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Papers authored by Agostinis P

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In vitro study of the photocytotoxicity of bathochromically-shifted hypericin derivatives.

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Roelants M, Lackner B, Waser M, Falk H, Agostinis P, Van Poppel H, and de Witte PA

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 8(6):822-9, 2009 Jun - Who cited this? | PubMed ID: 19492110 | Fulltext

Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response.

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Szokalska A, Makowski M, Nowis D, Wilczynski GM, Kujawa M, Wójcik C, Mlynarczuk-Bialy I, Salwa P, Bil J, Janowska S, Agostinis P, Verfaillie T, Bugajski M, Gietka J, Issat T, Glodkowska E,

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Cancer research 69(10):4235-43, 2009 May 15 - Who cited this? | PubMed ID: 19435917 | Fulltext

Autophagy in disease: a double-edged sword with therapeutic potential.

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Martinet W, Agostinis P, Vanhoecke B, Dewaele M, and de Meyer GR

Clinical science (London, England : 1979) 116(9):697-712, 2009 May - Who cited this? | PubMed ID: 19323652 | Fulltext

Cell death in the skin.

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Lippens S, Hoste E, Vandenabeele P, Agostinis P, and Declercq W

Apoptosis : an international journal on programmed cell death 14(4):549-69, 2009 Apr - Who cited this? | PubMed ID: 19221876 | Fulltext

Starting and propagating apoptotic signals in UVB irradiated keratinocytes.

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Van Laethem A, Garmyn M, and Agostinis P

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 8(3):299-308, 2009 Mar - Who cited this? | PubMed ID: 19255669 | Fulltext

Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.

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Buytaert E, Matroule JY, Durinck S, Close P, Kocanova S, Vandenheede JR, de Witte PA, Piette J, and Agostinis P

Oncogene 27(13):1916-29, 2008 Mar 20 - Who cited this? | PubMed ID: 17952126 | Fulltext

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

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Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS,

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Autophagy 4(2):151 - Who cited this? | PubMed ID: 18188003 | Fulltext

The Aryl hydrocarbon receptor: an illuminating effector of the UVB response.

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Agostinis P, Garmyn M, and Van Laethem A

Science's STKE : signal transduction knowledge environment 2007(403), 2007 Sep 11 - Who cited this? | PubMed ID: 17848686 | Fulltext

Molecular effectors of multiple cell death pathways initiated by photodynamic therapy.

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Buytaert E, Dewaele M, and Agostinis P

Biochimica et biophysica acta 1776(1):86-107, 2007 Sep - Who cited this? | PubMed ID: 17693025 | Fulltext

Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy.

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Kocanova S, Buytaert E, Matroule JY, Piette J, Golab J, de Witte P, and Agostinis P

Apoptosis : an international journal on programmed cell death 12(4):731-41, 2007 Apr - Who cited this? | PubMed ID: 17219054 | Fulltext

In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems.

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Crnolatac I, Huygens A, Agostinis P, Kamuhabwa AR, Maes J, van Aerschot A, and De Witte PA

International journal of oncology 30(2):319-24, 2007 Feb - Who cited this? | PubMed ID: 17203212 | Fulltext

AKT delays the early-activated apoptotic pathway in UVB-irradiated keratinocytes via BAD translocation.

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Claerhout S, Decraene D, Van Laethem A, Van Kelst S, Agostinis P, and Garmyn M

The Journal of investigative dermatology 127(2):429-38, 2007 Feb - Who cited this? | PubMed ID: 16932738 | Fulltext

Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes.

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Van Laethem A, Nys K, Van Kelst S, Claerhout S, Ichijo H, Vandenheede JR, Garmyn M, and Agostinis P

Free radical biology & medicine 41(9):1361-71, 2006 Nov 1 - Who cited this? | PubMed ID: 17023263 | Fulltext

Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy.

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Buytaert E, Callewaert G, Hendrickx N, Scorrano L, Hartmann D, Missiaen L, Vandenheede JR, Heirman I, Grooten J, and Agostinis P

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20(6):756, 2006 Apr - Who cited this? | PubMed ID: 16455754 | Fulltext

Pathways involved in sunburn cell formation: deregulation in skin cancer.

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Claerhout S, Van Laethem A, Agostinis P, and Garmyn M

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 5(2):199-207, 2006 Feb - Who cited this? | PubMed ID: 16465306 | Fulltext

Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.

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Heirman I, Ginneberge D, Brigelius-Flohé R, Hendrickx N, Agostinis P, Brouckaert P, Rottiers P, and Grooten J

Free radical biology & medicine 40(2):285-94, 2006 Jan 15 - Who cited this? | PubMed ID: 16413410 | Fulltext

Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum.

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Buytaert E, Callewaert G, Vandenheede JR, and Agostinis P

Autophagy 2(3):238-40, 2006 - Who cited this? | PubMed ID: 16874066 | Fulltext

New strategies of photoprotection.

