A 75-year-old Japanese man was admitted to our hospital for treatment of advanced
hepatocellular carcinoma (HCC)with HCV-related
liver cirrhosis. He had been treated earlier with transarterial
chemoembolization(
TACE)in both another and our own hospital before this admission. At this time,
abdominal CT revealed multiple HCCs(maximum 4.0 cm in diameter)located in
hepatic S6, S5, and S8. An infused port system had been
subcutaneously implanted, and he was treated with
hepatic arterial infusion chemotherapy with 3 days' FPL(
5-FU at a dose of 500 mg/m2 on days 1-3 and
cisplatin(CDDP/IA call)-
Lipiodol(LPD)
suspension(10 mg/mL)at a dose of 50 mg/body on day 2) every 6-10 weeks. He was also treated with
selective TACE for HCC that was supplied by extra-hepatic
arterial branches. He had been treated with 3 courses of 3 days' FPL, and the
selective TACE, HCCs in S6, S5 and S8 disappeared completely and multiple HCCs almost entirely vanished. During the 3-day treatment with FPL, his
performance status (PS)was maintained and no severe side effects were observed. Although multiple recurrent HCC is potentially fatal and QOL is lost,
hepatic arterial infusion chemotherapy with 3 days' FPL was effective and contributed to improve the patient's prognosis and QOL.
