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Papers authored by Avkiran M

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Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress?.

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Cook AR, Bardswell SC, Pretheshan S, Dighe K, Kanaganayagam GS, Jabr RI, Merkle S, Marber MS, Engelhardt S, and Avkiran M

Journal of molecular and cellular cardiology 46(2):225-33, 2009 Feb - Who cited this? | PubMed ID: 19027022 | Fulltext

Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1.

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Snabaitis AK, Cuello F, and Avkiran M

Circulation research 103(8):881-90, 2008 Oct 10 - Who cited this? | PubMed ID: 18757828 | Fulltext

Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.

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Nishino Y, Webb IG, Davidson SM, Ahmed AI, Clark JE, Jacquet S, Shah AM, Miura T, Yellon DM, Avkiran M, and Marber MS

Circulation research 103(3):307-14, 2008 Aug 1 - Who cited this? | PubMed ID: 18583716 | Fulltext

Translating molecular target into drug therapy in cardiovascular disease.

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Bril A and Avkiran M

Current opinion in pharmacology 8(2):111-3, 2008 Apr - Who cited this? | PubMed ID: 18294914 | Fulltext

Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach?.

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Avkiran M, Cook AR, and Cuello F

Current opinion in pharmacology 8(2):133-40, 2008 Apr - Who cited this? | PubMed ID: 18222727 | Fulltext

Ca2+/Calmodulin-Dependent Protein Kinase II{delta} and Protein Kinase D Overexpression Reinforce the Histone Deacetylase 5 Redistribution in Heart Failure.

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Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM, and Bers DM

Circulation research 102(6):695-702, 2008 Mar 28 - Who cited this? | PubMed ID: 18218981 | Fulltext

Blowing off acid: a new tool to study Na(+)/HCO(3)(-) co-transport.

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Avkiran M

British journal of pharmacology 153(5):844-5, 2008 Mar - Who cited this? | PubMed ID: 18204484 | Fulltext

Protein kinase d in the cardiovascular system: emerging roles in health and disease.

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Avkiran M, Rowland AJ, Cuello F, and Haworth RS

Circulation research 102(2):157-63, 2008 Feb 1 - Who cited this? | PubMed ID: 18239146 | Fulltext

Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A.

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Haworth RS, Roberts NA, Cuello F, and Avkiran M

Journal of molecular and cellular cardiology 43(6):686-95, 2007 Dec - Who cited this? | PubMed ID: 17964599 | Fulltext

Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes.

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Cuello F, Bardswell SC, Haworth RS, Yin X, Lutz S, Wieland T, Mayr M, Kentish JC, and Avkiran M

Circulation research 100(6):864-73, 2007 Mar 30 - Who cited this? | PubMed ID: 17322173 | Fulltext

Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation.

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Cuello F, Snabaitis AK, Cohen MS, Taunton J, and Avkiran M

Molecular pharmacology 71(3):799-806, 2007 Mar - Who cited this? | PubMed ID: 17142297 | Fulltext

Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes.

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Haworth RS, Dashnyam S, and Avkiran M

The Biochemical journal 399(3):493-501, 2006 Nov 1 - Who cited this? | PubMed ID: 16831126 | Fulltext

Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor.

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Bellahcene M, Jacquet S, Cao XB, Tanno M, Haworth RS, Layland J, Kabir AM, Gaestel M, Davis RJ, Flavell RA, Shah AM, Avkiran M, and Marber MS

Journal of the American College of Cardiology 48(3):545-55, 2006 Aug 1 - Who cited this? | PubMed ID: 16875982 | Fulltext

A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1.

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Snabaitis AK, D'Mello R, Dashnyam S, and Avkiran M

The Journal of biological chemistry 281(29):20252-62, 2006 Jul 21 - Who cited this? | PubMed ID: 16707501 | Fulltext

Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes.

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Roberts NA, Haworth RS, and Avkiran M

British journal of pharmacology 145(4):477-89, 2005 Jun - Who cited this? | PubMed ID: 15821757 | Fulltext

Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.

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Snabaitis AK, Muntendorf A, Wieland T, and Avkiran M

Cellular signalling 17(5):655-64, 2005 May - Who cited this? | PubMed ID: 15683740 | Fulltext

Na+/H+ exchange inhibition in hypertrophied myocardium subjected to cardioplegic arrest: an effective cardioprotective approach.

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Kevelaitis E, Qureshi AA, Mouas C, Marotte F, Kevelaitiene S, Avkiran M, and Menasché P

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 27(1):111-6, 2005 Jan - Who cited this? | PubMed ID: 15621481 | Fulltext

Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function.

