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Papers authored by Brodsky JL

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The Mammalian Hsp40 ERdj3 Requires Its Hsp70 Interaction and Substrate-binding Properties to Complement Various Yeast Hsp40-dependent Functions.

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Vembar SS, Jin Y, Brodsky JL, and Hendershot LM

The Journal of biological chemistry 284(47):32462-71, 2009 Nov 20 - Who cited this? | PubMed ID: 19748898 | Fulltext

Changes in Maternal Cigarette Smoking Among Pregnant WIC Participants in Rhode Island.

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Brodsky JL, Viner-Brown S, and Handler AS

Maternal and child health journal 13(6):822-31, 2009 Nov - Who cited this? | PubMed ID: 18830809 | Fulltext

Substrate-specific mediators of ER associated degradation (ERAD).

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Brodsky JL and Wojcikiewicz RJ

Current opinion in cell biology 21(4):516-21, 2009 Aug - Who cited this? | PubMed ID: 19443192 | Fulltext

Identification of Hsp70 modulators through modeling of the substrate binding domain.

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Haney CM, Schneider C, Beck B, Brodsky JL, and Dömling A

Bioorganic & medicinal chemistry letters 19(14):3828-31, 2009 Jul 15 - Who cited this? | PubMed ID: 19435667 | Fulltext

A soluble sulfogalactosyl ceramide mimic promotes Delta F508 CFTR escape from endoplasmic reticulum associated degradation.

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Park HJ, Mylvaganum M, McPherson A, Fewell SW, Brodsky JL, and Lingwood CA

Chemistry & biology 16(4):461-70, 2009 Apr 24 - Who cited this? | PubMed ID: 19389632 | Fulltext

Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities.

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Patham B, Duffy J, Lane A, Davis RC, Wipf P, Fewell SW, Brodsky JL, and Mensa-Wilmot K

The Biochemical journal 419(2):507-17, 2009 Apr 15 - Who cited this? | PubMed ID: 19196237 | Fulltext

Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen.

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Wright CM, Seguin SP, Fewell SW, Zhang H, Ishwad C, Vats A, Lingwood CA, Wipf P, Fanning E, Pipas JM, and Brodsky JL

Virus research 141(1):71-80, 2009 Apr - Who cited this? | PubMed ID: 19200446 | Fulltext

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.

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Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, and Brodsky JL

Bioorganic & medicinal chemistry 17(4):1527-33, 2009 Feb 15 - Who cited this? | PubMed ID: 19195901 | Fulltext

One step at a time: endoplasmic reticulum-associated degradation.

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Vembar SS and Brodsky JL

Nature reviews. Molecular cell biology, 2008 Nov 12 - Who cited this? | PubMed ID: 19002207 | Fulltext

The many intersecting pathways underlying apolipoprotein B secretion and degradation.

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Brodsky JL and Fisher EA

Trends in endocrinology and metabolism: TEM, 2008 Aug 6 - Who cited this? | PubMed ID: 18691900 | Fulltext

A precursor specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum.

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Rabu C, Wipf P, Brodsky JL, and High S

The Journal of biological chemistry, 2008 Jul 29 - Who cited this? | PubMed ID: 18667436 | Fulltext

The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding.

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Goeckeler JL, Petruso AP, Aguirre J, Clement CC, Chiosis G, and Brodsky JL

FEBS letters 582(16):2393-6, 2008 Jul 9 - Who cited this? | PubMed ID: 18539149 | Fulltext

Design of a fluorescence polarization assay platform for the study of human Hsp70.

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Kang Y, Taldone T, Clement CC, Fewell SW, Aguirre J, Brodsky JL, and Chiosis G

Bioorganic & medicinal chemistry letters 18(13):3749, 2008 Jul 1 - Who cited this? | PubMed ID: 18515098 | Fulltext

The Recognition and Retrotranslocation of Misfolded Proteins from the Endoplasmic Reticulum.

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Nakatsukasa K and Brodsky JL

Traffic (Copenhagen, Denmark), 2008 Mar 25 - Who cited this? | PubMed ID: 18315532 | Fulltext

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.

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Wright CM, Chovatiya RJ, Jameson NE, Turner DM, Zhu G, Werner S, Huryn DM, Pipas JM, Day BW, Wipf P, and Brodsky JL

Bioorganic & medicinal chemistry 16(6):3291-301, 2008 Mar 15 - Who cited this? | PubMed ID: 18164205 | Fulltext

Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions.

