Aim Our aim was to investigate the effectiveness of aminoguanidine (AMG), an inducible
nitric oxide synthase inhibitor, and
hyperbaric oxygen (HBO) treatment in an experimental
colitis model. Methods We induced
colitis in rats. In the control group, we applied 2 ml serum physiologic
intraperitoneally for 7 days. In the HBO group, 100% oxygen at 2.4 atm pressure was applied for 7 days. In the AMG group, 100 mg/kg AMG was applied
intraperitoneally for 7 days. In the HBO + AMG group, HBO and AMG were applied, respectively. At the end of 7 days, rats were sacrificed and the
distal 10 cm part of colon was examined macro- and
microscopically. Results Severity of
colitis and NO activities were reduced by AMG, HBO, and HBO + AMG application. There was
histologically significant improvement, especially in the HBO + AMG group Conclusions Both HBO and AMG were significantly effective in preventing
weight loss, reducing NO activities, and severity of
colitis, when comparing HBO and AMG separately.
