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Papers authored by Brady HJ

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Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia.

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Stam RW, Den Boer ML, Schneider P, de Boer J, Hagelstein J, Valsecchi MG, de Lorenzo P, Sallan SE, Brady HJ, Armstrong SA, and Pieters R

Blood 115(5):1018-25, 2010 Feb 4 - Who cited this? | PubMed ID: 19965632 | Fulltext

Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes.

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Woodward MJ, de Boer J, Heidorn S, Hubank M, Kioussis D, Williams O, and Brady HJ

Cell death and differentiation 17(2):316-23, 2010 Feb - Who cited this? | PubMed ID: 19730441 | Fulltext

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.

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Gascoyne DM, Long E, Veiga-Fernandes H, de Boer J, Williams O, Seddon B, Coles M, Kioussis D, and Brady HJ

Nature immunology 10(10):1118-24, 2009 Oct - Who cited this? | PubMed ID: 19749763 | Fulltext

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1.

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Duffin R, Leitch AE, Sheldrake TA, Hallett JM, Meyer C, Fox S, Alessandri AL, Martin MC, Brady HJ, Teixeira MM, Dransfield I, Haslett C, and Rossi AG

FEBS letters 583(15):2540-6, 2009 Aug 6 - Who cited this? | PubMed ID: 19616548 | Fulltext

ERG is a megakaryocytic oncogene.

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Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, and Brady HJ

Cancer research 69(11):4665-73, 2009 Jun 1 - Who cited this? | PubMed ID: 19487285 | Fulltext

Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells.

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Roig MB, Roset R, Ortet L, Balsiger NA, Anfosso A, Cabellos L, Garrido M, Alameda F, Brady HJ, and Gil-Gómez G

Cell death and differentiation, 2008 Oct 17 - Who cited this? | PubMed ID: 18927588 | Fulltext

The Ikaros splice isoform, Ikaros 6, immortalizes murine haematopoietic progenitor cells.

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Ruiz A, Williams O, and Brady HJ

International journal of cancer. Journal international du cancer 123(6):1240, 2008 Jul 11 - Who cited this? | PubMed ID: 18623087 | Fulltext

Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.

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Crescenzi E, Palumbo G, de Boer J, and Brady HJ

Clinical cancer research : an official journal of the American Association for Cancer Research 14(6):1877-87, 2008 Mar 15 - Who cited this? | PubMed ID: 18347191 | Fulltext

Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia.

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Chowdhury T and Brady HJ

Blood cells, molecules & diseases 40(2):192-9, 2008 - Who cited this? | PubMed ID: 17905612 | Fulltext

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

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McMahon KA, Hiew SY, Hadjur S, Veiga-Fernandes H, Menzel U, Price AJ, Kioussis D, Williams O, and Brady HJ

Cell stem cell 1(3):338-45, 2007 Sep 13 - Who cited this? | PubMed ID: 18371367 | Fulltext

TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL.

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Morrow M, Samanta A, Kioussis D, Brady HJ, and Williams O

Oncogene 26(30):4404-14, 2007 Jun 28 - Who cited this? | PubMed ID: 17237815 | Fulltext

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis.

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Rossi AG, Sawatzky DA, Walker A, Ward C, Sheldrake TA, Riley NA, Caldicott A, Martinez-Losa M, Walker TR, Duffin R, Gray M, Crescenzi E, Martin MC, Brady HJ, Savill JS, Dransfield I,

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Nature medicine 12(9):1056-64, 2006 Sep - Who cited this? | PubMed ID: 16951685 | Fulltext

Emerging role of Mcl-1 in actively counteracting BH3-only proteins in apoptosis.

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Zhuang J and Brady HJ

Cell death and differentiation 13(8):1263, 2006 Aug - Who cited this? | PubMed ID: 16676002 | Fulltext

The MLL recombinome of acute leukemias.

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Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, den Boer ML, Pieters R, Ennas MG, Angelucci E, Koehl U, Greil J, Griesinger F,

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Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 20(5):777-84, 2006 May - Who cited this? | PubMed ID: 16511515 | Fulltext

Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis.

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Clohessy JG, Zhuang J, de Boer J, Gil-Gómez G, and Brady HJ

The Journal of biological chemistry 281(9):5750-9, 2006 Mar 3 - Who cited this? | PubMed ID: 16380381 | Fulltext

Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells.

