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Papers authored by Brüning J

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Hormone and glucose signalling in POMC and AgRP neurons.

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Belgardt BF, Okamura T, and Brüning JC

The Journal of physiology 587(Pt 22):5305-14, 2009 Nov 15 - Who cited this? | PubMed ID: 19770186 | Fulltext

Highly Enantioselective and Regioselective Carbonyl Reduction of Cyclic alpha,beta-Unsaturated Ketones Using TarB-NO(2) and Sodium Borohydride.

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Kim J, Bruning J, Park KE, Lee DJ, and Singaram B

Organic letters 11(19):4358-61, 2009 Oct 1 - Who cited this? | PubMed ID: 19711968 | Fulltext

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

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Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, Köhler C, Udelhoven M, Leeser U, Müller M, Kubota N, Kadowaki T, Krone W, Schröder H, Brüning JC, and Schubert M

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23(10):3315-24, 2009 Oct - Who cited this? | PubMed ID: 19487308 | Fulltext

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity.

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Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, and Brüning JC

Cell metabolism 10(4):249-59, 2009 Oct - Who cited this? | PubMed ID: 19808018 | Fulltext

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

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Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, and Wunderlich FT

The Journal of neuroscience : the official journal of the Society for Neuroscience 29(37):11582-93, 2009 Sep 16 - Who cited this? | PubMed ID: 19759305 | Fulltext

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

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Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, and Krönke M

Nature 460(7259):1159-63, 2009 Aug 27 - Who cited this? | PubMed ID: 19641494 | Fulltext

Control of energy homeostasis by insulin and leptin: targeting the arcuate nucleus and beyond.

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Könner AC, Klöckener T, and Brüning JC

Physiology & behavior 97(5):632-8, 2009 Jul 14 - Who cited this? | PubMed ID: 19351541 | Fulltext

Three solvates of a bis-mesoionic fluorescent yellow pigment.

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Brüning J, Bolte M, and Schmidt MU

Acta crystallographica. Section C, Crystal structure communications 65(Pt 7):o352-6, 2009 Jul - Who cited this? | PubMed ID: 19578271 | Fulltext

PLRG1 Is an Essential Regulator of Cell Proliferation and Apoptosis during Vertebrate Development and Tissue Homeostasis.

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Kleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, Hammerschmidt M, and Brüning JC

Molecular and cellular biology 29(11):3173-85, 2009 Jun - Who cited this? | PubMed ID: 19307306 | Fulltext

VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding.

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Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Müller C, Paulsson M, Brüning JC, and Oldenburg J

Thrombosis and haemostasis 101(6):1044-50, 2009 Jun - Who cited this? | PubMed ID: 19492146 | Fulltext

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.

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Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Brüning JC, Niessen CM, Hoeijmakers JH, and Schumacher B

Nature cell biology 11(5):604-15, 2009 May - Who cited this? | PubMed ID: 19363488 | Fulltext

[Central regulation of energy and glucose metabolism].

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Rother E, Jordan SD, and Brüning JC

Deutsche medizinische Wochenschrift (1946) 134(20):1057-9, 2009 May - Who cited this? | PubMed ID: 19421928 | Fulltext

Inactivation of the Fto gene protects from obesity.

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Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, and Rüther U

Nature 458(7240):894-8, 2009 Apr 16 - Who cited this? | PubMed ID: 19234441 | Fulltext

Electron diffraction, X-ray powder diffraction and pair-distribution-function analyses to determine the crystal structures of Pigment Yellow 213, C(23)H(21)N(5)O(9).

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Schmidt MU, Brühne S, Wolf AK, Rech A, Brüning J, Alig E, Fink L, Buchsbaum C, Glinnemann J, van de Streek J, Gozzo F, Brunelli M, Stowasser F, Gorelik T, Mugnaioli E, and Kolb U

Acta crystallographica. Section B, Structural science 65(Pt 2):189-99, 2009 Apr - Who cited this? | PubMed ID: 19299875 | Fulltext

Structures of six industrial benzimidazolone pigments from laboratory powder diffraction data.

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van de Streek J, Brüning J, Ivashevskaya SN, Ermrich M, Paulus EF, Bolte M, and Schmidt MU

Acta crystallographica. Section B, Structural science 65(Pt 2):200-11, 2009 Apr - Who cited this? | PubMed ID: 19299876 | Fulltext

Structure determination of seven phases and solvates of Pigment Yellow 183 and Pigment Yellow 191 from X-ray powder and single-crystal data.

