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Papers authored by Becherer JD

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Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model.

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Yao X, Anderson DL, Ross SA, Lang DG, Desai BZ, Cooper DC, Wheelan P, McIntyre MS, Bergquist ML, Mackenzie KI, Becherer JD, and Hashim MA

British journal of pharmacology 154(7):1446, 2008 Aug - Who cited this? | PubMed ID: 18587422 | Fulltext

Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP).

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Haffner CD, Diaz CJ, Miller AB, Reid RA, Madauss KP, Hassell A, Hanlon MH, Porter DJ, Becherer JD, and Carter LH

Bioorganic & medicinal chemistry letters 18(15):4360-3, 2008 Aug 1 - Who cited this? | PubMed ID: 18606544 | Fulltext

Increased TNF{alpha} and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.

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Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, and Kirkland JL

American journal of physiology. Endocrinology and metabolism 293(6):E1810-9, 2007 Dec - Who cited this? | PubMed ID: 17911345 | Fulltext

Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19.

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Kawaguchi N, Horiuchi K, Becherer JD, Toyama Y, Besmer P, and Blobel CP

Journal of cell science 120(Pt 6):943, 2007 Mar 15 - Who cited this? | PubMed ID: 17344430 | Fulltext

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.

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Weskamp G, Ford JW, Sturgill J, Martin S, Docherty AJ, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Sehara-Fujisawa A, Black RA, Ludwig A, Becherer JD, Conrad DH, and Blobel CP

Nature immunology 7(12):1293-8, 2006 Dec - Who cited this? | PubMed ID: 17072319 | Fulltext

Propranolol inhibits the human ether-a-go-go-related gene potassium channels.

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Yao X, McIntyre MS, Lang DG, Song IH, Becherer JD, and Hashim MA

European journal of pharmacology 519(3):208-11, 2005 Sep 20 - Who cited this? | PubMed ID: 16150441 | Fulltext

Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping.

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Lambert MH, Blackburn RK, Seaton TD, Kassel DB, Kinder DS, Leesnitzer MA, Bickett DM, Warner JR, Andersen MW, Badiang JG, Cowan DJ, Gaul MD, Petrov KG, Rabinowitz MH, Wiethe RW, Becherer JD,

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Combinatorial chemistry & high throughput screening 8(4):327-39, 2005 Jun - Who cited this? | PubMed ID: 16101009 | Fulltext

Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

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Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, and Becherer JD

Combinatorial chemistry & high throughput screening 8(2):161-71, 2005 Mar - Who cited this? | PubMed ID: 15777180 | Fulltext

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

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Weskamp G, Schlöndorff J, Lum L, Becherer JD, Kim TW, Saftig P, Hartmann D, Murphy G, and Blobel CP

The Journal of biological chemistry 279(6):4241-9, 2004 Feb 6 - Who cited this? | PubMed ID: 14638693 | Fulltext

CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.

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Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, Laethem R,

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Drug metabolism and disposition: the biological fate of chemicals 31(7):870-7, 2003 Jul - Who cited this? | PubMed ID: 12814963 | Fulltext

Catalytic properties of ADAM19.

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Chesneau V, Becherer JD, Zheng Y, Erdjument-Bromage H, Tempst P, and Blobel CP

The Journal of biological chemistry 278(25):22331-40, 2003 Jun 20 - Who cited this? | PubMed ID: 12682046 | Fulltext

Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs).

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Becherer JD and Blobel CP

Current topics in developmental biology 54:101-23, 2003 - Who cited this? | PubMed ID: 12696747 | Fulltext

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.

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Amour A, Knight CG, English WR, Webster A, Slocombe PM, Knäuper V, Docherty AJ, Becherer JD, Blobel CP, and Murphy G

FEBS letters 524(1-3):154-8, 2002 Jul 31 - Who cited this? | PubMed ID: 12135759 | Fulltext

The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity.

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Mohan MJ, Seaton T, Mitchell J, Howe A, Blackburn K, Burkhart W, Moyer M, Patel I, Waitt GM, Becherer JD, Moss ML, and Milla ME

Biochemistry 41(30):9462-9, 2002 Jul 30 - Who cited this? | PubMed ID: 12135369 | Fulltext

The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3.

