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Papers authored by Auwerx J

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The Phthalocyanine Prototype Derivative Alcian Blue Is the First Synthetic Agent with Selective Anti-Human Immunodeficiency Virus Activity Due to Its gp120 Glycan-Binding Potential.

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François KO, Pannecouque C, Auwerx J, Lozano V, Pérez-Pérez MJ, Schols D, and Balzarini J

Antimicrobial agents and chemotherapy 53(11):4852-9, 2009 Nov - Who cited this? | PubMed ID: 19721061 | Fulltext

TGR5-mediated bile acid sensing controls glucose homeostasis.

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Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, and Schoonjans K

Cell metabolism 10(3):167-77, 2009 Sep - Who cited this? | PubMed ID: 19723493 | Fulltext

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.

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Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, and Goldfine AB

Obesity (Silver Spring, Md.) 17(9):1671-7, 2009 Sep - Who cited this? | PubMed ID: 19360006 | Fulltext

Caloric restriction, SIRT1 and longevity.

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Cantó C and Auwerx J

Trends in endocrinology and metabolism: TEM 20(7):325-31, 2009 Sep - Who cited this? | PubMed ID: 19713122 | Fulltext

The role of sirtuins in the control of metabolic homeostasis.

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Yu J and Auwerx J

Annals of the New York Academy of Sciences 1173 Suppl 1:E10-9, 2009 Sep - Who cited this? | PubMed ID: 19751409 | Fulltext

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.

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Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring HU, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, and Auwerx J

PLoS genetics 5(8):e1000591, 2009 Aug - Who cited this? | PubMed ID: 19662162 | Fulltext

Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions.

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Auwerx J, François KO, Vanstreels E, Van Laethem K, Daelemans D, Schols D, and Balzarini J

Antiviral research 83(1):61-70, 2009 Jul - Who cited this? | PubMed ID: 19514109 | Fulltext

mTOR complex 2 in adipose tissue negatively controls whole-body growth.

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Cybulski N, Polak P, Auwerx J, Rüegg MA, and Hall MN

Proceedings of the National Academy of Sciences of the United States of America 106(24):9902-7, 2009 Jun 16 - Who cited this? | PubMed ID: 19497867 | Fulltext

Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication.

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Auwerx J, Isacsson O, Söderlund J, Balzarini J, Johansson M, and Lundberg M

The international journal of biochemistry & cell biology 41(6):1269-75, 2009 Jun - Who cited this? | PubMed ID: 19038358 | Fulltext

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

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Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, and Auwerx J

Nature 458(7241):1056-60, 2009 Apr 23 - Who cited this? | PubMed ID: 19262508 | Fulltext

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure.

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Cantó C and Auwerx J

Current opinion in lipidology 20(2):98-105, 2009 Apr - Who cited this? | PubMed ID: 19276888 | Fulltext

The Pro12Ala PPARgamma2 Variant Determines Metabolism at the Gene-Environment Interface.

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Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy MF, Dali-Youcef N, Schadt EE, Laakso M, and Auwerx J

Cell metabolism 9(1):88-98, 2009 Jan 7 - Who cited this? | PubMed ID: 19117549 | Fulltext

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.

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Terrand J, Bruban V, Zhou L, Gong W, El Asmar Z, May P, Zurhove K, Hafner P, Philippe C, Woldt E, Matz RL, Gracia C, Metzger D, Auwerx J, Herz J, and Boucher P

The Journal of biological chemistry, 2008 Nov 6 - Who cited this? | PubMed ID: 18990694 | Fulltext

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

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Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, and Auwerx J

Proceedings of the National Academy of Sciences of the United States of America 105(44):17187-92, 2008 Nov 4 - Who cited this? | PubMed ID: 18957541 | Fulltext

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation.

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Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, and Auwerx J

Cell metabolism 8(5):347-58, 2008 Nov - Who cited this? | PubMed ID: 19046567 | Fulltext

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration.

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Polak P, Cybulski N, Feige JN, Auwerx J, Rüegg MA, and Hall MN

Cell metabolism 8(5):399-410, 2008 Nov - Who cited this? | PubMed ID: 19046571 | Fulltext

Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention.

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Auwerx J, François KO, Covens K, Van Laethem K, and Balzarini J

Virology, 2008 Oct 17 - Who cited this? | PubMed ID: 18930512 | Fulltext

Dietary manipulation of mouse metabolism.

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Feige JN, Lagouge M, and Auwerx J

Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] Chapter 29:Unit29B.5, 2008 Oct - Who cited this? | PubMed ID: 18972384 | Fulltext

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.

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Mandillo S, Tucci V, Hölter SM, Meziane H, Banchaabouchi MA, Kallnik M, Lad HV, Nolan PM, Ouagazzal AM, Coghill EL, Gale K, Golini E, Jacquot S, Krezel W, Parker A, Riet F,

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Physiological genomics 34(3):243-55, 2008 Aug 15 - Who cited this? | PubMed ID: 18505770 | Fulltext

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships, and Molecular Modeling Studies.