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Ivashevskaya SN, van de Streek J, Djanhan JE, Brüning J, Alig E, Bolte M, Schmidt MU, Blaschka P, Höffken HW, and Erk P

Acta crystallographica. Section B, Structural science 65(Pt 2):212-22, 2009 Apr - Who cited this? | PubMed ID: 19299877 | Fulltext

Secondary Consequences of beta Cell Inexcitability: Identification and Prevention in a Murine Model of K(ATP)-Induced Neonatal Diabetes Mellitus.

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Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, and Nichols CG

Cell metabolism 9(2):140-51, 2009 Feb - Who cited this? | PubMed ID: 19187772 | Fulltext

Response to Comment on: Kloting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074-2082.

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Brüning JC and Blüher M

Diabetes 58(1):e4, 2009 Jan - Who cited this? | PubMed ID: 19114719 | Fulltext

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

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Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R,

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The Journal of clinical investigation 119(1):80-90, 2009 Jan - Who cited this? | PubMed ID: 19065048 | Fulltext

Retraction for Ma et al., Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.

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Ma X, Bruning J, and Ashcroft FM

The Journal of neuroscience : the official journal of the Society for Neuroscience 28(47):preceding 12147, 2008 Nov 19 - Who cited this? | PubMed ID: 19035023 | Fulltext

Rasagiline ethanedisulfonate: an inhibitor for monoamine oxygenase B (MAO(B)).

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Brüning J, Bats JW, and Schmidt MU

Acta crystallographica. Section C, Crystal structure communications 64(Pt 11):o613-5, 2008 Nov - Who cited this? | PubMed ID: 18989091 | Fulltext

Two azo pigments based on beta-naphthol.

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Schmidt MU, Brüning J, Wirth D, and Bolte M

Acta crystallographica. Section C, Crystal structure communications 64(Pt 9):o474-7, 2008 Sep - Who cited this? | PubMed ID: 18758013 | Fulltext

IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination.

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Freude S, Leeser U, Müller M, Hettich MM, Udelhoven M, Schilbach K, Tobe K, Kadowaki T, Köhler C, Schröder H, Krone W, Brüning JC, and Schubert M

Journal of neurochemistry, 2008 Aug 20 - Who cited this? | PubMed ID: 18717815 | Fulltext

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.

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Stachelscheid H, Ibrahim H, Koch L, Schmitz A, Tscharntke M, Wunderlich FT, Scott J, Michels C, Wickenhauser C, Haase I, Brüning JC, and Niessen CM

The EMBO journal 27(15):2091-101, 2008 Aug 6 - Who cited this? | PubMed ID: 18650937 | Fulltext

Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth.

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Klöting N, Koch L, Wunderlich T, Kern M, Ruschke K, Krone W, Brüning JC, and Blüher M

Diabetes 57(8):2074-82, 2008 Aug - Who cited this? | PubMed ID: 18443199 | Fulltext

Corrigendum: NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

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Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachimiak A, and Greene GL

Nature chemical biology 4(6):379, 2008 Jun - Who cited this? | PubMed ID: 18488012 | Fulltext

Central insulin action regulates peripheral glucose and fat metabolism in mice.

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Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant G, Kahn CR, Schwenk F, and Brüning JC

The Journal of clinical investigation 118(6):2132-47, 2008 Jun - Who cited this? | PubMed ID: 18451994 | Fulltext

Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.

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Dai SY, Chalmers MJ, Bruning J, Bramlett KS, Osborne HE, Montrose-Rafizadeh C, Barr RJ, Wang Y, Wang M, Burris TP, Dodge JA, and Griffin PR

Proceedings of the National Academy of Sciences of the United States of America 105(20):7171-6, 2008 May 20 - Who cited this? | PubMed ID: 18474858 | Fulltext

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism.

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Rother E, Könner AC, and Brüning JC

American journal of physiology. Endocrinology and metabolism 294(5):E810-6, 2008 May - Who cited this? | PubMed ID: 18285523 | Fulltext

Forkhead transcription factors and ageing.

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Partridge L and Brüning JC

Oncogene 27(16):2351-63, 2008 Apr 7 - Who cited this? | PubMed ID: 18391977 | Fulltext

NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

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Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachmiak A, and Greene GL

Nature chemical biology 4(4):241, 2008 Apr - Who cited this? | PubMed ID: 18344977 | Fulltext

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.

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Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klöckener T, Alessi D, Kloppenburg P, and Brüning JC

Cell metabolism 7(4):291, 2008 Apr - Who cited this? | PubMed ID: 18396135 | Fulltext

Activation of Stat3 signaling in AgRP neurons promotes locomotor activity.

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Mesaros A, Koralov SB, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, and Brüning JC

Cell metabolism 7(3):236, 2008 Mar - Who cited this? | PubMed ID: 18316029 | Fulltext

Hepatic NF-kappaB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.

