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Papers authored by Aplan PD

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Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.

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Caudell D, Harper DP, Novak RL, Pierce RM, Slape C, Wolff L, and Aplan PD

Blood 115(6):1194-203, 2010 Feb 11 - Who cited this? | PubMed ID: 20007546 | Fulltext

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.

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Lin YW, Beharry ZM, Hill EG, Song JH, Wang W, Xia Z, Zhang Z, Aplan PD, Aster JC, Smith CD, and Kraft AS

Blood 115(4):824-33, 2010 Jan 28 - Who cited this? | PubMed ID: 19965690 | Fulltext

Efficient repair of DNA double-strand breaks in malignant cells with structural instability.

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Cheng Y, Zhang Z, Keenan B, Roschke AV, Nakahara K, and Aplan PD

Mutation research 683(1-2):115-22, 2010 Jan 5 - Who cited this? | PubMed ID: 19909760 | Fulltext

A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement.

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Choi CW, Chung YJ, Slape C, and Aplan PD

Journal of immunology (Baltimore, Md. : 1950) 183(10):6227-35, 2009 Nov 15 - Who cited this? | PubMed ID: 19841179 | Fulltext

Cytogenetics and molecular genetics of acute lymphoblastic leukemia.

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Mrózek K, Harper DP, and Aplan PD

Hematology/oncology clinics of North America 23(5):991-1010, 2009 Oct - Who cited this? | PubMed ID: 19825449 | Fulltext

Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.

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Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, and Blackshear PJ

Blood 114(12):2401-10, 2009 Sep 17 - Who cited this? | PubMed ID: 19633199 | Fulltext

Chromosomal Rearrangements Leading to MLL Gene Fusions: Clinical and Biological Aspects.

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Harper DP and Aplan PD

Cancer research 68(24):10024-7, 2008 Dec 15 - Who cited this? | PubMed ID: 19074864 | Fulltext

Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell.

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Chung YJ, Choi CW, Slape C, Fry T, and Aplan PD

Proceedings of the National Academy of Sciences of the United States of America 105(37):14088, 2008 Sep 16 - Who cited this? | PubMed ID: 18768819 | Fulltext

The mitotic checkpoint gene, SIL is regulated by E2F1.

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Erez A, Chaussepied M, Castiel A, Colaizzo-Anas T, Aplan PD, Ginsberg D, and Izraeli S

International journal of cancer. Journal international du cancer, 2008 Jul 22 - Who cited this? | PubMed ID: 18649360 | Fulltext

Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome.

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Choi CW, Chung YJ, Slape C, and Aplan PD

Haematologica, 2008 Jul 4 - Who cited this? | PubMed ID: 18603548 | Fulltext

Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.

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Slape C, Liu LY, Beachy S, and Aplan PD

Blood, 2008 Jun 19 - Who cited this? | PubMed ID: 18566322 | Fulltext

The role of CALM-AF10 gene fusion in acute leukemia.

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Caudell D and Aplan PD

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 22(4):678, 2008 Apr - Who cited this? | PubMed ID: 18094714 | Fulltext

NUP98-HOX Translocations Lead to Myelodysplastic Syndrome in Mice and Men.

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Slape C, Lin YW, Hartung H, Zhang Z, Wolff L, and Aplan PD

Journal of the National Cancer Institute. Monographs(39):64, 2008 - Who cited this? | PubMed ID: 18648006 | Fulltext

p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.

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Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, and Regnault A

Blood 110(7):2610-9, 2007 Oct 1 - Who cited this? | PubMed ID: 17507663 | Fulltext

Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice.

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Caudell D, Zhang Z, Chung YJ, and Aplan PD

Cancer research 67(17):8022, 2007 Sep 1 - Who cited this? | PubMed ID: 17804713 | Fulltext

Gene expression profiling of precursor T-cell lymphoblastic leukemia/lymphoma identifies oncogenic pathways that are potential therapeutic targets.

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Lin YW and Aplan PD

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 21(6):1276, 2007 Jun - Who cited this? | PubMed ID: 17429429 | Fulltext

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

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Slape C, Chung YJ, Soloway PD, Tessarollo L, and Aplan PD

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 21(6):1239, 2007 Jun - Who cited this? | PubMed ID: 17377591 | Fulltext

Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.

