Antimicrobial activity of stereoisomers of butane-type lignans.

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Antimicrobial activity of stereoisomers of butane-type lignans.
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The relationship between the stereochemistry and antimicrobial activity of butane-type lignans was clarified. All stereoisomers of dihydroguaiaretic acid (DGA) showed both antibacterial and antifungal activity. The (+)- and (-)-7,7'-dioxodihydroguaiaretic acid (ODGA) also showed both antibacterial and antifungal activity, while meso-ODGA did not show antibacterial activity, but showed antifungal activity. No activity of any stereoisomer of secoisolariciresinol (SECO) was apparent.
Kawaguchi Y, Yamauchi S, Masuda K, Nishiwaki H, Akiyama K, Maruyama M, Sugahara T, Kishida T, and Koba Y
Bioscience, biotechnology, and biochemistry 73(8):1806-10, 2009 Aug - Who cited this? | PubMed ID: 19661689 | Fulltext
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