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Haworth RS, Cuello F, Herron TJ, Franzen G, Kentish JC, Gautel M, and Avkiran M

Circulation research 95(11):1091, 2004 Nov 26 - Who cited this? | PubMed ID: 15514163 | Fulltext

Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70kDa ribosomal S6 kinase in cardiac myocytes?.

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Roberts NA, Marber MS, and Avkiran M

Biochemical pharmacology 68(10):1923-8, 2004 Nov 15 - Who cited this? | PubMed ID: 15476663 | Fulltext

Inhibition of the Na+/H+ exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits.

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Aker S, Snabaitis AK, Konietzka I, Van De Sand A, Böngler K, Avkiran M, Heusch G, and Schulz R

Cardiovascular research 63(2):273-82, 2004 Aug 1 - Who cited this? | PubMed ID: 15249185 | Fulltext

Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform 1, in an experimental model of cardiopulmonary bypass.

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Clements-Jewery H, Sutherland FJ, Allen MC, Tracey WR, and Avkiran M

British journal of pharmacology 142(1):57, 2004 May - Who cited this? | PubMed ID: 15037516 | Fulltext

Influence of isoprostane F2alpha-III on reflow after myocardial infarction.

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Greaves K, Dixon SR, Coker IO, Mallet AI, Avkiran M, Shattock MJ, Fejka MJ, O'Neill WW, Senior R, Redwood S, and Marber MS

European heart journal 25(10):847-53, 2004 May - Who cited this? | PubMed ID: 15140532 | Fulltext

Experimental studies on myocardial protection with intermittent cross-clamp fibrillation: additive effect of the sodium-hydrogen exchanger inhibitor, cariporide.

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Fujii M, Avkiran M, and Chambers DJ

The Annals of thoracic surgery 77(4):1398-407, 2004 Apr - Who cited this? | PubMed ID: 15063274 | Fulltext

Susceptibility to ischemia and reperfusion arrhythmias in myocardial hypertrophy: due to flow of injury current?.

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Shimada Y and Avkiran M

Japanese heart journal 44(6):989-1004, 2003 Nov - Who cited this? | PubMed ID: 14711193 | Fulltext

Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.

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Haworth RS, McCann C, Snabaitis AK, Roberts NA, and Avkiran M

The Journal of biological chemistry 278(34):31676-84, 2003 Aug 22 - Who cited this? | PubMed ID: 12791686 | Fulltext

Regulatory effects of G protein-coupled receptors on cardiac sarcolemmal Na+/H+ exchanger activity: signalling and significance.

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Avkiran M and Haworth RS

Cardiovascular research 57(4):942-52, 2003 Mar 15 - Who cited this? | PubMed ID: 12650872 | Fulltext

Basic biology and pharmacology of the cardiac sarcolemmal sodium/hydrogen exchanger.

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Avkiran M

Journal of cardiac surgery 18 Suppl 1:3-12, 2003 - Who cited this? | PubMed ID: 12691374 | Fulltext

Left and right coronary circulation in left ventricular hypertrophy: effects of angiotensin converting enzyme inhibition.

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Shimada Y and Avkiran M

Circulation journal : official journal of the Japanese Circulation Society 66(12):1168-72, 2002 Dec - Who cited this? | PubMed ID: 12499626 | Fulltext

The ERK pathway regulates Na(+)-HCO(3)(-) cotransport activity in adult rat cardiomyocytes.

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Baetz D, Haworth RS, Avkiran M, and Feuvray D

American journal of physiology. Heart and circulatory physiology 283(5), 2002 Nov - Who cited this? | PubMed ID: 12384488 | Fulltext

Inhibition of angiotensin-converting enzyme reduces susceptibility of hypertrophied rat myocardium to ventricular fibrillation.

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Shimada Y, Gunasegaram S, Yokoyama H, and Avkiran M

Circulation journal : official journal of the Japanese Circulation Society 66(11):1045-53, 2002 Nov - Who cited this? | PubMed ID: 12419938 | Fulltext

Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.

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Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, and Wieland T

Journal of molecular and cellular cardiology 34(4):441-53, 2002 Apr - Who cited this? | PubMed ID: 11991733 | Fulltext

Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects.

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Avkiran M and Marber MS

Journal of the American College of Cardiology 39(5):747-53, 2002 Mar 6 - Who cited this? | PubMed ID: 11869836 | Fulltext

Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.

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Snabaitis AK, Hearse DJ, and Avkiran M

Cardiovascular research 53(2):470-80, 2002 Feb 1 - Who cited this? | PubMed ID: 11827698 | Fulltext

Inhibition of protein kinase D by resveratrol.

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Haworth RS and Avkiran M

Biochemical pharmacology 62(12):1647-51, 2001 Dec 15 - Who cited this? | PubMed ID: 11755118 | Fulltext

Effects of moderate hypothermia on sarcolemmal Na(+)/H(+) exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes.

