2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor ...

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2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs.
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Structure-activity relationships and efforts to optimize the pharmacokinetic profile of isosteric analogs of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among those examined, compound 25 showed potent affinity for cannabinoid receptor 1 (CB1) and receptor 2 (CB2). This compound displayed oral bioavailability and analgesic activity.
Bioorganic & medicinal chemistry letters, 2008 Oct 19 - Who cited this? | PubMed ID: 18977140 | Fulltext
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