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Papers authored by Bedford MT

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Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1).

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Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, and Sbardella G

ChemMedChem 5(3):398-414, 2010 Mar 1 - Who cited this? | PubMed ID: 20091730 | Fulltext

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.

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Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, and Simeonov A

Nucleic acids research 38(2):e11, 2010 Feb - Who cited this? | PubMed ID: 19897549 | Fulltext

Enzymatic activity is required for the in vivo functions of CARM1.

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Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, and Bedford MT

The Journal of biological chemistry 285(2):1147-52, 2010 Jan 8 - Who cited this? | PubMed ID: 19897492 | Fulltext

Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150.

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Lu M, Yang J, Ren Z, Sabui S, Espejo A, Bedford MT, Jacobson RH, Jeruzalmi D, McMurray JS, and Chen X

Journal of molecular biology 393(2):397-408, 2009 Oct 23 - Who cited this? | PubMed ID: 19660470 | Fulltext

Epigenetic regulation of transcriptional activity of pregnane x receptor by protein arginine methyltransferase 1.

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Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, and Tian Y

The Journal of biological chemistry 284(14):9199-205, 2009 Apr 3 - Who cited this? | PubMed ID: 19144646 | Fulltext

Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.

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Dacwag CS, Bedford MT, Sif S, and Imbalzano AN

Molecular and cellular biology 29(7):1909-21, 2009 Apr - Who cited this? | PubMed ID: 19188441 | Fulltext

IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells.

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Repass JF, Laurent MN, Carter C, Reizis B, Bedford MT, Cardenas K, Narang P, Coles M, and Richie ER

Genesis (New York, N.Y. : 2000) 47(4):281-7, 2009 Apr - Who cited this? | PubMed ID: 19263498 | Fulltext

Human protein arginine methyltransferases in vivo - distinct properties of eight canonical members of the PRMT family.

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Herrmann F, Pably P, Eckerich C, Bedford MT, and Fackelmayer FO

Journal of cell science 122(Pt 5):667-77, 2009 Mar 1 - Who cited this? | PubMed ID: 19208762 | Fulltext

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

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Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, and Cheng X

Nature structural & molecular biology 16(3):312-7, 2009 Mar - Who cited this? | PubMed ID: 19219047 | Fulltext

EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells.

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Zagurovskaya M, Shareef MM, Das A, Reeves A, Gupta S, Sudol M, Bedford MT, Prichard J, Mohiuddin M, and Ahmed MM

Oncogene 28(8):1121-31, 2009 Feb 26 - Who cited this? | PubMed ID: 19137013 | Fulltext

Protein arginine methylation in mammals: who, what, and why.

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Bedford MT and Clarke SG

Molecular cell 33(1):1-13, 2009 Jan 16 - Who cited this? | PubMed ID: 19150423 | Fulltext

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification.

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Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, Lotz M, Bedford MT, and Asahara H

BMC developmental biology 9:47, 2009 - Who cited this? | PubMed ID: 19725955 | Fulltext

Generation and characterization of mice carrying a conditional allele of the wwox tumor suppressor gene.

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Ludes-Meyers JH, Kil H, Parker-Thornburg J, Kusewitt DF, Bedford MT, and Aldaz CM

PLoS ONE 4(11):e7775, 2009 - Who cited this? | PubMed ID: 19936220 | Fulltext

Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks.

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Bua DJ, Kuo AJ, Cheung P, Liu CL, Migliori V, Espejo A, Casadio F, Bassi C, Amati B, Bedford MT, Guccione E, and Gozani O

PLoS ONE 4(8):e6789, 2009 - Who cited this? | PubMed ID: 19956676 | Fulltext

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

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Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, and Jenuwein T

Genes & development 22(15):2048, 2008 Aug 1 - Who cited this? | PubMed ID: 18676810 | Fulltext

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

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Mai A, Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, and Altucci L

Journal of medicinal chemistry 51(7):2279, 2008 Apr 10 - Who cited this? | PubMed ID: 18348515 | Fulltext

Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.

