Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.

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Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.
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Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at a concentration of 170 microM, but inhibited 18.3% and 38.7% against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 microM.
The Journal of antibiotics 52(12):1095-100, 1999 Dec - Who cited this? | PubMed ID: 10695672 | Fulltext
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