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Yeung J, Kempski H, Neat M, Bailey S, Smith O, and Brady HJ

Haematologica 91(3):422-4, 2006 Mar - Who cited this? | PubMed ID: 16531271 | Fulltext

Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer.

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Hughes TA and Brady HJ

Cancer letters 233(2):338-47, 2006 Feb 28 - Who cited this? | PubMed ID: 15885887 | Fulltext

Roscovitine modulates DNA repair and senescence: implications for combination chemotherapy.

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Crescenzi E, Palumbo G, and Brady HJ

Clinical cancer research : an official journal of the American Association for Cancer Research 11(22):8158-71, 2005 Nov 15 - Who cited this? | PubMed ID: 16299248 | Fulltext

Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.

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Horton SJ, Grier DG, McGonigle GJ, Thompson A, Morrow M, De Silva I, Moulding DA, Kioussis D, Lappin TR, Brady HJ, and Williams O

Cancer research 65(20):9245-52, 2005 Oct 15 - Who cited this? | PubMed ID: 16230385 | Fulltext

cMet and Fas receptor interaction inhibits death-inducing signaling complex formation in endothelial cells.

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Smyth LA and Brady HJ

Hypertension 46(1):100-6, 2005 Jul - Who cited this? | PubMed ID: 15911745 | Fulltext

E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation.

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Hughes TA and Brady HJ

Biochemical and biophysical research communications 329(4):1267-74, 2005 Apr 22 - Who cited this? | PubMed ID: 15766563 | Fulltext

Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA.

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Hughes TA and Brady HJ

The Journal of biological chemistry 280(9):8581-8, 2005 Mar 4 - Who cited this? | PubMed ID: 15611123 | Fulltext

Cross-talk between pRb/E2F and Wnt/beta-catenin pathways: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death.

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Hughes TA and Brady HJ

Experimental cell research 303(1):32-46, 2005 Feb 1 - Who cited this? | PubMed ID: 15572025 | Fulltext

Cdk2 activation acts upstream of the mitochondrion during glucocorticoid induced thymocyte apoptosis.

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Granés F, Roig MB, Brady HJ, and Gil-Gómez G

European journal of immunology 34(10):2781-90, 2004 Oct - Who cited this? | PubMed ID: 15368294 | Fulltext

E4BP4 expression is regulated by the t(17;19)-associated oncoprotein E2A-HLF in pro-B cells.

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Yeung J, O'Sullivan E, Hubank M, and Brady HJ

British journal of haematology 125(5):560-7, 2004 Jun - Who cited this? | PubMed ID: 15147370 | Fulltext

Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells.

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Clohessy JG, Zhuang J, and Brady HJ

British journal of haematology 125(5):655-65, 2004 Jun - Who cited this? | PubMed ID: 15147382 | Fulltext

TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity.

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Morrow M, Horton S, Kioussis D, Brady HJ, and Williams O

Blood 103(10):3890-6, 2004 May 15 - Who cited this? | PubMed ID: 14726384 | Fulltext

Overexpression of the Ikaros 6 isoform is restricted to t(4;11) acute lymphoblastic leukaemia in children and infants and has a role in B-cell survival.

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Ruiz A, Jiang J, Kempski H, and Brady HJ

British journal of haematology 125(1):31-7, 2004 Apr - Who cited this? | PubMed ID: 15015965 | Fulltext

Apoptosis and leukaemia.

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Brady HJ

British journal of haematology 123(4):577-85, 2003 Nov - Who cited this? | PubMed ID: 14616959 | Fulltext

Bcl-2 activates a programme of premature senescence in human carcinoma cells.

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Crescenzi E, Palumbo G, and Brady HJ

The Biochemical journal 375(Pt 2):263-74, 2003 Oct 15 - Who cited this? | PubMed ID: 12871207 | Fulltext

Elevated Bcl-2 is not a causal event in the positive selection of T cells.

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Williams O, Mok CL, Norton T, Harker N, Kioussis D, and Brady HJ

European journal of immunology 31(6):1876-82, 2001 Jun - Who cited this? | PubMed ID: 11433384 | Fulltext

The role of molecules that mediate apoptosis in T-cell selection.

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Williams O and Brady HJ

Trends in immunology 22(2):107-11, 2001 Feb - Who cited this? | PubMed ID: 11286713 | Fulltext

Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection.

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Williams O, Gil-Gómez G, Norton T, Kioussis D, and Brady HJ

European journal of immunology 30(2):709-13, 2000 Feb - Who cited this? | PubMed ID: 10671231 | Fulltext

Bad can act as a key regulator of T cell apoptosis and T cell development.

