Papers authored by Brash AR

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Omega-3 fatty acids are oxygenated at the n-7 carbon by the lipoxygenase domain of a fusion protein in the cyanobacterium Acaryochloris marina.
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Gao B, Boeglin WE, and Brash AR
Biochimica et biophysica acta 1801(1):58-63, 2010 Jan - Who cited this? | PubMed ID: 19786119 | Fulltext
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The structure and peroxidase activity of a 33-kDa catalase-related protein from Mycobacterium avium ssp. paratuberculosis.
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Pakhomova S, Gao B, Boeglin WE, Brash AR, and Newcomer ME
Protein science : a publication of the Protein Society 18(12):2559-68, 2009 Dec - Who cited this? | PubMed ID: 19827095 | Fulltext
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Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes.
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Brash AR
Phytochemistry 70(13-14):1522-31, 2009 Sep - Who cited this? | PubMed ID: 19747698 | Fulltext
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The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
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Neau DB, Gilbert NC, Bartlett SG, Boeglin W, Brash AR, and Newcomer ME
Biochemistry 48(33):7906-15, 2009 Aug 25 - Who cited this? | PubMed ID: 19594169 | Fulltext
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Evidence for an Ionic Intermediate in the Transformation of Fatty Acid Hydroperoxide by a Catalase-related Allene Oxide Synthase from the Cyanobacterium Acaryochloris marina.
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Gao B, Boeglin WE, Zheng Y, Schneider C, and Brash AR
The Journal of biological chemistry 284(33):22087-98, 2009 Aug 14 - Who cited this? | PubMed ID: 19531485 | Fulltext
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Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis.
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Niisuke K, Boeglin WE, Murray JJ, Schneider C, and Brash AR
Journal of lipid research 50(7):1448-55, 2009 Jul - Who cited this? | PubMed ID: 19244216 | Fulltext
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A covalent linker allows for membrane targeting of an oxylipin biosynthetic complex.
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Gilbert NC, Niebuhr M, Tsuruta H, Bordelon T, Ridderbusch O, Dassey A, Brash AR, Bartlett SG, and Newcomer ME
Biochemistry 47(40):10665-76, 2008 Oct 7 - Who cited this? | PubMed ID: 18785758 | Fulltext
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Investigation of Substrate Binding and Product Stereochemistry Issues in Two Linoleate 9-Lipoxygenases.
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Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, and Brash AR
Lipids, 2008 Sep 16 - Who cited this? | PubMed ID: 18795358 | Fulltext
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Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): Mutations affect the rate but not the essential chemistry of the enzymatic transformations.
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Gao B, Boeglin WE, and Brash AR
Archives of biochemistry and biophysics, 2008 Jul 17 - Who cited this? | PubMed ID: 18652800 | Fulltext
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Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation.
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Schneider C, Porter NA, and Brash AR
The Journal of biological chemistry 283(23):15539, 2008 Jun 6 - Who cited this? | PubMed ID: 18285327 | Fulltext
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Intermolecular Peroxyl Radical Reactions during Autoxidation of Hydroxy and Hydroperoxy Arachidonic Acids Generate a Novel Series of Epoxidized Products.
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Schneider C, Boeglin WE, Yin H, Porter NA, and Brash AR
Chemical research in toxicology 21(4):895-903, 2008 Apr - Who cited this? | PubMed ID: 18324788 | Fulltext
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A 49-kDa Mini-lipoxygenase from Anabaena sp. PCC 7120 Retains Catalytically Complete Functionality.
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Zheng Y, Boeglin WE, Schneider C, and Brash AR
The Journal of biological chemistry 283(8):5138-47, 2008 Feb 22 - Who cited this? | PubMed ID: 18070874 | Fulltext
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Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120.
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Schneider C, Niisuke K, Boeglin WE, Voehler M, Stec DF, Porter NA, and Brash AR
Proceedings of the National Academy of Sciences of the United States of America 104(48):18941-5, 2007 Nov 27 - Who cited this? | PubMed ID: 18025466 | Fulltext
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Identification of the Peroxidation Products of 13-Hydroxy-gamma-linolenate and 15-Hydroxyarachidonate: Mechanistic Studies on the Formation of Leukotriene-like Diols.
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Rector CL, Stec DF, Brash AR, and Porter NA
Chemical research in toxicology 20(11):1582-93, 2007 Nov - Who cited this? | PubMed ID: 17907784 | Fulltext
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A critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15.
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Valmsen K, Boeglin WE, Järving R, Järving I, Varvas K, Brash AR, and Samel N
The Journal of biological chemistry 282(38):28157-63, 2007 Sep 21 - Who cited this? | PubMed ID: 17652088 | Fulltext
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A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier.