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Lee MH, Verma V, Maskos K, Becherer JD, Knäuper V, Dodds P, Amour A, and Murphy G

FEBS letters 520(1-3):102-6, 2002 Jun 5 - Who cited this? | PubMed ID: 12044879 | Fulltext

Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.

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Xu H, Uysal KT, Becherer JD, Arner P, and Hotamisligil GS

Diabetes 51(6):1876-83, 2002 Jun - Who cited this? | PubMed ID: 12031976 | Fulltext

Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

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Rabinowitz MH, Andrews RC, Becherer JD, Bickett DM, Bubacz DG, Conway JG, Cowan DJ, Gaul M, Glennon K, Lambert MH, Leesnitzer MA, McDougald DL, Moss ML, Musso DL, and Rizzolio MC

Journal of medicinal chemistry 44(24):4252-67, 2001 Nov 22 - Who cited this? | PubMed ID: 11708926 | Fulltext

Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases.

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Conway JG, Andrews RC, Beaudet B, Bickett DM, Boncek V, Brodie TA, Clark RL, Crumrine RC, Leenitzer MA, McDougald DL, Han B, Hedeen K, Lin P, Milla M, Moss M, Pink H,

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The Journal of pharmacology and experimental therapeutics 298(3):900-8, 2001 Sep - Who cited this? | PubMed ID: 11504783 | Fulltext

N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution.

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Musso DL, Andersen MW, Andrews RC, Austin R, Beaudet EJ, Becherer JD, Bubacz DG, Bickett DM, Chan JH, Conway JG, Cowan DJ, Gaul MD, Glennon KC, Hedeen KM, Lambert MH, Leesnitzer MA,

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Bioorganic & medicinal chemistry letters 11(16):2147-51, 2001 Aug 20 - Who cited this? | PubMed ID: 11514157 | Fulltext

Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase.

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Lee MH, Knäuper V, Becherer JD, and Murphy G

Biochemical and biophysical research communications 280(3):945-50, 2001 Jan 26 - Who cited this? | PubMed ID: 11162616 | Fulltext

Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE).

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Schlöndorff J, Becherer JD, and Blobel CP

The Biochemical journal 347 Pt 1:131-8, 2000 Apr 1 - Who cited this? | PubMed ID: 10727411 | Fulltext

Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE).

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Milla ME, Leesnitzer MA, Moss ML, Clay WC, Carter HL, Miller AB, Su JL, Lambert MH, Willard DH, Sheeley DM, Kost TA, Burkhart W, Moyer M, Blackburn RK, Pahel GL, Mitchell JL,

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The Journal of biological chemistry 274(43):30563-70, 1999 Oct 22 - Who cited this? | PubMed ID: 10521439 | Fulltext

Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival.

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Lum L, Wong BR, Josien R, Becherer JD, Erdjument-Bromage H, Schlöndorff J, Tempst P, Choi Y, and Blobel CP

The Journal of biological chemistry 274(19):13613-8, 1999 May 7 - Who cited this? | PubMed ID: 10224132 | Fulltext

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.

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Roghani M, Becherer JD, Moss ML, Atherton RE, Erdjument-Bromage H, Arribas J, Blackburn RK, Weskamp G, Tempst P, and Blobel CP

The Journal of biological chemistry 274(6):3531-40, 1999 Feb 5 - Who cited this? | PubMed ID: 9920899 | Fulltext

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.

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Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G,

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Nature 385(6618):733-6, 1997 Feb 20 - Who cited this? | PubMed ID: 9034191 | Fulltext

Structural features and biochemical properties of TNF-alpha converting enzyme (TACE).

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Moss ML, Jin SL, Becherer JD, Bickett DM, Burkhart W, Chen WJ, Hassler D, Leesnitzer MT, McGeehan G, Milla M, Moyer M, Rocque W, Seaton T, Schoenen F, Warner J, and Willard D

Journal of neuroimmunology 72(2):127-9, 1997 Feb - Who cited this? | PubMed ID: 9042103 | Fulltext

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

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Sadoul R, Fernandez PA, Quiquerez AL, Martinou I, Maki M, Schröter M, Becherer JD, Irmler M, Tschopp J, and Martinou JC

The EMBO journal 15(15):3845-52, 1996 Aug 1 - Who cited this? | PubMed ID: 8670889 | Fulltext

Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component.