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Hassa PO, Covic M, Bedford MT, and Hottiger MO

Journal of molecular biology 377(3):668, 2008 Mar 28 - Who cited this? | PubMed ID: 18280497 | Fulltext

Arginine methylation of the histone H3 tail impedes effector binding.

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Iberg AN, Espejo A, Cheng D, Kim D, Michaud-Levesque J, Richard S, and Bedford MT

The Journal of biological chemistry 283(6):3006, 2008 Feb 8 - Who cited this? | PubMed ID: 18077460 | Fulltext

CARM1 promotes adipocyte differentiation by coactivating PPARgamma.

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Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, and Bedford MT

EMBO reports 9(2):193-8, 2008 Feb - Who cited this? | PubMed ID: 18188184 | Fulltext

Arginine methylation at a glance.

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Bedford MT

Journal of cell science 120(Pt 24):4243, 2007 Dec 15 - Who cited this? | PubMed ID: 18057026 | Fulltext

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.

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Sayegh J, Webb K, Cheng D, Bedford MT, and Clarke SG

The Journal of biological chemistry 282(50):36444, 2007 Dec 14 - Who cited this? | PubMed ID: 17925405 | Fulltext

WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.

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Ludes-Meyers JH, Kil H, Nuñez MI, Conti CJ, Parker-Thornburg J, Bedford MT, and Aldaz CM

Genes, chromosomes & cancer 46(12):1129-36, 2007 Dec - Who cited this? | PubMed ID: 17823927 | Fulltext

p53 is regulated by the lysine demethylase LSD1.

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Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, and Berger SL

Nature 449(7158):105, 2007 Sep 6 - Who cited this? | PubMed ID: 17805299 | Fulltext

Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors.

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Mai A, Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, and Bedford MT

ChemMedChem 2(7):987-91, 2007 Jul - Who cited this? | PubMed ID: 17458842 | Fulltext

Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice.

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Swiercz R, Cheng D, Kim D, and Bedford MT

The Journal of biological chemistry 282(23):16917, 2007 Jun 8 - Who cited this? | PubMed ID: 17439947 | Fulltext

Protein methylation and DNA repair.

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Lake AN and Bedford MT

Mutation research 618(1-2):91-101, 2007 May 1 - Who cited this? | PubMed ID: 17306845 | Fulltext

Reprogramming the histone code.

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Shaaban SA and Bedford MT

Chemistry & biology 14(3):242-4, 2007 Mar - Who cited this? | PubMed ID: 17379139 | Fulltext

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.

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Shi X, Kachirskaia I, Walter KL, Kuo JH, Lake A, Davrazou F, Chan SM, Martin DG, Fingerman IM, Briggs SD, Howe L, Utz PJ, Kutateladze TG, Lugovskoy AA, Bedford MT, and Gozani O

The Journal of biological chemistry 282(4):2450-5, 2007 Jan 26 - Who cited this? | PubMed ID: 17142463 | Fulltext

The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.

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Cheng D, Côté J, Shaaban S, and Bedford MT

Molecular cell 25(1):71, 2007 Jan 12 - Who cited this? | PubMed ID: 17218272 | Fulltext

The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation.

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Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford MT, and Torchia J

Molecular and cellular biology 27(1):120-34, 2007 Jan - Who cited this? | PubMed ID: 17043108 | Fulltext

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.

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El Messaoudi S, Fabbrizio E, Rodriguez C, Chuchana P, Fauquier L, Cheng D, Theillet C, Vandel L, Bedford MT, and Sardet C

Proceedings of the National Academy of Sciences of the United States of America 103(36):13351-6, 2006 Sep 5 - Who cited this? | PubMed ID: 16938873 | Fulltext

Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A.

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Huang Y, Fang J, Bedford MT, Zhang Y, and Xu RM

Science (New York, N.Y.) 312(5774):748-51, 2006 May 5 - Who cited this? | PubMed ID: 16601153 | Fulltext

Tudor, MBT and chromo domains gauge the degree of lysine methylation.

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Kim J, Daniel J, Espejo A, Lake A, Krishna M, Xia L, Zhang Y, and Bedford MT

EMBO reports 7(4):397-403, 2006 Apr - Who cited this? | PubMed ID: 16415788 | Fulltext

The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6.