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Moran JL, Qiu H, Turbe-Doan A, Yun Y, Boeglin WE, Brash AR, and Beier DR
The Journal of investigative dermatology 127(8):1893-7, 2007 Aug - Who cited this? | PubMed ID: 17429434 | Fulltext
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The hepoxilin connection in the epidermis.
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Brash AR, Yu Z, Boeglin WE, and Schneider C
The FEBS journal 274(14):3494-502, 2007 Jul - Who cited this? | PubMed ID: 17608720 | Fulltext
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Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.
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Yu Z, Schneider C, Boeglin WE, and Brash AR
Lipids 42(6):491-7, 2007 Jun - Who cited this? | PubMed ID: 17436029 | Fulltext
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Control of oxygenation in lipoxygenase and cyclooxygenase catalysis.
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Schneider C, Pratt DA, Porter NA, and Brash AR
Chemistry & biology 14(5):473-88, 2007 May - Who cited this? | PubMed ID: 17524979 | Fulltext
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Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography.
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Schneider C, Yu Z, Boeglin WE, Zheng Y, and Brash AR
Methods in enzymology 433:145-57, 2007 - Who cited this? | PubMed ID: 17954233 | Fulltext
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Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.
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Yu Z, Schneider C, Boeglin WE, and Brash AR
Archives of biochemistry and biophysics 455(2):188-96, 2006 Nov 15 - Who cited this? | PubMed ID: 17045234 | Fulltext
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Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expression.
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Melner MH, Haas AL, Klein JM, Brash AR, Boeglin WE, Nagdas SK, Winfrey VP, and Olson GE
Biology of reproduction 75(3):395, 2006 Sep - Who cited this? | PubMed ID: 16760379 | Fulltext
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Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.
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Chen B, Tsui S, Boeglin WE, Douglas RS, Brash AR, and Smith TJ
The Journal of biological chemistry 281(27):18296-306, 2006 Jul 7 - Who cited this? | PubMed ID: 16675443 | Fulltext
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On the relationship of coral allene oxide synthase to catalase. A single active site mutation that induces catalase activity in coral allene oxide synthase.
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Tosha T, Uchida T, Brash AR, and Kitagawa T
The Journal of biological chemistry 281(18):12610-7, 2006 May 5 - Who cited this? | PubMed ID: 16513636 | Fulltext
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Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity.
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Furse KE, Pratt DA, Schneider C, Brash AR, Porter NA, and Lybrand TP
Biochemistry 45(10):3206-18, 2006 Mar 14 - Who cited this? | PubMed ID: 16519515 | Fulltext
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Identification and characterization of an arachidonate 11R-lipoxygenase.
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Mortimer M, Järving R, Brash AR, Samel N, and Järving I
Archives of biochemistry and biophysics 445(1):147-55, 2006 Jan 1 - Who cited this? | PubMed ID: 16321357 | Fulltext
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A comprehensive model of positional and stereo control in lipoxygenases.
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Coffa G, Schneider C, and Brash AR
Biochemical and biophysical research communications 338(1):87-92, 2005 Dec 9 - Who cited this? | PubMed ID: 16111652 | Fulltext
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Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality.
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Oldham ML, Brash AR, and Newcomer ME
The Journal of biological chemistry 280(47):39545-52, 2005 Nov 25 - Who cited this? | PubMed ID: 16162493 | Fulltext
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On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.
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Coffa G, Imber AN, Maguire BC, Laxmikanthan G, Schneider C, Gaffney BJ, and Brash AR
The Journal of biological chemistry 280(46):38756-66, 2005 Nov 18 - Who cited this? | PubMed ID: 16157595 | Fulltext
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Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal.
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Schneider C, Boeglin WE, Yin H, Ste DF, Hachey DL, Porter NA, and Brash AR
Lipids 40(11):1155-62, 2005 Nov - Who cited this? | PubMed ID: 16459928 | Fulltext
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Detection and subcellular localization of two 15S-lipoxygenases in human cornea.
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Chang MS, Schneider C, Roberts RL, Shappell SB, Haselton FR, Boeglin WE, and Brash AR
Investigative ophthalmology & visual science 46(3):849-56, 2005 Mar - Who cited this? | PubMed ID: 15728540 | Fulltext
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The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide.
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Oldham ML, Brash AR, and Newcomer ME
Proceedings of the National Academy of Sciences of the United States of America 102(2):297-302, 2005 Jan 11 - Who cited this? | PubMed ID: 15625113 | Fulltext
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Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
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Yu Z, Schneider C, Boeglin WE, and Brash AR
Biochimica et biophysica acta 1686 3:238-47, 2005 Jan 5 - Who cited this? | PubMed ID: 15629692 | Fulltext
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Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities.
