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Papers authored by Bluestone JA

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Autoimmunity.

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Bluestone JA and Kuchroo V

Current opinion in immunology 21(6):579-81, 2009 Dec - Who cited this? | PubMed ID: 19879742 | Fulltext

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

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Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, and Bluestone JA

Nature immunology 10(11):1185-92, 2009 Nov - Who cited this? | PubMed ID: 19783989 | Fulltext

The functional plasticity of T cell subsets.

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Bluestone JA, Mackay CR, O'Shea JJ, and Stockinger B

Nature reviews. Immunology 9(11):811-6, 2009 Nov - Who cited this? | PubMed ID: 19809471 | Fulltext

Is antigen specificity of autoreactive T cells the key to islet entry?.

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Penaranda C and Bluestone JA

Immunity 31(4):534-6, 2009 Oct 16 - Who cited this? | PubMed ID: 19833083 | Fulltext

Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.

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Coquerelle C, Oldenhove G, Acolty V, Denoeud J, Vansanten G, Verdebout JM, Mellor A, Bluestone JA, and Moser M

Gut 58(10):1363-73, 2009 Oct - Who cited this? | PubMed ID: 19505881 | Fulltext

How suppressor cells led to anergy, costimulation, and beyond.

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Bour-Jordan H and Bluestone JA

Journal of immunology (Baltimore, Md. : 1950) 183(7):4147-9, 2009 Oct 1 - Who cited this? | PubMed ID: 19767564 | Fulltext

Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice.

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Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, and White MF

Endocrinology 150(10):4531-40, 2009 Oct - Who cited this? | PubMed ID: 19574401 | Fulltext

Regulatory T cells as therapeutic targets in rheumatoid arthritis.

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Esensten JH, Wofsy D, and Bluestone JA

Nature reviews. Rheumatology 5(10):560-5, 2009 Oct - Who cited this? | PubMed ID: 19798031 | Fulltext

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.

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Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, and Bluestone JA

Nature immunology 10(9):1000-7, 2009 Sep - Who cited this? | PubMed ID: 19633673 | Fulltext

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.

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Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, Sayre P, Bianchine P, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA, and Immune Tolerance Network ITN007AI Study Group

Clinical immunology (Orlando, Fla.) 132(2):166-73, 2009 Aug - Who cited this? | PubMed ID: 19443276 | Fulltext

Lethal Effect of CD3-Specific Antibody in Mice Deficient in TGF-{beta}1 by Uncontrolled Flu-Like Syndrome.

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Perruche S, Zhang P, Maruyama T, Bluestone JA, Saas P, and Chen W

Journal of immunology (Baltimore, Md. : 1950) 183(2):953-61, 2009 Jul 15 - Who cited this? | PubMed ID: 19561097 | Fulltext

T-bet-deficient NOD mice are protected from diabetes due to defects in both T Cell and innate immune system function.

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Esensten JH, Lee MR, Glimcher LH, and Bluestone JA

Journal of immunology (Baltimore, Md. : 1950) 183(1):75-82, 2009 Jul 1 - Who cited this? | PubMed ID: 19535634 | Fulltext

Plasticity of CD4(+) FoxP3(+) T cells.

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Zhou X, Bailey-Bucktrout S, Jeker LT, and Bluestone JA

Current opinion in immunology 21(3):281-5, 2009 Jun - Who cited this? | PubMed ID: 19500966 | Fulltext

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.

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Bour-Jordan H and Bluestone JA

Immunological reviews 229(1):41-66, 2009 May - Who cited this? | PubMed ID: 19426214 | Fulltext

The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.

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Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, and Anderson MS

Clinical immunology (Orlando, Fla.) 131(1):139-44, 2009 Apr - Who cited this? | PubMed ID: 19150256 | Fulltext

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.

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Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, and Bluestone JA

The Journal of experimental medicine 206(3):507-14, 2009 Mar 16 - Who cited this? | PubMed ID: 19221395 | Fulltext

Expansion of human regulatory T-cells from patients with type 1 diabetes.

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Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, and Bluestone JA

Diabetes 58(3):652-62, 2009 Mar - Who cited this? | PubMed ID: 19074986 | Fulltext

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

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Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, and Bluestone JA

Proceedings of the National Academy of Sciences of the United States of America 105(48):18895-900, 2008 Dec 2 - Who cited this? | PubMed ID: 19015530 | Fulltext

The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation.

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Bluestone JA, Liu W, Yabu JM, Laszik ZG, Putnam A, Belingheri M, Gross DM, Townsend RM, and Vincenti F

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 8(10):2086-96, 2008 Oct - Who cited this? | PubMed ID: 18828769 | Fulltext

Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

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Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, and Chervonsky AV

Nature, 2008 Sep 21 - Who cited this? | PubMed ID: 18806780 | Fulltext

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.

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Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, and Bluestone JA

The Journal of experimental medicine 205(9):1983, 2008 Sep 1 - Who cited this? | PubMed ID: 18725525 | Fulltext

T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects.

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Bluestone JA, Tang Q, and Sedwick CE

Journal of clinical immunology, 2008 Aug 21 - Who cited this? | PubMed ID: 18716861 | Fulltext

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.

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Fife BT and Bluestone JA

Immunological reviews 224(1):166, 2008 Aug 4 - Who cited this? | PubMed ID: 18759926 | Fulltext

Spontaneous Development of a Pancreatic Exocrine Disease in CD28-Deficient NOD Mice.

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Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, and Bluestone JA

Journal of immunology (Baltimore, Md. : 1950) 180(12):7793, 2008 Jun 15 - Who cited this? | PubMed ID: 18523243 | Fulltext

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.

