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Papers authored by Cane DE

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Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates (,).

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Aaron JA, Lin X, Cane DE, and Christianson DW

Biochemistry 49(8):1787-97, 2010 Mar 2 - Who cited this? | PubMed ID: 20131801 | Fulltext

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.

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Komatsu M, Uchiyama T, Omura S, Cane DE, and Ikeda H

Proceedings of the National Academy of Sciences of the United States of America 107(6):2646-51, 2010 Feb 9 - Who cited this? | PubMed ID: 20133795 | Fulltext

Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases.

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Wong FT, Chen AY, Cane DE, and Khosla C

Biochemistry 49(1):95-102, 2010 Jan 12 - Who cited this? | PubMed ID: 19921859 | Fulltext

The biochemical basis for stereochemical control in polyketide biosynthesis.

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Valenzano CR, Lawson RJ, Chen AY, Khosla C, and Cane DE

Journal of the American Chemical Society 131(51):18501-11, 2009 Dec 30 - Who cited this? | PubMed ID: 19928853 | Fulltext

Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site.

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Zhao B, Lei L, Vassylyev DG, Lin X, Cane DE, Kelly SL, Yuan H, Lamb DC, and Waterman MR

The Journal of biological chemistry 284(52):36711-9, 2009 Dec 25 - Who cited this? | PubMed ID: 19858213 | Fulltext

Genome Mining in Streptomyces avermitilis: A Biochemical Baeyer-Villiger Reaction and Discovery of a New Branch of the Pentalenolactone Family Tree.

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Jiang J, Tetzlaff CN, Takamatsu S, Iwatsuki M, Komatsu M, Ikeda H, and Cane DE

Biochemistry 48(27):6431-40, 2009 Jul 14 - Who cited this? | PubMed ID: 19485417 | Fulltext

Biosynthesis of the Sesquiterpene Botrydial in Botrytis cinerea. Mechanism and Stereochemistry of the Enzymatic Formation of Presilphiperfolan-8beta-ol.

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Wang CM, Hopson R, Lin X, and Cane DE

Journal of the American Chemical Society 131(24):8360-1, 2009 Jun 24 - Who cited this? | PubMed ID: 19476353 | Fulltext

Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor. Mechanism and stereochemistry of the enzymatic formation of epi-isozizaene.

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Lin X and Cane DE

Journal of the American Chemical Society 131(18):6332-3, 2009 May 13 - Who cited this? | PubMed ID: 19385616 | Fulltext

Revisiting the modularity of modular polyketide synthases.

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Khosla C, Kapur S, and Cane DE

Current opinion in chemical biology 13(2):135-43, 2009 Apr - Who cited this? | PubMed ID: 19217343 | Fulltext

The enzymology of polyether biosynthesis.

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Liu T, Cane DE, and Deng Z

Methods in enzymology 459:187-214, 2009 - Who cited this? | PubMed ID: 19362641 | Fulltext

Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea.

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Pinedo C, Wang CM, Pradier JM, Dalmais B, Choquer M, Le Pêcheur P, Morgant G, Collado IG, Cane DE, and Viaud M

ACS chemical biology 3(12):791-801, 2008 Dec 19 - Who cited this? | PubMed ID: 19035644 | Fulltext

Isolation and characterization of the gene associated with geosmin production in cyanobacteria.

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Giglio S, Jiang J, Saint CP, Cane DE, and Monis PT

Environmental science & technology 42(21):8027-32, 2008 Nov 1 - Who cited this? | PubMed ID: 19031897 | Fulltext

Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.

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Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, and Cane DE

Journal of the American Chemical Society 130(35):11598-9, 2008 Sep 3 - Who cited this? | PubMed ID: 18693734 | Fulltext

Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.

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Wang CM and Cane DE

Journal of the American Chemical Society 130(28):8908, 2008 Jul 16 - Who cited this? | PubMed ID: 18563898 | Fulltext

X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis.

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Shishova EY, Yu F, Miller DJ, Faraldos JA, Zhao Y, Coates RM, Allemann RK, Cane DE, and Christianson DW

The Journal of biological chemistry 283(22):15431, 2008 May 30 - Who cited this? | PubMed ID: 18385128 | Fulltext

Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase.

