Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane ...

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Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
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A series of novel 2-azabicyclo[2.2.2]octane derivatives was synthesized and evaluated as long chain fatty acid elongase 6 (ELOVL6) inhibitors. Screening of our corporate chemical collections against ELOVL6 resulted in the identification of lead 1. Exploratory chemistry efforts were applied to lead 1 to identify the orally available, potent, and selective ELOVL6 inhibitor 28a.
Sasaki T, Nagase T, Takahashi T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, and Sato N
Bioorganic & medicinal chemistry 17(15):5639-47, 2009 Aug 1 - Who cited this? | PubMed ID: 19596583 | Fulltext
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