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Slape C, Hartung H, Lin YW, Bies J, Wolff L, and Aplan PD

Cancer research 67(11):5148-55, 2007 Jun 1 - Who cited this? | PubMed ID: 17545593 | Fulltext

Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.

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Cheng Y, Zhang Z, Slape C, and Aplan PD

Neoplasia (New York, N.Y.) 9(4):315, 2007 Apr - Who cited this? | PubMed ID: 17460775 | Fulltext

The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute myeloid leukemia in children: an evidence-based review.

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Oliansky DM, Rizzo JD, Aplan PD, Arceci RJ, Leone L, Ravindranath Y, Sanders JE, Smith FO, Wilmot F, McCarthy PL, and Hahn T

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 13(1):1-25, 2007 Jan - Who cited this? | PubMed ID: 17222748 | Fulltext

Chromosomal translocations involving the MLL gene: molecular mechanisms.

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Aplan PD

DNA repair 5(9-10):1265-72, 2006 Sep 8 - Who cited this? | PubMed ID: 16797254 | Fulltext

Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma.

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Lin YW, Nichols RA, Letterio JJ, and Aplan PD

Blood 107(6):2540-3, 2006 Mar 15 - Who cited this? | PubMed ID: 16282337 | Fulltext

Causes of oncogenic chromosomal translocation.

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Aplan PD

Trends in genetics : TIG 22(1):46-55, 2006 Jan - Who cited this? | PubMed ID: 16257470 | Fulltext

Chromosomal aberrations induced by double strand DNA breaks.

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Varga T and Aplan PD

DNA repair 4(9):1038-46, 2005 Aug 15 - Who cited this? | PubMed ID: 15935739 | Fulltext

OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.

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Lin YW, Deveney R, Barbara M, Iscove NN, Nimer SD, Slape C, and Aplan PD

Cancer research 65(16):7151-8, 2005 Aug 15 - Who cited this? | PubMed ID: 16103065 | Fulltext

NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia.

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Lin YW, Slape C, Zhang Z, and Aplan PD

Blood 106(1):287-95, 2005 Jul 1 - Who cited this? | PubMed ID: 15755899 | Fulltext

"You break it, you fix it.".

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Aplan PD

Blood 105(5):1843-4, 2005 Mar 1 - Who cited this? | PubMed ID: 15747400 | Fulltext

NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation.

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Gurevich RM, Aplan PD, and Humphries RK

Blood 104(4):1127-36, 2004 Aug 15 - Who cited this? | PubMed ID: 15100157 | Fulltext

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

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Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE, Byfield S, Felici A, Flanders KC, Walz TM, Roberts AB, Aplan PD, Balis FM, and Letterio JJ

The New England journal of medicine 351(6):552-9, 2004 Aug 5 - Who cited this? | PubMed ID: 15295048 | Fulltext

The role of NUP98 gene fusions in hematologic malignancy.

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Slape C and Aplan PD

Leukemia & lymphoma 45(7):1341-50, 2004 Jul - Who cited this? | PubMed ID: 15359631 | Fulltext

Distinct mechanisms lead to HPRT gene mutations in leukemic cells.

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Lin YW, Perkins JJ, Zhang Z, and Aplan PD

Genes, chromosomes & cancer 39(4):311-23, 2004 Apr - Who cited this? | PubMed ID: 14978792 | Fulltext

Leukemic transformation.

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Lin YW and Aplan PD

Cancer biology & therapy 3(1):13-20, 2004 Jan - Who cited this? | PubMed ID: 14726677 | Fulltext

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

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Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, and Magli MC

Proceedings of the National Academy of Sciences of the United States of America 100(18):10299-303, 2003 Sep 2 - Who cited this? | PubMed ID: 12934017 | Fulltext

Insertion of MLL sequences into chromosome band 5q31 results in an MLL-AF5Q31 fusion and is a rare but recurrent abnormality associated with infant leukemia.

