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Papers authored by Boshoff HI

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The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance.

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Singh R, Barry CE, and Boshoff HI

Journal of bacteriology 192(5):1279-91, 2010 Mar - Who cited this? | PubMed ID: 20061486 | Fulltext

Spectrum of latent tuberculosis - existing tests cannot resolve the underlying phenotypes: author's reply.

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Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, and Young D

Nature reviews. Microbiology 8(3):242, 2010 Mar - Who cited this? | PubMed ID: 20084058 | Fulltext

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.

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Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, and Young D

Nature reviews. Microbiology 7(12):845-55, 2009 Dec - Who cited this? | PubMed ID: 19855401 | Fulltext

Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals.

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Lowery CA, Park J, Gloeckner C, Meijler MM, Mueller RS, Boshoff HI, Ulrich RL, Barry CE, Bartlett DH, Kravchenko VV, Kaufmann GF, and Janda KD

Journal of the American Chemical Society 131(40):14473-9, 2009 Oct 14 - Who cited this? | PubMed ID: 19807189 | Fulltext

Corrections to structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.

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Kim P, Kang S, Boshoff HI, Jiricek J, Collins M, Singh R, Manjunatha UH, Niyomrattanakit P, Patel S, Zhang L, Goodwin M, Dick T, Keller TH, Dowd CS, and Barry CE

Journal of medicinal chemistry 52(18):5770, 2009 Sep 24 - Who cited this? | PubMed ID: 19722524 | Fulltext

The mechanism of action of PA-824: Novel insights from transcriptional profiling.

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Manjunatha U, Boshoff HI, and Barry CE

Communicative & integrative biology 2(3):215-8, 2009 May - Who cited this? | PubMed ID: 19641733 | Fulltext

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.

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O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, and Gibbons S

Journal of natural products 72(3):360-5, 2009 Mar 27 - Who cited this? | PubMed ID: 19093848 | Fulltext

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.

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Kim P, Zhang L, Manjunatha UH, Singh R, Patel S, Jiricek J, Keller TH, Boshoff HI, Barry CE, and Dowd CS

Journal of medicinal chemistry 52(5):1317-28, 2009 Mar 12 - Who cited this? | PubMed ID: 19209889 | Fulltext

Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.

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Kim P, Kang S, Boshoff HI, Jiricek J, Collins M, Singh R, Manjunatha UH, Niyomrattanakit P, Zhang L, Goodwin M, Dick T, Keller TH, Dowd CS, and Barry CE

Journal of medicinal chemistry 52(5):1329-44, 2009 Mar 12 - Who cited this? | PubMed ID: 19209893 | Fulltext

Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis.

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Hugonnet JE, Tremblay LW, Boshoff HI, Barry CE, and Blanchard JS

Science (New York, N.Y.) 323(5918):1215-8, 2009 Feb 27 - Who cited this? | PubMed ID: 19251630 | Fulltext

Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein.

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Burns KE, Liu WT, Boshoff HI, Dorrestein PC, and Barry CE

The Journal of biological chemistry 284(5):3069-75, 2009 Jan 30 - Who cited this? | PubMed ID: 19028679 | Fulltext

HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis.

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Ranjbar S, Boshoff HI, Mulder A, Siddiqi N, Rubin EJ, and Goldfeld AE

PLoS ONE 4(7):e6116, 2009 - Who cited this? | PubMed ID: 19568431 | Fulltext

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.

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Gupte A, Boshoff HI, Wilson DJ, Neres J, Labello NP, Somu RV, Xing C, Barry CE, and Aldrich CC

Journal of medicinal chemistry 51(23):7495-507, 2008 Dec 11 - Who cited this? | PubMed ID: 19053762 | Fulltext

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.

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Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, and Barry CE

Science (New York, N.Y.) 322(5906):1392-5, 2008 Nov 28 - Who cited this? | PubMed ID: 19039139 | Fulltext

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.

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Neres J, Labello NP, Somu RV, Boshoff HI, Wilson DJ, Vannada J, Chen L, Barry CE, Bennett EM, and Aldrich CC

Journal of medicinal chemistry 51(17):5349, 2008 Sep 11 - Who cited this? | PubMed ID: 18690677 | Fulltext

Biosynthesis and Recycling of Nicotinamide Cofactors in Mycobacterium tuberculosis: AN ESSENTIAL ROLE FOR NAD IN NONREPLICATING BACILLI.

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Boshoff HI, Xu X, Tahlan K, Dowd CS, Pethe K, Camacho LR, Park TH, Yun CS, Schnappinger D, Ehrt S, Williams KJ, and Barry CE

The Journal of biological chemistry 283(28):19329, 2008 Jul 11 - Who cited this? | PubMed ID: 18490451 | Fulltext

5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.

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Qiao C, Gupte A, Boshoff HI, Wilson DJ, Bennett EM, Somu RV, Barry CE, and Aldrich CC

Journal of medicinal chemistry 50(24):6080, 2007 Nov 29 - Who cited this? | PubMed ID: 17967002 | Fulltext

Chemical genetics: an evolving toolbox for target identification and lead optimization.

