Ketene aminal-based lactam derivatives as a novel class of orally active FXa inh...

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Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.
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N,N'-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors.
Shi Y, Zhang J, Stein PD, Shi M, O'Connor SP, Bisaha SN, Li C, Atwal KS, Bisacchi GS, Sitkoff D, Pudzianowski AT, Liu EC, Hartl KS, Seiler SM, Youssef S and Steinbacher TE, 
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Bioorganic & medicinal chemistry letters 15(24):5453-8, 2005 Dec 15 - Who cited this? | PubMed ID: 16213711 | Fulltext
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