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Tonsor SJ, Scott C, Boumaza I, Liss TR, Brodsky JL, and Vierling E

Molecular ecology 17(6):1614, 2008 Mar - Who cited this? | PubMed ID: 18321256 | Fulltext

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

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Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS,

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Autophagy 4(2):151 - Who cited this? | PubMed ID: 18188003 | Fulltext

Dissecting the ER-associated degradation of a misfolded polytopic membrane protein.

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Nakatsukasa K, Huyer G, Michaelis S, and Brodsky JL

Cell 132(1):101, 2008 Jan 11 - Who cited this? | PubMed ID: 18191224 | Fulltext

The activities and function of molecular chaperones in the endoplasmic reticulum.

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Buck TM, Wright CM, and Brodsky JL

Seminars in cell & developmental biology 18(6):751, 2007 Dec - Who cited this? | PubMed ID: 17964199 | Fulltext

Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast.

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Sparvero LJ, Patz S, Brodsky JL, and Coughlan CM

Analytical biochemistry 370(2):162-70, 2007 Nov 15 - Who cited this? | PubMed ID: 17869211 | Fulltext

The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD).

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Hrizo SL, Gusarova V, Habiel DM, Goeckeler JL, Fisher EA, and Brodsky JL

The Journal of biological chemistry 282(45):32665, 2007 Nov 9 - Who cited this? | PubMed ID: 17823116 | Fulltext

The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p.

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Feng D, Zhao X, Soromani C, Toikkanen J, Römisch K, Vembar SS, Brodsky JL, Keränen S, and Jäntti J

The Journal of biological chemistry 282(42):30618, 2007 Oct 19 - Who cited this? | PubMed ID: 17699516 | Fulltext

ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.

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Scott CM, Kruse KB, Schmidt BZ, Perlmutter DH, McCracken AA, and Brodsky JL

Molecular biology of the cell 18(10):3776-87, 2007 Oct - Who cited this? | PubMed ID: 17634286 | Fulltext

Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression.

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Kashlan OB, Mueller GM, Qamar MZ, Poland PA, Ahner A, Rubenstein RC, Hughey RP, Brodsky JL, and Kleyman TR

The Journal of biological chemistry 282(38):28149-56, 2007 Sep 21 - Who cited this? | PubMed ID: 17664274 | Fulltext

Localization of a Drosophila DRIP-like aquaporin in the Malpighian tubules of the house cricket, Acheta domesticus.

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Spring JH, Robichaux SR, Kaufmann N, and Brodsky JL

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 148(1):92, 2007 Sep - Who cited this? | PubMed ID: 17267256 | Fulltext

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

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Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL,

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Nature chemical biology 3(8):498-507, 2007 Aug - Who cited this? | PubMed ID: 17603540 | Fulltext

Golgi-associated maturation of very low density lipoproteins involves conformational changes in apolipoprotein B, but is not dependent on apolipoprotein E.

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Gusarova V, Seo J, Sullivan ML, Watkins SC, Brodsky JL, and Fisher EA

The Journal of biological chemistry 282(27):19453-62, 2007 Jul 6 - Who cited this? | PubMed ID: 17500069 | Fulltext

The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation).

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Brodsky JL

The Biochemical journal 404(3):353, 2007 Jun 15 - Who cited this? | PubMed ID: 17521290 | Fulltext

Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.

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Wahlman J, DeMartino GN, Skach WR, Bulleid NJ, Brodsky JL, and Johnson AE

Cell 129(5):943, 2007 Jun 1 - Who cited this? | PubMed ID: 17540174 | Fulltext

Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review.

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Perlmutter DH, Brodsky JL, Balistreri WF, and Trapnell BC

Hepatology (Baltimore, Md.) 45(5):1313, 2007 May - Who cited this? | PubMed ID: 17464974 | Fulltext

The Hsp40 molecular chaperone Ydj1p, along with the protein kinase C pathway, affects cell-wall integrity in the yeast Saccharomyces cerevisiae.

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Wright CM, Fewell SW, Sullivan ML, Pipas JM, Watkins SC, and Brodsky JL

Genetics 175(4):1649-64, 2007 Apr - Who cited this? | PubMed ID: 17237519 | Fulltext

A J domain virulence effector of Pseudomonas syringae remodels host chloroplasts and suppresses defenses.

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Jelenska J, Yao N, Vinatzer BA, Wright CM, Brodsky JL, and Greenberg JT

Current biology : CB 17(6):499-508, 2007 Mar 20 - Who cited this? | PubMed ID: 17350264 | Fulltext

Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation.

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Ahner A, Nakatsukasa K, Zhang H, Frizzell RA, and Brodsky JL

Molecular biology of the cell 18(3):806, 2007 Mar - Who cited this? | PubMed ID: 17182856 | Fulltext

Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.