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Mok CL, Gil-Gómez G, Williams O, Coles M, Taga S, Tolaini M, Norton T, Kioussis D, and Brady HJ

The Journal of experimental medicine 189(3):575-86, 1999 Feb 1 - Who cited this? | PubMed ID: 9927519 | Fulltext

The cell cycle and apoptosis.

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Brady HJ and Gil-Gómez G

Results and problems in cell differentiation 23:127-44, 1999 - Who cited this? | PubMed ID: 9950032 | Fulltext

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

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Gil-Gómez G, Berns A, and Brady HJ

The EMBO journal 17(24):7209-18, 1998 Dec 15 - Who cited this? | PubMed ID: 9857178 | Fulltext

The action of Bax and bcl-2 on T cell selection.

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Williams O, Norton T, Halligey M, Kioussis D, and Brady HJ

The Journal of experimental medicine 188(6):1125-33, 1998 Sep 21 - Who cited this? | PubMed ID: 9743531 | Fulltext

Transgenic mice in apoptosis research.

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Gil-Gómez G and Brady HJ

Apoptosis : an international journal on programmed cell death 3(4):215-28, 1998 Sep - Who cited this? | PubMed ID: 14646485 | Fulltext

Bax. The pro-apoptotic Bcl-2 family member, Bax.

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Brady HJ and Gil-Gómez G

The international journal of biochemistry & cell biology 30(6):647-50, 1998 Jun - Who cited this? | PubMed ID: 9695020 | Fulltext

HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism.

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Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, and Abraham DJ

Genes and function 1(5-6):321-35, 1997 Dec - Who cited this? | PubMed ID: 17366702 | Fulltext

The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia.

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Salomons GS, Brady HJ, Verwijs-Janssen M, Van Den Berg JD, Hart AA, Van Den Berg H, Behrendt H, Hählen K, and Smets LA

International journal of cancer. Journal international du cancer 71(6):959-65, 1997 Jun 11 - Who cited this? | PubMed ID: 9185697 | Fulltext

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

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Brady HJ, Gil-Gómez G, Kirberg J, and Berns AJ

The EMBO journal 15(24):6991-7001, 1996 Dec 16 - Who cited this? | PubMed ID: 9003775 | Fulltext

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

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Brady HJ, Salomons GS, Bobeldijk RC, and Berns AJ

The EMBO journal 15(6):1221-30, 1996 Mar 15 - Who cited this? | PubMed ID: 8635454 | Fulltext

Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice.

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Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S, and Dzierzak EA

Journal of virology 69(12):7622-9, 1995 Dec - Who cited this? | PubMed ID: 7494270 | Fulltext

Transgenic mice as models of human immunodeficiency virus expression and related cellular effects.

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Brady HJ, Pennington DJ, and Dzierzak EA

The Journal of general virology 75 ( Pt 10):2549-58, 1994 Oct - Who cited this? | PubMed ID: 7931142 | Fulltext

Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses.

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Brady HJ, Miles CG, Pennington DJ, and Dzierzak EA

Proceedings of the National Academy of Sciences of the United States of America 91(1):365-9, 1994 Jan 4 - Who cited this? | PubMed ID: 8278395 | Fulltext

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

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Brady HJ, Pennington DJ, Miles CG, and Dzierzak EA

The EMBO journal 12(13):4923-32, 1993 Dec 15 - Who cited this? | PubMed ID: 8262036 | Fulltext

Studies of HIV-2 promoter activity and cell specific ablation.

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Brady HJ, Miles CG, Pennington DJ, and Dzierzak EA

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 7 Suppl 2:S61-5, 1993 Aug - Who cited this? | PubMed ID: 8361235 | Fulltext

The human carbonic anhydrase I gene has two promoters with different tissue specificities.

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Brady HJ, Lowe N, Sowden JC, Edwards M, and Butterworth PH

The Biochemical journal 277 ( Pt 3):903-5, 1991 Aug 1 - Who cited this? | PubMed ID: 1908227 | Fulltext

Structure and methylation patterns of the gene encoding human carbonic anhydrase I.

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Lowe N, Brady HJ, Barlow JH, Sowden JC, Edwards M, and Butterworth PH

Gene 93(2):277-83, 1990 Sep 14 - Who cited this? | PubMed ID: 2121614 | Fulltext

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