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Boshoff HI and Dowd CS

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 64:49, 51-77, 2007 - Who cited this? | PubMed ID: 17195471 | Fulltext

Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.

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Somu RV, Wilson DJ, Bennett EM, Boshoff HI, Celia L, Beck BJ, Barry CE, and Aldrich CC

Journal of medicinal chemistry 49(26):7623-35, 2006 Dec 28 - Who cited this? | PubMed ID: 17181146 | Fulltext

Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.

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Vannada J, Bennett EM, Wilson DJ, Boshoff HI, Barry CE, and Aldrich CC

Organic letters 8(21):4707-10, 2006 Oct 12 - Who cited this? | PubMed ID: 17020283 | Fulltext

The impact of genomics on discovering drugs against infectious diseases.

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Boshoff HI and Manjunatha UH

Microbes and infection / Institut Pasteur 8(6):1654-61, 2006 May - Who cited this? | PubMed ID: 16690340 | Fulltext

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.

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Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE, and Dowd CS

Journal of medicinal chemistry 49(1):159-71, 2006 Jan 12 - Who cited this? | PubMed ID: 16392800 | Fulltext

Effects of clofazimine on potassium uptake by a Trk-deletion mutant of Mycobacterium tuberculosis.

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Cholo MC, Boshoff HI, Steel HC, Cockeran R, Matlola NM, Downing KJ, Mizrahi V, and Anderson R

The Journal of antimicrobial chemotherapy 57(1):79-84, 2006 Jan - Who cited this? | PubMed ID: 16286358 | Fulltext

Quantification of small molecule organic acids from Mycobacterium tuberculosis culture supernatant using ion exclusion liquid chromatography/mass spectrometry.

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Goodwin MB, Boshoff HI, Barry CE, and Dowd CS

Rapid communications in mass spectrometry : RCM 20(22):3345-50, 2006 - Who cited this? | PubMed ID: 17044117 | Fulltext

In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates.

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Barczak AK, Domenech P, Boshoff HI, Reed MB, Manca C, Kaplan G, and Barry CE

The Journal of infectious diseases 192(4):600-6, 2005 Aug 15 - Who cited this? | PubMed ID: 16028128 | Fulltext

A low-carb diet for a high-octane pathogen.

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Boshoff HI and Barry CE

Nature medicine 11(6):599-600, 2005 Jun - Who cited this? | PubMed ID: 15937469 | Fulltext

The relA homolog of Mycobacterium smegmatis affects cell appearance, viability, and gene expression.

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Dahl JL, Arora K, Boshoff HI, Whiteford DC, Pacheco SA, Walsh OJ, Lau-Bonilla D, Davis WB, and Garza AG

Journal of bacteriology 187(7):2439, 2005 Apr - Who cited this? | PubMed ID: 15774887 | Fulltext

Tuberculosis - metabolism and respiration in the absence of growth.

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Boshoff HI and Barry CE

Nature reviews. Microbiology 3(1):70-80, 2005 Jan - Who cited this? | PubMed ID: 15608701 | Fulltext

The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.

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Boshoff HI, Myers TG, Copp BR, McNeil MR, Wilson MA, and Barry CE

The Journal of biological chemistry 279(38):40174-84, 2004 Sep 17 - Who cited this? | PubMed ID: 15247240 | Fulltext

Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis.

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Barry CE, Boshoff HI, and Dowd CS

Current pharmaceutical design 10(26):3239-62, 2004 - Who cited this? | PubMed ID: 15544513 | Fulltext

The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice.

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Dahl JL, Kraus CN, Boshoff HI, Doan B, Foley K, Avarbock D, Kaplan G, Mizrahi V, Rubin H, and Barry CE

Proceedings of the National Academy of Sciences of the United States of America 100(17):10026-31, 2003 Aug 19 - Who cited this? | PubMed ID: 12897239 | Fulltext

DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis.

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Boshoff HI, Reed MB, Barry CE, and Mizrahi V

Cell 113(2):183-93, 2003 Apr 18 - Who cited this? | PubMed ID: 12705867 | Fulltext

Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.

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Boshoff HI, Mizrahi V, and Barry CE

Journal of bacteriology 184(8):2167-72, 2002 Apr - Who cited this? | PubMed ID: 11914348 | Fulltext

DNA metabolism in mycobacterium tuberculosis: implications for drug resistance and strain variability.

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Boshoff HI, Durbach SI, and Mizrahi V

Scandinavian journal of infectious diseases 33(2):101-5, 2001 - Who cited this? | PubMed ID: 11233842 | Fulltext

Expression of Mycobacterium smegmatis pyrazinamidase in Mycobacterium tuberculosis confers hypersensitivity to pyrazinamide and related amides.

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Boshoff HI and Mizrahi V

Journal of bacteriology 182(19):5479-85, 2000 Oct - Who cited this? | PubMed ID: 10986252 | Fulltext

Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis.

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Boshoff HI and Mizrahi V

Journal of bacteriology 180(22):5809-14, 1998 Nov - Who cited this? | PubMed ID: 9811635 | Fulltext

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