):3868, 2006 May 15 - Who cited this? | PubMed ID: 16434494 | Fulltext

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.

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Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, and Kahn CR

Cell metabolism 3(5):343, 2006 May - Who cited this? | PubMed ID: 16679292 | Fulltext

Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.

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Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, and Cantley LC

Cell metabolism 3(5):355, 2006 May - Who cited this? | PubMed ID: 16679293 | Fulltext

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