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Mandal AK, Lee P, Chen JA, Nillegoda N, Heller A, DiStasio S, Oen H, Victor J, Nair DM, Brodsky JL, and Caplan AJ

The Journal of cell biology 176(3):319-28, 2007 Jan 29 - Who cited this? | PubMed ID: 17242065 | Fulltext

Tipping the delicate balance: defining how proteasome maturation affects the degradation of a substrate for autophagy and endoplasmic reticulum associated degradation (ERAD).

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Brodsky JL and Scott CM

Autophagy 3(6):623-5, 2007 - Who cited this? | PubMed ID: 17786020 | Fulltext

Autophagy: an ER protein quality control process.

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Kruse KB, Brodsky JL, and McCracken AA

Autophagy 2(2):135 - Who cited this? | PubMed ID: 16874086 | Fulltext

Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis.

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Zhang H, Schmidt BZ, Sun F, Condliffe SB, Butterworth MB, Youker RT, Brodsky JL, Aridor M, and Frizzell RA

The Journal of biological chemistry 281(16):11312-21, 2006 Apr 21 - Who cited this? | PubMed ID: 16469739 | Fulltext

Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.

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Kruse KB, Brodsky JL, and McCracken AA

Molecular biology of the cell 17(1):203, 2006 Jan - Who cited this? | PubMed ID: 16267277 | Fulltext

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators.

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Brodsky JL and Chiosis G

Current topics in medicinal chemistry 6(11):1215-25, 2006 - Who cited this? | PubMed ID: 16842158 | Fulltext

Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin.

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Kaufmann N, Mathai JC, Hill WG, Dow JA, Zeidel ML, and Brodsky JL

American journal of physiology. Cell physiology 289(2):C397-407, 2005 Aug - Who cited this? | PubMed ID: 15800049 | Fulltext

Use of yeast as a model system to investigate protein conformational diseases.

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Coughlan CM and Brodsky JL

Molecular biotechnology 30(2):171, 2005 Jun - Who cited this? | PubMed ID: 15920289 | Fulltext

Small molecule microarrays: from proteins to mammalian cells - are we there yet?.

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Chiosis G and Brodsky JL

Trends in biotechnology 23(6):271-4, 2005 Jun - Who cited this? | PubMed ID: 15922078 | Fulltext

Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).

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Nishikawa S, Brodsky JL, and Nakatsukasa K

Journal of biochemistry 137(5):551-5, 2005 May - Who cited this? | PubMed ID: 15944407 | Fulltext

An in vitro assay for the selective endoplasmic reticulum associated degradation of an unglycosylated secreted protein.

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Brodsky JL

Methods (San Diego, Calif.) 35(4):354, 2005 Apr - Who cited this? | PubMed ID: 15804607 | Fulltext

Distinct but overlapping functions of Hsp70, Hsp90, and an Hsp70 nucleotide exchange factor during protein biogenesis in yeast.

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Ahner A, Whyte FM, and Brodsky JL

Archives of biochemistry and biophysics 435(1):32-41, 2005 Mar 1 - Who cited this? | PubMed ID: 15680904 | Fulltext

Conditional osmotic stress in yeast: a system to study transport through aquaglyceroporins and osmostress signaling.

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Karlgren S, Pettersson N, Nordlander B, Mathai JC, Brodsky JL, Zeidel ML, Bill RM, and Hohmann S

The Journal of biological chemistry 280(8):7186-93, 2005 Feb 25 - Who cited this? | PubMed ID: 15611083 | Fulltext

Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.

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Shomura Y, Dragovic Z, Chang HC, Tzvetkov N, Young JC, Brodsky JL, Guerriero V, Hartl FU, and Bracher A

Molecular cell 17(3):367, 2005 Feb 4 - Who cited this? | PubMed ID: 15694338 | Fulltext

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum.

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Alder NN, Shen Y, Brodsky JL, Hendershot LM, and Johnson AE

The Journal of cell biology 168(3):389, 2005 Jan 31 - Who cited this? | PubMed ID: 15684029 | Fulltext

Reconstitution of endoplasmic reticulum-associated degradation using yeast membranes and cytosol.

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Lee RJ, McCracken AA, and Brodsky JL

Methods in molecular biology (Clifton, N.J.) 301:175-84, 2005 - Who cited this? | PubMed ID: 15917632 | Fulltext

Recognition and delivery of ERAD substrates to the proteasome and alternative paths for cell survival.

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McCracken AA and Brodsky JL

Current topics in microbiology and immunology 300:17-40, 2005 - Who cited this? | PubMed ID: 16573235 | Fulltext

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