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Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, and Auwerx J

Journal of medicinal chemistry 51(15):4849, 2008 Aug 14 - Who cited this? | PubMed ID: 18610994 | Fulltext

Molecular Field Analysis and 3D-Quantitative Structure-Activity Relationship Study (MFA 3D-QSAR) Unveil Novel Features of Bile Acid Recognition at TGR5.

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Macchiarulo A, Gioiello A, Thomas C, Massarotti A, Nuti R, Rosatelli E, Sabbatini P, Schoonjans K, Auwerx J, and Pellicciari R

Journal of chemical information and modeling, 2008 Aug 13 - Who cited this? | PubMed ID: 18698841 | Fulltext

Targeting bile-acid signalling for metabolic diseases.

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Thomas C, Pellicciari R, Pruzanski M, Auwerx J, and Schoonjans K

Nature reviews. Drug discovery 7(8):678, 2008 Aug - Who cited this? | PubMed ID: 18670431 | Fulltext

Simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of HIV: implications for further preclinical drug development.

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François KO, Auwerx J, Schols D, and Balzarini J

Molecular pharmacology 74(2):330, 2008 Aug - Who cited this? | PubMed ID: 18474667 | Fulltext

Liver receptor homolog 1 is essential for ovulation.

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Duggavathi R, Volle DH, Mataki C, Antal MC, Messaddeq N, Auwerx J, Murphy BD, and Schoonjans K

Genes & development 22(14):1871-6, 2008 Jul 15 - Who cited this? | PubMed ID: 18628394 | Fulltext

Glucose restriction: longevity SIRTainly, but without building muscle?.

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Cantó C and Auwerx J

Developmental cell 14(5):642, 2008 May - Who cited this? | PubMed ID: 18477447 | Fulltext

Genetic background determines metabolic phenotypes in the mouse.

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Champy MF, Selloum M, Zeitler V, Caradec C, Jung B, Rousseau S, Pouilly L, Sorg T, and Auwerx J

Mammalian genome : official journal of the International Mammalian Genome Society 19(5):318-31, 2008 May - Who cited this? | PubMed ID: 18392653 | Fulltext

IL-13 attenuates gastrointestinal candidiasis in normal and immunodeficient RAG-2(-/-) mice via peroxisome proliferator-activated receptor-gamma activation.

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Coste A, Lagane C, Filipe C, Authier H, Galès A, Bernad J, Douin-Echinard V, Lepert JC, Balard P, Linas MD, Arnal JF, Auwerx J, and Pipy B

Journal of immunology (Baltimore, Md. : 1950) 180(7):4939-47, 2008 Apr 1 - Who cited this? | PubMed ID: 18354219 | Fulltext

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships, and Molecular Modeling Studies.

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Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, and Auwerx J

Journal of medicinal chemistry 51(6):1831-41, 2008 Mar 27 - Who cited this? | PubMed ID: 18307294 | Fulltext

Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate.

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Delayre-Orthez C, Becker J, Auwerx J, Frossard N, and Pons F

European journal of pharmacology 581(1-2):177-84, 2008 Feb 26 - Who cited this? | PubMed ID: 18096152 | Fulltext

Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism.

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Thomas C, Auwerx J, and Schoonjans K

Thyroid : official journal of the American Thyroid Association 18(2):167, 2008 Feb - Who cited this? | PubMed ID: 18279017 | Fulltext

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer.

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Bai P, Houten SM, Huber A, Schreiber V, Watanabe M, Kiss B, de Murcia G, Auwerx J, and Ménissier-de Murcia J

The Journal of biological chemistry 282(52):37738, 2007 Dec 28 - Who cited this? | PubMed ID: 17951580 | Fulltext

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

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Mataki C, Magnier BC, Houten SM, Annicotte JS, Argmann C, Thomas C, Overmars H, Kulik W, Metzger D, Auwerx J, and Schoonjans K

Molecular and cellular biology 27(23):8330-9, 2007 Dec - Who cited this? | PubMed ID: 17908794 | Fulltext

Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea.

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Sato H, Genet C, Strehle A, Thomas C, Lobstein A, Wagner A, Mioskowski C, Auwerx J, and Saladin R

Biochemical and biophysical research communications 362(4):793-8, 2007 Nov 3 - Who cited this? | PubMed ID: 17825251 | Fulltext

DisSIRTing on LXR and cholesterol metabolism.

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Feige JN and Auwerx J

Cell metabolism 6(5):343-5, 2007 Nov - Who cited this? | PubMed ID: 17983578 | Fulltext

Systematic gene expression mapping clusters nuclear receptors according to their function in the brain.

