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Papers authored by Alnemri ES

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Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

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Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM,

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Cell death and differentiation 16(8):1093-107, 2009 Aug - Who cited this? | PubMed ID: 19373242 | Fulltext

THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

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Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, and Zervos AS

American journal of physiology. Heart and circulatory physiology 297(2):H643-53, 2009 Aug - Who cited this? | PubMed ID: 19502560 | Fulltext

Cutting Edge: NF-{kappa}B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression.

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Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, Macdonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, and Latz E

Journal of immunology (Baltimore, Md. : 1950) 183(2):787-91, 2009 Jul 15 - Who cited this? | PubMed ID: 19570822 | Fulltext

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.

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Fernandes-Alnemri T, Yu JW, Datta P, Wu J, and Alnemri ES

Nature 458(7237):509-13, 2009 Mar 26 - Who cited this? | PubMed ID: 19158676 | Fulltext

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.

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Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G,

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Cell death and differentiation 16(1):3-11, 2009 Jan - Who cited this? | PubMed ID: 18846107 | Fulltext

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.

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Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, and Rajalingam K

Nature cell biology 11(1):110, 2009 Jan - Who cited this? | PubMed ID: 19122597 | Fulltext

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.

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Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, and Rajalingam K

Nature cell biology 10(12):1447-55, 2008 Dec - Who cited this? | PubMed ID: 19011619 | Fulltext

The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.

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Khan FS, Fujioka M, Datta P, Fernandes-Alnemri T, Jaynes JB, and Alnemri ES

Cell death and differentiation 15(6):1073, 2008 Jun - Who cited this? | PubMed ID: 18259196 | Fulltext

The NLR gene family: a standard nomenclature.

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Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, MacKenzie A, Maltais LJ, Nunez G,

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Immunity 28(3):285, 2008 Mar - Who cited this? | PubMed ID: 18341998 | Fulltext

Mutations in NALP12 cause hereditary periodic fever syndromes.

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Jéru I, Duquesnoy P, Fernandes-Alnemri T, Cochet E, Yu JW, Lackmy-Port-Lis M, Grimprel E, Landman-Parker J, Hentgen V, Marlin S, McElreavey K, Sarkisian T, Grateau G, Alnemri ES, and Amselem S

Proceedings of the National Academy of Sciences of the United States of America 105(5):1614, 2008 Feb 5 - Who cited this? | PubMed ID: 18230725 | Fulltext

Chapter Thirteen Assembly, Purification, and Assay of the Activity of the ASC Pyroptosome.

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Fernandes-Alnemri T and Alnemri ES

Methods in enzymology 442:251-70, 2008 - Who cited this? | PubMed ID: 18662574 | Fulltext

HtrA2 and Parkinson's disease: think PINK?.

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Alnemri ES

Nature cell biology 9(11):1227, 2007 Nov - Who cited this? | PubMed ID: 17975547 | Fulltext

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.

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Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, and Alnemri ES

Molecular cell 28(2):214, 2007 Oct 26 - Who cited this? | PubMed ID: 17964261 | Fulltext

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.

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Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J, and Alnemri ES

Cell death and differentiation 14(9):1590-604, 2007 Sep - Who cited this? | PubMed ID: 17599095 | Fulltext

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

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Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J, Fernandes-Alnemri T, and Alnemri ES

Cell death and differentiation 13(2):236, 2006 Feb - Who cited this? | PubMed ID: 16037825 | Fulltext

Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.

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Cilenti L, Kyriazis GA, Soundarapandian MM, Stratico V, Yerkes A, Park KM, Sheridan AM, Alnemri ES, Bonventre JV, and Zervos AS

American journal of physiology. Renal physiology 288(2):F371-9, 2005 Feb - Who cited this? | PubMed ID: 15454391 | Fulltext

Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.

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Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, and Ma XL

Circulation 111(1):90-6, 2005 Jan 4 - Who cited this? | PubMed ID: 15611365 | Fulltext

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.

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Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, Gupta S, Bonventre JV, Alnemri ES, and Zervos AS

The Journal of biological chemistry 279(48):50295-301, 2004 Nov 26 - Who cited this? | PubMed ID: 15371414 | Fulltext

The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.