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Verschooten L, Claerhout S, Van Laethem A, Agostinis P, and Garmyn M

Photochemistry and photobiology 82(4):1016-23, 2006 - Who cited this? | PubMed ID: 16709145 | Fulltext

Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy.

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Hendrickx N, Dewaele M, Buytaert E, Marsboom G, Janssens S, Van Boven M, Vandenheede JR, de Witte P, and Agostinis P

Biochemical and biophysical research communications 337(3):928-35, 2005 Nov 25 - Who cited this? | PubMed ID: 16214108 | Fulltext

The sunburn cell: regulation of death and survival of the keratinocyte.

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Van Laethem A, Claerhout S, Garmyn M, and Agostinis P

The international journal of biochemistry & cell biology 37(8):1547-53, 2005 Aug - Who cited this? | PubMed ID: 15896663 | Fulltext

Ultraviolet radiation-induced apoptosis in keratinocytes: on the role of cytosolic factors.

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Assefa Z, Van Laethem A, Garmyn M, and Agostinis P

Biochimica et biophysica acta 1755(2):90-106, 2005 Jul 25 - Who cited this? | PubMed ID: 15964692 | Fulltext

Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation.

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Huygens A, Kamuhabwa AR, Van Laethem A, Roskams T, Van Cleynenbreugel B, Van Poppel H, Agostinis P, and De Witte PA

International journal of oncology 26(6):1691-7, 2005 Jun - Who cited this? | PubMed ID: 15870887 | Fulltext

Elucidation of the tumoritropic principle of hypericin.

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Van de Putte M, Roskams T, Vandenheede JR, Agostinis P, and de Witte PA

British journal of cancer 92(8):1406-13, 2005 Apr 25 - Who cited this? | PubMed ID: 15812555 | Fulltext

Distinct transduction mechanisms of cyclooxygenase 2 gene activation in tumour cells after photodynamic therapy.

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Volanti C, Hendrickx N, Van Lint J, Matroule JY, Agostinis P, and Piette J

Oncogene 24(18):2981-91, 2005 Apr 21 - Who cited this? | PubMed ID: 15735712 | Fulltext

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes.

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Van Laethem A, Van Kelst S, Lippens S, Declercq W, Vandenabeele P, Janssens S, Vandenheede JR, Garmyn M, and Agostinis P

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18(15):1946-8, 2004 Dec - Who cited this? | PubMed ID: 15388671 | Fulltext

Regulatory pathways in photodynamic therapy induced apoptosis.

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Agostinis P, Buytaert E, Breyssens H, and Hendrickx N

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 3(8):721-9, 2004 Aug - Who cited this? | PubMed ID: 15295626 | Fulltext

Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder.

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Kamuhabwa A, Agostinis P, Ahmed B, Landuyt W, van Cleynenbreugel B, van Poppel H, and de Witte P

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 3(8):772-80, 2004 Aug - Who cited this? | PubMed ID: 15295634 | Fulltext

AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway.

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Decraene D, Van Laethem A, Agostinis P, De Peuter L, Degreef H, Bouillon R, and Garmyn M

The Journal of investigative dermatology 123(1):207-12, 2004 Jul - Who cited this? | PubMed ID: 15191562 | Fulltext

Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.

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Hendrickx N, Volanti C, Moens U, Seternes OM, de Witte P, Vandenheede JR, Piette J, and Agostinis P

The Journal of biological chemistry 278(52):52231-9, 2003 Dec 26 - Who cited this? | PubMed ID: 14557269 | Fulltext

Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers.

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Piette J, Volanti C, Vantieghem A, Matroule JY, Habraken Y, and Agostinis P

Biochemical pharmacology 66(8):1651-9, 2003 Oct 15 - Who cited this? | PubMed ID: 14555246 | Fulltext

Ultraviolet B radiation-induced apoptosis in human keratinocytes: cytosolic activation of procaspase-8 and the role of Bcl-2.

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Assefa Z, Garmyn M, Vantieghem A, Declercq W, Vandenabeele P, Vandenheede JR, and Agostinis P

FEBS letters 540(1-3):125-32, 2003 Apr 10 - Who cited this? | PubMed ID: 12681495 | Fulltext

Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis.

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Vantieghem A, Xu Y, Assefa Z, Piette J, Vandenheede JR, Merlevede W, De Witte PA, and Agostinis P

The Journal of biological chemistry 277(40):37718-31, 2002 Oct 4 - Who cited this? | PubMed ID: 12101183 | Fulltext

Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes.

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Decraene D, Agostinis P, Bouillon R, Degreef H, and Garmyn M

The Journal of biological chemistry 277(36):32587-95, 2002 Sep 6 - Who cited this? | PubMed ID: 12070137 | Fulltext

Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.

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Chen B, Roskams T, Xu Y, Agostinis P, and de Witte PA

International journal of cancer. Journal international du cancer 98(2):284-90, 2002 Mar 10 - Who cited this? | PubMed ID: 11857421 | Fulltext

Hypericin in cancer treatment: more light on the way.