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Deveney R, Chervinsky DS, Jani-Sait SN, Grossi M, and Aplan PD

Genes, chromosomes & cancer 37(3):326-31, 2003 Jul - Who cited this? | PubMed ID: 12759932 | Fulltext

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.

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Pineault N, Buske C, Feuring-Buske M, Abramovich C, Rosten P, Hogge DE, Aplan PD, and Humphries RK

Blood 101(11):4529-38, 2003 Jun 1 - Who cited this? | PubMed ID: 12543865 | Fulltext

Cloning and characterization of the SIL promoter.

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Colaizzo-Anas T and Aplan PD

Biochimica et biophysica acta 1625(2):207-13, 2003 Jan 27 - Who cited this? | PubMed ID: 12531481 | Fulltext

The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells.

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Ramage JG, Vallera DA, Black JH, Aplan PD, Kees UR, and Frankel AE

Leukemia research 27(1):79-84, 2003 Jan - Who cited this? | PubMed ID: 12479856 | Fulltext

Gradient of E2A activity in B-cell development.

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Herblot S, Aplan PD, and Hoang T

Molecular and cellular biology 22(3):886-900, 2002 Feb - Who cited this? | PubMed ID: 11784864 | Fulltext

NUP98 gene fusions in hematologic malignancies.

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Lam DH and Aplan PD

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 15(11):1689-95, 2001 Nov - Who cited this? | PubMed ID: 11681408 | Fulltext

Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context.

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Stanulla M, Chhalliyil P, Wang J, Jani-Sait SN, and Aplan PD

Human molecular genetics 10(22):2481-91, 2001 Oct 15 - Who cited this? | PubMed ID: 11709535 | Fulltext

scid Thymocytes with TCRbeta gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes.

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Chervinsky DS, Lam DH, Melman MP, Gross KW, and Aplan PD

Cancer research 61(17):6382-7, 2001 Sep 1 - Who cited this? | PubMed ID: 11522630 | Fulltext

A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

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Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K, Cross NC, Cheng JF, Aplan PD, Kearney L, Boultwood J, and Wainscoat JS

Blood 98(4):1264-7, 2001 Aug 15 - Who cited this? | PubMed ID: 11493482 | Fulltext

Characterization of DNA fragmentation events caused by genotoxic and non-genotoxic agents.

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Ploski JE and Aplan PD

Mutation research 473(2):169-80, 2001 Feb 20 - Who cited this? | PubMed ID: 11166035 | Fulltext

Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice.

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Chervinsky DS, Lam DH, Zhao XF, Melman MP, and Aplan PD

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 15(1):141-7, 2001 Jan - Who cited this? | PubMed ID: 11243382 | Fulltext

t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).

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Ahuja HG, Hong J, Aplan PD, Tcheurekdjian L, Forman SJ, and Slovak ML

Cancer research 60(22):6227-9, 2000 Nov 15 - Who cited this? | PubMed ID: 11103774 | Fulltext

Short-term storage of blood samples and DNA isolation in serum separator tubes for application in epidemiological studies and clinical research.

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Schünemann HJ, Stanulla M, Trevisan M, Aplan PD, Freudenheim JL, and Muti P

Annals of epidemiology 10(8):538-44, 2000 Nov - Who cited this? | PubMed ID: 11118934 | Fulltext

Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations.

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Ahuja HG, Felix CA, and Aplan PD

Genes, chromosomes & cancer 29(2):96, 2000 Oct - Who cited this? | PubMed ID: 10959088 | Fulltext

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression.

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Herblot S, Steff AM, Hugo P, Aplan PD, and Hoang T

Nature immunology 1(2):138-44, 2000 Aug - Who cited this? | PubMed ID: 11248806 | Fulltext

The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.

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Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, and Aplan PD

Proceedings of the National Academy of Sciences of the United States of America 97(7):3497-502, 2000 Mar 28 - Who cited this? | PubMed ID: 10737801 | Fulltext

MAGOH interacts with a novel RNA-binding protein.

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Zhao XF, Nowak NJ, Shows TB, and Aplan PD

Genomics 63(1):145-8, 2000 Jan 1 - Who cited this? | PubMed ID: 10662555 | Fulltext

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