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Sgarra R, Lee J, Tessari MA, Altamura S, Spolaore B, Giancotti V, Bedford MT, and Manfioletti G

The Journal of biological chemistry 281(7):3764-72, 2006 Feb 17 - Who cited this? | PubMed ID: 16293633 | Fulltext

Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo.

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Herrmann F, Lee J, Bedford MT, and Fackelmayer FO

The Journal of biological chemistry 280(45):38005-10, 2005 Nov 11 - Who cited this? | PubMed ID: 16159886 | Fulltext

PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family.

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Lee J, Sayegh J, Daniel J, Clarke S, and Bedford MT

The Journal of biological chemistry 280(38):32890-6, 2005 Sep 23 - Who cited this? | PubMed ID: 16051612 | Fulltext

Arginine methylation an emerging regulator of protein function.

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Bedford MT and Richard S

Molecular cell 18(3):263, 2005 Apr 29 - Who cited this? | PubMed ID: 15866169 | Fulltext

Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3).

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Swiercz R, Person MD, and Bedford MT

The Biochemical journal 386(Pt 1):85-91, 2005 Feb 15 - Who cited this? | PubMed ID: 15473865 | Fulltext

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression.

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Covic M, Hassa PO, Saccani S, Buerki C, Meier NI, Lombardi C, Imhof R, Bedford MT, Natoli G, and Hottiger MO

The EMBO journal 24(1):85-96, 2005 Jan 12 - Who cited this? | PubMed ID: 15616592 | Fulltext

Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression.

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Boulanger MC, Liang C, Russell RS, Lin R, Bedford MT, Wainberg MA, and Richard S

Journal of virology 79(1):124-31, 2005 Jan - Who cited this? | PubMed ID: 15596808 | Fulltext

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.

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Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT, and Aldaz CM

Oncogene 23(29):5049, 2004 Jun 24 - Who cited this? | PubMed ID: 15064722 | Fulltext

Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development.

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Kim J, Lee J, Yadav N, Wu Q, Carter C, Richard S, Richie E, and Bedford MT

The Journal of biological chemistry 279(24):25339-44, 2004 Jun 11 - Who cited this? | PubMed ID: 15096520 | Fulltext

Small molecule regulators of protein arginine methyltransferases.

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Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, and Bedford MT

The Journal of biological chemistry 279(23):23892, 2004 Jun 4 - Who cited this? | PubMed ID: 15056663 | Fulltext

Protein-domain microarrays.

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Espejo A and Bedford MT

Methods in molecular biology (Clifton, N.J.) 264:173-81, 2004 - Who cited this? | PubMed ID: 15020789 | Fulltext

Techniques in protein methylation.

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Lee J, Cheng D, and Bedford MT

Methods in molecular biology (Clifton, N.J.) 284:195-208, 2004 - Who cited this? | PubMed ID: 15173617 | Fulltext

Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice.

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Yadav N, Lee J, Kim J, Shen J, Hu MC, Aldaz CM, and Bedford MT

Proceedings of the National Academy of Sciences of the United States of America 100(11):6464, 2003 May 27 - Who cited this? | PubMed ID: 12756295 | Fulltext

Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.

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Côté J, Boisvert FM, Boulanger MC, Bedford MT, and Richard S

Molecular biology of the cell 14(1):274-87, 2003 Jan - Who cited this? | PubMed ID: 12529443 | Fulltext

14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).

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Liu MY, Cai S, Espejo A, Bedford MT, and Walker CL

Cancer research 62(22):6475-80, 2002 Nov 15 - Who cited this? | PubMed ID: 12438239 | Fulltext

A protein-domain microarray identifies novel protein-protein interactions.

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Espejo A, Côté J, Bednarek A, Richard S, and Bedford MT

The Biochemical journal 367(Pt 3):697-702, 2002 Nov 1 - Who cited this? | PubMed ID: 12137563 | Fulltext

PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.

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Lee J and Bedford MT

EMBO reports 3(3):268-73, 2002 Mar - Who cited this? | PubMed ID: 11850402 | Fulltext

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