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Agostinis P, Vantieghem A, Merlevede W, and de Witte PA

The international journal of biochemistry & cell biology 34(3):221-41, 2002 Mar - Who cited this? | PubMed ID: 11849990 | Fulltext

Acute response of human skin to solar radiation: regulation and function of the p53 protein.

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Decraene D, Agostinis P, Pupe A, de Haes P, and Garmyn M

Journal of photochemistry and photobiology. B, Biology 63(1-3):78-83, 2001 Oct - Who cited this? | PubMed ID: 11684454 | Fulltext

Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells.

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Kamuhabwa AR, Agostinis PM, D'Hallewin MA, Baert L, and de Witte PA

Photochemistry and photobiology 74(2):126-32, 2001 Aug - Who cited this? | PubMed ID: 11547545 | Fulltext

Different pathways mediate cytochrome c release after photodynamic therapy with hypericin.

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Vantieghem A, Xu Y, Declercq W, Vandenabeele P, Denecker G, Vandenheede JR, Merlevede W, de Witte PA, and Agostinis P

Photochemistry and photobiology 74(2):133-42, 2001 Aug - Who cited this? | PubMed ID: 11547546 | Fulltext

In vitro photobiological evaluation of Rhodac, a new rhodacyanine photosensitizer.

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Delaey EM, Vantieghem AM, Derycke A, Agostinis PM, and de Witte PA

Photochemistry and photobiology 74(2):331-8, 2001 Aug - Who cited this? | PubMed ID: 11547573 | Fulltext

Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model.

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Chen B, Xu Y, Roskams T, Delaey E, Agostinis P, Vandenheede JR, and de Witte P

International journal of cancer. Journal international du cancer 93(2):275-82, 2001 Jul 15 - Who cited this? | PubMed ID: 11410877 | Fulltext

Synergistic effect of photodynamic therapy with hypericin in combination with hyperthermia on loss of clonogenicity of RIF-1 cells.

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Chen B, Xu Y, Agostinis P, and De Witte PA

International journal of oncology 18(6):1279-85, 2001 Jun - Who cited this? | PubMed ID: 11351263 | Fulltext

p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis.

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Assefa Z, Vantieghem A, Garmyn M, Declercq W, Vandenabeele P, Vandenheede JR, Bouillon R, Merlevede W, and Agostinis P

The Journal of biological chemistry 275(28):21416-21, 2000 Jul 14 - Who cited this? | PubMed ID: 10748072 | Fulltext

Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin.

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Agostinis P, Assefa Z, Vantieghem A, Vandenheede JR, Merlevede W, and De Witte P

Advances in enzyme regulation 40:157-82, 2000 - Who cited this? | PubMed ID: 10828351 | Fulltext

Photodynamic activity of hypericin in human urinary bladder carcinoma cells.

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Kamuhabwa AR, Agostinis P, D'Hallewin MA, Kasran A, and de Witte PA

Anticancer research 20(4):2579-84, 2000 - Who cited this? | PubMed ID: 10953329 | Fulltext

JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor.

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Assefa Z, Valius M, Vántus T, Agostinis P, Merlevede W, and Vandenheede JR

Biochemical and biophysical research communications 261(3):641-5, 1999 Aug 11 - Who cited this? | PubMed ID: 10441479 | Fulltext

Confluence dependent resistance to photo-activated hypericin in HeLa cells.

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Delaey EM, Vandenbogaerde AL, Agostinis P, and De Witte PA

International journal of oncology 14(4):759-63, 1999 Apr - Who cited this? | PubMed ID: 10087326 | Fulltext

The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin.

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Assefa Z, Vantieghem A, Declercq W, Vandenabeele P, Vandenheede JR, Merlevede W, de Witte P, and Agostinis P

The Journal of biological chemistry 274(13):8788, 1999 Mar 26 - Who cited this? | PubMed ID: 10085120 | Fulltext

Bursting metastasis in thymic carcinoma.

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Aprile G, Agostinis P, Maurizio R, Soardo G, Pizzolitto S, and Bartoli E

Advances in clinical pathology : the official journal of Adriatic Society of Pathology 3(1-2):35-41, 1999 - Who cited this? | PubMed ID: 10655572 | Fulltext

Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.

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Vantieghem A, Assefa Z, Vandenabeele P, Declercq W, Courtois S, Vandenheede JR, Merlevede W, de Witte P, and Agostinis P

FEBS letters 440(1-2):19-24, 1998 Nov 27 - Who cited this? | PubMed ID: 9862416 | Fulltext

Differential stimulation of ERK and JNK activities by ultraviolet B irradiation and epidermal growth factor in human keratinocytes.

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Assefa Z, Garmyn M, Bouillon R, Merlevede W, Vandenheede JR, and Agostinis P

The Journal of investigative dermatology 108(6):886-91, 1997 Jun - Who cited this? | PubMed ID: 9182816 | Fulltext

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