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Brusko TM, Putnam AL, and Bluestone JA

Immunological reviews 223:371, 2008 Jun - Who cited this? | PubMed ID: 18613848 | Fulltext

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

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Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, and Bluestone JA

Immunity 28(5):687, 2008 May - Who cited this? | PubMed ID: 18468463 | Fulltext

CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.

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Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, and Chen W

Nature medicine 14(5):528-35, 2008 May - Who cited this? | PubMed ID: 18438416 | Fulltext

Regulated {beta}-Cell Regeneration in the Adult Mouse Pancreas.

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Cano DA, Rulifson IC, Heiser PW, Swigart LB, Pelengaris S, German M, Evan GI, Bluestone JA, and Hebrok M

Diabetes 57(4):958-66, 2008 Apr - Who cited this? | PubMed ID: 18083786 | Fulltext

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation.

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Tang Q and Bluestone JA

Nature immunology 9(3):239-44, 2008 Mar - Who cited this? | PubMed ID: 18285775 | Fulltext

Safer, longer-lasting regulatory T cells with beta-catenin.

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Bluestone JA and Hebrok M

Nature medicine 14(2):118-9, 2008 Feb - Who cited this? | PubMed ID: 18256611 | Fulltext

B cell depletion: a novel therapy for autoimmune diabetes?.

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Bour-Jordan H and Bluestone JA

The Journal of clinical investigation 117(12):3642, 2007 Dec - Who cited this? | PubMed ID: 18060022 | Fulltext

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

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Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, and Herold KC

Endocrinology 148(11):5136-44, 2007 Nov - Who cited this? | PubMed ID: 17673522 | Fulltext

Mechanisms of PDL1-mediated regulation of autoimmune diabetes.

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Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, and Sayegh MH

Clinical immunology (Orlando, Fla.) 125(1):16-25, 2007 Oct - Who cited this? | PubMed ID: 17627890 | Fulltext

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

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Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, and Sheppard D

Nature 449(7160):361-5, 2007 Sep 20 - Who cited this? | PubMed ID: 17694047 | Fulltext

CD3-specific antibodies: a portal to the treatment of autoimmunity.

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Chatenoud L and Bluestone JA

Nature reviews. Immunology 7(8):622-32, 2007 Aug - Who cited this? | PubMed ID: 17641665 | Fulltext

What does the future hold for cell-based tolerogenic therapy?.

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Bluestone JA, Thomson AW, Shevach EM, and Weiner HL

Nature reviews. Immunology 7(8):650-4, 2007 Aug - Who cited this? | PubMed ID: 17653127 | Fulltext

Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.

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Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas AK, and Bluestone JA

Journal of immunology (Baltimore, Md. : 1950) 179(2):1004-12, 2007 Jul 15 - Who cited this? | PubMed ID: 17617592 | Fulltext

CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects.

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Kang SM, Tang Q, and Bluestone JA

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 7(6):1457-63, 2007 Jun - Who cited this? | PubMed ID: 17511675 | Fulltext

Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.

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Chikuma S and Bluestone JA

European journal of immunology 37(5):1285-9, 2007 May - Who cited this? | PubMed ID: 17429849 | Fulltext

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment.

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You S, Leforban B, Garcia C, Bach JF, Bluestone JA, and Chatenoud L

Proceedings of the National Academy of Sciences of the United States of America 104(15):6335-40, 2007 Apr 10 - Who cited this? | PubMed ID: 17389382 | Fulltext

Murine pancreatic islet isolation.

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Szot GL, Koudria P, and Bluestone JA

Journal of visualized experiments(7):255, 2007 - Who cited this? | PubMed ID: 18989427 | Fulltext

Regulatory T cells: therapeutic potential for treating transplant rejection and type I diabetes.

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Bluestone JA

Journal of visualized experiments(7):257, 2007 - Who cited this? | PubMed ID: 18989429 | Fulltext

Transplantation of pancreatic islets into the kidney capsule of diabetic mice.

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Szot GL, Koudria P, and Bluestone JA

Journal of visualized experiments(9):404, 2007 - Who cited this? | PubMed ID: 18989445 | Fulltext

Sensory neurons link the nervous system and autoimmune diabetes.

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Bour-Jordan H and Bluestone JA

Cell 127(6):1097, 2006 Dec 15 - Who cited this? | PubMed ID: 17174888 | Fulltext

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

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Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, and Bluestone JA

The Journal of experimental medicine 203(12):2737-47, 2006 Nov 27 - Who cited this? | PubMed ID: 17116737 | Fulltext

Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.

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Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, and Herold KC

Diabetes 55(9):2588, 2006 Sep - Who cited this? | PubMed ID: 16936208 | Fulltext

Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.

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Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, and Daikh DI

Journal of immunology (Baltimore, Md. : 1950) 177(3):1451-9, 2006 Aug 1 - Who cited this? | PubMed ID: 16849451 | Fulltext

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

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Fife BT, Griffin MD, Abbas AK, Locksley RM, and Bluestone JA

The Journal of clinical investigation 116(8):2252-61, 2006 Aug - Who cited this? | PubMed ID: 16886063 | Fulltext

Regulatory T-cell physiology and application to treat autoimmunity.

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Tang Q and Bluestone JA

Immunological reviews 212:217-37, 2006 Aug - Who cited this? | PubMed ID: 16903917 | Fulltext

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.

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Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, and Bluestone JA

The Journal of experimental medicine 203(7):1701, 2006 Jul 10 - Who cited this? | PubMed ID: 16818678 | Fulltext

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