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Gupta S, Singh R, Datta P, Zhang Z, Orr C, Lu Z, Dubois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, and Alnemri ES

The Journal of biological chemistry 279(44):45844-54, 2004 Oct 29 - Who cited this? | PubMed ID: 15294909 | Fulltext

Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils.

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Blink E, Maianski NA, Alnemri ES, Zervos AS, Roos D, and Kuijpers TW

Cell death and differentiation 11(8):937-9, 2004 Aug - Who cited this? | PubMed ID: 15044964 | Fulltext

Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.

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Guo Y, Cheong N, Zhang Z, De Rose R, Deng Y, Farber SA, Fernandes-Alnemri T, and Alnemri ES

The Journal of biological chemistry 279(23):24813-25, 2004 Jun 4 - Who cited this? | PubMed ID: 15044455 | Fulltext

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.

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Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, and Nicholson DW

Nature 429(6987):75-9, 2004 May 6 - Who cited this? | PubMed ID: 15129283 | Fulltext

Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis.

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Maianski NA, Geissler J, Srinivasula SM, Alnemri ES, Roos D, and Kuijpers TW

Cell death and differentiation 11(2):143-53, 2004 Feb - Who cited this? | PubMed ID: 14576767 | Fulltext

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.

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Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, and Alnemri ES

Nature 425(6959):721, 2003 Oct 16 - Who cited this? | PubMed ID: 14534547 | Fulltext

The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.

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Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, and Alnemri ES

The Journal of biological chemistry 278(40):38699-706, 2003 Oct 3 - Who cited this? | PubMed ID: 12865429 | Fulltext

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.

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Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, and Alnemri ES

The Journal of biological chemistry 278(34):31469-72, 2003 Aug 22 - Who cited this? | PubMed ID: 12835328 | Fulltext

Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.

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Zeuner A, Eramo A, Testa U, Felli N, Pelosi E, Mariani G, Srinivasula SM, Alnemri ES, Condorelli G, Peschle C, and De Maria R

Cell death and differentiation 10(8):905-13, 2003 Aug - Who cited this? | PubMed ID: 12867998 | Fulltext

Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.

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Chang DW, Ditsworth D, Liu H, Srinivasula SM, Alnemri ES, and Yang X

The Journal of biological chemistry 278(19):16466-9, 2003 May 9 - Who cited this? | PubMed ID: 12637514 | Fulltext

Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.

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Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, and Srivastava RK

Cancer research 63(7):1712, 2003 Apr 1 - Who cited this? | PubMed ID: 12670926 | Fulltext

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

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Cilenti L, Lee Y, Hess S, Srinivasula S, Park KM, Junqueira D, Davis H, Bonventre JV, Alnemri ES, and Zervos AS

The Journal of biological chemistry 278(13):11489-94, 2003 Mar 28 - Who cited this? | PubMed ID: 12529364 | Fulltext

Role of Smac in human leukaemic cell apoptosis and proliferation.

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Jia L, Patwari Y, Kelsey SM, Srinivasula SM, Agrawal SG, Alnemri ES, and Newland AC

Oncogene 22(11):1589-99, 2003 Mar 20 - Who cited this? | PubMed ID: 12642862 | Fulltext

Mechanism of XIAP-mediated inhibition of caspase-9.

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Shiozaki EN, Chai J, Rigotti DJ, Riedl SJ, Li P, Srinivasula SM, Alnemri ES, Fairman R, and Shi Y

Molecular cell 11(2):519-27, 2003 Feb - Who cited this? | PubMed ID: 12620238 | Fulltext

Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.

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Pistritto G, Jost M, Srinivasula SM, Baffa R, Poyet JL, Kari C, Lazebnik Y, Rodeck U, and Alnemri ES

Cell death and differentiation 9(9):995-1006, 2002 Sep - Who cited this? | PubMed ID: 12181750 | Fulltext

The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.

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Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, and Alnemri ES

The Journal of biological chemistry 277(24):21119-22, 2002 Jun 14 - Who cited this? | PubMed ID: 11967258 | Fulltext

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.