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Hoshino K and Avkiran M

British journal of pharmacology 134(7):1587-95, 2001 Dec - Who cited this? | PubMed ID: 11724767 | Fulltext

Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase.

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Martin JL, Avkiran M, Quinlan RA, Cohen P, and Marber MS

Circulation research 89(9):750-2, 2001 Oct 26 - Who cited this? | PubMed ID: 11679403 | Fulltext

Protection of the ischaemic myocardium by Na+/H+ exchange inhibitors: potential mechanisms of action.

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Avkiran M

Basic research in cardiology 96(4):306-11, 2001 Jul - Who cited this? | PubMed ID: 11518185 | Fulltext

Na+/H+ exchange in ischemia, reperfusion and preconditioning.

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Avkiran M, Gross G, Karmazyn M, Klein H, Murphy E, and Ytrehus K

Cardiovascular research 50(1):162-6, 2001 Apr - Who cited this? | PubMed ID: 11345942 | Fulltext

Adenosine A(1) receptor stimulation inhibits alpha(1)-adrenergic activation of the cardiac sarcolemmal Na(+)/H(+) exchanger.

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Avkiran M and Yokoyama H

British journal of pharmacology 131(4):659-62, 2000 Oct - Who cited this? | PubMed ID: 11030712 | Fulltext

Anti-arrhythmic effects of levcromakalim in the ischaemic rat heart: a dual mechanism of action?.

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Coetzee WA, Wells T, and Avkiran M

European journal of pharmacology 402(3):263-74, 2000 Aug 25 - Who cited this? | PubMed ID: 10958894 | Fulltext

Sarcolemmal Na+/H+ exchanger activity and expression in human ventricular myocardium.

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Yokoyama H, Gunasegaram S, Harding SE, and Avkiran M

Journal of the American College of Cardiology 36(2):534-40, 2000 Aug - Who cited this? | PubMed ID: 10933369 | Fulltext

Expression and activity of protein kinase D/protein kinase C mu in myocardium: evidence for alpha1-adrenergic receptor- and protein kinase C-mediated regulation.

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Haworth RS, Goss MW, Rozengurt E, and Avkiran M

Journal of molecular and cellular cardiology 32(6):1013-23, 2000 Jun - Who cited this? | PubMed ID: 10888254 | Fulltext

Roles of mitogen-activated protein kinases and protein kinase C in alpha(1A)-adrenoceptor-mediated stimulation of the sarcolemmal Na(+)-H(+) exchanger.

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Snabaitis AK, Yokoyama H, and Avkiran M

Circulation research 86(2):214-20, 2000 Feb 4 - Who cited this? | PubMed ID: 10666418 | Fulltext

Protein kinase D inhibits plasma membrane Na(+)/H(+) exchanger activity.

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Haworth RS, Sinnett-Smith J, Rozengurt E, and Avkiran M

The American journal of physiology 277(6 Pt 1):C1202-9, 1999 Dec - Who cited this? | PubMed ID: 10600772 | Fulltext

Regulation of sarcolemmal Na(+)/H(+) exchanger activity by angiotensin II in adult rat ventricular myocytes: opposing actions via AT(1) versus AT(2) receptors.

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Gunasegaram S, Haworth RS, Hearse DJ, and Avkiran M

Circulation research 85(10):919-30, 1999 Nov 12 - Who cited this? | PubMed ID: 10559139 | Fulltext

The acid test: Na+/H+ exchange and its inhibitors in acute myocardial ischaemia.

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Avkiran M

European heart journal 20(14):995-6, 1999 Jul - Who cited this? | PubMed ID: 10381850 | Fulltext

Regulation of cardiac sarcolemmal Na+/H+ exchanger activity: potential pathophysiological significance of endogenous mediators and oxidant stress.

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Avkiran M and Snabaitis AK

Journal of thrombosis and thrombolysis 8(1):25-32, 1999 Jul - Who cited this? | PubMed ID: 10481211 | Fulltext

Regulation of cardiac sarcolemmal Na+/H+ exchanger activity by endogenous ligands. Relevance to ischemia.

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Avkiran M and Haworth RS

Annals of the New York Academy of Sciences 874:335-45, 1999 Jun 30 - Who cited this? | PubMed ID: 10415545 | Fulltext

Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia.

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Avkiran M

The American journal of cardiology 83(10A):10G-17G; discussion 17G-18G, 1999 May 20 - Who cited this? | PubMed ID: 10482175 | Fulltext

Protection of the myocardium during ischemia and reperfusion : Na(+)/H(+) exchange inhibition versus ischemic preconditioning.

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Avkiran M

Circulation 100(25):2469-72, 1999 - Who cited this? | PubMed ID: 10604882 | Fulltext

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