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Kapur S, Worthington A, Tang Y, Cane DE, Burkart MD, and Khosla C

Bioorganic & medicinal chemistry letters 18(10):3034-8, 2008 May 15 - Who cited this? | PubMed ID: 18243693 | Fulltext

Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin.

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Liu T, Lin X, Zhou X, Deng Z, and Cane DE

Chemistry & biology 15(5):449, 2008 May - Who cited this? | PubMed ID: 18482697 | Fulltext

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2).

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Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, and Cane DE

The Journal of biological chemistry 283(13):8183-9, 2008 Mar 28 - Who cited this? | PubMed ID: 18234666 | Fulltext

Identification of (8S,9S,10S)-8,10-dimethyl-1-octalin, a key intermediate in the biosynthesis of geosmin in bacteria.

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Nawrath T, Dickschat JS, Müller R, Jiang J, Cane DE, and Schulz S

Journal of the American Chemical Society 130(2):430-1, 2008 Jan 16 - Who cited this? | PubMed ID: 18095691 | Fulltext

Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin.

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Jiang J and Cane DE

Journal of the American Chemical Society 130(2):428-9, 2008 Jan 16 - Who cited this? | PubMed ID: 18095692 | Fulltext

Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.

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Vedula LS, Jiang J, Zakharian T, Cane DE, and Christianson DW

Archives of biochemistry and biophysics 469(2):184-94, 2008 Jan 15 - Who cited this? | PubMed ID: 17996718 | Fulltext

Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis.

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You Z, Omura S, Ikeda H, Cane DE, and Jogl G

The Journal of biological chemistry 282(50):36552, 2007 Dec 14 - Who cited this? | PubMed ID: 17942405 | Fulltext

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase.

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Castonguay R, He W, Chen AY, Khosla C, and Cane DE

Journal of the American Chemical Society 129(44):13758-69, 2007 Nov 7 - Who cited this? | PubMed ID: 17918944 | Fulltext

Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme.

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Jiang J, He X, and Cane DE

Nature chemical biology 3(11):711-5, 2007 Nov - Who cited this? | PubMed ID: 17873868 | Fulltext

Exploring biosynthetic diversity with trichodiene synthase.

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Vedula LS, Zhao Y, Coates RM, Koyama T, Cane DE, and Christianson DW

Archives of biochemistry and biophysics 466(2):260-6, 2007 Oct 15 - Who cited this? | PubMed ID: 17678871 | Fulltext

Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.

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Alekseyev VY, Liu CW, Cane DE, Puglisi JD, and Khosla C

Protein science : a publication of the Protein Society 16(10):2093-107, 2007 Oct - Who cited this? | PubMed ID: 17893358 | Fulltext

Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase.

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Tang Y, Chen AY, Kim CY, Cane DE, and Khosla C

Chemistry & biology 14(8):931-43, 2007 Aug - Who cited this? | PubMed ID: 17719492 | Fulltext

Structure-based dissociation of a type I polyketide synthase module.

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Chen AY, Cane DE, and Khosla C

Chemistry & biology 14(7):784, 2007 Jul - Who cited this? | PubMed ID: 17656315 | Fulltext

Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.

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You Z, Omura S, Ikeda H, and Cane DE

Archives of biochemistry and biophysics 459(2):233-40, 2007 Mar 15 - Who cited this? | PubMed ID: 17178094 | Fulltext

X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.

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Shishova EY, Di Costanzo L, Cane DE, and Christianson DW

Biochemistry 46(7):1941-51, 2007 Feb 20 - Who cited this? | PubMed ID: 17261032 | Fulltext

Structure and mechanism of the 6-deoxyerythronolide B synthase.

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Khosla C, Tang Y, Chen AY, Schnarr NA, and Cane DE

Annual review of biochemistry 76:195, 2007 - Who cited this? | PubMed ID: 17328673 | Fulltext

Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis.

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Quaderer R, Omura S, Ikeda H, and Cane DE

Journal of the American Chemical Society 128(40):13036-7, 2006 Oct 11 - Who cited this? | PubMed ID: 17017767 | Fulltext

Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis.