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Lambris JD, Lao Z, Oglesby TJ, Atkinson JP, Hack CE, and Becherer JD

Journal of immunology (Baltimore, Md. : 1950) 156(12):4821-32, 1996 Jun 15 - Who cited this? | PubMed ID: 8648130 | Fulltext

Monoclonal antibodies against human collagenase and stromelysin.

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Su JL, Becherer JD, Edwards C, Bukhart W, McGeehan GM, and Champion BR

Hybridoma 14(4):383-90, 1995 Aug - Who cited this? | PubMed ID: 8522351 | Fulltext

Granzyme A is an interleukin 1 beta-converting enzyme.

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Irmler M, Hertig S, MacDonald HR, Sadoul R, Becherer JD, Proudfoot A, Solari R, and Tschopp J

The Journal of experimental medicine 181(5):1917-22, 1995 May 1 - Who cited this? | PubMed ID: 7722467 | Fulltext

Expression of tissue inhibitor of metalloproteinases by recombinant baculovirus-infected insect cells cultured in an airlift fermentor.

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Overton LK, Patel I, Becherer JD, Chandra G, and Kost TA

Methods in molecular biology (Clifton, N.J.) 39:225-42, 1995 - Who cited this? | PubMed ID: 7620552 | Fulltext

Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor.

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McGeehan GM, Becherer JD, Bast RC, Boyer CM, Champion B, Connolly KM, Conway JG, Furdon P, Karp S, and Kidao S

Nature 370(6490):558-61, 1994 Aug 18 - Who cited this? | PubMed ID: 8052311 | Fulltext

Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B.

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Becherer JD, Alsenz J, Esparza I, Hack CE, and Lambris JD

Biochemistry 31(6):1787-94, 1992 Feb 18 - Who cited this? | PubMed ID: 1371073 | Fulltext

Phylogeny of the third component of complement, C3: analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species.

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Alsenz J, Avila D, Huemer HP, Esparza I, Becherer JD, Kinoshita T, Wang Y, Oppermann S, and Lambris JD

Developmental and comparative immunology 16(1):63-76, 1992 - Who cited this? | PubMed ID: 1535601 | Fulltext

Evidence for multiple sites of interaction in C3 for complement receptor type 2 (C3d/EBV receptor, CD21).

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Esparza I, Becherer JD, Alsenz J, De la Hera A, Lao Z, Tsoukas CD, and Lambris JD

European journal of immunology 21(11):2829-38, 1991 Nov - Who cited this? | PubMed ID: 1834472 | Fulltext

Structural and functional analysis of C3 using monoclonal antibodies.

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Alsenz J, Becherer JD, Nilsson B, and Lambris JD

Current topics in microbiology and immunology 153:235-48, 1990 - Who cited this? | PubMed ID: 1688755 | Fulltext

Molecular aspects of C3 interactions and structural/functional analysis of C3 from different species.

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Becherer JD, Alsenz J, and Lambris JD

Current topics in microbiology and immunology 153:45-72, 1990 - Who cited this? | PubMed ID: 2404697 | Fulltext

Cell surface proteins reacting with activated complement components.

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Becherer JD, Alsenz J, Servis C, Myones BL, and Lambris JD

Complement and inflammation 6(3):142-65, 1989 - Who cited this? | PubMed ID: 2526003 | Fulltext

Identification of the C3b receptor-binding domain in third component of complement.

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Becherer JD and Lambris JD

The Journal of biological chemistry 263(28):14586-91, 1988 Oct 5 - Who cited this? | PubMed ID: 2971659 | Fulltext

A discontinuous factor H binding site in the third component of complement as delineated by synthetic peptides.

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Lambris JD, Avila D, Becherer JD, and Müller-Eberhard HJ

The Journal of biological chemistry 263(24):12147-50, 1988 Aug 25 - Who cited this? | PubMed ID: 2969896 | Fulltext

A 34-amino acid peptide of the third component of complement mediates properdin binding.

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Daoudaki ME, Becherer JD, and Lambris JD

Journal of immunology (Baltimore, Md. : 1950) 140(5):1577-80, 1988 Mar 1 - Who cited this? | PubMed ID: 3279119 | Fulltext

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Papers authored by Becherer JD

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