AIM: We previously reported significant
antimicrobial activity against
Gram-positive bacteria from the extract of the Atun tree (Atuna racemosa), identified through rapid digital bioprospecting of a 400-year-old historic herbal text.
Toxicity studies in
human cell lines showing safety, combined with the ethnomedical descriptions of botanical use, suggested that this extract might be clinically useful against
topical Gram-positive bacteria infections. MATERIALS AND METHODS: Using a
minimal inhibitory concentration assay, we examined the susceptibility of
methicillin-resistant Staphylococcus aureus (
MRSA) to an extract of the kernel of the Atun tree (Atuna racemosa). Additionally, a maximum tolerated
topical application of the extract was determined in a
randomized,
double-blind, placebo-controlled pilot
clinical trial. RESULTS: Here we report that the effectiveness of this Atuna racemosa extract against
MRSA (MIC=16-32mug/mL) is on par with currently available last-line
antibiotics, while it remains well tolerated in short-term
topical applications of 10 times the minimally
inhibitory concentration. CONCLUSIONS: Although further studies are needed to determine safety and clinical efficacy, this effective extract, identified in a 400-year-old historic herbal text, may prove to be clinically useful in the treatment of
MRSA.