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Gofflot F, Chartoire N, Vasseur L, Heikkinen S, Dembele D, Le Merrer J, and Auwerx J

Cell 131(2):405-18, 2007 Oct 19 - Who cited this? | PubMed ID: 17956739 | Fulltext

[SIRT1/PGC-1: a neuroprotective axis?].

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Rasouri S, Lagouge M, and Auwerx J

Médecine sciences : M/S 23(10):840-4, 2007 Oct - Who cited this? | PubMed ID: 17937892 | Fulltext

Tissue collection for systematic phenotyping in the mouse.

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Antal C, Teletin M, Wendling O, Dgheem M, Auwerx J, and Mark M

Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] Chapter 29:Unit29A.4, 2007 Oct - Who cited this? | PubMed ID: 18265401 | Fulltext

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

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Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, and Auwerx J

Journal of medicinal chemistry 50(18):4265-8, 2007 Sep 6 - Who cited this? | PubMed ID: 17685603 | Fulltext

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.

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Coste A, Dubuquoy L, Barnouin R, Annicotte JS, Magnier B, Notti M, Corazza N, Antal MC, Metzger D, Desreumaux P, Brunner T, Auwerx J, and Schoonjans K

Proceedings of the National Academy of Sciences of the United States of America 104(32):13098-103, 2007 Aug 7 - Who cited this? | PubMed ID: 17670946 | Fulltext

Sirtuin functions in health and disease.

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Yamamoto H, Schoonjans K, and Auwerx J

Molecular endocrinology (Baltimore, Md.) 21(8):1745-55, 2007 Aug - Who cited this? | PubMed ID: 17456799 | Fulltext

PPARgamma in human and mouse physiology.

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Heikkinen S, Auwerx J, and Argmann CA

Biochimica et biophysica acta 1771(8):999-1013, 2007 Aug - Who cited this? | PubMed ID: 17475546 | Fulltext

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.

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Dali-Youcef N, Mataki C, Coste A, Messaddeq N, Giroud S, Blanc S, Koehl C, Champy MF, Chambon P, Fajas L, Metzger D, Schoonjans K, and Auwerx J

Proceedings of the National Academy of Sciences of the United States of America 104(25):10703-8, 2007 Jun 19 - Who cited this? | PubMed ID: 17556545 | Fulltext

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

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Berry A, Balard P, Coste A, Olagnier D, Lagane C, Authier H, Benoit-Vical F, Lepert JC, Séguéla JP, Magnaval JF, Chambon P, Metzger D, Desvergne B, Wahli W, Auwerx J, and Pipy B

European journal of immunology 37(6):1642, 2007 Jun - Who cited this? | PubMed ID: 17458857 | Fulltext

Transcriptional coregulators in the control of energy homeostasis.

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Feige JN and Auwerx J

Trends in cell biology 17(6):292, 2007 Jun - Who cited this? | PubMed ID: 17475497 | Fulltext

In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.

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Houten SM, Volle DH, Cummins CL, Mangelsdorf DJ, and Auwerx J

Molecular endocrinology (Baltimore, Md.) 21(6):1312-23, 2007 Jun - Who cited this? | PubMed ID: 17426284 | Fulltext

Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function.

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Dubrac S, Stoitzner P, Pirkebner D, Elentner A, Schoonjans K, Auwerx J, Saeland S, Hengster P, Fritsch P, Romani N, and Schmuth M

Journal of immunology (Baltimore, Md. : 1950) 178(7):4362-72, 2007 Apr 1 - Who cited this? | PubMed ID: 17371993 | Fulltext

Histopathology in mouse metabolic investigations.

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Mark M, Teletin M, Antal C, Wendling O, Auwerx J, Heikkinen S, Khetchoumian K, Argmann CA, and Dgheem M

Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] Chapter 29:Unit29B.4, 2007 Apr - Who cited this? | PubMed ID: 18265402 | Fulltext

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.

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Volle DH, Duggavathi R, Magnier BC, Houten SM, Cummins CL, Lobaccaro JM, Verhoeven G, Schoonjans K, and Auwerx J

Genes & development 21(3):303, 2007 Feb 1 - Who cited this? | PubMed ID: 17289919 | Fulltext

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome.

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Boucher P, Li WP, Matz RL, Takayama Y, Auwerx J, Anderson RG, and Herz J

PLoS ONE 2(5), 2007 - Who cited this? | PubMed ID: 17505534 | Fulltext

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects.

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Grarup N, Andersen MK, Andreasen CH, Albrechtsen A, Borch-Johnsen K, Jørgensen T, Auwerx J, Schmitz O, Hansen T, and Pedersen O

The Journal of clinical endocrinology and metabolism 92(1):363-6, 2007 Jan - Who cited this? | PubMed ID: 17077128 | Fulltext

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