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Papers authored by Bieschke J

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A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis.

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Bieschke J, Cohen E, Murray A, Dillin A, and Kelly JW

Protein science : a publication of the Protein Society 18(11):2231-41, 2009 Nov - Who cited this? | PubMed ID: 19701939 | Fulltext

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.

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Ehrnhoefer DE, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R, Engemann S, Pastore A, and Wanker EE

Nature structural & molecular biology 15(6):558-66, 2008 Jun - Who cited this? | PubMed ID: 18511942 | Fulltext

Alzheimer's Abeta Peptides Containing an Isostructural Backbone Mutation Afford Distinct Aggregate Morphologies but Analogous Cytotoxicity. Evidence for a Common Low-Abundance Toxic Structure(s)?.

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Bieschke J, Siegel SJ, Fu Y, and Kelly JW

Biochemistry 47(1):50-9, 2008 Jan 8 - Who cited this? | PubMed ID: 18078350 | Fulltext

The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.

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Siegel SJ, Bieschke J, Powers ET, and Kelly JW

Biochemistry 46(6):1503-10, 2007 Feb 13 - Who cited this? | PubMed ID: 17279615 | Fulltext

Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies.

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Fu Y, Gao J, Bieschke J, Dendle MA, and Kelly JW

Journal of the American Chemical Society 128(50):15948-9, 2006 Dec 20 - Who cited this? | PubMed ID: 17165703 | Fulltext

Opposing activities protect against age-onset proteotoxicity.

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Cohen E, Bieschke J, Perciavalle RM, Kelly JW, and Dillin A

Science (New York, N.Y.) 313(5793):1604, 2006 Sep 15 - Who cited this? | PubMed ID: 16902091 | Fulltext

Small molecule oxidation products trigger disease-associated protein misfolding.

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Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P, and Kelly JW

Accounts of chemical research 39(9):611-9, 2006 Sep - Who cited this? | PubMed ID: 16981677 | Fulltext

Structure-function-folding relationship in a WW domain.

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Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP, Gruebele M, and Kelly JW

Proceedings of the National Academy of Sciences of the United States of America 103(28):10648-53, 2006 Jul 11 - Who cited this? | PubMed ID: 16807295 | Fulltext

E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: probing the requirements for Alzheimer's amyloidogenesis.

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Fu Y, Bieschke J, and Kelly JW

Journal of the American Chemical Society 127(44):15366-7, 2005 Nov 9 - Who cited this? | PubMed ID: 16262389 | Fulltext

Single particle detection and characterization of synuclein co-aggregation.

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Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C, and Kretzschmar H

Biochemical and biophysical research communications 333(4):1202, 2005 Aug 12 - Who cited this? | PubMed ID: 15978545 | Fulltext

Automated PrPres amplification using indirect sonication.

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Sarafoff NI, Bieschke J, Giese A, Weber P, Bertsch U, and Kretzschmar HA

Journal of biochemical and biophysical methods 63(3):213, 2005 Jun 30 - Who cited this? | PubMed ID: 15967508 | Fulltext

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.

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Bertsch U, Winklhofer KF, Hirschberger T, Bieschke J, Weber P, Hartl FU, Tavan P, Tatzelt J, Kretzschmar HA, and Giese A

Journal of virology 79(12):7785-91, 2005 Jun - Who cited this? | PubMed ID: 15919931 | Fulltext

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation.

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Bieschke J, Zhang Q, Powers ET, Lerner RA, and Kelly JW

Biochemistry 44(13):4977-83, 2005 Apr 5 - Who cited this? | PubMed ID: 15794636 | Fulltext

Autocatalytic self-propagation of misfolded prion protein.

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Bieschke J, Weber P, Sarafoff N, Beekes M, Giese A, and Kretzschmar H

Proceedings of the National Academy of Sciences of the United States of America 101(33):12207-11, 2004 Aug 17 - Who cited this? | PubMed ID: 15297610 | Fulltext

Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

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Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, and Kelly JW

Proceedings of the National Academy of Sciences of the United States of America 101(14):4752-7, 2004 Apr 6 - Who cited this? | PubMed ID: 15034169 | Fulltext

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets.

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Bieschke J, Giese A, Schulz-Schaeffer W, Zerr I, Poser S, Eigen M, and Kretzschmar H

Proceedings of the National Academy of Sciences of the United States of America 97(10):5468-73, 2000 May 9 - Who cited this? | PubMed ID: 10805803 | Fulltext

Differential constitutive and activation-dependent expression of prion protein in human peripheral blood leucocytes.

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Dürig J, Giese A, Schulz-Schaeffer W, Rosenthal C, Schmücker U, Bieschke J, Dührsen U, and Kretzschmar HA

British journal of haematology 108(3):488-95, 2000 Mar - Who cited this? | PubMed ID: 10759704 | Fulltext

Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases.

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Giese A, Bieschke J, Eigen M, and Kretzschmar HA

Archives of virology. Supplementum(16):161-71, 2000 - Who cited this? | PubMed ID: 11214919 | Fulltext

Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: high throughput screening for enzyme activity.

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Koltermann A, Kettling U, Bieschke J, Winkler T, and Eigen M

Proceedings of the National Academy of Sciences of the United States of America 95(4):1421-6, 1998 Feb 17 - Who cited this? | PubMed ID: 9465030 | Fulltext

Kinetic investigations by fluorescence correlation spectroscopy: the analytical and diagnostic potential of diffusion studies.

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Schwille P, Bieschke J, and Oehlenschläger F

Biophysical chemistry 66(2-3):211-28, 1997 Jun 30 - Who cited this? | PubMed ID: 9362560 | Fulltext

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