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Schneider C, Boeglin WE, and Brash AR
The Biochemical journal 385(Pt 1):57-64, 2005 Jan 1 - Who cited this? | PubMed ID: 15361066 | Fulltext
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A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation.
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Coffa G and Brash AR
Proceedings of the National Academy of Sciences of the United States of America 101(44):15579-84, 2004 Nov 2 - Who cited this? | PubMed ID: 15496467 | Fulltext
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Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla.
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Valmsen K, Boeglin WE, Järving I, Schneider C, Varvas K, Brash AR, and Samel N
European journal of biochemistry / FEBS 271(17):3533-8, 2004 Sep - Who cited this? | PubMed ID: 15317588 | Fulltext
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Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal.
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Schneider C, Porter NA, and Brash AR
Chemical research in toxicology 17(7):937-41, 2004 Jul - Who cited this? | PubMed ID: 15257619 | Fulltext
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On the evolutionary origin of cyclooxygenase (COX) isozymes: characterization of marine invertebrate COX genes points to independent duplication events in vertebrate and invertebrate lineages.
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Järving R, Järving I, Kurg R, Brash AR, and Samel N
The Journal of biological chemistry 279(14):13624-33, 2004 Apr 2 - Who cited this? | PubMed ID: 14732711 | Fulltext
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Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation.
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West JD, Ji C, Duncan ST, Amarnath V, Schneider C, Rizzo CJ, Brash AR, and Marnett LJ
Chemical research in toxicology 17(4):453-62, 2004 Apr - Who cited this? | PubMed ID: 15089087 | Fulltext
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Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice.
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Schneider C, Strayhorn WD, Brantley DM, Nanney LB, Yull FE, and Brash AR
The Journal of investigative dermatology 122(3):691-8, 2004 Mar - Who cited this? | PubMed ID: 15086555 | Fulltext
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Identification of two cyclooxygenase active site residues, Leucine 384 and Glycine 526, that control carbon ring cyclization in prostaglandin biosynthesis.
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Schneider C, Boeglin WE, and Brash AR
The Journal of biological chemistry 279(6):4404-14, 2004 Feb 6 - Who cited this? | PubMed ID: 14594816 | Fulltext
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Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes.
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Melner MH, Ducharme NA, Brash AR, Winfrey VP, and Olson GE
Biology of reproduction 70(2):406-14, 2004 Feb - Who cited this? | PubMed ID: 14561654 | Fulltext
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The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
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Yu Z, Schneider C, Boeglin WE, Marnett LJ, and Brash AR
Proceedings of the National Academy of Sciences of the United States of America 100(16):9162-7, 2003 Aug 5 - Who cited this? | PubMed ID: 12881489 | Fulltext
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Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma.
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Shappell SB, Olson SJ, Hannah SE, Manning S, Roberts RL, Masumori N, Jisaka M, Boeglin WE, Vader V, Dave DS, Shook MF, Thomas TZ, Funk CD, Brash AR, and Matusik RJ
Cancer research 63(9):2256-67, 2003 May 1 - Who cited this? | PubMed ID: 12727848 | Fulltext
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Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
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Thuillier P, Brash AR, Kehrer JP, Stimmel JB, Leesnitzer LM, Yang P, Newman RA, and Fischer SM
The Biochemical journal 366(Pt 3):901-10, 2002 Sep 15 - Who cited this? | PubMed ID: 12069687 | Fulltext
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Lipoxygenase-catalyzed formation of R-configuration hydroperoxides.
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Schneider C and Brash AR
Prostaglandins & other lipid mediators 68-69:291-301, 2002 Aug - Who cited this? | PubMed ID: 12432924 | Fulltext
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Allene oxide synthases and allene oxides.
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Tijet N and Brash AR
Prostaglandins & other lipid mediators 68-69:423-31, 2002 Aug - Who cited this? | PubMed ID: 12432934 | Fulltext
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15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.
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Kozak KR, Gupta RA, Moody JS, Ji C, Boeglin WE, DuBois RN, Brash AR, and Marnett LJ
The Journal of biological chemistry 277(26):23278-86, 2002 Jun 28 - Who cited this? | PubMed ID: 11956198 | Fulltext
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Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla.
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Schneider C, Manier ML, Hachey DL, and Brash AR
Lipids 37(2):217-21, 2002 Feb - Who cited this? | PubMed ID: 11908914 | Fulltext
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Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349.
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Schneider C, Boeglin WE, Prusakiewicz JJ, Rowlinson SW, Marnett LJ, Samel N, and Brash AR
The Journal of biological chemistry 277(1):478-85, 2002 Jan 4 - Who cited this? | PubMed ID: 11677234 | Fulltext
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