One-pot fermentation of pladienolide D by Streptomyces platens...

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One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene.
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Pladienolide D is a 16-hydroxylated derivative of pladienolide B, produced by Streptomyces platensis. To facilitate the production of pladienolide D, the gene encoding a pladienolide B 16-hydroxylase from S. bungoensis was introduced into S. platensis. The recombinant produced pladienolide D at a production level comparable to that of pladienolide B.
Machida K, Aritoku Y, and Tsuchida T
Journal of bioscience and bioengineering 107(6):596-8, 2009 Jun - Who cited this? | PubMed ID: 19447333 | Fulltext
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