Tetrazole based amides as growth hormone secretagogues.

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Tetrazole based amides as growth hormone secretagogues.
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A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
Li JJ, Wang H, Li J, Qu F, Swartz SG, Hernández AS, Biller SA, Robl JA, Tino JA, Slusarchyk D, Seethala R, Sleph P, Yan M, Grover G, Flynn N, Murphy BJ, 
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Bioorganic & medicinal chemistry letters 18(8):2536-9, 2008 Apr 15 - Who cited this? | PubMed ID: 18378446 | Fulltext
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