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Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, and Shi Y

Nature structural biology 9(6):436-41, 2002 Jun - Who cited this? | PubMed ID: 11967569 | Fulltext

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.

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Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, and Alnemri ES

The Journal of biological chemistry 277(16):13430, 2002 Apr 19 - Who cited this? | PubMed ID: 11832478 | Fulltext

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

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Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, and Alnemri ES

The Journal of biological chemistry 277(16):13952-8, 2002 Apr 19 - Who cited this? | PubMed ID: 11821383 | Fulltext

Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.

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Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, and Alnemri ES

Cell death and differentiation 9(4):439-47, 2002 Apr - Who cited this? | PubMed ID: 11965497 | Fulltext

Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.

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Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, and Hajnóczky G

The Journal of biological chemistry 277(7):5651-9, 2002 Feb 15 - Who cited this? | PubMed ID: 11741882 | Fulltext

sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.

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Srinivasula SM, Datta P, Kobayashi M, Wu JW, Fujioka M, Hegde R, Zhang Z, Mukattash R, Fernandes-Alnemri T, Shi Y, Jaynes JB, and Alnemri ES

Current biology : CB 12(2):125-30, 2002 Jan 22 - Who cited this? | PubMed ID: 11818063 | Fulltext

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.

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Hegde R, Srinivasula SM, Zhang Z, Wassell R, Mukattash R, Cilenti L, DuBois G, Lazebnik Y, Zervos AS, Fernandes-Alnemri T, and Alnemri ES

The Journal of biological chemistry 277(1):432-8, 2002 Jan 4 - Who cited this? | PubMed ID: 11606597 | Fulltext

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

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van Loo G, van Gurp M, Depuydt B, Srinivasula SM, Rodriguez I, Alnemri ES, Gevaert K, Vandekerckhove J, Declercq W, and Vandenabeele P

Cell death and differentiation 9(1):20-6, 2002 Jan - Who cited this? | PubMed ID: 11803371 | Fulltext

Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.

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Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, and Shi Y

Cell 107(3):399-407, 2001 Nov 2 - Who cited this? | PubMed ID: 11701129 | Fulltext

c-IAP1 blocks TNFalpha-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells.

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Partheniou F, Kelsey SM, Srinivasula SM, Newland AC, Alnemri ES, and Jia L

Biochemical and biophysical research communications 287(1):181-9, 2001 Sep 14 - Who cited this? | PubMed ID: 11549272 | Fulltext

Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis.

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Jia L, Patwari Y, Srinivasula SM, Newland AC, Fernandes-Alnemri T, Alnemri ES, and Kelsey SM

Oncogene 20(35):4817-26, 2001 Aug 9 - Who cited this? | PubMed ID: 11521193 | Fulltext

Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.

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Komata T, Kondo Y, Kanzawa T, Hirohata S, Koga S, Sumiyoshi H, Srinivasula SM, Barna BP, Germano IM, Takakura M, Inoue M, Alnemri ES, Shay JW, Kyo S, and Kondo S

Cancer research 61(15):5796-802, 2001 Aug 1 - Who cited this? | PubMed ID: 11479218 | Fulltext

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.

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Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, and Alnemri ES

The Journal of biological chemistry 276(30):28309-13, 2001 Jul 27 - Who cited this? | PubMed ID: 11390368 | Fulltext

Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.

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Jia L, Srinivasula SM, Liu FT, Newland AC, Fernandes-Alnemri T, Alnemri ES, and Kelsey SM

Blood 98(2):414-21, 2001 Jul 15 - Who cited this? | PubMed ID: 11435311 | Fulltext

FGF induces a switch in death receptor pathways in neuronal cells.

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Eves EM, Skoczylas C, Yoshida K, Alnemri ES, and Rosner MR

The Journal of neuroscience : the official journal of the Society for Neuroscience 21(14):4996-5006, 2001 Jul 15 - Who cited this? | PubMed ID: 11438575 | Fulltext

Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.

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Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, and Bertin J

The Journal of biological chemistry 276(24):21405-9, 2001 Jun 15 - Who cited this? | PubMed ID: 11259443 | Fulltext

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