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Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane DE, and Deng Z

Chemistry & biology 13(9):945-55, 2006 Sep - Who cited this? | PubMed ID: 16984884 | Fulltext

Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase.

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Cane DE, He X, Kobayashi S, Omura S, and Ikeda H

The Journal of antibiotics 59(8):471-9, 2006 Aug - Who cited this? | PubMed ID: 17080683 | Fulltext

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

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Tang Y, Kim CY, Mathews II, Cane DE, and Khosla C

Proceedings of the National Academy of Sciences of the United States of America 103(30):11124-9, 2006 Jul 25 - Who cited this? | PubMed ID: 16844787 | Fulltext

Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.

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Jiang J, He X, and Cane DE

Journal of the American Chemical Society 128(25):8128-9, 2006 Jun 28 - Who cited this? | PubMed ID: 16787064 | Fulltext

Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis.

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You Z, Omura S, Ikeda H, and Cane DE

Journal of the American Chemical Society 128(20):6566-7, 2006 May 24 - Who cited this? | PubMed ID: 16704250 | Fulltext

A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis.

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Tetzlaff CN, You Z, Cane DE, Takamatsu S, Omura S, and Ikeda H

Biochemistry 45(19):6179-86, 2006 May 16 - Who cited this? | PubMed ID: 16681390 | Fulltext

Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.

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Lin X, Hopson R, and Cane DE

Journal of the American Chemical Society 128(18):6022-3, 2006 May 10 - Who cited this? | PubMed ID: 16669656 | Fulltext

Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate.

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Picaud S, Mercke P, He X, Sterner O, Brodelius M, Cane DE, and Brodelius PE

Archives of biochemistry and biophysics 448(1-2):150-5, 2006 Apr 15 - Who cited this? | PubMed ID: 16143293 | Fulltext

Brushes with sage.

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Cane DE

Archives of biochemistry and biophysics 448(1-2):117-22, 2006 Apr 15 - Who cited this? | PubMed ID: 16259939 | Fulltext

How to evolve a silk purse from a sow's ear.

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Cane DE

Nature chemical biology 2(4):179-80, 2006 Apr - Who cited this? | PubMed ID: 16547477 | Fulltext

Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase.

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Chen AY, Schnarr NA, Kim CY, Cane DE, and Khosla C

Journal of the American Chemical Society 128(9):3067-74, 2006 Mar 8 - Who cited this? | PubMed ID: 16506788 | Fulltext

Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase.

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He W, Wu J, Khosla C, and Cane DE

Bioorganic & medicinal chemistry letters 16(2):391-4, 2006 Jan 15 - Who cited this? | PubMed ID: 16249083 | Fulltext

Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2.

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Moffet DA, Khosla C, and Cane DE

Bioorganic & medicinal chemistry letters 16(1):213-6, 2006 Jan 1 - Who cited this? | PubMed ID: 16213712 | Fulltext

Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.

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Wu J, Zaleski TJ, Valenzano C, Khosla C, and Cane DE

Journal of the American Chemical Society 127(49):17393-404, 2005 Dec 14 - Who cited this? | PubMed ID: 16332089 | Fulltext

Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase.

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Wu J, He W, Khosla C, and Cane DE

Angewandte Chemie (International ed. in English) 44(46):7557-60, 2005 Nov 25 - Who cited this? | PubMed ID: 16247819 | Fulltext

Role of arginine-304 in the diphosphate-triggered active site closure mechanism of trichodiene synthase.

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Vedula LS, Cane DE, and Christianson DW

Biochemistry 44(38):12719-27, 2005 Sep 27 - Who cited this? | PubMed ID: 16171386 | Fulltext

Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry.

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Schnarr NA, Chen AY, Cane DE, and Khosla C

Biochemistry 44(35):11836, 2005 Sep 6 - Who cited this? | PubMed ID: 16128585 | Fulltext

Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.

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Vedula LS, Rynkiewicz MJ, Pyun HJ, Coates RM, Cane DE, and Christianson DW

Biochemistry 44(16):6153-63, 2005 Apr 26 - Who cited this? | PubMed ID: 15835903 | Fulltext

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