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Wunderlich FT, Luedde T, Singer S, Schmidt-Supprian M, Baumgartl J, Schirmacher P, Pasparakis M, and Brüning JC

Proceedings of the National Academy of Sciences of the United States of America 105(4):1297-302, 2008 Jan 29 - Who cited this? | PubMed ID: 18216263 | Fulltext

Rad GTPase deficiency leads to cardiac hypertrophy.

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Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, and Chen YE

Circulation 116(25):2976-83, 2007 Dec 18 - Who cited this? | PubMed ID: 18056528 | Fulltext

Enhanced leptin-stimulated pi3k activation in the CNS promotes white adipose tissue transdifferentiation.

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Plum L, Rother E, Münzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Könner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, and Brüning JC

Cell metabolism 6(6):431-45, 2007 Dec - Who cited this? | PubMed ID: 18054313 | Fulltext

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.

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Hövelmeyer N, Wunderlich FT, Massoumi R, Jakobsen CG, Song J, Wörns MA, Merkwirth C, Kovalenko A, Aumailley M, Strand D, Brüning JC, Galle PR, Wallach D, Fässler R, and Waisman A

The Journal of experimental medicine 204(11):2615, 2007 Oct 29 - Who cited this? | PubMed ID: 17923499 | Fulltext

Partial agonists activate PPARgamma using a helix 12 independent mechanism.

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Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, and Griffin PR

Structure (London, England : 1993) 15(10):1258-71, 2007 Oct - Who cited this? | PubMed ID: 17937915 | Fulltext

Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.

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Ma X, Bruning J, and Ashcroft FM

The Journal of neuroscience : the official journal of the Society for Neuroscience 27(27):7125-9, 2007 Jul 4 - Who cited this? | PubMed ID: 17611265 | Fulltext

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.

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Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S, Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, and Katzenellenbogen JA

Chemistry & biology 14(6):659, 2007 Jun - Who cited this? | PubMed ID: 17584613 | Fulltext

Structural plasticity in the oestrogen receptor ligand-binding domain.

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Nettles KW, Bruning JB, Gil G, O'Neill EE, Nowak J, Guo Y, Kim Y, DeSombre ER, Dilis R, Hanson RN, Joachimiak A, and Greene GL

EMBO reports 8(6):563-8, 2007 Jun - Who cited this? | PubMed ID: 17468738 | Fulltext

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

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Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, and Brüning JC

Cell metabolism 5(6):438-49, 2007 Jun - Who cited this? | PubMed ID: 17550779 | Fulltext

Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin.

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Ma X, Zubcevic L, Brüning JC, Ashcroft FM, and Burdakov D

The Journal of neuroscience : the official journal of the Society for Neuroscience 27(7):1529, 2007 Feb 14 - Who cited this? | PubMed ID: 17301161 | Fulltext

Reversible gene knockdown in mice using a tight, inducible shRNA expression system.

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Seibler J, Kleinridders A, Küter-Luks B, Niehaves S, Brüning JC, and Schwenk F

Nucleic acids research 35(7):e54, 2007 - Who cited this? | PubMed ID: 17376804 | Fulltext

gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor.

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Janoschek R, Plum L, Koch L, Münzberg H, Diano S, Shanabrough M, Müller W, Horvath TL, and Brüning JC

Proceedings of the National Academy of Sciences of the United States of America 103(28):10707-12, 2006 Jul 11 - Who cited this? | PubMed ID: 16818888 | Fulltext

Central insulin action in energy and glucose homeostasis.

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Plum L, Belgardt BF, and Brüning JC

The Journal of clinical investigation 116(7):1761, 2006 Jul - Who cited this? | PubMed ID: 16823473 | Fulltext

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

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Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C,

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The Journal of clinical investigation 116(7):1886-901, 2006 Jul - Who cited this? | PubMed ID: 16794735 | Fulltext

Effects of a group forgiveness intervention on forgiveness, perceived stress, and trait-anger.

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Harris AH, Luskin F, Norman SB, Standard S, Bruning J, Evans S, and Thoresen CE

Journal of clinical psychology 62(6):715-33, 2006 Jun - Who cited this? | PubMed ID: 16538652 | Fulltext

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

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Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, and Brüning JC

Cell metabolism 3(4):247, 2006 Apr - Who cited this? | PubMed ID: 16581002 | Fulltext

p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.

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Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, and Roth BL

Proceedings of the National Academy of Sciences of the United States of America 103(12):4717-22, 2006 Mar 21 - Who cited this? | PubMed ID: 16537434 | Fulltext

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